Some of the Immunogenetics Aspects of Aging by Bushra N. Al Hadra

“…The human life span could be influenced by the combined effect of environment, lifestyle, and genetic factors. …”
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Obesity and Mechanisms of its Negative Impact on the Cardiovascular System by S. V. Miklishanskaya, L. V. Solomasova, M. A. Mazur

“…The development of endothelial dysfunction in obesity ultimately leads to the development of atherosclerosis and coronary heart disease. …”
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Challenges in the implementation of cardio-oncology trials: lessons learnt from investigating statins in the prevention of anthracycline cardiotoxicity by John Lee, Sean Tan, Satish Ramkumar

“…Future studies should emphasize both immediate cardioprotective effects and long-term cardiovascular benefits of statins, especially in the context of atherosclerotic cardiovascular disease in cancer survivors.…”
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Current Status of Plant-Based Bioactive Compounds as Therapeutics in Alzheimer’s Diseases by Dan Chen, Yun Sun

“…The pathogenesis of AD remains unclear and current Western medicines treatment are purely symptomatic, with a singular pathway, limited efficacy, and substantial toxicity and side effects. In recent years, as research into AD has deepened, there has been a gradual increase in the exploration and application of medicinal plants for the treatment of AD. …”
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Involvement of liver kinase B1 in the ameliorative action of epigallocatechin-3-gallate against MAFLD progression in mice by Mahardian Rahmadi, Chia-Wei Phan, Santhra Segaran Balan, Athallah Syauqi Zumarthana, Ellyna Majesty Ayundari, Ismailia Wienda Yasmin Pratama Putri, Salsabila, Ahmad Dzulfikri Nurhan

“…This study investigated the effects of epigallocatechin-3-gallate (EGCG) on reducing MAFLD severity. …”
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Intralesional and topical treatments for Peyronie’s disease: a narrative review of current knowledge by Antonio Minore, Loris Cacciatore, Fabrizio Presicce, Andrea Iannuzzi, Antonio Testa, Gianluigi Raso, Rocco Papalia, Marco Martini, Roberto Mario Scarpa, Francesco Esperto

“…Peyronie’s disease (PD) presents a multifaceted challenge in contemporary urological practice, marked by penile deformity, pain, and the potential for erectile dysfunction. We meticulously explored the existing literature of intralesional/topical interventions, aiming to provide clinicians with a nuanced understanding of available options for comprehensive PD management. …”
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Rivastigmine as a Symptomatic Treatment for Apathy in Parkinson’s Dementia Complex: New Aspects for This Riddle by Rita Moretti, Paola Caruso, Matteo Dal Ben

“…Rivastigmine did not have a prolonged benefic effect on apathy, in our work, on the contrary of what had been observed in the literature, probably due to the longer follow-up of our patients.…”
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Modulation of Oxidative Stress in Diabetic Retinopathy: Therapeutic Role of Natural Polyphenols by Verónica Gómez-Jiménez, Raquel Burggraaf-Sánchez de las Matas, Ángel Luis Ortega

“…Polyphenols, such as resveratrol, curcumin, and pterostilbene, exhibit multitarget antioxidant, anti-inflammatory, and anti-angiogenic effects, showing promise in preclinical and limited clinical studies. …”
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Serum levels of magnesium in sudden cardiac deaths among people with schizophrenia: hit or miss? by Fulvio A. Scorza, Marly de Albuquerque, Ricardo M. Arida, Roberta Monterazzo Cysneiros

“…., QT interval prolongation, metabolic dysfunction, blood pressure and heart rate alterations. …”
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Melatonin in the management of perinatal hypoxic-ischemic encephalopathy: light at the end of the tunnel? by Hendaus M, Jomha F, Alhammadi A

“…Melatonin emerges as a very interesting medication, because of its capacity to cross all physiological barriers extending to subcellular compartments and its safety and effectiveness. The purpose of this commentary is to detail the evidence on the use of melatonin as a neuroprotection agent. …”
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6-Methoxydihydroavicine is a benzophenanthridine alkaloid with anti-leukemia activity by Yingying Yang, Paul A. Spagnuolo

“…Mechanistically, 6-methoxydihydroavicine triggered accumulation of mitochondrial ROS and disrupted electron transport chain (ETC) function.ConclusionOur findings demonstrate that 6-methoxydihydroavicine exerts strong cytotoxic effects against AML cells through mitochondrial dysfunction and ROS-mediated apoptosis. …”
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Molecular pathways involved in the control of contractile and metabolic properties of skeletal muscle fibers as potential therapeutic targets for Duchenne muscular dystrophy by Agnese Bonato, Giada Raparelli, Maurizia Caruso

“…This results in increased calcium influx, oxidative stress, and mitochondrial dysfunction, leading to chronic inflammation, myofiber degeneration, and reduced muscle regenerative capacity. …”
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Transient changes in white matter microstructure during general anesthesia. by Cheuk Y Tang, Victoria X Wang, Min Yin Lun, Joshua S Mincer, Johnny C Ng, Jess W Brallier, Arthur E Schwartz, Helen Ahn, Patrick J McCormick, Tommer Nir, Bradley Delman, Mary Sano, Stacie G Deiner, Mark G Baxter

“…Cognitive dysfunction after surgery under general anesthesia is a well-recognized clinical phenomenon in the elderly. …”
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Potential Moderators of Physical Activity on Brain Health by Regina L. Leckie, Andrea M. Weinstein, Jennifer C. Hodzic, Kirk I. Erickson

“…In this paper, we highlight genes including apolipoprotein E (APOE), brain derived neurotrophic factor (BDNF), and catechol-O-methyltransferase (COMT) along with dietary omega-3 fatty acid, docosahexaenoic acid (DHA), as potential moderators of the effect of physical activity on brain health. There are a growing number of studies indicating that physical activity might mitigate the genetic risks for disease and brain dysfunction and that the combination of greater amounts of DHA intake with physical activity might promote better brain function than either treatment alone. …”
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Ocular Hypotonia and Transient Decrease of Vision as a Consequence of Exposure to a Common Toad Poison by Renato Pejic, Marija Simic Prskalo, Josip Simic

“…Inhibition of Na+/K+-ATPase is a well-known effect of the toad venom. Na+/K+-ATPase is a part of corneal endothelial cells, ciliary body, and iris, and its inhibition caused by exposure to bufadienolides induces corneal dysfunction, decreased vision, and ocular hypotonia. …”
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Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus. by Jarod Swant, Sanika Chirwa, Gregg Stanwood, Habibeh Khoshbouei

“…Pretreatment with eticlopride (D2-like receptor antagonist) did not alter the effects of METH on synaptic transmission or LTP. In contrast, pretreatment with D1/D5 dopamine receptor antagonist SCH23390 or 5-HT1A receptor antagonist NAN-190 abrogated the effect of METH on synaptic transmission. …”
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Curcumin and exercise prevent depression via alleviating hippocampus injury and improve depressive-like behaviors in chronically stressed depression rats by Elaheh Ahmadi, Ali Pourmotabbed, Nilofar Aghaz, Seyed Ershad Nedaei, Mojgan Veisi, Zahra Salimi, Fatemeh Zarei, Cyrus Jalili, Farshad Moradpour, Motahareh Zeinivand

“…Findings/Results: In the current study, curcumin treatment combined with exercise effectively improved immobility behavior, locomotor activity, and increased hippocampal cell survival resulted in preventing the development of hippocampus dysfunction and depressive-like behaviors. …”
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Promoting the sustainable development of the provincial electricity spot market: supervision obstacle identification, analysis, and solutions based on the ISM-DEMATEL model by Yi Li, Wulei Xue, Yi Zhang, Xiande Zheng, Liumao Yang

“…However, it still faces challenges of supervision dysfunction that have led to market imbalances and unfair trade. …”
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A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy by Zhichao Wang, Yuqi Tang, Quan Li

“…Therefore, after targeting lysosomes, M@P can cause lysosome dysfunction through the generation of reactive oxygen species and heat under light irradiation, triggering pyroptosis and ferroptosis of tumor cells, achieving immunogenic cell death, and further enhancing immunotherapy through the combined effect with the immunoadjuvant Poly(I: C). …”
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COVID-19 pandemic and quarantine-related health disorders in combatants of Ukraine by N. V. Danilevska

“…These stressful thoughts associated with the COVID-19 pandemic and quarantine provoke the development of hypertensive emergency (57 % vs 18 %), anxiety syndrome (29 %), dissociative [conversion] disorder (7 %), and exacerbate the negative effects of pre-pandemic diseases, namely, hypertension (43 % vs 27 %), somatoform autonomic dysfunction of the cardiovascular system (29 %), panic disorder [episodic paroxysmal anxiety] (7 %), adjustment disorders (7 %), post-traumatic stress disorder (7 %). …”
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