Circadian clock dysfunction in Parkinson’s disease: mechanisms, consequences, and therapeutic strategy by Müge Yalçin, Valentina Grande, Tiago Fleming Outeiro, Angela Relόgio

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Targeting Lysosomal Dysfunction and Oxidative Stress in Age-Related Macular Degeneration by Ana S. Falcão, Margarida L. Pedro, Sandra Tenreiro, Miguel C. Seabra

“…Age-related macular degeneration (AMD) is the leading cause of vision loss in the Western world, and it currently lacks effective therapy. It is believed that AMD initiates in the aged retinal pigment epithelium (RPE), which presents lysosomal dysfunction and oxidative stress (OxS) that ultimately leads to RPE damage and AMD progression. …”
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The role of mitochondrial dysfunction in ovarian granulosa cells in polycystic ovary syndrome by Xuejun Yan, Dan Ma, Rongnian Li, Jing Xu, Ying Zou, Minmin He

“…This review meticulously examines the effects of mitochondrial dysfunction specifically in ovarian granulosa cells, delving into the intricate mechanisms of action that contribute to the development and progression of PCOS, as well as identifying potential therapeutic targets that could be explored for effective treatment. …”
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Nitric oxide role in development of the endothelial dysfunction in diabetic foot syndrome by O. O. Bilyayeva, H. P. Kozynets, O. I. Osadcha, Ye. Ye. Kryzhevskyy, M. A. Knivets

“…Purpose of the study. The nitric oxide effect features on the development of endothelial dysfunctions in patients with diabetic foot syndrome are explored. …”
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Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation by Honghui Zhang, Zhuan Shen, Qiangui Zhao, Luyao Yan, Lin Du, Zichen Deng

“…Then, we explore the control effects after different external stimulations applying to thalamic neuronal population. …”
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Transplantation of exogenous mitochondria mitigates myocardial dysfunction after cardiac arrest by Zhen Wang, Jie Zhu, Mengda Xu, Xuyuan Ma, Maozheng Shen, Jingyu Yan, Guosheng Gan, Xiang Zhou

“…The incidence of post-cardiac arrest myocardial dysfunction (PAMD) is high, and there is currently no effective treatment available. …”
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Efficacy of medications in controlling cognitive dysfunction in Alzheimer’s : a systematic review by Sâmia Moreira de Andrade, Ítalo Sávio Mendes Rodrigues, Luís Marcelo Vieira Rosa, Rodrigo Luís Taminato, Gustavo Alves Andrade dos Santos

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EFFECT OF PELVIC FLOOR MUSCLE BIOFEEDBACK ON IMPROVED ERECTILE FUNCTION IN PATIENTS WITH LOWER URINARY TRACT SYMPTOMS: PRELIMINARY STUDY by Astrid Meilinda, Herdiman Bernard Purba, Ponco Birowo, Aria Kekalih

“… Objective: This study aims to determine the effect of giving pelvic floor muscle biofeedback on improving erectile function in patients with LUTS. …”
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Organo-protective effects of a calcium antagonist nifedipine SR in elderly patients with isolated and systolo-diastolic arterial hypertension by V. E. Oleynikov, V. A. Budanova, S. S. Fadeeva, N. A. Borisova, E. E. Grishaeva, L. I. Gusakovskaya

“…In addition, nifedipine SR facilitated arterial remodeling regression in elderly patients: in ISAH participants, its effect was mostly targeted at elastic vessels; in SDAH individuals, on muscular vessels and endothelial dysfunction correction.Conclusion. …”
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Effect of mild posterior capsule opacification on visual outcomes in trifocal diffractive pseudophakic eyes: A multicenter prospective study by Limei Zhang, Runhan Shi, Xuanzhu Chen, Xuefen Gu, Jiying Shen, Aijun Wang, Shuang Ni, Lei Cai, Haike Guo, Jin Yang

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Cancer-Therapy-Related Cardiac Dysfunction: Latest Advances in Prevention and Treatment by Carla Contaldi, Carmine D’Aniello, Domenico Panico, Andrea Zito, Paolo Calabrò, Emilio Di Lorenzo, Paolo Golino, Vincenzo Montesarchio

“…Early detection through serum biomarkers and advanced imaging techniques is crucial for effective monitoring and risk stratification. Preventive strategies include pharmacological interventions such as ACE inhibitors/angiotensin receptor blockers, beta-blockers, and statins. …”
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Mechanism-based myofilament manipulation to treat diastolic dysfunction in HFpEF by Katherine L. Dominic, Alexandra V. Schmidt, Henk Granzier, Kenneth S. Campbell, Kenneth S. Campbell, Julian E. Stelzer

“…This is due in part to the complexity of normal diastolic function, and the challenge of isolating the mechanisms responsible for dysfunction in HFpEF. Without a clear understanding of the mechanisms driving diastolic dysfunction, progress in treatment development has been slow. …”
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The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction? by Marco Paolo Donadini, Francesca Calcaterra, Erica Romualdi, Roberta Ciceri, Assunta Cancellara, Corrado Lodigiani, Monica Bacci, Silvia Della Bella, Walter Ageno, Domenico Mavilio

“…Finally, we propose future clinical scenarios where targeting endothelial health could pave the way for more effective prevention and treatment strategies in thrombosis management.…”
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Management of erectile dysfunction: perceptions and practices of Nigerian primary care clinicians by Adekunle J. Ariba, Olufemi T. Oladapo, Christianah A. Iyaniwura, Olukayode A. Dada

“…Background: Erectile dysfunction (ED) is a prevalent health problem in many societies, but the diagnosis is seldom documented in primary care. …”
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HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis by Céline Van Dender, Céline Van Dender, Steven Timmermans, Steven Timmermans, Maxime Roes, Maxime Roes, Madeleine Hellemans, Madeleine Hellemans, Elise Moens, Elise Moens, Louise Nuyttens, Louise Nuyttens, Maarten Claes, Bart Roman, Karolien De Bosscher, Karolien De Bosscher, Jolien Vandewalle, Jolien Vandewalle, Claude Libert, Claude Libert

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Pemafibrate Ameliorates Steatotic Liver Disease Regardless of Endothelial Dysfunction in Mice by Tomoyo Hara, Hiroki Yamagami, Ryoko Uemoto, Akiko Sekine, Yousuke Kaneko, Kohsuke Miyataka, Taiki Hori, Mayuko Ichimura-Shimizu, Masafumi Funamoto, Takeshi Harada, Tomoyuki Yuasa, Shingen Nakamura, Itsuro Endo, Ken-ichi Matsuoka, Yutaka Kawano, Koichi Tsuneyama, Yasumasa Ikeda, Ken-ichi Aihara

“…Pemafibrate has been shown to ameliorate MASLD in basic and clinical studies, but it is unclear whether it is also effective in the status of endothelial dysfunction. …”
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Imidazoline receptor agonists: more than blood pressure reduction? by D. V. Nebieridze, S. V. Nedogoda

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Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice. by Qiang Wang, Antonina I Frolova, Scott Purcell, Katie Adastra, Erica Schoeller, Maggie M Chi, Tim Schedl, Kelle H Moley

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Applicability of Statins in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Thaninee Prasoppokakorn

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is the novel terminology encompassing liver disease associated with metabolic dysfunction, replacing the previous terminology of non-alcoholic fatty liver disease (NAFLD). …”
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Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction by Maria Teresa Bayo Jimenez, Omar Hahad, Marin Kuntic, Andreas Daiber, Thomas Münzel

“…On a mechanistic level, a significant number of studies suggest the involvement of endothelial dysfunction to fundamentally drive the adverse endothelium health effects of the different pollutants. …”
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