Evaluation of Integrated Arterial Filter Oxygenator vs. External Arterial Filters on Clinical Outcomes and Neurocognitive Function in Pediatric Cardiac Surgery: A Prospective Rando... by Vishal Vinayak Bhende, Mathangi Krishnakumar, Dushyantkumar Mukundbhai Parmar, Arunkumar Ghanshyambhai Rudakiya, Tanishq Shashikant Sharma, Amit Kumar, Paresh Dilip Nerurkar, Saptak Piyush Mankad, Mamta Roshan Patel

“…ABSTRACT Background and Aims Innovative advancements in cardiopulmonary bypass (CPB) configurations, such as surface coating, blood filtration, and miniaturization, aim to reduce gaseous microemboli (GME) that contribute to embolic organ damage, particularly neurological dysfunction. Arterial line filters are effective in mitigating embolism risk. …”
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Association Between Vertebral Artery Stiffness and Idiopathic Subjective Tinnitus: A Prospective Study by Ismail Aytac, Alper Yazici, Orhan Tunc, Rauf Gul, Yusuf Inanc, Koray Tumuklu

“…Emerging evidence suggests a link between vascular dysfunction, particularly arterial stiffness, and tinnitus. …”
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Amelioration of female menopausal syndrome by intravenous administration of autologous menstrual blood-derived stem cells by Hiromi Izawa, Charlie Xiang, Seiji Ogawa, Ichiro Hisanaga, Takayuki Yoshimoto

“…Various treatments have been used to manage the symptoms, including hormone replacement therapy, but no effective causal therapies have yet been identified. …”
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Alterations of static and dynamic changes in intrinsic brain activity and its relation to behavioral outcomes in subcortical ischemic stroke after one-month intervention by Yongxin Li, Jianping Wang, Maohua Yao, Yun Ran

“…Abstract Ischemic stroke is a prominent contributor to cognitive dysfunction and disability. Gaining a comprehensive understanding of the neuronal activity and longitudinal changes underlying stroke is crucial for designing effective rehabilitative strategies. …”
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Antithrombotic Activity of an Indolinone Derivative – a Soluble Guanylate Cyclase Stimulator by V. V. Bykov, A. V. Bykova, V. I. Smolyakova, G. A. Chernysheva, O. I. Alyev, A. M. Anishenko, A. V. Sidekhmenova, S. A. Stankevich, V. A. Khazanov, A. I. Vengerovsky

“…Antithrombotic action of GRS compound results not only from its antiplatelet action, but also from the alleviation of endothelial dysfunction in arteries and veins.…”
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Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1 by Yijian Deng, Liying Zeng, Huaxi Liu, Anna Zuo, Jie Zhou, Ying Yang, Yanting You, Xinghong Zhou, Baizhao Peng, Hanqi Lu, Shuai Ji, Ming Wang, Yigui Lai, Hiu Yee Kwan, Xiaomin Sun, Qi Wang, Xiaoshan Zhao

“…Finally, the inhibitory effects of silibinin on ferroptosis were reversed by knocking down FTH1 in vitro. …”
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Radiation dosimetry and fasting-dependent hepatobiliary clearance of the VAChT-specific PET radioligand 18F-VAT in humans by Scott A. Norris, Noah L. Goldman, Mahdjoub Hamdi, Stephen M. Moerlein, Richard Laforest, Morvarid Karimi, Joel S. Perlmutter, Zhude Tu

“…Abstract Background The vesicular acetylcholine transporter ligand (-)-(1-((2R,3R)-8-(2-[(18)F]fluoro-ethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)(4-fluorophenyl)-methanone (18F -VAT) enables positron emission tomography PET quantification of cholinergic dysfunction in neurologic and psychiatric disorders. …”
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PD-1/PD-L1 inhibitors monotherapy vs. combination therapy in elderly advanced NSCLC: a real-world study and nomogram for survival prognosis by Yunye Mao, An Wang, Xiangwei Ge, Jinzhao Zhai, Yi Hu, Jinliang Wang

“…Elderly patients (≥ 65 years) exhibit immune senescence (e.g., T-cell dysfunction, chronic inflammation), which may compromise immunotherapy efficacy and amplify toxicity risks, yet direct comparisons of monotherapy versus combination regimens in this population are lacking. …”
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Parvalbumin interneurons in the hippocampal formation of individuals with Alzheimer’s disease: a neuropathological study of abnormal phosphorylated tau in neurons by Paula Merino-Serrais, Paula Merino-Serrais, Paula Merino-Serrais, Sergio Plaza-Alonso, Sergio Plaza-Alonso, Sergio Plaza-Alonso, Silvia Tapia-Gonzalez, Gonzalo León-Espinosa, Gonzalo León-Espinosa, Javier DeFelipe, Javier DeFelipe, Javier DeFelipe

“…While AD is commonly conceptualized as a disorder characterized by synaptic failure, substantial knowledge gaps persist regarding the mechanisms underlying the onset and progression of the disease, underscoring the need for novel and more effective therapeutic approaches. In this context, the impairment of GABAergic paravalbumin (PV+) neurons has been proposed as a crucial factor contributing to neuronal network dysfunction and cognitive decline in AD. …”
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Exercise Therapy Using the Lumbar-Type Hybrid Assistive Limb Ameliorates Locomotive Function after Lumbar Fusion Surgery in an Elderly Patient by Yoshihiro Yasunaga, Kousei Miura, Masao Koda, Toru Funayama, Hiroshi Takahashi, Hiroshi Noguchi, Kentaro Mataki, Tomoyuki Asada, Keiji Wada, Yoshiyuki Sankai, Masashi Yamazaki

“…The unique characteristics of the lumbar-type HAL to prevent the lumbar overload and assist the voluntary hip joint motion during exercise therapy may be effective for this patient with lumbar stiffness after LFS. …”
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IMPACT OF MULTIPLE MYELOMA: REVEALING CLINICAL AND GENETIC ASPECTS by VC Pereira, AM Cavalcante, CBMM Neto, DRR Firmino, IO Córdoba, LA Coelho, LB Cerreti, SZ Jorge, VCC Oliveira, G Suhett

“…Furthermore, its high expression suppressed the proliferation and migration of MM cells and had a synergistic effect with bortezomib on the cells’ proliferation capacity. …”
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Dimethyl α-ketoglutarate ameliorates cisplatin-induced acute kidney injury by modulating mitophagy through the PINK1/Parkin pathway by Haijing Dou, Huihui Hao, Ruoyi Zhao, Hailun Li, Fangshu Wei, Yong Xu, Donghui Zheng, Juan Xie, Xiang Li

“…In conclusion, our study provides a novel strategy for the effective treatment of AKI.…”
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Moxibustion for medical personnel with negative emotion and insomnia during COVID-19 pandemic: A randomized, controlled trial by Xiying Li, Xiaojuan Li, Xian Wang, Xuan Yin, Shanshan Li, Junyi Wu, Xiumei Ren, Wei Zhang, Yiqun Mi, Shifen Xu

“…There were no significant adverse effects reported. Conclusion: Moxibustion at SP6 may be an effective treatment to improve anxiety, depression, sleep quality, and quality of life for healthcare workers during COVID-19. …”
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Mitochondrial Fitness Science Communication for Aging Adults: Prospective Formative Pilot Study by Cathy A Maxwell, Brandon Grubbs, Mary S Dietrich, Jeffrey T Boon, John Dunavan, Kelly J Knickerbocker, Maulik R Patel

“…ConclusionsMitoFit was enthusiastically embraced and is a cost-effective, scalable, and potentially efficacious intervention to advance with community-dwelling older adults.…”
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Case Report: Hydroa vacciniforme-like lymphoproliferative disorder, an EBV-associated disease, successfully treated with hematopoietic stem cell transplantation by Eduardo Liquidano-Perez, Eduardo Liquidano-Perez, Gibert Maza-Ramos, Marco Yamazaki-Nakashimada, Rodolfo Rodríguez-Jurado, Alfonso G. Ramírez Ristori, Juan Carlos Bustamante-Ogando, Mario Ernesto Cruz-Munoz, Arturo Gutierrez-Guerrero, Marimar Saez-de-Ocariz, Sara Espinosa-Padilla, Nideshda Ramirez-Uribe, Selma C. Scheffler-Mendoza

“…Additionally, cases of GATA2 and TACI deficiency presenting with HVLD suggest a potential link to underlying immune dysfunction. Further research in this area is crucial to understand the immunological basis of HVLD. …”
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Single-center experience in kidney transplantation: outcomes, conclusions, and perspectives by M. Sh. Khubutia, I. V. Dmitriev, A. G. Balkarov, Yu. A. Anisimov, N. V. Shmarina, N. V. Zagorodnikova, N. V. Borovkova, M. G. Minina, D. V. Lonshakov, V. O. Aleksandrova, V. Smirnova, A. U. Rustambek

“…The cumulative uncensored in-hospital graft and recipient survival rates were 97.5% (n = 1078) and 98.9% (n = 1094), respectively.Conclusion. KT is an effective and safe transplant modality for stage 4–5 CKD. …”
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The Gluten-free diet and oncological prevention – the importance of a conscious lifestyle for physically active people – A Literature Review by Julia Wątor, Alicja Podolska, Patrycja Kolano, Jerzy Krzeszowiak, Barbara Chojnacka, Tomasz Pulanecki, Barbara Boba, Sylwia Bryksy, Aleksandra Ożga, Agnieszka Woźniacka

“…If untreated, it leads to villous atrophy, chronic inflammation, and immune dysfunction. Studies show that active, untreated celiac disease increases cancer risk, particularly for lymphomas and gastrointestinal malignancies. …”
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A Novel DNA Repair‐Gene Model to Predict Responses to Immunotherapy and Prognosis in Patients With EGFR‐Mutant Non‐Small Cell Lung Cancer by Fen Wang, Xue‐Wu Wei, Ming‐Yi Yang, Chang Lu, Xiao‐Rong Yang, Jia‐Yi Deng, Zhi‐Hong Chen, Qing Zhou

“…The T‐cell inflammation and Tumor Immune Dysfunction and Exclusion (TIDE) scores differed between the high‐ and low‐risk subgroups, with both showing enhanced effectiveness of immunotherapy in the low‐risk subgroup. …”
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Serum uric acid to creatinine ratio in patients with early-onset post-stroke cognitive impairment: a retrospective cohort study by Libin Liao, Weiquan Huang, Rongchao Ma, Wentong Hu, Hui Wu, Moxi Su, Dujuan Sha, Dujuan Sha, Dujuan Sha

“…The serum uric acid to serum creatinine ratio (SUA/SCr) is an independent risk factor for poor outcomes of acute ischemic stroke and can potentially become an effective diagnostic indicator for cognitive decline. …”
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The indicator of osteogenesis is a potential marker of the risk of cardiovascular diseases in patients with type 2 diabetes mellitus by A.V. Кovalchuk, O.V. Zinych, N.M. Kushnarоva, V.M. Kovalchuk, O.V. Prybyla, K.O. Shyshkan-Shyshova

“…An increase in mortality due to cardiovascular diseases in patients with diabetes mellitus necessitates the search for effective prevention and treatment strategies. Osteocalcin, a proven marker of bone metabolism playing a key role in the pathogenesis of cardiovascular diseases, is considered one of the potential therapeutic targets. …”
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