TLR4 Enhances Cerebral Ischemia/Reperfusion Injury via Regulating NLRP3 Inflammasome and Autophagy by Li Mao, Da-Hua Wu, Guo-Huang Hu, Jian-Hu Fan

“…The present study characterizes the effects of TLR4 activation on inflammation and autophagy in CI/R injury. …”
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Safety and Efficacy Endpoints for Mesenchymal Stromal Cell Therapy in Renal Transplant Recipients by J. R. Bank, T. J. Rabelink, J. W. de Fijter, M. E. J. Reinders

“…It has become evident that a combination of sustained alloreactivity and calcineurin-inhibitor- (CNI-) related nephrotoxicity results in fibrosis and consequently dysfunction of the graft. New immunosuppressive regimens that can minimize or eliminate side effects, while maintaining efficacy, are required to improve long-term graft survival. …”
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Gut Akkermansia enhances liver protection and facilitates copper removal during D-penicillamine treatment in a Wilson’s disease model by Xi Huang, Yanqi Jin, Tianyuan Wang, Danting Fu, Jindi Ma, Xiaopeng Yu, Yingfeng Lu, Jingyuan Song, Yu Chen, Ren Yan, Yimin Zhang

“…The findings demonstrated that the presence of Akkermansia significantly enhances the efficacy of DPA, leading to a more efficient elimination of copper from tissues and a greater improvement in liver injury, liver dysfunction, and gut dysbiosis. In contrast, Butyricimonas has an antagonistic effect. …”
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Managing adherence, exposure, and toxicity in oral anticancer therapies by Kazuo Kobayashi

“…Abstract The management of adherence, exposure risk, and adverse effects in oral anticancer agents (OAAs) is essential for optimizing patient outcomes in oncology pharmacy. …”
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Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic–reperfusion injury by targeting the NOX2/AMPK pathway by Yuqiong Chen, Bo Guan, Jian Lu, Xiaopei Yan, Chao Huang, Yuli Qiu, Xinyan Li, Xiangyu Sun, Lin Chen, Wei Li, Wenjun Mao, Zhongqi Sun, Bin Xu, Su Li, Chao Chen, Chao Chen

“…Moreover, NOX2 promoted mitochondrial dysfunction by suppressing the AMP-activated protein kinase (AMPK)–PGC-1α–Sirt3 signaling pathway. …”
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Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice by Siyuan Sun, Yuanqi Liu, Jiping Sun, Bingxin Zan, Yiwen Cui, Anting Jin, Hongyuan Xu, Xiangru Huang, Yanfei Zhu, Yiling Yang, Xin Gao, Tingwei Lu, Xinyu Wang, Jingyi Liu, Li Mei, Lei Shen, Qinggang Dai, Lingyong Jiang

“…RA can relieve osteopetrosis symptoms in some animal models, while its effect on bone health is still controversial and the underlying mechanisms remain unclear. …”
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Application and Suggestions of Morpholine Ring as a Lysosome Targeting Group by Xuelian Liu, Ximeng Zhang, Yinghong Han, Xingrui Li, Jinyao Li

“…Lysosomes are widely present in eukaryotic cells and play an extremely important role in cell growth and development, and their dysfunction is closely related to a variety of diseases. …”
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Chronic NaHS Treatment Is Vasoprotective in High-Fat-Fed ApoE−/− Mice by Asha Ford, Mohammad Al-Magableh, Tracey A. Gaspari, Joanne L. Hart

“…Hydrogen sulfide is emerging as an important mediator of vascular function that has antioxidant and cytoprotective effects. The aim of this study was to investigate the role of endogenous H2S and the effect of chronic exogenous H2S treatment on vascular function during the progression of atherosclerotic disease. …”
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Evaluation of Change in Center of Pressure During Perturbation of Balance Including Blindfolding in Healthy Dogs by Hayley Hall, Richard B. Evans, Makayla Balogh, Wanda J. Gordon-Evans

“…Physiotherapy aims to improve postural dysfunction, often using balance exercises. The effects of rehabilitation-based balance exercises on postural control in dogs remains understudied. …”
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The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila. by Jenna M Gregory, Teresa P Barros, Sarah Meehan, Christopher M Dobson, Leila M Luheshi

“…We have investigated this relationship in the present study by probing the effect of altering TDP-43 aggregation behaviour in vivo by modulating the levels of molecular chaperones in a Drosophila model. …”
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The Impact of Micro-Nanoplastics on Mitochondria in the Context of Diet and Diet-Related Diseases by Mónica G. Silva, Maria Manuel Oliveira, Francisco Peixoto

“…Some studies have identified mitochondrial dysfunction as a potential underlying mechanism driving these effects. …”
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Precision therapy targeting CAMK2 to overcome resistance to EGFR inhibitors in FAT1-mutated oral squamous cell carcinoma by Yumeng Lin, Yibo Huang, Bowen Yang, You Zhang, Ning Ji, Jing Li, Yu Zhou, Ying-Qiang Shen, Qianming Chen, Xiangxiang Pan

“…Moreover, we analyzed mitochondrial dysfunction. Besides, the effects of combination therapy on mitochondrial dynamics were also evaluated. …”
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Role of Achyranthes aspera in neurodegenerative diseases: current evidence and future directions by Huaiqing Luo, Huaiqing Luo, Siwen Wei, Shujun Fu, Shujun Fu, Li Han

“…Furthermore, the neuroprotective effects of Achyranthes aspera have been confirmed by numerous scientific studies. …”
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Emerging insights into the gut microbiota as a key regulator of immunity and response to immunotherapy in hepatocellular carcinoma by Siqi Ren, Yinping Zhang, Xingyue Wang, Jiahong Su, Xiang Wang, Zijun Yuan, Xinyu He, Sipeng Guo, Yu Chen, Yu Chen, Yu Chen, Shuai Deng, Shuai Deng, Shuai Deng, Xu Wu, Xu Wu, Xu Wu, Mingxing Li, Mingxing Li, Mingxing Li, Fukuan Du, Fukuan Du, Fukuan Du, Yueshui Zhao, Yueshui Zhao, Yueshui Zhao, Jing Shen, Jing Shen, Jing Shen, Wei Hu, Xiaobing Li, Zhangang Xiao, Zhangang Xiao, Zhangang Xiao, Zhangang Xiao, Zhangang Xiao

“…Numerous studies have underscored its role in the onset and progression of liver disorders, including alcoholic liver disease, metabolic dysfunction-associated steatotic liver disease (MASLD), metabolic dysfunction-associated steatohepatitis (MASH), liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). …”
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Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2 by Tianwei Guo, Hongyue Wang, Fujian Wu, Wenjing Lu, Min Zhu, Shuhong Ma, Yongshuai Zhang, Yuting Yan, Meng Zhou, Didaer Talanaite, Siyu Liu, Man Qi, Feng Lan, Xujie Liu

“…Wild-type JPH2 was overexpressed through lentiviral transfection to evaluate rescue effects, and two JPH2 variants—one benign (G505S) and one pathogenic (E85K)—were introduced to study mutation-specific effects. …”
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Pharmacological Inhibition of Microglial Proliferation Supports Blood–Brain Barrier Integrity in Experimental Autoimmune Encephalomyelitis by Nozha Borjini, Mercedes Fernandez, Luciana Giardino, Lydia Sorokin, Laura Calzà

“…Blood–brain barrier dysfunction (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). …”
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Exploring the Potential of Ribes nigrum L., Aronia melanocarpa (Michx.) Elliott, and Sambucus nigra L. Fruit Polyphenol-Rich Composition and Metformin Synergy in Type 2 Diabetes Ma... by Katarzyna Zima, Barbara Khaidakov, Laura Banaszkiewicz, Krzysztof Lemke, Paulina Karolina Kowalczyk

“…Although metformin is generally well-tolerated, it may cause gastrointestinal adverse effects and, in rare cases, precipitate lactic acidosis, necessitating cautious use in individuals with renal dysfunction. …”
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N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells. by Arwa Alnahdi, Annie John, Haider Raza

“…Elevated levels of glucose and fatty acids are the main characteristics of diabetes, obesity and other metabolic disorders, associated with increased oxidative stress, mitochondrial dysfunction and inflammation. Once the primary pathogenesis of diabetes is established, which is potentially linked to both genetic and environmental factors, hyperglycemia and hyperlipidemia exert further destructive and/or toxic effects on β-cells. …”
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Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function by Fengzhi Yu, Dandan Jia, Ru Wang

“…It is well established that moderate exercise has a beneficial effect on the regulation of arterial function. This study examines the effect of exercise on proton concentrations in the microenvironment of the organism and its influence on proton-sensing G protein-coupled receptors located on cell membranes, as well as possible mechanisms involved in the regulation of arterial function. …”
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The impact of desflurane and sevoflurane on the intraoperative and early postoperative period in liver transplantation by S. V. Zhuravel, N. K. Kuznetsova, V. E. Aleksandrova, I. I. Goncharova

“…It is important to understand the effects of desflurane and sevoflurane on the severity of ischemia-reperfusion injury of the liver graftAim. …”
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