From the foot-mouth reflex to the hand-mouth reflex a continuum of responses to Appendicular Compression Do reflexo pé-boca ao reflexo mão-boca: um continuum de respostas à Compres... by Fleming S. Pedroso, Newra T. Rotta

“…Stimulation of the foot was more effective in eliciting a mouth opening response when compared to equivalent stimulation of the lower leg (p<0.05). …”
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Narirutin mitigates inflammatory arthritis and osteoporosis through modulating macrophage phenotype and osteoclastogenesis by Qing Wang, Xiaole Peng, Hao Xu, Yuhu Zhao, Xiaoheng Lu, Chengyao Lu, Qihan Wang, Wei Lu, Qifeng Sheng, Xiaomin Lu, Yaozeng Xu, Dechun Geng

“…A classical collagen-induced arthritis (CIA) model was established to investigate the therapeutic effects of NRT administration on inflammatory arthritis and osteoporosis. …”
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Co-expression of IL-15 and CCL21 strengthens CAR-NK cells to eliminate tumors in concert with T cells and equips them with PI3K/AKT/mTOR signal signature by Jie Zhou, Lu Tang, Yu Hu, Jun Deng, Yingying Li, Wei Xiong, Jianghua Wu, Jia Xu, Wenjing Luo, Heng Mei, Xindi Wang, Zhaozhao Chen, Chenggong Li, Zhongpei Huang, Zhuolin Wu, Yinqiang Zhang, Yun Kang, Qiaolin Liu

“…The recruitment and cooperative effects also result in effective tumor control in mouse models. …”
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Epigallocatechin Gallate in <i>Camellia sinensis</i> Ameliorates Skin Aging by Reducing Mitochondrial ROS Production by Ji Ho Park, Eun Young Jeong, Ye Hyang Kim, So Yoon Cha, Ha Yeon Kim, Yeon Kyung Nam, Jin Seong Park, So Yeon Kim, Yoo Jin Lee, Jee Hee Yoon, Byeonghyeon So, Duyeol Kim, Minseon Kim, Youngjoo Byun, Yun Haeng Lee, Song Seok Shin, Joon Tae Park

“…<b>Background:</b> Reactive oxygen species (ROS) generated by mitochondrial dysfunction damage cellular organelles and contribute to skin aging. …”
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Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration by Jiangminghao Zhao, Peichuan Xu, Tao Li, Jinghong Yuan, Wenrui Zhao, Rui Ding, Guoyu Yang, Jiajun Xie, Guanfeng Huang, Zhidong Peng, Xinxin Miao, Xigao Cheng

“…This highlights promising targets and effective strategies for mitigating the impact of IVDD.…”
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Investigating intra‐tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single‐cell RNA sequencing by Jingyuan Huo, Zhen Wang, Wenting Zhao, Miao Chen, Haoyang Li, Fengpu He, Xiao Tian, Yaqi Ma, Firyuza Husanova, Liang Ma, Yiming Ni, Hongda Ding, Weidong Li, Hongfei Xu

“…Understanding cellular heterogeneity and tumour microenvironment (TME) is crucial for the development of effective therapies. Here, we investigated the intratumoural heterogeneity and TME diversity of PCAS using single‐cell RNA sequencing (scRNA‐seq). …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…Advanced maternal age (AMA) placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise reasons and mechanisms of trophoblast aging in AMA placenta remain unclear, posing a significant limitation to provide effective guidance for prenatal healthcare in clinical settings. …”
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Efficacy of Kinesio Taping Combined with Vitalstim Electrical Stimulation Therapy in Patients with Post-Stroke Dysphagia by FU Shanshan, TANG Jian

“…Comparison of nutritional indicators showed that BMI, ALB, and Hb indexes increased in all three groups after treatment (<italic>P</italic>&lt;0.05), with the increase in the combined group being more pronounced than the Vitalstim electrical stimulation group and the kinesio tape group (<italic>P</italic>&lt;0.05), and no significant difference between the Vitalstim electrical stimulation group and the the kinesio tape group (<italic>P</italic>&gt;0.05).ConclusionThe application of kinesio taping combined with Vitalstim electrical stimulation therapy in patients with post-stroke swallowing dysfunction can significantly improve therapeutic efficacy, reduce the incidence of aspiration, improve feeding safety, and improve swallowing function as well as nutritional status.…”
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Risk factor analysis and predictive model construction of lean MAFLD: a cross-sectional study of a health check-up population in China by Ruya Zhu, Caicai Xu, Suwen Jiang, Jianping Xia, Boming Wu, Sijia Zhang, Jing Zhou, Hongliang Liu, Hongshan Li, Jianjun Lou

“…Abstract Aim Cardiovascular disease morbidity and mortality rates are high in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). …”
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Cardiometabolic risk assessment by anthropometric and biochemical indices in mexican population by Luz Quirino-Vela, Miguel Mayoral-Chavez, Yobana Pérez-Cervera, Yobana Pérez-Cervera, Osiris Ildefonso-García, Elizabeth Cruz-Altamirano, Monserrat Ruiz-García, Juan Alpuche

“…These accessible, cost-effective tools offer superior diagnostic accuracy and enhance early identification of high-risk individuals in resource-limited healthcare settings. …”
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Warfarin for Priapism With Primary Antiphospholipid Syndrome: From Culprit to Cure by Yashashree Vegi, Sri Harsha Kanuri, Mohamed Ghoweba, Ogechi Agogbuo, Lijo John, Paul Bradley

“…It poses significant adverse effects on quality of life, and if left untreated, it can possibly lead to permanent erectile dysfunction. …”
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Cholemic Nephropathy: Hyperbilirubinemia and its Impact on Renal Function by Jonathan S Chávez-Iñiguez, Alejandra Meza-Ríos, Arturo Santos-Garcia, Guillermo García-García, Juan Armendáriz-Borunda

“…Cholemic nephropathy represents a spectrum of renal injury, from proximal tubulopathy to intrarenal bile cast formation, found in patients with severe liver dysfunction. It is caused by hyperbilirubinemia, usually in jaundiced patients. …”
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Overall leukocyte levels link risk factors to Von Willebrand factor and Neutrophil Extracellular Traps in stroke thrombi: a Structural Equation Modeling analysis by Lin Shi, Chunxiao Wei, Guowei Ye, Panpan Zhao, Shiqiang Ma, Yiming Qi, Yiming Qi, Ruolin Zhou, Ruolin Zhou, Yaru Zhang, Yaru Zhang, Yan Zhang, Lingjie Meng, Weihang Xu, Chao Li, Shouchun Wang, Li Sun

“…The Partial Least Squares Structural Equation Modeling (PLS-SEM) assessed direct and indirect associations, with leukocyte and its subtype counts as mediating variables, VWF and NETs as endogenous variables, and cerebrovascular risk factors as exogenous variables.ResultsHeart dysfunction and blood glucose showed a significant negative indirect effect on VWF through the overall leukocyte levels (indirect effect = −0.119 and −0.118, p &lt; 0.05). …”
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Chemotherapy‐Induced Peripheral Polyneuropathy in Pediatric Acute Lymphoblastic Leukemia: A Case Report on Manifestation, Management, and Outcome by Eman Al Mattar, Sondus Al Sharidah, Omnia A. Hashem

“…ABSTRACT Background Chemotherapy‐induced peripheral polyneuropathy (CIPN) is a debilitating side effect of cancer treatment such as in acute lymphoblastic leukemia (ALL). …”
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Clinical and pathogenetic aspects of neutrophilic bronchial inflammation in asthma patients with cold-induced airway hyperresponsiveness (literature review) by A. B. Pirogov, A. G. Prikhodko, N. A. Pirogova, J. M. Perelman

“…The review presents data on the effect of neutrophilic bronchial inflammation on the clinical course, external respiration, and formation of the airway response to cold air in patients with asthma. …”
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An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease by Aurèle Besse-Patin, Jennifer L. Estall

“…Reactive oxygen species (ROS) emission, resulting from nutrient overload and mitochondrial dysfunction, is thought to be a principal mediator in NAFLD progression, particularly toward the development of hepatic insulin resistance. …”
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PREINFARCTION ANGINA AS A CLINICAL FORM OF THE ISCHEMIC PRECONDITIONING PHENOMENON by E. A. Lykasova, V. V. Todosiychuk, V. A. Kuznetsov, Y. A. Yurkina

“…There is evidence that elderly age, presence of diabetes mellitus, left ventricular hypertrophy and hypercholesterolemia do reduce the cardioprotective effect of preinfarction angina. Preinfarction angina may be an additional criterion of risk stratification in myocardial infarction patients. …”
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Regulation of the immune microenvironment by SUMO in diabetes mellitus by Yuting Zhuo, Yuting Zhuo, Shangui Fu, Yue Qiu

“…The pathogenesis of diabetes, particularly type 1 and type 2 diabetes, has been closely associated with immune dysfunction, which constitutes the primary focus of this review. …”
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JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models by Peng Zhang, Zhipeng Li, Minxue Liang, Jinxian Yuan, Jinyu Zhou, Jie Zhang, Jing Deng, Yalan Chen, Hao Tang, Chengjie Xu, Chenjun Shi, Limin Ma, Qiankun Liu, Yong Liu, Yangmei Chen, Hui Zhang

“…Graphical Abstract Schematic illustration of the mechanisms by which JC124 exerts neuroprotective effects in epilepsy…”
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Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD+/SIRT3 signaling pathway-mediated mitochondrial autophagy... by Zixuan Sun, Jiali Li, Yuzhou Zheng, Jiaxin Zhang, Wenhuan Bai, Xinyi Deng, Zhijing Wu, XueZhong Xu, Wei Ding, Hui Qian, Yulin Tan

“…In addition, the defense effects of NMN-sEVs against cellular senescence were verified by reactive oxygen species assay, β-galactosidase staining, qRT-PCR, Western blot, and cellular immunofluorescence. …”
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