Ornidazole-induced involuntary tremor in a Chinese woman: a rare case report and literature review by Hui Wang, Yanling Huang, Xuefei Wang, Fulan Yang, Chunjing Jiang, Yueqin Zhou, Liu Yang

“…Abstract Nitromidazole antibiotics, exemplified by metronidazole and ornidazole, have been reported to trigger a spectrum of adverse effects. These encompass ataxia, hearing loss, visual impairment, psychomotor dysfunction, intellectual impairment, and epileptic seizures (Rinsho Shinkeigaku 64:637-641, 2024). …”
Get full text

Apoptosis in Critical Conditions by A. M. Golubev, E. Yu. Moskaleva, S. E. Severin, T. P. Vesnyanko, A. N. Kouzovlev, A. S. Alkadarsky, G. G. Poroshenko

“…The data of studies dealing with the effects of inhaled and non-inhaled anesthetics on the apoptosis of neurons of the brain and lymphocytes are given. …”
Get full text

Advance in molecular mechanisms underlying diabetes related to viral hepatitis infection by Chuyan Wang, Miao Yu, Yilin Che, Ruyi Du, Yaoyao Xu, Junqi Niu, Xiumei Chi

“…Future research directions include exploring the synergistic effects of these pathways and leveraging advanced technologies for personalized treatment strategies.…”
Get full text

Novel Insights into the Vasoprotective Role of Heme Oxygenase-1 by Emanuela Marcantoni, Luigia Di Francesco, Melania Dovizio, Annalisa Bruno, Paola Patrignani

“…Recent evidence supports the involvement of HO-1 in the antioxidant and antiinflammatory effect of cyclooxygenase(COX)-2-dependent prostacyclin in the vasculature. …”
Get full text

Harnessing exercise to combat chronic diseases: the role of Drp1-Mediated mitochondrial fission by Yingxin Sun, Junchen He, Junchen He, Lei Bao, Xiaoming Shi, Jinghong Wang, Qingwen Li

“…Studies indicate that exercise mitigates mitochondrial dysfunction by modulating Drp1-related signaling targets, thereby inhibiting Drp1 activity and reducing excessive mitochondrial fission. …”
Get full text

Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis by Ran Guo, Hao Wang, Na Cui

“…Sepsis is defined as a life-threatening disease involving multiple organ dysfunction caused by dysregulated host responses to infection. …”
Get full text

Programmed cell death in the cognitive impairment of obstructive sleep apnea by Yanru Ou, Xiufang Wang, Dandan Zong, Ruoyun Ouyang

“…A growing number of studies find that PCD is responsible for cognitive dysfunction and plays an important role in various neurological diseases, which involve apoptosis, necroptosis, pyroptosis, ferroptosis, and cell death associated with autophagy. …”
Get full text

The contribution of type-I IFN-mediated neuroinflammation to Parkinson's disease progression by Shuyan Chen, Peter J. Crack, Juliet M. Taylor

“…Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by motor dysfunction. Pathological hallmarks of the disease include selective dopaminergic neuronal death, intraneuronal deposits known as Lewy bodies and extensive neuroinflammation within the central nervous system (CNS). …”
Get full text

Advances in brain and religion studies: a review and synthesis of recent representative studies by Patrick McNamara, Patrick McNamara, Patrick McNamara, Jordan Grafman, Jordan Grafman

“…Future research should examine neurodevelopmental mechanisms of acquired SA perceptions as well as societal-level effects such as brain mediated religious beliefs of in-group cohesion and out-group hostility.…”
Get full text

PPARγ Plays an Important Role in Acute Hepatic Ischemia-Reperfusion Injury via AMPK/mTOR Pathway by Liwei Wu, Qiang Yu, Ping Cheng, Chuanyong Guo

“…Hepatic ischemia-reperfusion (IR) injury is one of the severe complications associated with liver surgery and leads to liver dysfunction. PPARγ is always linked with various physiologic pathways, and it can alleviate liver damage in IR injury. …”
Get full text

Role of FHOD1 in tumor cells and tumor immune microenvironment by Yang Yang, Zhanting Kang, Jinlong Cai, Shan Jia, Shangqian Fan, Huifang Zhu

“…Aberrant expression and dysfunction of the FHOD1 protein play a key role in tumor immunosuppression. …”
Get full text

A Case Series on Cholera Amongst Migrant Workers in a Semi-Urban Area of Western Maharashtra by Mukesh Bawa, Pawan Giram, Sachin Deorukhkar, Atul Desale, Harshal Pandve, Pandurang Thatkar

“…This study underscores the imperative of timely medical intervention and robust public health interventions to effectively manage cholera outbreaks.…”
Get full text

Risk factors and prevention of cardiovascular complications in breast cancer by M. N. Mamedov, A. K. Karimov, E. K. Saribekyan, A. D. Zikiryakhodjaev

“…Strategies for the prevention and treatment of left ventricular dysfunction or heart failure in such patients should include a comprehensive cardiovascular risk evaluation and individual clinical assessment.…”
Get full text

Redox Biology and Insulin-like Growth Factor-Binding Protein-6: A Potential Relationship by Anna Rita Daniela Coda, Arcangelo Liso, Francesco Bellanti

“…Insulin-like growth factor-binding protein 6 (IGFBP-6) is primarily recognized for its inhibitory effects on insulin-like growth factor 2 (IGF-2), regulating processes such as cell proliferation, differentiation, and survival. …”
Get full text

Influence of urokinase continuous micro-pump on the malfunction of tunneled cuffed catheters in the hemodialysis patients by WANG Yan-jiang, XIE Xi-sheng, FENG Sheng-gang

“…Objective To explore the influence of urokinase continuous micro-pump on the malfunction of tunneled cuffed catheters in the hemodialysis patients.Methods Thirty maintenance hemodialysis patients with the malfunction of tunneled cuffed catheters were chosen from the Hemodialysis Room of Nanchong Central Hospital.Patients were randomly divided into observation group(n=10),urokinase traditional sealed tube group(n=10)and urokinase continuous micro-pump into group(n=10).Blood flow velocity,dialysis adequacy and the occurrence of adverse catheter function within one month and complications were observed and compared among the groups.Results As compared with the observation group,the blood flow velocity of the dialysis and the dialysis adequacy in the urokinase traditional sealed tube group and the rokinase continuous micro-pump into group were significantly higher,and the occurrence frequency of adverse catheter function within one month was lower(P<0.05).Compared with the urokinase traditional sealed tube group,the blood flow velocity of the dialysis and the dialysis adequacy of the rokinase continuous micro-pump into group were higher,and the occurrence of adverse catheter function within one month was significantly lower(P<0.05).No bleeding complications occurred in all patients.Conclusions The dysfunction of the tunneled cuffed catheters can be significantly improved by the continuous micro pump of the urokinase.The effect of the continuous micro pump of the urokinase was significant,which was worthy of clinical application.…”
Get full text

The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies by Vharoon Sharma Nunkoo, Alexander Cristian, Anamaria Jurcau, Razvan Gabriel Diaconu, Maria Carolina Jurcau

“…To date, side effects seriously limit the use of these drugs. However, since rejuvenation is a dream of mankind, future research is expected to improve the tolerability of the available drugs and highlight novel strategies. …”
Get full text

The epigenetic impact of lifestyle factors on metabolic syndrome: A systematic review by Temitope Gabriel Adedeji

“…While poor habits worsen metabolic dysfunction, exercise and proper diet can mitigate epigenetic damage. …”
Get full text

The Putative Role of the Antiageing Protein Klotho in Cardiovascular and Renal Disease by Giuseppe Maltese, Janaka Karalliedde

“…Klotho is mainly expressed in the renal tubules but it also exists as circulating soluble form detectable in the blood, with systemic effects. Reduction in soluble Klotho has been associated with renal disease, hyperphosphataemia, increased oxidative stress, endothelial dysfunction, and diffuse vascular calcification. …”
Get full text

The differences in the adrenergic receptors of proximal urethra between sexes by Po-Chun Hsieh, Shang-Jen Chang, Hsi-Hsien Chang, Stephen Shei-Dei Yang

“…The use of β-adrenergic receptor blocker agents might have the potential for the treatment of female voiding dysfunction.…”
Get full text

Multi-omics strategy reveals that Cordyceps sinensis ameliorates sepsis-associated acute kidney injury via reprogramming of mitochondrial energy metabolism and macrophage polariz... by Lin Chen, Tong Yang, Jiangpeng Wu, Guangqing Cheng, Minghong Zhao, Yanyan Zhou, Yin Kwan Wong, Junzhe Zhang, Qiuyan Guo, Huan Tang, Jigang Wang

“…Herein, we investigated the potential pharmacological action of CS against S-AKI and the underlying mechanisms. CS treatment effectively ameliorated renal dysfunction and injury in mice with lipopolysaccharide (LPS)-induced S-AKI, as indicated by the suppression of inflammatory cytokine expression and secretion. …”
Get full text