Identification of Exhaled Metabolites Correlated with Respiratory Function and Clinical Features in Adult Patients with Cystic Fibrosis by Real-Time Proton Mass Spectrometry by Malika Mustafina, Artemiy Silantyev, Stanislav Krasovskiy, Alexander Chernyak, Zhanna Naumenko, Aleksandr Suvorov, Daria Gognieva, Magomed Abdullaev, Olga Suvorova, Anna Schmidt, Aida Gadzhiakhmedova, Aleksandra Bykova, Sergey Avdeev, Vladimir Betelin, Abram Syrkin, Philipp Kopylov

“…The purpose of the study was to identify volatile organic compounds (VOCs) as predictors of respiratory dysfunction, chronic respiratory infections of <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, <i>Burkholderia cepacia</i>, and VOCs associated with severe genotype and highly effective modulator treatment (HEMT). …”
Get full text

Immunosuppressive cells in acute myeloid leukemia: mechanisms and therapeutic target by Mengnan Liu, Mengting Yang, Mengting Yang, Yue Qi, Yue Qi, Yuting Ma, Yuting Ma, Qulian Guo, Qulian Guo, Ling Guo, Ling Guo, Chunyan Liu, Chunyan Liu, Wenjun Liu, Wenjun Liu, Lan Xiao, Lan Xiao, You Yang, You Yang

“…The immunosuppressive AML microenvironment, characterized by profound immune dysfunction, critically impairs anti-leukemic immune surveillance. …”
Get full text

Evaluation of molecular mouse sepsis panel: new portable and rapid tests for microorganism detection in suspected blood stream infection by Claudia Colosimo, Claudia Colosimo, Maria Sofia Montanari, Maria Sofia Montanari, Anna Marzucco, Anna Marzucco, Giulia Gatti, Giulia Gatti, Lucrezia Puccini, Laura Grumiro, Laura Grumiro, Laura Dionisi, Laura Dionisi, Martina Brandolini, Martina Brandolini, Ludovica Ingletto, Ludovica Ingletto, Massimiliano Guerra, Giorgio Dirani, Silvia Zannoli, Alessandra Scagliarini, Alessandra Mistral De Pascali, Alessandra Mistral De Pascali, Vittorio Sambri, Vittorio Sambri, Monica Cricca, Monica Cricca

“…A timely and accurate diagnosis of BSIs is crucial for ensuring effective management and treatment of critically ill patients. …”
Get full text

TJ0113-induced mitophagy in acute liver failure detected by Raman microspectroscopy by Chunlian Huang, Jiaqi Liao, Xufeng Cen, Changwei Jiao, Sijia Chen, Dong Liu, Hang-Shuai Qu, Jiansheng Zhu, Sailing He

“…Impaired mitophagy underlies the pathophysiology of acute liver failure (ALF) and is closely associated with tissue damage and dysfunction. A novel mitophagy inducer, TJ0113, was used for treatment during ALF pathogenesis. …”
Get full text

Prognostic value of β1 adrenergic receptor autoantibodies for microvascular obstruction in patients with STEMI with Post-PCI: A prospective cohort study by Ning Cao, Wenxi Dang, Yanguo Xin, Jiayu Li, Shaohua Guo, Qitian Li, Hui Chen, Shun Li

“…The combination of β1-AA with pNT-proBNP and pTNI improves predictive accuracy, providing a more robust and effective strategy for assessing MVO risk.…”
Get full text

Motivations, acceptability and ethical considerations for interventional HIV cure research at the end of life: perspectives from long-term survivors of HIV in the United States by Ali Ahmed, Jeff Taylor, Whitney Tran, Simran Swaitch, Samuel O. Ndukwe, Rachel Lau, Kris H. Oliveira, Stephanie Solso, Cheryl Dullano, Andy Kaytes, Davey Smith, Robert Deiss, Sara Gianella, Karine Dubé

Get full text

Semaglutide in MASLD Patients: Improved Survival and Liver Outcomes by Mohamad Suki, Johnny Amer, Yael Milgrom, Muhammad Massarwa, Wadi Hazou, Yariv Tiram, Ofer Perzon, Yousra Sharif, Joseph Sackran, Revital Alon, Nachum Emil Eliezer Lourie, Itamar Raz, Ashraf Imam, Abed Khalaileh, Rifaat Safadi

“…<b>Introduction</b>: Semaglutide (SEMA) has shown potential benefits in metabolic dysfunction-associated steatotic liver disease (MASLD). …”
Get full text

Evaluation of the Biological Properties and Antibacterial Activities of the Natural Food Supplement “Epavin” for Liver Detoxification and Protection by Alexia Barbarossa, Maria Pia Argentieri, Maria Valeria Diella, Anita Caforio, Antonio Carrieri, Filomena Corbo, Antonio Rosato, Alessia Carocci

“…Background/Objectives: The liver, the body’s primary detoxifying organ, is often affected by various inflammatory diseases, including hepatitis, cirrhosis, and non-alcoholic fatty liver disease (NAFLD), many of which can be exacerbated by secondary infections such as spontaneous bacterial peritonitis, bacteremia, and sepsis—particularly in patients with advanced liver dysfunction. The global rise in these conditions underscores the need for effective interventions. …”
Get full text

Therapeutic potential of naturally derived carbon dots in sepsis-associated acute kidney injury by Lei Wang, Zhong-Yao Li, Chong-Lei Zhong, Zi-Yang Teng, Bin Wang, Asma Rehman, Li-Wen Han, Ke-Wu Zeng, Ji-Guo Zhang, Zhi-Yuan Lu

“…Methods To avoid the generation of toxic effects, the natural CDs derived from Ziziphi Spinosae Semen (Z-CDs) were synthesized employing a hydrothermal method. …”
Get full text

Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD by Roger Bentanachs, Patricia Ramírez-Carrasco, Bianca Braster, Anastasia Emmanouilidou, Endrina Mujica, Maite Rodrigo-Calvo, Cristina Rodríguez, Núria Roglans, Marcel den Hoed, Juan C. Laguna, Marta Alegret

“…Drug combination and repurposing are potential therapeutic strategies for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). …”
Get full text

Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…Abstract Background Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder characterized by symptoms of esophageal dysfunction and eosinophil-predominant inflammation. …”
Get full text

Development and application of an early prediction model for risk of bloodstream infection based on real-world study by Xiefei Hu, Shenshen Zhi, Yang Li, Yuming Cheng, Haiping Fan, Haorong Li, Zihao Meng, Jiaxin Xie, Shu Tang, Wei Li

“…Early identification of BSI is crucial for effective intervention, reducing mortality, and improving patient outcomes. …”
Get full text

CORRELATIONS OF DIFFERENT STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF ARTERIAL WALL WITH TRADITIONAL CARDIOVASCULAR RISK FACTORS IN HEALTHY PEOPLE OF DIFFERENT AGE. PART 2 by I. D. Strazhesko, O. N. Tkacheva, D. U. Akasheva, E. V. Dudinskaya, M. V. Agaltsov, A. S. Kruglikova, N. V. Brailova, V. S. Pykhtina, E. V. Plokhova, N. V. Sharashkina, O. Yu. Isaykina, V. A. Vygodin, S. A. Boytsov

“…Detection of principal subclinical arterial wall lesions is one of the most important aspects of effective cardiovascular disease (CVD) primary prevention. …”
Get full text

Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization by Xudong Su, Jianye Yang, Zhenghao Xu, Li Wei, Shuhao Yang, Feilong Li, Min Sun, Yingkun Hu, Wenge He, Chen Zhao, Li Chen, Yonghua Yuan, Leilei Qin, Ning Hu

“…Macrophages play a key role in wound healing. Dysfunction of their M0 polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation, which affects wound healing. …”
Get full text

miRNA let-7f-5p-encapsulated labial gland MSC-derived EVs ameliorate experimental Sjögren’s syndrome by suppressing Th17 cells via targeting RORC/IL-17A signaling axis by Yufei Xie, Maosheng Chai, Yixiao Xing, Peiru Zhou, Pan Wei, Hong Hua

“…Therefore, the development of novel and effective therapeutic strategies is a pressing demand in clinical research. …”
Get full text

Huashi Baidu formula alleviates lipopolysaccharide-induced inflammation and acute lung injury in mice by targeting nuclear factor κB/phosphatidylinositol 3-kinase and peroxiredoxin... by Shengnan Shen, Liwei Gu, Qiaoli Shi, Yongping Zhu, Yanqing Liu, Junzhe Zhang, Yuqing Meng, Yinkwan Wong, Wennan Luo, Mengyao Jiang, Ping Song, Jigang Wang

“…Huashi Baidu formula treatment mitigated ALI and inflammatory cytokine dysfunction in LPS-induced mice, thus exerting a therapeutic effect on COVID-19. …”
Get full text

Myofascial pain syndrome in female patients with chronic nonspecific back pain: diagnosis and treatment by D. O. Rozhkov, O. E. Zinovyeva, A. N. Barinov, I. M. Vikhlyantsev, G. Z. Mikhailova, N. V. Penkov, A. M. Nosovsky

“…When the treatment was insufficiently effective, ultrasonography of the muscle straightening the spinal column was additionally performed; a local anesthetic was injected into myofascial trigger points (MTPs).Results and discussion. …”
Get full text

(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway by Shengnan Li, Shengnan Li, Shengnan Li, Jingjing Zhang, Jingjing Zhang, Jingjing Zhang, Yuewen Zhao, Li Kang, Haipeng Jie, Haipeng Jie, Haipeng Jie, Bo Dong, Bo Dong, Bo Dong

“…However, the lack of effective treatments for DCM remains a clinical challenge. …”
Get full text

The hexapeptide functionalized gold nanoparticles protect against sepsis-associated encephalopathy by forming specific protein corona and regulating macrophage activation by Zichen Song, Hongguang Chen, Wenfei Xu, Xiaoye Zong, Xiaoyu Wang, Yuting Ji, Jiameng Gong, Mimi Pang, Shan-Yu Fung, Hong Yang, Yonghao Yu

“…Currently, there are no effective pharmacological therapeutics to treat SAE. …”
Get full text

Creation of a collection of different biological sample types from elderly patients to study the relationship of clinical, systemic, tissue and cellular biomarkers of accumulation... by A. G. Sorokina, Ya. A. Orlova, O. A. Grigorieva, E. S. Novoseletskaya, N. A. Basalova, N. A. Alexandrushkina, M. A. Vigovsky, K. I. Kirillova, A. V. Balatsky, L. M. Samokhodskaya, N. V. Danilova, U. D. Dyachkova, D. А. Fedotov, A. A. Akopyan, V. V. Kakotkin, D. A. Asratyan, Zh. A. Akopyan, A. Yu. Efimenko

“…With aging, tissue homeostasis and their effective recovery after damage is violated. It has been shown that this may be due to the excessive accumulation of senescent (SC) cells in various tissues, which leads to the activation of chronic sterile inflammation, tissue dysfunction and, as a result, to the development of age-related diseases. …”
Get full text