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5681
Left Bundle Branch Pacing in a Patient With Dextroposed Heart: A Case Report
Published 2025-04-01“…ABSTRACT The Right Ventricular (RV) apex has been the standard site for pacing in symptomatic bradyarrhythmias, but chronic RV pacing can cause adverse effects such as atrial arrhythmias and left ventricular dysfunction. …”
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5682
COMPENSATORY-ADAPTIVE MECHANISMS OF CHANGES IN THE ENDOTHELIAL SYSTEM IN MINERS OF KUZBASS (CLINICAL AND MORPHOLOGICAL ASPECTS)
Published 2022-08-01“…The severity of systemic lesions with pathomorphological changes in the hemodynamic system were characteristic of many internal organs and depended on the length of work experience. Endothelial dysfunction was manifested by pronounced and progressive fibroplastic processes in the internal organs leading to functional and then structural changes. …”
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5683
The Impact of Obesity on Cardiovascular Diseases: Heart Failure
Published 2025-02-01“…Obesity alters cardiac structure and function, leading to ventricular systolic and diastolic dysfunction. However, weight loss interventions, whether through lifestyle changes, pharmacological agents, or bariatric surgery, can improve cardiac function, reduce symptoms, and lower hospitalization rates. …”
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5684
Chemerin as a Driver of Cardiovascular Diseases: New Perspectives and Future Directions
Published 2025-06-01“…Adipokines—hormones produced by adipose tissue—exert diverse endocrine and immunomodulatory effects. Among them, chemerin, discovered in the early 20th century, is a chemotactic molecule that recruits dendritic cells, endothelial cells, macrophages, and lymphocytes during early immune responses. …”
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5685
Impact of Diquat on the Intestinal Health and the Composition and Function of the Gut Microbiome
Published 2025-06-01“…Our review summarizes the toxic effects of DQ on the intestinal barrier integrity, gut microbiome, and microbial metabolites (e.g., short-chain fatty acids [SCFAs], bile acids). …”
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5686
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1 mousmodel of Alzheimer’s disease
Published 2025-04-01“…Although PBM has been employed in the treatment of AD, the effect and precise mechanism of PBM on AD-induced neurological damage are still unclear. …”
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5687
Efficacy of intra-articular injections for the treatment of osteoarthritis: A narrative review
Published 2025-06-01“…Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive cartilage loss, inflammation, and joint dysfunction. With profound effects on joint function and quality of life, OA imposes a substantial socio-economic burden. …”
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5688
The Role of IL-33 in Experimental Heart Transplantation
Published 2020-01-01“…Under conditions of cell injury or death, IL-33 is passively released from the nucleus and acts as an “alarmin” upon binding to its specific receptor ST2, which leads to proinflammatory or anti-inflammatory effects depending on the pathological environment. …”
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5689
Control of Mitochondrial Quality: A Promising Target for Diabetic Kidney Disease Treatment
Published 2025-04-01“…Mitochondrial-targeted drugs show potential; however, challenges remain because of adverse effects and unclear mechanisms. Future research should aim to comprehensively explore therapeutic potential of MQC in DKD. …”
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5690
Myonectin and metabolic health: a systematic review
Published 2025-07-01“…This is a bibliometric and bioinformatics-complemented systematic review aimed to comprehensively analyze the structure, regulation and effects of myonectin on metabolic outcomes relevant to the pathophysiology of chronic metabolic diseases. …”
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5691
Application of magnesium and its compounds in biomaterials for nerve injury repair
Published 2025-07-01“…Neural injuries, including peripheral nerve injury and spinal cord injury, are prevalent clinical conditions that can lead to significant sensory and motor dysfunction. Due to the limited regenerative capacity of neural tissues, current treatment methods often yield unsatisfactory outcomes. …”
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5692
Pathogenicity of Arcobacter cryaerophilus in two human intestinal cell lines
Published 2025-06-01“…As structural factors correlate with the barrier dysfunction, immunofluorescence staining of the tight junction domain was performed, and revealed an altered distribution of claudin-5 in infected cells. …”
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5693
Integrated multi-omics profiling to establish an IGFBP-based prognostic score for pancreatic ductal adenocarcinoma: unraveling prognostic biomarkers, immune microenvironment crosst...
Published 2025-05-01“…BackgroundPancreatic ductal adenocarcinoma (PDAC) is accompanied by endocrine dysfunction, particularly involving dysregulation of the insulin and insulin-like growth factor (IGF) signaling pathways. …”
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5694
Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer’s disease
Published 2024-09-01“…Few studies modulating the expression of UCP4 in astrocytes or neurons have highlighted protective effects against neurodegeneration and aging, suggesting that pharmacological strategies aimed at activating UCPs, such as protonophoric uncouplers, hold promise for therapeutic interventions in AD and other neurodegenerative diseases. …”
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5695
Influence of Residential Area on Social Media Usage and Sleep Problems among Young Adults
Published 2025-01-01“…Introduction: Extensive use of social media has been linked to reduced sleep quality, daily dysfunction, sleep disorders, and depression. A study emphasized the notable effects of engaging with social media at night and emotionally investing in it, particularly affecting young adults’ sleep and general well-being. …”
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5696
Microcirculation and cardiovascular risk: Diagnostic value and clinical relevance
Published 2025-05-01“…Microcirculatory endothelial dysfunction plays a central role in the pathogenesis and progression of the disease, contributing to the development of organ complications. …”
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5697
Surgery impairs glymphatic activity and cognitive function in aged mice
Published 2025-01-01“…Using in vivo two-photon imaging, we examined the effects of surgery (laparotomy) on glymphatic function in adult (6 months) and aged (18 months) mice 24 h post-surgery. …”
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5698
Metallothioneins in the Pathogenesis of Liver Diseases: A Review
Published 2025-01-01“…Reduced MTs expression is associated with disease progression in several chronic hepatic disorders. In metabolic dysfunction–associated steatotic liver disease (MASLD), MT1 downregulation has been linked to the transition from simple steatosis to steatohepatitis. …”
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5699
Method of Analysis of the Temporomandibular Joint Parameters According to Magnetic Resonance Imaging
Published 2022-10-01“…The existing variety of approaches to the treatment of temporomandibular joint (TMJ) dysfunction corresponds to the variety of methods for its diagnosing. …”
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5700
Synaptic plasticity in fronto-insular circuits underlying stress susceptibility and resilience
Published 2025-02-01“…In the short term, stress effects on neuronal activity may be adaptive, but repeated engagement of these adaptations may lead to circuit dysfunction—a phenomenon known as allostatic load. …”
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