Obstructive Sleep-Disordered Breathing in Children: Impact on the Developing Brain by Lisa M Walter, Rosemary SC Horne

“…Studies have identified that the effect of SDB on cerebral oxygenation in children is minimal and not clinically significant. …”
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Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation by Yin‐Li Zhang, Wei Zheng, Peipei Ren, Huiling Hu, Xiaomei Tong, Shuo‐Ping Zhang, Xiang Li, Haichao Wang, Jun‐Chao Jiang, Jiamin Jin, Weijie Yang, Lanrui Cao, Yuanlin He, Yerong Ma, Yingyi Zhang, Yifan Gu, Liang Hu, Keli Luo, Fei Gong, Guang‐Xiu Lu, Ge Lin, Heng‐Yu Fan, Songying Zhang

“…These MOS variants encoded proteins that resulted in decreased phosphorylated ERK1/2 level in cells and oocytes, and displayed attenuated rescuing effects on cortical F‐actin assembly. Using oocyte‐specific Erk1/2 knockout mice, we verified that MOS‐ERK signal pathway inactivation in oocytes caused EEAF as human. …”
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Regulating Integrin β1 to Restore Gonadotropin-Releasing Hormone–Tanycyte Unit Function in Polycystic Ovary Syndrome-Related Hypothalamic Dysregulation by Yu Wang, Xiaoyu Tong, Yan Xiao, Yicong Wang, Wei Hu, Wenhan Lu, Yuning Chen, Jiajia Li, Wenhao Gao, Hongru Gao, Yicheng Tian, Sizhe Dai, Yi Feng

“…Both selective deletion of AR and overexpression of Itgb1 in tanycytes counteracted the detrimental effects of androgens, alleviating endocrine dysfunction. …”
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Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis by Zimeng Ma, Zimeng Ma, Shuo Yan, Shuo Yan, Huimin Zhang, Huimin Zhang, Ruilin Du, Ruilin Du, Xinyue Cheng, Xinyue Cheng, Siqin Bao, Siqin Bao, Xihe Li, Xihe Li, Xihe Li, Yongli Song, Yongli Song

“…Integrated transcriptomic-proteomic analysis revealed cadmium disrupted mitochondrial dysfunction via oxidative phosphorylation pathway inhibition. …”
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Renal-clearable and mitochondria-targeted metal-engineered carbon dot nanozymes for regulating mitochondrial oxidative stress in acute kidney injury by Jiangpeng Pan, Juntao Wang, Wei Wang, Ziyang Liu, Shuai Huo, Lei Yan, Wei Jiang, Fengmin Shao, Yue Gu

“…Mitochondrial dysfunction-induced oxidative stress is a key pathogenic factor in acute kidney injury (AKI). …”
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Contemporary insights into rehabilitation of cervical cancer patients by D. V. Blinov, A. G. Solopova, E. E. Achkasov, D. I. Korabelnikov, S. A. Akavova, V. N. Galkin, Ph. V. Nenakhov, G. K. Bykovshchenko, D. A. Petrenko

“…Vigorous antitumor treatment approaches employed in CC management have detrimental effects on various aspects of a woman's life. In addition to causing morphofunctional alterations in diverse host organs and systems, such treatment protocols result in psychological and emotional disturbances, sexual dysfunction, and social maladjustment, which collectively profoundly reduce the quality of life (QoL). …”
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Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinflammation in a food-borne polystyrene microplastic exposed mouse model by Chong Liu, Yan Zhao, Wei Zhang, Ji-Ji Dao, Qian Li, Jia Huang, Zhen-Feng Li, Yu-Ke Ma, Chen-Meng Qiao, Chun Cui, Shuang-Xi Chen, Li Yu, Yan-Qin Shen, Wei-Jiang Zhao

“…In vitro experiments demonstrated that E4A partially alleviated PS-MPs-induced hippocampal neuronal injury and its effects on microglial inflammation. In conclusion, the findings of this study indicate that targeted activation of ErbB4 receptor may mitigate neuronal damage and subsequent neuroinflammation, thereby alleviating hippocampal neuronal injury induced by PS-MPs exposure and ameliorating cognitive dysfunction. …”
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Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis by Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo

“…Few mechanism‐based therapies against cardiotoxicity are available. Dysfunction in mitochondrial energy metabolism contributes to Dox‐induced cardiomyopathy. …”
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A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings by Andrea Gogos, Alyssa M. Sbisa, Jeehae Sun, Andrew Gibbons, Madhara Udawela, Brian Dean

“…In this review, we comprehensively analyse studies that have investigated the effects of estrogen, in particular 17β-estradiol, in clinical, animal, and molecular research with relevance to schizophrenia. …”
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Trial of Zolpidem, Eszopiclone, and Other GABA Agonists in a Patient with Progressive Supranuclear Palsy by Andrew Young Chang, Erica Weirich

“…In an effort to find a sustainable medication that maximized these beneficial effects while minimizing side effects and addressing some of her comorbid neuropsychological conditions, a trial of five other GABA receptor agonists was performed with the patient’s consent, while she and her caregivers were blinded to the specific medications. …”
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Improving the efficacy of musculoskeletal pain therapy: the role of B-group vitamins combination (descriptive review) by A. E. Karateev

“…This is due to the complex, multifactorial pathogenesis of MSP, involving persistent inflammation, inadequate tissue repair, nociceptive system dysfunction, biomechanical disturbances, and psycho-emotional factors.Therefore, the mainstay of pain management today is a multimodal approach that utilizes treatments and agents with different mechanisms of action to achieve a synergistic analgesic effect. …”
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The enabling control systems and work performance in higher education: the role of intrinsic motivation in overcoming task difficulty by Kristin Rosalina, Ruzita Jusoh

“…Hence, overlooking academics’ intrinsic motivation consequences in the organisation’s control design will lead to the systems’ dysfunction.…”
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GRAPE SEED (VITIS VINIFERA L.) ALLEVIATE REPRODUCTIVE TOXICITY CAUSED BY LINDANE IN NEW ZEELAND WHITE MALE RABBITS by Salma H. ABU HAFSA, Hassan A. AYMAN, Assadi Soumeh ELHAM, Agatha POPESCU, Dorina MOCUTA

“…The present study aimed to investigate the protective effect of GS against the possible testicular dysfunction caused by Lindane in male rabbits. …”
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Cardiovascular system state changes in non-Hodgkin’s lymphoma patients during chemotherapy by A.-S. O. Bady, S. S. Fedorova, D. A. Yakhontov, T. I. Pospelova

“…Chemotherapy is one of reliable and proven methods of malignant tumor and blood diseases treatment but however the drug side effects (particularly cardiotoxicity) occur. More often cardiovascular complications connect with anthracyclines and related drugs (doxorubicin, daunorubicyn, epirubicyn, idarubicyn, mitoxantron) which usually used at medical scheme because of wide spectrum of action and high effectiveness prescription. …”
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Liraglutide attenuates autoimmune myocarditis by inhibiting NLRP3 and NF-κb pathways by Lijuan Zhang, Lishuai Han, Yang Lu, Quanzhou Chen

“…Abstract Myocarditis, an inflammatory heart disease, often leads to severe cardiac dysfunction, including dilated cardiomyopathy and sudden death. …”
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Omega-3 fatty acids: multi-target mechanisms and therapeutic applications in neurodevelopmental disorders and epilepsy by Miao Li, Zhiqiang Li, Yuying Fan

“…Epilepsy, characterized by recurrent seizures due to neuronal hyperexcitability, shares pathological mechanisms with NDDs, such as neuroinflammation, synaptic dysfunction, and oxidative stress. Omega-3 fatty acids—primarily docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)—exert neuroprotective and neuromodulatory effects in these conditions through multifaceted mechanisms. …”
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THE IMPACT OF COMPLEX THERAPY ON QUALITY OF LIFE AND COGNITIVE IMPAIRMENT IN THE REHABILITATION OF PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA by Максим Владимирович Авров, Валентина Михайловна Алифирова, Андрей Владимирович Коваленко

“…Patients receiving complex (drug and non-drug) treatment showed a more significant effect of treatment.…”
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Circulating Biomarkers of Diabetic Retinopathy: An Overview Based on Physiopathology by Olga Simó-Servat, Rafael Simó, Cristina Hernández

“…The currently available treatments for DR are applicable only at advanced stages of the disease and are associated with significant adverse effects. In early stages of DR the only therapeutic strategy that physicians can offer is a tight control of the risk factors for DR. …”
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Revamping Parkinson’s disease therapy using PLGA-based drug delivery systems by Jude Majed Lababidi, Hassan Mohamed El-Said Azzazy

“…Abstract Parkinson’s Disease (PD) involves degeneration of dopamine-producing neurons, mitochondrial dysfunction, alpha-synuclein aggregation, neuroinflammation, and gut-brain axis disturbances. …”
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Unlocking the Potential of Vitamin D: A Comprehensive Exploration of Its Role in Neurological Health and Diseases by Rehana Khatoon

“…Moreover, emerging reports underscore VD’s potential in mitigating the pathophysiology of neurodegenerative diseases, including memory and motor impairments, mitochondrial dysfunction, and neuronal loss. Extensive in vitro and in vivo studies elucidate VD’s multifaceted neuroprotective mechanisms, effectively mitigating neuronal damage and ATP deprivation, thus reducing mortality and morbidity. …”
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