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  1. 5681

    Left Bundle Branch Pacing in a Patient With Dextroposed Heart: A Case Report by Dilip Kumar, Amit Malviya, Rabin Chakraborty, Ashesh Halder, Subhro Sekhar Chakraborty, Anand Kumar Pandey, Pinak Pani Das, Rinchin Dorjee Meegeji

    Published 2025-04-01
    “…ABSTRACT The Right Ventricular (RV) apex has been the standard site for pacing in symptomatic bradyarrhythmias, but chronic RV pacing can cause adverse effects such as atrial arrhythmias and left ventricular dysfunction. …”
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  2. 5682

    COMPENSATORY-ADAPTIVE MECHANISMS OF CHANGES IN THE ENDOTHELIAL SYSTEM IN MINERS OF KUZBASS (CLINICAL AND MORPHOLOGICAL ASPECTS) by Сергей Людовикович Кан, Олег Иванович Бондарев, Андрей Александрович Косовских, Константин Владимирович Лукашев, Олеся Сергеевна Золоева, Александр Владимирович Екимовских, Тамара Ивановна Борщикова, Денис Николаевич Макаров

    Published 2022-08-01
    “…The severity of systemic lesions with pathomorphological changes in the hemodynamic system were characteristic of many internal organs and depended on the length of work experience. Endothelial dysfunction was manifested by pronounced and progressive fibroplastic processes in the internal organs leading to functional and then structural changes. …”
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  3. 5683

    The Impact of Obesity on Cardiovascular Diseases: Heart Failure by Hatem Alansari, Gina Lazzara, Mohamad B. Taha, Janardhana R. Gorthi

    Published 2025-02-01
    “…Obesity alters cardiac structure and function, leading to ventricular systolic and diastolic dysfunction. However, weight loss interventions, whether through lifestyle changes, pharmacological agents, or bariatric surgery, can improve cardiac function, reduce symptoms, and lower hospitalization rates. …”
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    Article
  4. 5684

    Chemerin as a Driver of Cardiovascular Diseases: New Perspectives and Future Directions by Anna M. Imiela, Jan Stępnicki, Patrycja Sandra Zawadzka, Angelika Bursa, Piotr Pruszczyk

    Published 2025-06-01
    “…Adipokines—hormones produced by adipose tissue—exert diverse endocrine and immunomodulatory effects. Among them, chemerin, discovered in the early 20th century, is a chemotactic molecule that recruits dendritic cells, endothelial cells, macrophages, and lymphocytes during early immune responses. …”
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    Article
  5. 5685

    Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome by Jiao He, Qing Tang, Yan-Cun Liu, Li-Jun Wang, Yan-Fen Chai

    Published 2025-06-01
    “…Our review summarizes the toxic effects of DQ on the intestinal barrier integrity, gut microbiome, and microbial metabolites (e.g., short-chain fatty acids [SCFAs], bile acids). …”
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  6. 5686

    Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer’s disease by Hongli Chen, Na Li, Na Liu, Hongyu Zhu, Chunyan Ma, Yutong Ye, Xinyu Shi, Guoshuai Luo, Xiaoxi Dong, Tao Tan, Xunbin Wei, Huijuan Yin

    Published 2025-04-01
    “…Although PBM has been employed in the treatment of AD, the effect and precise mechanism of PBM on AD-induced neurological damage are still unclear. …”
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    Article
  7. 5687

    Efficacy of intra-articular injections for the treatment of osteoarthritis: A narrative review by Sam Si-Hyeong Park, Biao Li, Christopher Kim

    Published 2025-06-01
    “…Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive cartilage loss, inflammation, and joint dysfunction. With profound effects on joint function and quality of life, OA imposes a substantial socio-economic burden. …”
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    Article
  8. 5688

    The Role of IL-33 in Experimental Heart Transplantation by Jie Chen, Yan He, Zhongming Xie, Yingying Wei, Lihua Duan

    Published 2020-01-01
    “…Under conditions of cell injury or death, IL-33 is passively released from the nucleus and acts as an “alarmin” upon binding to its specific receptor ST2, which leads to proinflammatory or anti-inflammatory effects depending on the pathological environment. …”
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    Article
  9. 5689

    Control of Mitochondrial Quality: A Promising Target for Diabetic Kidney Disease Treatment by Qi Li, Jin Shang, Reiko Inagi

    Published 2025-04-01
    “…Mitochondrial-targeted drugs show potential; however, challenges remain because of adverse effects and unclear mechanisms. Future research should aim to comprehensively explore therapeutic potential of MQC in DKD. …”
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    Article
  10. 5690

    Myonectin and metabolic health: a systematic review by Jorge L. Petro, Jorge L. Petro, Jaime Gallo-Villegas, Jaime Gallo-Villegas, Juan C. Calderón

    Published 2025-07-01
    “…This is a bibliometric and bioinformatics-complemented systematic review aimed to comprehensively analyze the structure, regulation and effects of myonectin on metabolic outcomes relevant to the pathophysiology of chronic metabolic diseases. …”
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    Article
  11. 5691

    Application of magnesium and its compounds in biomaterials for nerve injury repair by Kong Weijian, Hao Tingting, Xiong Xiaoliang, Shi Xue, Zhang Haijing, Zhao Yinlong

    Published 2025-07-01
    “…Neural injuries, including peripheral nerve injury and spinal cord injury, are prevalent clinical conditions that can lead to significant sensory and motor dysfunction. Due to the limited regenerative capacity of neural tissues, current treatment methods often yield unsatisfactory outcomes. …”
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    Article
  12. 5692

    Pathogenicity of Arcobacter cryaerophilus in two human intestinal cell lines by Antonia Bachus, Sarah Beyer, Roland Bücker, Soroush Sharbati, Thomas Alter, Greta Gölz

    Published 2025-06-01
    “…As structural factors correlate with the barrier dysfunction, immunofluorescence staining of the tight junction domain was performed, and revealed an altered distribution of claudin-5 in infected cells. …”
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    Article
  13. 5693

    Integrated multi-omics profiling to establish an IGFBP-based prognostic score for pancreatic ductal adenocarcinoma: unraveling prognostic biomarkers, immune microenvironment crosst... by Xiao Guan, Yongrun Mu, Xin Jin, Chengfeng Wang

    Published 2025-05-01
    “…BackgroundPancreatic ductal adenocarcinoma (PDAC) is accompanied by endocrine dysfunction, particularly involving dysregulation of the insulin and insulin-like growth factor (IGF) signaling pathways. …”
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  14. 5694

    Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer’s disease by Simone M. Crivelli, Aisylu Gaifullina, Jean-Yves Chatton

    Published 2024-09-01
    “…Few studies modulating the expression of UCP4 in astrocytes or neurons have highlighted protective effects against neurodegeneration and aging, suggesting that pharmacological strategies aimed at activating UCPs, such as protonophoric uncouplers, hold promise for therapeutic interventions in AD and other neurodegenerative diseases. …”
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    Article
  15. 5695

    Influence of Residential Area on Social Media Usage and Sleep Problems among Young Adults by Thongam Victory Khanganbi, M. Priya

    Published 2025-01-01
    “…Introduction: Extensive use of social media has been linked to reduced sleep quality, daily dysfunction, sleep disorders, and depression. A study emphasized the notable effects of engaging with social media at night and emotionally investing in it, particularly affecting young adults’ sleep and general well-being. …”
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  16. 5696

    Microcirculation and cardiovascular risk: Diagnostic value and clinical relevance by Mariana Bacelova, Julia Nikolova, Adolf Alakidi, Valentina Petkova, Vanina Mihaylova, Ivica Dimov, Radka Tafradzhiyska-Hadjiolova, Tsvetanka Dzhiganska, Rene Mileva-Popova, Anelia Bivolarska

    Published 2025-05-01
    “…Microcirculatory endothelial dysfunction plays a central role in the pathogenesis and progression of the disease, contributing to the development of organ complications. …”
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  17. 5697

    Surgery impairs glymphatic activity and cognitive function in aged mice by Kai Chen, Xingyu Du, Melissa A. Chao, Zhongcong Xie, Guang Yang

    Published 2025-01-01
    “…Using in vivo two-photon imaging, we examined the effects of surgery (laparotomy) on glymphatic function in adult (6 months) and aged (18 months) mice 24 h post-surgery. …”
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  18. 5698

    Metallothioneins in the Pathogenesis of Liver Diseases: A Review by Anna A. Nowicka, Agnieszka Gomułkiewicz, Sylwia Serafińska, Krzysztof A. Simon, Piotr Dzięgiel

    Published 2025-01-01
    “…Reduced MTs expression is associated with disease progression in several chronic hepatic disorders. In metabolic dysfunction–associated steatotic liver disease (MASLD), MT1 downregulation has been linked to the transition from simple steatosis to steatohepatitis. …”
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    Article
  19. 5699

    Method of Analysis of the Temporomandibular Joint Parameters According to Magnetic Resonance Imaging by D. К. Yudin, S. А. Gette

    Published 2022-10-01
    “…The existing variety of approaches to the treatment of temporomandibular joint (TMJ) dysfunction corresponds to the variety of methods for its diagnosing. …”
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    Article
  20. 5700

    Synaptic plasticity in fronto-insular circuits underlying stress susceptibility and resilience by Devin Rocks, Conor Liston

    Published 2025-02-01
    “…In the short term, stress effects on neuronal activity may be adaptive, but repeated engagement of these adaptations may lead to circuit dysfunction—a phenomenon known as allostatic load. …”
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    Article