Liver and renal function profile of mucormycosis cases receiving amphotericin B - A retrospective study by Bhoomi Bavadiya, Jugal Hiren Bhatt, Shubhangi Vishwas Deshpande, Kedar Gautambhai Mehta, Rikin Raj

“…Conclusion: Amphotericin B drug does have adverse effects on the liver and kidneys. The three consecutive RFT and LFT reports revealed liver and kidney dysfunction due to damage induced by the drug. …”
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Quetiapine Attenuates the Neuroinflammation and Executive Function Deficit in Streptozotocin-Induced Diabetic Mice by Kexin Wang, Feng Song, Hongxing Wang, Jun-hui Wang, Yu Sun

“…QTP may be a potential treatment compound to handle the memory and cognitive dysfunction in diabetic patients.…”
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Upregulated LIMD1 alleviates pressure overload-induced cardiac hypertrophy via inhibits YAP1/AKT/GSK3β signaling. by Fengwen Xie, Bin Yuan, Ye Zhang, Liru Chen, Yingmei Zhong, Quan Xu

“…Compared with wild-type (WT) mice, those injected with AAV-9-LIMD1 exhibited significantly reduced TAC-induced cardiac dysfunction, hypertrophy, and fibrosis. Mechanistically, both in vitro and in vivo experiments suggested that the beneficial effects of LIMD1 might be associated with the inhibition of the YAP1/AKT/GSK3β signaling pathway.…”
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Clinical Observation on Digital OT Cognitive Training for Decreased Attention of Stroke Patients by Chunhua LU, Kai WANG, Zhen ZENG, Zhenghao WU, Wen HE, Xiating WEI

“…Objective:To explore the effect of digital OT cognitive training on attention and activities of daily living of stroke patients with decreased attention.Methods:50 patients with post-stroke attention dysfunction were randomly assigned to the observation group (<italic>n</italic>=24) and control group (<italic>n</italic>=26). …”
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Upstream therapy of reperfusion disorders of hemodynamics, rhythm and conduction in patients with acute myocardial infarction with diabetes mellitus and metabolic syndrome (second... by M.I. Shved, I.O. Yastremska, R.M. Ovsiychuk, L.P. Martyniuk, O.A. Prokopovych, Ya.M. Kitsak

“…There is a lack of scientific data on the me­chanisms of influence of type 2 diabetes mellitus (T2DM) and meta­bolic syndrome (MS) on the incidence of complications in patients with myocardial infarction; no effective methods of their correction have been developed. …”
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Investigation of potential protein biomarkers for the screening of placental-mediated fetal growth restriction disorders using targeted proteomics Olink technology by Xinyao Zhou, Wuqian Wang, Wuqian Wang, Luan Chen, Yingjun Yang, Xing Wei, Jia Zhou, Kuan Sun, Ping Tang, Xiaofang Sun, Shengying Qin, Luming Sun, Luming Sun

“…Enrichment analyses revealed that several pathways, including placental dysfunction, inflammatory responses, and oxidative stress, may play crucial roles in FGR pathophysiology. …”
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Deep learning radiomics of elastography for diagnosing compensated advanced chronic liver disease: an international multicenter study by Xue Lu, Haoyan Zhang, Hidekatsu Kuroda, Matteo Garcovich, Victor de Ledinghen, Ivica Grgurević, Runze Linghu, Hong Ding, Jiandong Chang, Min Wu, Cheng Feng, Xinping Ren, Changzhu Liu, Tao Song, Fankun Meng, Yao Zhang, Ye Fang, Sumei Ma, Jinfen Wang, Xiaolong Qi, Jie Tian, Xin Yang, Jie Ren, Ping Liang, Kun Wang

“…Abstract Accurate, noninvasive diagnosis of compensated advanced chronic liver disease (cACLD) is essential for effective clinical management but remains challenging. …”
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Small extracellular vesicles from human umbilical cord mesenchymal stem cells delivering miR-202-5p alleviate renal ischemia-reperfusion injury by targeting the GOLIM4/PI3K/AKT axi... by Xiang Peng, Xiang Peng, Wei Shi, Wei Shi, Haitao Yu, Haitao Yu, Zhenwei Feng, Zhenwei Feng, Zongjie Wei, Weiyang He, Xin Gou, Yongpeng Xie, Yongpeng Xie

“…BackgroundIschemia–reperfusion injury (IRI) is a leading contributor to acute kidney injury (AKI), resulting in severe renal dysfunction and increased mortality. Despite progress in medical research, effective therapies for IRI remain limited. …”
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Blocking ITGA5 potentiates the efficacy of anti‐PD‐1 therapy on glioblastoma by remodeling tumor‐associated macrophages by Rongrong Zhao, Ziwen Pan, Jiawei Qiu, Boyan Li, Yanhua Qi, Zijie Gao, Wei Qiu, Weijie Tang, Xiaofan Guo, Lin Deng, Gang Li, Hao Xue

“…Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM. This study aimed to dissect the molecular mechanisms of specific immunosuppressive subpopulations to drive anti‐PD‐1 resistance in GBM. …”
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Advances in the treatment of lower-extremity ischemia-reperfusion injury by Jin Peng, Jin Peng, Jin Peng, Tang Deng, Tang Deng, Xunkai Wang, Xunkai Wang, Xunkai Wang, Jinxi Liang, Jiangpeng Wu, Jiangpeng Wu, Jiangpeng Wu, Binglong Li, Binglong Li, Binglong Li, Jun Lv, Jun Lv, Jun Lv, Shenmei Wu, Shenmei Wu, Shenmei Wu, Shijie Zhong, Shijie Zhong, Shijie Zhong, Chen Yao, Guiyun Jin, Guiyun Jin, Guiyun Jin

“…Despite its clinical significance, the mechanisms underlying IRI remain poorly understood, and no specific targeted drugs or effective emergency interventions are currently available. …”
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Dihydromyricetin protects against cisplatin-induced renal injury and mitochondria-mediated apoptosis via the EGFR/HSP27/STAT3 signaling pathway by Zheming Xu, Minjing Zhang, Xue Zhang, Huirong Han, Weifeng Ye, Zhenjie Chen, Zhisu Lv, Yang Liu, Zhengye Liu, Jianguang Gong, Bin Zhu, Suhan Zhou, Runzhi Zhu, Chang Tao, Gensheng Zhang, Xiang Yan

“…Background Cisplatin (CP) has been used as an effective chemotherapy drug for different types of cancers. …”
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Meningococcal infection in children in the period 2012–2021. Main results of a retrospective multicenter study, issues of the day by A. A. Vilnits, Yu. V. Lobzin, N. V. Skripchenko, L. N. Mazankova, O. I. Klimova, A. Yu. Rtishchev, I. M. Osmanov, K. V. Markova, N. H. Tkhakushinova, G. P. Martinova, A. U. Sabitov, R. K. Babik, I. Ya. Izvekova, V. V. Krasnov, E. V. Sidorenkova, O. V. Borisova, N. M. Bochkareva, O. V. Samodova, V. V. Sokolovskaya, A. A. Girina, A. Yu. Kurganskaya, E. M. Simovanyan, M. A. Kim, O. A. Rychkova, L. V. Khanipova, S. G. Grigorev

“…Considering the epidemiological features of meningococcal infection – the risk of a sharp increase in morbidity in short periods of time, the life-threatening nature of the disease itself, it is necessary to remain alert to these risks and take all possible measures to prevent the disease using all available means, the most effective of which is vaccine prevention.…”
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PERINATAL ASPECTS OF DELIVERY OF WOMEN WITH OBESITY AND GESTATIONAL DIABETES by О. Железняков, В. Лазуренко, І. Васильєва, Т. Фролова, Р. Сафонов, О. Лященко, О. Овчаренко

“…Doppler examination of the hemodynamics of the fetoplacental complex in pregnant women revealed signs of uteroplacental and fetoplacental circulation disorders in 5 (15.5%) obese pregnant women, in 8 (22.9%) women with combined pathology (GDM in the setting of obesity), in 4 (10.5%) women with GDM, which was considered as placental dysfunction. Fetal anomalies according to CTG with STV (short-term variation) were observed in 6 (18.2%) obese pregnant women, 5 (15.2%) women with obesity, and 4 (10.5%) women with GDM. …”
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L-carnitine ameliorates myocardial injury by alleviating endoplasmic reticulum stress via inhibition of PERK pathway in exertional heatstroke rats by Bo-Yi Zhang, Gen-Lin He, Ze-Ze Wang, Huan Zhou, Xue-Yan Huang, Ting-Ting Shen, Xiao-Qian Liu, Yi-Shan Liu, Zhen Luo, Ping Li, Yu-Long Tan, Xue Luo, Xue-Sen Yang

“…Here, we found that LC exerted a greater protective effect on EHS-induced cardiac dysfunction and mortality, which also significantly attenuated certain negative effects, including increased myocardial apoptosis, pathological changes, and ultrastructural impairment, enhanced activity levels of such serum enzymes as AST, LDH, CK, and CK-MB, reduced BCL-2 expression, increased the expression of cleaved caspase-3 and the critical endoplasmic reticulum stress (ERS) indices like CHOP and GRP78 in EHS rats. …”
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Mesenchymal stem cells derived from hPSC via neural crest attenuate chemotherapy-induced premature ovarian insufficiency by ameliorating apoptosis and oxidative stress in granulosa... by Xinran Li, Jinrong Liao, Youhong Zheng, Wei Cai, Jie Chen, Yu Liang, Yuanmei Chen, Xiaoxuan Li, Jiamao Luo, Jiaxin Xie, Manping Zhou, Lilin Hang, Xiujuan Sun, Xin Yue, Xuefeng Wang, Yifeng Wang, Huiyan Wang

“…The underlying mechanisms are likely associated with paracrine-mediated effects on GC apoptosis, oxidative stress, and mitochondrial dysfunction.…”
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Performing the HINTS-exam using a mixed-reality head-mounted display in patients with acute vestibular syndrome: a feasibility study by Nadia Sadok, Gijs Luijten, Gijs Luijten, Gijs Luijten, Fin H. Bahnsen, Christina Gsaxner, Lorenz Peters, Theda Eichler, Theresa Rombach, Stephan Lang, Sameh Khattab, Jens Kleesiek, Jens Kleesiek, Jens Kleesiek, Jens Kleesiek, Jens Kleesiek, Dagny Holle, Moritz Meyer, Jan Egger, Jan Egger, Jan Egger, Jan Egger, Jan Egger

“…The eye-tracking technology determined gaze direction and position, while the internal measurement unit and gyroscope recorded head movements in terms of position and velocity.ResultsThe MR-OST-HMD detected abnormal eye movements, including nystagmus, saccades, and skew deviation effectively. The device proved effective even for patients with severe nausea and elderly participants, who completed the eye calibration and HINTS-Exam without difficulty. …”
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First Russian experience in liver and kidney transplantation from donors with out-of-hospital cardiac arrest: 3 years’ results by O. N. Reznik, A. E. Skvortsov, V. S. Daineko, I. V. Loginov, A. A. Kutenkov, S. S. Komedev, V. M. Teplov, D. O. Kuzmin, A. N. Ananiev, I. V. Uliankina, D. V. Gogolev, A. A. Kukushkin, M. E. Malyshev, A. A. Boykov, V. E. Savello, A. N. Morozov, S. F. Bagnenko

“…In 1 (20%) case, there was severe liver allograft dysfunction for 33 days with subsequent complete restoration of function. …”
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A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID by Stefanie M. Bader, Dale J. Calleja, Shane M. Devine, Nathan W. Kuchel, Bernadine G. C. Lu, Xinyu Wu, Richard W. Birkinshaw, Reet Bhandari, Katie Loi, Rohan Volpe, Yelena Khakham, Amanda E. Au, Timothy R. Blackmore, Liana Mackiewicz, Merle Dayton, Jan Schaefer, Lena Scherer, Angus T. Stock, James P. Cooney, Kael Schoffer, Ana Maluenda, Elizabeth A. Kleeman, Kathryn C. Davidson, Cody C. Allison, Gregor Ebert, Gong Chen, Kasiram Katneni, Theresa A. Klemm, Ueli Nachbur, Smitha Rose Georgy, Peter E. Czabotar, Anthony J. Hannan, Tracy L. Putoczki, Maria Tanzer, Marc Pellegrini, Bernhard C. Lechtenberg, Susan A. Charman, Melissa J. Call, Jeffrey P. Mitchell, Kym N. Lowes, Guillaume Lessene, Marcel Doerflinger, David Komander

“…Our lead compound offers protection against a range of PASC symptoms in this model, prevents lung pathology and reduces brain dysfunction. This provides proof-of-principle that PLpro inhibition may have clinical relevance for PASC prevention and treatment going forward.…”
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Association of fetal growth trajectory with mitochondrial DNA copy number in the cord blood of newborns: evidence from a birth cohort by Kai Chen, Kai Chen, Junwei Li, Luli Xu, Xiaoxuan Fan, Zhongqiang Cao, Lulu Song, Youjie Wang, Youjie Wang, Chao Xiong, Chao Xiong, Aifen Zhou, Aifen Zhou

“…ObjectiveMitochondrial DNA copy number (mtDNAcn), an indicator of mitochondrial damage and dysfunction, is widely used in research related to growth and metabolic health. …”
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Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism by Manhang Hu, Xiaolu Hua, Xiaolu Hua, Wei Xiong, Enhui Zheng, Xingyue Yang, Yu Lu, Bing He, Xiaolin Zhong, Zongzhe Jiang, Qingbi Zhang, Qingbi Zhang, Yan Liu

“…IntroductionCholestatic liver injury (CLI) is a liver dysfunction closely associated with oxidative stress and bile acid (BA) metabolic disorders, but effective therapies are lacking.The use of ursolic acid (UA) and α-Tocopherol succinate (VES) together for treating CLI is promising due to their respective effects on regulating bile acid metabolism and providing antioxidant activity.MethodsIn this study, we synthesized drug-drug nanocrystals (UA-NSps) composed of UA and VES to treat CLI and evaluated their synergistic therapeutic effects by regulating bile acid metabolism and inhibiting oxidative stress in ANIT-induced CLI mice.Results and discussionOur investigation demonstrated that UA-NSps exhibited high drug-loading capacity, spherical morphology, and improved dissolution and oral bioavailability. …”
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