Incretin-Based Therapy for Prevention of Diabetic Vascular Complications by Akira Mima

“…Additionally, the loss of tissue-specific insulin signaling induced by hyperglycemia and toxic metabolites can induce cellular dysfunction and both macro- and microvascular complications characteristic of diabetes. …”
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Escitalopram-induced Hypersexuality—Imbalance of the Sexual Seesaw by Souganyadevi Mahalakshmi, Barath Ramanathan, Arun Selvaraj, Perarul Sivakumar, Priyanka Ponnusamy

“…SSRI-induced hypersexuality is very rarely reported in the literature. Sexual dysfunction predisposes loss of treatment compliance. …”
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The Impact of Dietary Melatonin on Heart and Lung Telomere Length and Shelterin Protein Gene Expression of Pulmonary Hypertensive Broiler Chickens by Peyman Gheytaspour, Shahab Bahadoran, Hossein Hassanpour

“…These findings suggest that melatonin could be a valuable tool in managing heart cell dysfunction associated with PHS in poultry.…”
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Analysis of Tyrosine Kinase Inhibitor-Mediated Decline in Contractile Force in Rat Engineered Heart Tissue. by Fabian Jacob, Amina Y Yonis, Friederike Cuello, Pradeep Luther, Thomas Schulze, Alexandra Eder, Thomas Streichert, Ingra Mannhardt, Marc N Hirt, Sebastian Schaaf, Justus Stenzig, Thomas Force, Thomas Eschenhagen, Arne Hansen

“…<h4>Introduction</h4>Left ventricular dysfunction is a frequent and potentially severe side effect of many tyrosine kinase inhibitors (TKI). …”
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Angiotensin receptor-1 antagonist eprosartan in patients with mild to moderate arterial hypertension by A. V. Shabalin, E. N. Gulyaeva, A. S. Krikovtsov

“…Eprosartan monotherapy was associated with moderate antihypertensive and sympatholytic effects, decreased diastolic dysfunction during psycho-emotional stress, and no negative influence on cognitive processes. …”
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Beyond conventional therapy: Synthesis of multifunctional nanoparticles for rheumatoid arthritis therapy by Ma Xinran

“…Rheumatoid arthritis (RA) is a persistent inflammatory illness that causes joint destruction and dysfunction due to the activation of macrophages and the generation of reactive oxygen species. …”
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Angiotensin II and Cardiovascular Disease: Balancing Pathogenic and Protective Pathways by Ulvi Bayraktutan

“…Angiotensin II, a key effector, is produced from angiotensin I by angiotensin-converting enzyme (ACE) and exerts its effects through binding to its type 1 (AT1R) or type 2 (AT2R) receptors. …”
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THE ROLE OF CARVEDILOL IN THE PREVENTION OF CARDIOMYOCYTE APOPTOSIS CAUSED BY ACUTE MYOCARDIAL INFARCTION by A. N. Zakirova, B. N. Garifullin, N. E. Zakirova

“…Carvedilol has antioxidant effects and prevents cell apoptosis due to reduction in calcium concentration in mitochondrial matrix. …”
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Possibilities of Conservative Treatment and Prevention of Cataract Development Using an Anti-cataract Drug by A. M. Razumovskaya, Yu. A. Korovyansky, E. S. Razumovskiy

“…These measures are aimed at improving the quality and effectiveness of medical rehabilitation activities and at reducing the morbidity and disability of various groups of patients. …”
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Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington's Disease T Lymphocytes. by James R C Miller, Ulrike Träger, Ralph Andre, Sarah J Tabrizi

“…This study increases our understanding of the effects of Huntington's disease on peripheral tissues, while further demonstrating the differential effects of the mutant protein on different but related cell types. …”
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Inhibitory mechanism of influence of thyroid hormones on cognitive function of the brain. by A. G. Rodynsky, E. M. Demchenko, E. J. Kondratieva, A. J. Golubka, D. S. Yaroshenko

“…Activity of serotonin- and GABA- ergic neurotransmitter systems of the brain in conditions of hyperthyroidism can be considered as increase of inhibitory processes in the  effect of feedback. In conditions of experimental hypothyroidism activation of the inhibitory effects of CNS serotonergic system may be one of the ways to reduce the metabolism.…”
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Green Tea: Conventional Facts and its Frontier Prospect on Health- A review by Swarup Kumar Kundu, Shonkor Kumar Das, M. Sohidullah

“…Polyphenols in tea are thought to exhibits anti-carcinogenic and anti-inflammatory effects. Green tea catechins acts as immune modulators in immune dysfunction and also play a role in protection from degenerative diseases. …”
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Lactobacillus reuteri-derived γ-amino butyric acid alleviates MPTP-induced Parkinson’s disease through inhibiting ferroptosis via the AKT-GSK3β-GPX4 axis by Xuechao Dong, Teng Yang, Zheng Jin

“…Abstract Parkinson’s disease (PD) is a debilitating neurological disorder characterized by motor dysfunction, which has been associated with alterations in the gut microbiota. …”
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Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease by Yan Wang, Mingshuai Bai, Qifan Peng, Leping Li, Feng Tian, Ying Guo, Changqing Jing

“…In the context of cardiovascular diseases, the gut microbiota promotes atherosclerosis and vascular dysfunction by producing trimethylamine N-oxide (TMAO) and other metabolites that promote inflammation and endothelial dysfunction. …”
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Strategy for prophylactic application of peripheral va-ecmo in transplantation involving expected extremely prolonged ischemia time by V. N. Poptsov, V. M. Zakharevich, E. A. Spirina, A. I. Skokova, A. K. Solodovnikova, A. S. Ignatkina, A. A. Kuznetsova, G. B. Glinkin

“…Objective: to determine the effect of prophylactic VA-ECMO on the perioperative period in HT with an expected graft ischemia &gt;6 hours. …”
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Efficacy and safety of prolonged-release hyaluronic acid derivative vaginal application in the postpartum period: a prospective randomised clinical trial by Claudio Gustavino, Paolo Sala, Nadia Cusini, Brunella Gravina, Cecilia Ronzini, Diletta Marcolin, Valerio Gaetano Vellone, Michele Paudice, Rossella Nappi, Sergio Costantini, Simone Ferrero, Fabio Barra

“…Introduction In puerperium, the hypoestrogenic state induced by delivery and subsequently sustained by lactation may lead to vaginal dryness, burning, and itching sensation, contributing to the onset of sexual dysfunction.Material and methods This was a prospective, randomized, controlled, open-label study (NCT04560283) for evaluating the effects of application of a prolonged-release hyaluronic acid derivative vaginal gel in restoring sexual function during the postpartum period. …”
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Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice by Maria Luisa De Paolis, Gilda Loffredo, Paraskevi Krashia, Livia La Barbera, Annalisa Nobili, Emma Cauzzi, Lucy Babicola, Matteo Di Segni, Roberto Coccurello, Stefano Puglisi-Allegra, Emanuele Claudio Latagliata, Marcello D’Amelio

“…Abstract Background Emerging evidence implicates early dysfunction of dopaminergic neurons in the Ventral Tegmental Area (VTA) as a key contributor to Alzheimer’s Disease (AD) pathophysiology. …”
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Peculiarities of clinical and metabolic profile of patients with coronary artery disease associated with type 2 diabetes mellitus (retrospective analysis) by N. S. Mykhailovska, T. O. Kulynych, O. V. Shershnova, Ye. I. Bazun, I. S. Bocharnykova, V. E. Padafa, A. O. Kolesnykova, Yu. V. Hura

“…Aim of the study: to determine the effect of type 2 diabetes mellitus on the clinical and metabolic features of patients with coronary artery disease. …”
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Preemptive Analgesia with Nonsteroidal Anti-Inflammatory Drugs in the Perioperative Period by M. S. Danilov, I. S. Simutis, D. S. Salygina, E. G. Polovtsev, A. A. Syrovatsky, V. A. Ratnikov, A. A. Bogatikov, A. E. Karelov

“…Both drugs showed no clinically significant effect on hemostasis and hematopoiesis. More rare occurrence of renal dysfunction in Group 1 patients is indicative of lower nephrotoxicity of ibuprofen.…”
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Cryotechnology in lung and heart-lung transplantation by M. T. Bekov, I. V. Pashkov, N. P. Mozheiko, R. A. Latypov, D. O. Oleshkevich, K. S. Smirnov, E. F. Shigaev, Ya. S. Yakunin, S. V. Gautier

“…Application of cryotechnology is based on the contact effect of extremely low temperatures on organs and tissues using a cryoprobe. …”
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