Endothelin-1 Role in Human Eye: A Review by Serena Salvatore, Enzo Maria Vingolo

“…In addition to its direct vasoconstrictor effects, enhanced levels of ET-1 may contribute to endothelial dysfunction through inhibitory effects on nitric oxide (NO) production. …”
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Cerebral perfusion and gray matter volume alterations associated with cognitive impairment in metabolic syndrome with cerebral small vessel disease by Han Liu, Han Liu, Wenhui Zheng, Jie Geng, Jie Geng, Xia Zhou, Yu Xia, Yan Liu, Gang Zhang, Gang Zhang, Xiaoqun Zhu, Daping Lv, Daping Lv, Zhongwu Sun

“…ObjectiveMetabolic syndrome (MetS) combined with cerebral small vessel disease (CSVD) is associated with cognitive dysfunction. However, the underlying mechanisms remain poorly understood. …”
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Short-term exposure to polystyrene microplastics alters cognition, immune, and metabolic markers in an apolipoprotein E (APOE) genotype and sex-dependent manner by Lauren Gaspar, Sydney Bartman, Hannah Tobias-Wallingford, Giuseppe Coppotelli, Jaime M Ross

“…Given the adverse health effects that are increasingly being associated with NMPs exposure, we sought to understand how the combination of APOE4 and NMPs exposure may work synergistically to promote cognitive dysfunction and alter key regulatory pathways to impact overall health. …”
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Critical role of ROCK1 in AD pathogenesis via controlling lysosomal biogenesis and acidification by Chenghuan Song, Wanying Huang, Pingao Zhang, Jiyun Shi, Ting Yu, Jing Wang, Yongbo Hu, Lanxue Zhao, Rui Zhang, Gang Wang, Yongfang Zhang, Hongzhuan Chen, Hao Wang

“…Impaired lysosomal biogenesis and acidification in Alzheimer’s disease (AD) pathogenesis leads to proteolytic dysfunction and neurodegeneration. However, the key regulatory factors and mechanisms of lysosomal homeostasis in AD remain poorly understood. …”
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T and NK cell functionality in a patient harboring heterozygous novel BCL11B p.Asp632fsAla∗91 and STX11 p.R129P mutations by Lorenzo Erra, Ana Colado, Franco Gino Brunello, Emma Prieto, Verónica Goris, Mariana Villa, Matías Oleastro, Marcelo Martí, Roberto Gabriel Pozner, Mercedes Borge, María Belén Almejun

“…We hypothesize that impaired IL-2 secretion caused by the BCL11B mutation may reduce the patient's ability to compensate for STX11 dysfunction, suggesting that the combined effect of BCL11B and STX11 mutations contributes to the observed immune dysfunction and the patient's complex phenotype. …”
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Single-nucleus transcriptomic profiling of the diaphragm during mechanical ventilation by Lei Li, Feng Jiang, Wenyan Hao, Yu Wang, Yaqian Li, Dong Zhang

“…Abstract Mechanical ventilation contributes to diaphragm atrophy and muscle weakness, which is referred to as ventilator-induced diaphragmatic dysfunction (VIDD). The pathogenesis of VIDD has not been fully understood until recently. …”
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Mapping Connection and Direction Among Symptoms of Sleep Disturbance and Perceived Stress in Firefighters: Embracing the Network Analysis Perspective by Liu B, Zou M, Liu L, Wu Z, Jin Y, Feng Y, Jia Q, Li M, Ren L, Yang Q

“…Through the implementation of interventions like mindfulness-based stress reduction, cognitive behavioral therapy, and group psychotherapy, tailored to address these targeted symptoms, it is feasible to effectively mitigate both sleep disturbances and perceived stress in firefighters, and ultimately improve the mental health of this particular occupational group.Keywords: sleep disturbances, perceived stress, network analysis, firefighters…”
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Association of serum copeptin levels with pulmonary complications and heart right ventricular functions in common variable immunodeficiency by Mehmet Kılınç, Fatih Çölkesen, Filiz Sadi Aykan, Recep Evcen, Eray Yıldız, Bahadır Feyzioğlu, Metin Doğan, Yakup Alsancak, Sefa Tatar, Şevket Arslan

“…Conclusion The development of pulmonary complications and RV dysfunction were associated with elevated serum copeptin levels in CVID. …”
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Early – versus late-onset preeclampsia: differences in risk factors and birth outcomes by Markin L., Medvyedyeva O.

“…Our study shows that effect of risk factors such nulliparity, chronic hypertension, and diabetes vary according to the subtype of preeclampsia. …”
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The impact of chronic heart failure on heart remodeling in patients with atrial fibrillation by V. А. Lysenko, V. V. Syvolap

“…Atrial fibrillation (AF) and chronic heart failure (CHF) often coexist due to common pathophysiological mechanisms and risk factors. However, the effect of CHF on heart remodeling in patients with permanent AF has been insufficiently studied. …”
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The Management of Cardiometabolic Risk in MAFLD: Therapeutic Strategies to Modulate Deranged Metabolism and Cholesterol Levels by Annalisa Pezzoli, Ludovico Abenavoli, Marialaura Scarcella, Carlo Rasetti, Gianluca Svegliati Baroni, Jan Tack, Emidio Scarpellini

“…<i>Materials and Methods:</i> For all these reasons, we conducted a narrative review of the literature, and we focused on metabolic dysfunction related to MAFLD, with a special regard for cholesterol metabolism. …”
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The Development and Assessment of a Unique Disulfidptosis-Associated lncRNA Profile for Immune Microenvironment Prediction and Personalized Therapy in Gastric Adenocarcinoma by Jiyue Zhu, Xiang Zhu, Tingting Su, Huiqing Zhou, Shouhua Wang, Weibin Shi

“…To further investigate immunotherapy response disparities between patient cohorts with elevated- and reduced-risk scores, analyses of tumor mutational burden (TMB), tumor immune dysfunction and exclusion (TIDE), and microsatellite instability (MSI) were implemented. …”
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Abstract 163: Total Spinal Cord Infarction, An Underrecognized Postoperative Complication by Hamza M. Ahmed, Jonathan L. Garcia‐Ramiu, Raman V. Singh, Ahmad Al‐Awwad

“…The resultant acute spinal cord dysfunction manifests as; motor weakness, loss of senses of pain and temperature, altered proprioception, bowel and bladder dysfunction Spinal blood supply comprises of the anterior spinal artery (ASA) and the two posterior spinal arteries, with supply to the spinal arteries being derived from various regional arteries: C1‐T3 is supplied by the vertebral arteries, T3‐T7 is served by a branch from the intercostal arteries, and the Adamkiewicz artery supplies T8 to the medullary conus. …”
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Pathological Femoral Fracture due to Osteoporosis and Hypophosphatemic Osteomalacia Following Adefovir Therapy in a Patient with Chronic Hepatitis B by Sevilay Batıbay, Duygu Geler Külcü, Nilgün Mesci, Borçak Çağlar Ruhi, Zerrin Şahin, Hasan Gündoğdu

“…Proximal renal tubular dysfunction is one of the adverse effects of this agent and characterized with hypophosphatemia and osteomalacia. …”
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A rare cause of fatal cardiac arrhythmia: Inhalation of butane gas by Utku Pamuk, Hazım Alper Gürsu, Serhat Emeksiz, Yasemin Özdemir-Sahan, İlker Çetin

“… Butane gas, especially available in lighters, is commonly misused among adolescents and its side effects are rarely observed but serious. A 14-yearold male was brought to our emergency department. …”
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Ventricular fibrillation caused by massive right coronary air embolism: a case report by Hongcai Zhang, Ai-ling Huang, Qian Nie, Haseeb Sattar, Xie Wen

“…The final fractional flow reserve showed no residual coronary microvascular dysfunction. Conclusion Our finding suggests that inducing strong myocardial contractions with a cardioverter defibrillator may effectively disperse large air emboli and restore coronary circulation.…”
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Radiation-associated Arrhythmias: Putative Pathophysiological Mechanisms, Prevalence, Screening and Management Strategies by Rohil Bedi, Ali Ahmad, Piotr Horbal, Philip L Mar

“…Radiation-associated cardiovascular disease, an increasingly recognised disease process, is a significant adverse effect of radiation therapy for common malignancies that involve the chest, and include lymphomas, lung, mediastinal and breast cancers. …”
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Modern techniques for TMJ evaluation - Modjaw versus Cadiax - a systematic review by Cristina Mihai, Mariana Păcurar, Emilia Prodea, Iulia Dumitrescu, Iuliana-Irina Nedelcu

“…Disorders of the TMJ can significantly impact a patient's quality of life, causing pain, dysfunction, and other systemic issues. Comprehensive TMJ evaluation is essential for accurately diagnosing and effectively treating these disorders. …”
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Celastrol improves endothelial function in diet-induced obesity mice via attenuating endoplasmic reticulum stress through the activation of AMPK pathway by Cheng Yu, Weihong Lin, Jing Yang, Qiong Jiang, Wenkun Liu, Hongjin Liu, Yong Lin, Litao Wang, Lei Chen, Yu Huang, Lianglong Chen

“…However, the specific protective effects and mechanisms of celastrol in preventing endothelial dysfunction in diet-induced obesity are not yet fully understood. …”
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Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy by Wenpeng Cui, Xu Min, Xiaohong Xu, Bing Du, Ping Luo

“…In current review, we discussed and summarized the therapeutic effects of Nrf2 activation on DN from both basic and clinical studies.…”
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