Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis Activity by Marcella Balbo, Rachel Leproult, Eve Van Cauter

“…Sleep has modest but clearly detectable modulatory effects on HPA axis activity. Sleep onset exerts an inhibitory effect on cortisol secretion while awakenings and sleep offset are accompanied by cortisol stimulation. …”
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Choice of pharmacotherapy for various clinical forms of dry eye disease by Yu. F. Maychuk, E. V. Yani

“…Group III-DED, stage 3, severe damage associated with meibomian gland dysfunction. Diagnostics — subjective symptoms, biomicroscopic data and diagnostic tests were assessed and scored: Schirmer test, Norn test, rose bengal and fluorescein staining, OCt assessment of tear meniscus, tear osmolar- ity measurement. the following agents were used as basis therapy in various algorithms: Visine Pure tears or Artificial tear, Hilabak, VitA-Pos and adjunctive anti-infective and anti-inflammatory therapies if needed.Results: Positive therapeutic effect was achieved in all patients. …”
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Tadalafil significantly reduces ischemia reperfusion injury in skin island flaps by Oguz Kayiran, Suat S. Cuzdan, Afsin Uysal, Ugur Kocer

“…Herein, the protective and therapeutical effect of tadalafil in I/R injury in rat skin flap model is evaluated. …”
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Interaction of vitamin D, homocystein and dental diseases by O.I. Kutelmakh

“…In this article, we discussed the main functions of vitamin D and homocysteine (НC) in the human body and their mechanisms and summarized the important reports on the effects of vitamin D and HC on the oral cavity. …”
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Early intensification of therapy for type 2 diabetes mellitus and achievement of the target level of glycohemoglobin HbA_1c are necessary factors to reduce the risk of mi... by M. S. Shamkhalova, O. Y. Sukhareva

“…The decrease in HbA1c may also play a role in mediating the positive effect on cardiovascular risk observed with the use of new hypoglycemic agents. …”
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The association between problematic smartphone use and subjective well-being in Bangladeshi youths: Mediating role of sleep quality by Md. Rohmotul Islam, Oli Ahmed, Lutfun Naher, Md. Nurul Islam

“…The results also showed that subjective sleep quality, sleep disturbances, and daytime dysfunction were particularly responsible for the mediation effect. …”
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Cavin-3 knockout mice show that cavin-3 is not essential for caveolae formation, for maintenance of body composition, or for glucose tolerance. by Libin Liu, Carsten G Hansen, Brian J Honeyman, Benjamin J Nichols, Paul F Pilch

“…We find that loss of cavin-3 has minimal or no effects on the levels of other caveolar proteins, does not appear to play a major role in formation of protein complexes important for caveolar morphogenesis, and has no significant effect on caveolae abundance. …”
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Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemia by Natasha Ting Lee, Ioanna Savvidou, Carly Selan, David K. Wright, Robert Brkljaca, Joanne S.J. Chia, Ilaria Calvello, Daphne D.D. Craenmehr, Pia Larsson, Volga Tarlac, Amy Vuong, Irena Carmichael, Xiaowei Wang, Karlheinz Peter, Simon C. Robson, Harshal H. Nandurkar, Maithili Sashindranath

“…Endothelial activation and dysfunction impairing small vessel blood flow is the cause of brain damage. …”
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Plasma EphA2 level is a superior biomarker to Del-1 for sepsis diagnosis and prognosis by Eun Hye Lee, Mi Hwa Shin, Se Hyun Kwak, Ji Soo Choi, Ah Young Leem, Su Hwan Lee, Kyung Soo Chung, Young Sam Kim, Sang-Guk Lee, Moo Suk Park

“…BackgroundSepsis, characterized by a dysregulated host response to infection, often leads to organ dysfunction, and vascular endothelial dysfunction plays a central role. …”
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The impact of obesity and weight loss treatment on metabolic parameters, cardiovascular autonomic and sensory nerve function and in vitro fertilization outcomes in infertile women:... by Anna Vágvölgyi, Viktor Vedelek, Nóra Keller, Dalma Szöllősi, Szilvia Lada, Attila Nemes, Péter Kempler, Adrienn Menyhárt, István Baczkó, Tamás Várkonyi, Csaba Lengyel, János Zádori

“…Cardiovascular autonomic dysfunction was revealed by 30/15 and Valsalva-ratio in patients with obesity, suggesting the presence of parasympathetic dysfunction. …”
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The “prostate-pelvic syndrome” theory used in patients with type-III prostatitis and its correlation with prostate volume by Xiao-Ma Zhang, Wei-Yi Li, Zong-Yao Hao, Lei Zhou, Cheng Yang, He-Xi Du, Chao-Zhao Liang

“…However, the practical application effectiveness of PPS theory in clinical practice is still unclear. …”
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Mitochondrial proteins and congenital birth defect risk: a mendelian randomization study by Xin-yu Li, Da-tao Li, Yi-yuan Li, Zhi-cheng Xu, Qun Zhang, Xia Chen, Feng Xu, Ru-hong Zhang

“…Abstract Background Mitochondrial dysfunction has been hypothesized to play a role in the etiology of congenital birth defects. …”
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Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis by Lu Gan, Jianli Zhao, Peng Yao, Theodore A. Christopher, Bernard Lopez, Wayne B. Lau, Walter Koch, Erhe Gao, Xinliang Ma, Yajing Wang

“…PGC-1α1/-a) as the direct downstream target of miR-130b-3p, whose downregulation causes mitochondrial dysfunction and apoptosis. Finally, treatment with diabetic adipocyte-derived sEV or a miR-130b-3p mimic significantly enhanced mitochondrial reactive oxygen species (ROS) production in SI/R cardiomyocytes. …”
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C3aR1 on β cells enhances β cell function and survival to maintain glucose homeostasis by Renan Pereira de Lima, Ang Li, Ankit Gilani, Alfonso Rubio-Navarro, Charles D. Warren, Isabella Y. Kong, Jacob B. Geri, James C. Lo

“…Objective: Pancreatic β cell dysfunction is critical to the development of type 2 diabetes (T2D). …”
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Multi-omics identify ribosome related causal genes methylation, splicing, and expression in prostate cancer by Chengcheng Wei, Jingke He, Yunfan Li, Yu Luo, Liangdong Song, Kun Han, Jindong Zhang, Shuai Su, Delin Wang

“…Previous studies suggest that dysfunction in ribosomal processes may contribute significantly to prostate cancer progression. …”
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Physiology, imaging and proteomics of non-ventilated vs. non-perfused lung injury: an experimental study by Anna Damia, Ines Marongiu, Elena Spinelli, Francesco Damarco, Clarissa Uslenghi, Giovanni Lorenzo Rumi, Michele Battistin, Caterina Lonati, Alessandra Maria Storaci, Gianluca Lopez, Maria Rosaria De Filippo, Fabiana Madotto, Cristina Banfi, Alice Mallia, Lorenzo Rosso, Valentina Vaira, Tommaso Mauri

“…Abstract Background The exclusion of one lung from ventilation or pulmonary artery perfusion triggers pathological mechanisms that can lead to lung injury. Although the final effect is similar for both insults, the underlying mechanisms may differ. …”
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Hepatocellular carcinoma risk scores for non-viral liver disease: A systematic review and meta-analysis by Laura Burke, Alexander Hinkson, Vincent Haghnejad, Rebecca Jones, Richard Parker, Ian A. Rowe

“…Measures of model performance (discrimination and calibration) to assess the risk of HCC at specified time points were identified. A random effects meta-analysis was performed on a subset of studies that reported performance of the same model. …”
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Comparative cohort study of post-acute COVID-19 infection with a nested, randomized controlled trial of ivabradine for those with postural orthostatic tachycardia syndrome (the COV... by David Saunders, Thomas B. Arnold, Thomas B. Arnold, Thomas B. Arnold, Jason M. Lavender, Jason M. Lavender, Jason M. Lavender, Daoqin Bi, Daoqin Bi, Daoqin Bi, Karl Alcover, Lydia D. Hellwig, Lydia D. Hellwig, Lydia D. Hellwig, Sahar T. Leazer, Sahar T. Leazer, Sahar T. Leazer, Roshila Mohammed, Roshila Mohammed, Roshila Mohammed, Bethelhem Markos, Bethelhem Markos, Bethelhem Markos, Kanchana Perera, Kanchana Perera, Kanchana Perera, Dutchabong Shaw, Dutchabong Shaw, Priscilla Kobi, Priscilla Kobi, Martin Evans, Autumn Mains, Autumn Mains, Autumn Mains, Marian Tanofsky-Kraff, Marian Tanofsky-Kraff, Emilie Goguet, Emilie Goguet, Edward Mitre, Kathleen P. Pratt, Clifton L. Dalgard, Clifton L. Dalgard, Mark C. Haigney, Mark C. Haigney

“…In our study we aim to identify risk factors underlying LHC, as well as the effectiveness of ivabradine in controlling heart rate dysregulations and POTS/IST related symptoms.Methods/designA detailed prospective phenotypic evaluation combined with multi-omic analysis of 200 LHC volunteers will be conducted to identify risk factors for autonomic dysfunction. …”
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Nitric Oxide Manipulation: A Therapeutic Target for Peripheral Arterial Disease? by Gareth Williams, Xu Shi-Wen, David Abraham, Sadasivam Selvakumar, Daryll M. Baker, Janice C. S. Tsui

“…This paper reviews experimental work implicating the ADMA-DDAH-NO pathway in PAD, focussing on both the vascular dysfunction and effects within the ischaemic muscle, and examines the potential of manipulating this pathway as a novel adjunct therapy in PAD.…”
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Interaction between mitochondrial quality control and metal-mediated cell death in sepsis and its clinical significance by Zhou Qiyuan, Li Jingyan, Tian Yingping, Yao Yongming

“…Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. …”
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