Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics? by Zhihong Yang, Duilio M. Potenza, Xiu-Fen Ming

“…However, recent studies have reported controversial results or detrimental effects caused by senolytic therapeutic approaches, including worsening of cardiac dysfunction, instability of atherosclerotic plaques, and even an increase in mortality in animal models, which challenges the translation of senolytic therapy into the clinical practice. …”
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Fasting the mitochondria to prevent neurodegeneration: the role of ceramides by Luis Armando Valenzuela-Ahumada, Octavio Fabián Mercado-Gómez, Rubi Viveros-Contreras, Rosalinda Guevara-Guzmán, Alberto Camacho-Morales

“…Preclinical and clinical advances have documented that altered energy homeostasis and mitochondria dysfunction is a hallmark of neurological disorders. …”
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Exercise and dietary interventions in the management of diabetic cardiomyopathy: mechanisms and implications by Ling Zhong, Xiaojie Hou, Yan Tian, Xianghui Fu

“…Despite advances in pharmacological therapies, the effectiveness of managing cardiac dysfunction in DCM remains challenging. …”
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Molecular Mechanisms and Signaling Pathways Underlying the Therapeutic Potential of Thymoquinone Against Colorectal Cancer by Amin F. Majdalawieh, Saud Al-Samaraie, Tala M. Terro

“…It causes mitochondrial dysfunction and activates caspases, contributing to its pro-apoptotic effects. …”
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4-Hydroxy-2-nonenal Induces Apoptosis by Inhibiting AKT Signaling in Human Osteosarcoma Cells by Guang-rong Ji, Nai-chun Yu, Xiang Xue, Zong-guang Li

“…The onset of lipid peroxidation within cellular membranes is associated with changes in their physiochemical properties and enzymatic dysfunction of the membrane environment. There are increasing bodies of evidence indicating that aldehydic molecules generated endogenously during the process of lipid peroxidation are causally involved in most of the pathophysiological effects associated with oxidative stress in cells and tissues. 4-Hydroxy-2-nonenal (4-HNE), among them, is believed to be largely responsible for cytopathological effects observed during oxidative stress in vivo and has achieved the status of one of the best recognized and most studied of the cytotoxic products of lipid peroxidation. …”
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Drug discovery with an RBM20 dependent titin splice reporter identifies cardenolides as lead structures to improve cardiac filling. by Martin Liss, Michael H Radke, Jamina Eckhard, Martin Neuenschwander, Vita Dauksaite, Jens-Peter von Kries, Michael Gotthardt

“…Diastolic dysfunction is increasingly prevalent in our ageing society and an important contributor to heart failure. …”
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Results of Emollient Therapy in a Child with Severe Atopic Dermatitis Treated with Genetically Engineered Biological Drug: Clinical Case by Eduard T. Ambarchyan, Anastasiya D. Alekseeva, Vladislav V. Ivanchikov

“…This clinical case confirms the feasibility of therapy with emollient-plus agents, as it was possible to achieve the correction of epidermal barrier dysfunction and significant clinical effect.…”
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Vildagliptin and its role in the treatment of diabetes mellitus by Yury Shavkatovich Khalimov

“…Results of international clinical studies show that Galvus and GalvusMet are efficacious and safe, they ensure adequate control of glycemiafree from complications and side effects. An important advantage of these preparations is the possibility of their use by elderly patients with arterialhypertension and moderate renal dysfunction and by those at risk of cardiovascular disorders. …”
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Impairing the interaction between Erg11 and cytochrome P450 reductase Ncp1 enhances azoles’ antifungal activities by Wanqian Li, Malcolm Whiteway, Sijin Hang, Jinhua Yu, Hui Lu, Yuanying Jiang

“…Abstract Azole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. …”
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The Parasite-Derived Peptide, FhHDM-1, Selectively Modulates miRNA Expression in β-Cells to Prevent Apoptotic Pathways Induced by Proinflammatory Cytokines by Inah Camaya, Meredith Hill, Dayna Sais, Nham Tran, Bronwyn O’Brien, Sheila Donnelly

“…As β-cell death/dysfunction underlies diabetes development, FhHDM-1 opens new therapeutic avenues.…”
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Overview of oxidative stress and inflammation in diabetes by Roni Weinberg Sibony, Omri Segev, Saar Dor, Itamar Raz

“…This review explores the effect of T2D on target organ damage and potential treatments to minimize this damage. …”
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The Pathogenesis of Oxidative Stress-Induced Chloasma and Its Therapeutic Implications by Wu Q, Zheng H, Wu J, Tang Y, Cheng H

“…However, the therapeutic efficacy of these treatments often falls short of patients’ expectations and is accompanied by notable side effects. Oxidative stress, characterized by an imbalance between oxidation and antioxidation, plays a crucial role in various clinical conditions and leads to oxidative damage, including cellular dysfunction, DNA damage, protein and lipid peroxidation, and even irreversible cell death. …”
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Interleukin-4 prevents increased endothelial permeability by inducing pericyte survival and modulating microglial responses in diabetic retinopathy by Jang-Hyuk Yun

“…Pericyte loss and microglia-mediated inflammation exacerbate this vascular dysfunction. Interleukin-4 (IL-4) is known for its anti-inflammatory and tissue-protective properties, but its role in DR remains unclear. …”
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Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model. by Yoon Seok Nam, Eun-Ji Gi, Yoo-Seung Ko, Sungsu Lee, Hyong-Ho Cho

“…HDAC inhibitors (HDACis) are chemical compounds that block the activity of histone deacetylase and are known to exert diverse biologic effects. We investigated the effect of Trichostatin A (TSA), an HDACi, to assess its potential to inhibit hearing deterioration in AS. …”
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Sequential administration of efgartigimod shortened the course of Guillain–Barré syndrome: a case series by Sihui Chen, Ruwei Ou, Qianqian Wei, Bi Zhao, Xueping Chen

“…This case series investigates the effects of sequential efgartigimod administration in patients with different GBS phenotypes and varying levels of disease severity. …”
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Local and Systemic Pathogenesis and Consequences of Regimen-Induced Inflammatory Responses in Patients with Head and Neck Cancer Receiving Chemoradiation by Elvio G. Russi, Judith E. Raber-Durlacher, Stephen T. Sonis

“…In addition, the finding that patients commonly develop toxicities representing tissue injury outside radiation fields and side effects such as fatigue or cognitive dysfunction suggests the generation of systemic as well as local mediators. …”
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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project by Andrea Cocci, Marta Pezzoli, Fernando Bianco, Franco Blefari, Pierluigi Bove, Francois Cornud, Gaetano De Rienzo, Paolo Destefanis, Danilo Di Trapani, Alessandro Giacobbe, Luca Giovanessi, Antonino Laganà, Giovanni Lughezzani, Guglielmo Manenti, Gianluca Muto, Gianluigi Patelli, Novello Pinzi, Stefano Regusci, Giorgio I. Russo, Juan I.M. Salamanca, Matteo Salvi, Luigi Silvestri, Fabrizio Verweij, Eric Walser, Riccardo G. Bertolo, Valerio Iacovelli, Alessandro Bertaccini, Debora Marchiori, Hugo Davila, Pasquale Ditonno, Paolo Gontero, Gennaro Iapicca, Theo M De Reijke, Vito Ricapito, Pierluca Pellegrini, Andrea Minervini, Sergio Serni, Francesco Sessa

“…During the final round, experts concluded that it can be used for intermediate-risk PCa and it should be proposed as an effective alternative to radical prostatectomy for patients with strong will of avoiding urinary incontinence and sexual dysfunction. …”
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Research Progress on the Role of Puerarin in the Prevention and Treatment of Alzheimer's Disease by Changsong Chu, Yaquan Jia, Yuan Liu, Ruofei Du, Zichuang Wang, Zhenqiang Zhang, Wanchun Zheng, Junying Song

“…It exerts potential therapeutic effects in multiple aspects, including regulating the expression of amyloid β-protein (Aβ), inhibiting abnormal phosphorylation of microtubule-associated protein-τ (Tau), scavenging free radicals, resisting oxidation, regulating metal metabolism to maintain cholinergic system stability, improving mitochondrial dysfunction, and resisting inflammation. …”
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Berberine and its derivatives: mechanisms of action in myocardial vascular endothelial injury - a review by Wenhui Zhang, Siyi Guo, Jinjin Dou, Xiwu Zhang, Fan Shi, Chun Zhang, Huxiao Zhang, Xiaodong Lan, Yi Su

“…Mechanisms such as endoplasmic reticulum stress, apoptosis, inflammation, oxidative stress, autophagy, platelet dysfunction, and gut microbiota imbalance are intimately linked to this condition. …”
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The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis by Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He

“…Abstract Fibrosis, characterized by abnormal deposition of structural proteins, is a major cause of tissue dysfunction in chronic diseases. The disease burden associated with progressive fibrosis is substantial, and currently approved drugs are unable to effectively reverse it. …”
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