A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. by Jamie L Barger, Tsuyoshi Kayo, James M Vann, Edward B Arias, Jelai Wang, Timothy A Hacker, Ying Wang, Daniel Raederstorff, Jason D Morrow, Christiaan Leeuwenburgh, David B Allison, Kurt W Saupe, Gregory D Cartee, Richard Weindruch, Tomas A Prolla

“…Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. …”
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Main Pharmacological Strategies Against SARS-CoV-2 by Thais Gonçalves Fontes, Afrânio Côgo Destefani

“…The main groups of drugs and their adverse effects and drug interactions were raised. Specific concerns in patients with COVID-19 include underlying structural heart disease, cardiac injury, kidney and liver dysfunction, limited resources for cardiac monitoring and drug interaction. …”
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Genetic dilemma: eNOS gene intron 4a/b VNTR polymorphism in sepsis and its clinical features in Turkish children by Umit Celik, Dinçer Yildizdaş, Emre Alhan, Tamer Celik, Gülen Attila, Yaşar Sertdemir, Tugay Tepe

“…This is the first study that evaluates the effect of eNOS4a/b polymorphism in sepsis. We were unable to show a relationship between eNOS gene intron 4 a/b VNTR polymorphism and MODS, ARDS, mortality and shock. …”
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Obstetrical and perinatal complications in women with body weight deficiency by L. P. Shelestova, R. S. Allahverdiev, V. G. Syusyuka

“…Women with body weight deficiency are characterized by high rate of threatened abortion, early toxicosis, anemia, placental dysfunction, fetal growth retardation, bones and ligaments diseases. …”
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Silica nanoparticle toxicity: cellular mechanisms, neurotoxicological concerns, and environmental perspectives by Yuji Kamikubo, Hakushun Sakairi

“…However, their extensive application has raised concerns about their potentially detrimental effects on human health and ecosystems. This mini-review summarizes current knowledge of the cellular mechanisms underlying SiNP cytotoxicity, with a focus on oxidative stress, NOD-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation, lysosomal destabilization, mitochondrial dysfunction, genotoxicity, and autophagy modulation. …”
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Sodium-Glucose Cotransporter-2 Inhibitor in Diabetic and Nondiabetic Renal Transplant Recipients by Lucie Maigret, Lucile Basle, Valérie Chatelet, Laure Ecotiere, Peggy Perrin, Léonard Golbin, Dominique Bertrand, Dany Anglicheau, Coralie Poulain, Cyril Garrouste, Clément Danthu, Charlotte Boud'hors, Yannick Le Meur, Manon Dekeyser, Fabien Duthe, Bénédicte Sautenet, Pierre-Guillaume Deliège, Philippe Gatault

“…The short-term antiproteinuric and antihypertensive effects are promising.…”
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β-Resorcylic acid prevents MASLD in ob/ob mice by modulating lipid metabolism and inflammation in the liver by Sergio López-Herrador, Sara Torres-Rusillo, Pilar González-García, Laura Jiménez-Sánchez, Julia Corral-Sarasa, Mohammed Bakkali, M. Elena Díaz-Casado, Luis C. López

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a significant global health challenge. …”
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KCNK2-mediated regulation of MMP-2/9 by PlGF influences uterine artery function in pregnancy-induced hypertension by Yinzhen Chen, Mingfu Chen, Ridong Zhou, Jichang Zheng, Gongxin Yang, Meiyu Chen, Jing Tu, Hongming Lin, Hu Zhao, Chen Lin, Xiaobin Chen

“…This study investigated the regulatory effect of PlGF on the two pore domain potassium channel KCNK2 and its downstream targets MMP 2/9, and explored the role of the PlGF KCNK2 MMP 2/9 axis in PIH related uterine arterial dysfunction. …”
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Progress on the Mechanisms and Neuroprotective Benefits of Dexmedetomidine in Brain Diseases by Zhenxing Tao, Pengpeng Li, Xudong Zhao

“…Results Dexmedetomidine has shown strong neuroprotective effects, such as protection of the blood‐brain barrier, decreased neuronal death, maintained hemodynamic stability, and reduced postoperative agitation and cognitive dysfunction. …”
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HIV, smoking, and the brain: a convergence of neurotoxicities by Benjamin L. Orlinick, Shelli F. Farhadian

“…Evidence also suggests the potential for synergistic effects of HIV and tobacco smoking on neurotoxicity. …”
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MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes by Alex M. Parker, Jarmon G. Lees, Mitchel Tate, Ren J. Phang, Anida Velagic, Minh Deo, Tayla Bishop, Thomas Krieg, Michael P. Murphy, Shiang Y. Lim, Miles J. De Blasio, Rebecca H. Ritchie

“…Mitoquinone mesylate (MitoQ), a mitochondrial-targeted antioxidant has been reported to be protective against vascular dysfunction in hypertension, diabetic kidney disease and alcohol-induced liver damage. …”
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Therapeutic mechanism of nano-selenium in hexavalent chromium poisoning in laying hens by Chang Zhou, Zhao Xu, Donghai Zhou

“…Nanoselenium treatment effectively counteracted these effects, restoring pathway balance and reducing oxidative damage and mitochondrial dysfunction. …”
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Incretin hormone agonists as promising antiobesity drugs - review of literature by Aleksandra Grzegorczyk, Justyna Korus, Marta Dziedziak, Nicol Dardzińska, Natalia Hopej

“…Dietary recommendations and recommendations regarding physical activity turned out not to show satisfactory effects in patients with obesity in terms of weight loss, but also in maintaining the effects of the actions taken. …”
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Child Health, Agriculture and Integrated Nutrition (CHAIN): protocol for a randomised controlled trial of improved infant and young child feeding in rural Zimbabwe by Paul Kelly, Lisa Langhaug, Robert Ntozini, Kuda Mutasa, Bernard Chasekwa, Andrew Prendergast, Batsirai Mutasa, Naume V Tavengwa, Tim Brown, Laura E Smith, Dexter. T Chagwena, Claire Bourke, Ruairi Robertson, Shamiso Fernando, Jill Cairns, Thokozile Ndhlela, Exhibit Matumbu, Kavita Datta, Alice Tengende, Dzivaidzo Chidhanguro, Maggie Makanza, Jonathan Swann

“…Introduction Over one-quarter of children in sub-Saharan Africa are stunted; however, commercial supplements only partially meet child nutrient requirements, cannot be sustainably produced, and do not resolve physiological barriers to adequate nutrition (eg, inflammation, microbiome dysbiosis and metabolic dysfunction). Redesigning current infant and young child feeding (IYCF) interventions using locally available foods to improve intake, uptake and utilisation of nutrients could ameliorate underlying pathogenic pathways and improve infant growth during the critical period of complementary feeding, to reduce the global burden of stunting.Methods and analysis Child Health Agriculture Integrated Nutrition is an open-label, individual household randomised trial comparing the effects of IYCF versus ‘IYCF-plus’ on nutrient intake during infancy. …”
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SMPDL3B a novel biomarker and therapeutic target in myalgic encephalomyelitis by Bita Rostami-Afshari, Wesam Elremaly, Anita Franco, Mohamed Elbakry, Marie-Yvonne Akoume, Ines Boufaied, Atefeh Moezzi, Corinne Leveau, Pierre Rompré, Christian Godbout, Olav Mella, Øystein Fluge, Alain Moreau

“…These findings warrant clinical trials to evaluate their potential in mitigating immune dysfunction and symptom burden in ME.…”
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Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? O dano neuronal e o déficit de memória após convulsões são revertidos pelo ácido ascórbico? by Adriana da Rocha Tomé, Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas

“…The objective of the present study was to evaluate the neuroprotective effects of ascorbic acid (AA) in rats, against the neuronal damage and memory deficit caused by seizures. …”
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A Randomized Controlled Trial Evaluating the Efficacy of Perioperative Acupuncture Combined with Traditional Chinese Medicine for Enhancing Upper Limb Functionality after Breast C... by PATIGULI Jiapaer, JIANG Ke, YUAN Minjia, LI Xiaofei, DONG Mengting, SHENG Jiayu

“…ObjectiveTo explore the effect of oral Qi-Zhu Formula combined with electroacupuncture on postoperative pain and upper limb dysfunction in patients with breast cancer during the perioperative period.MethodsA total of 90 patients who underwent radical mastectomy in the department of breast diseases of Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine between January 2022 and December 2022 were randomly assigned to either a conventional medicine group or a combined electroacupuncture and medicine group, with 45 cases in each group. …”
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Comparative evaluation of blood biochemical parameters and changes of the internal organs under the influence of doxorubicin and nanostructured doxorubicin in condition of transpla... by I. N. Chairkin, O. N. Deryabina, N. V. Chairkina, I. V. Kargina, V. Yu. Medvezhonkov, A. E. Strizhkov, K. V. Bulygin

“…The use of doxorubicin is accompanied by dysfunction and inhibition of blood sprouts, and also has nephrotoxic and hepatotoxic effects, which is confirmed by changes in the biochemical parameters of blood serum while the use of nanostructured doxorubicin is accompanied by normalization of these indicators.…”
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Management of Atrial Fibrillation in Critically Ill Patients by Mattia Arrigo, Dominique Bettex, Alain Rudiger

“…The optimal substance should be selected depending on its potential adverse effects. A beta-1 antagonist with a very short half-life (e.g., esmolol) is an advantage for ICU patients because the effect of beta-blockade on cardiovascular stability is unpredictable in those patients. …”
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Addressing quality of life in the patient with interstitial cystitis/bladder pain syndrome by Vinaya Vasudevan, Robert Moldwin

“…The effects of IC/BPS and co-morbid conditions on QoL are described using current validated metrics. …”
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