Thyroxine Affects Lipopolysaccharide-Induced Macrophage Differentiation and Myocardial Cell Apoptosis via the NF-κB p65 Pathway Both In Vitro and In Vivo by Shan Zhu, Yuan Wang, Hongtao Liu, Wen Wei, Yi Tu, Chuang Chen, Junlong Song, Zhiliang Xu, Juanjuan Li, Changhua Wang, Shengrong Sun

“…Bone marrow-derived macrophages (Mø) were treated with LPS and thyroxine, and Mø differentiation and Mø-related cytokine expression were measured. The effect of Mø differentiation on mouse cardiomyocyte (MCM) apoptosis was also detected in vitro. …”
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Optimizing the treatment for gastroesophageal reflux disease in young people: the role and place of rebamipide by I.M. Skrypnyk, I.M. Gorodnytska, G.S. Maslova, B.M. Fylenko

“…Objective: to evaluate the effect of rebami­pide on the restoration of the esophageal protective barrier in the presence of erosive or non-erosive forms of gastroesophageal reflux disease in young patients. …”
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Adverse outcome pathway for the neurotoxicity of per- and polyfluoroalkyl substances: A systematic review by Shenpan Li, Shuangjian Qin, Huixian Zeng, Weichun Chou, Anna Oudin, Katja M. Kanninen, Pasi Jalava, Guanghui Dong, Xiaowen Zeng

“…These KEs culminate in synaptic dysfunction at organ and tissue levels. Further insights were offered into MIE2 and upstream KEs associated with altered thyroid hormone levels, contributing to synaptic dysfunction and hypomyelination at the organ and tissue levels. …”
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Vitamin C Treatment Rescues Prelamin A-Induced Premature Senescence of Subchondral Bone Mesenchymal Stem Cells by Yan-Nv Qu, Li Zhang, Ting Wang, He-Yang Zhang, Ze-Ji Yang, Fang-Fang Yuan, Yan Wang, Si-Wei Li, Xiao-Xia Jiang, Xiao-Hua Xie

“…Aging is a predominant risk factor for many chronic conditions. Stem cell dysfunction plays a pivotal role in the aging process. …”
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Faecalibacterium prausnitzii prevents age-related heart failure by suppressing ferroptosis in cardiomyocytes through butyrate-mediated LCN2 regulation by Yun Zhang, Ying Wei, Xuejie Han, Ling Shi, Hui Yu, Xuanrui Ji, Yunlong Gao, Qianhui Gao, Linwei Zhang, Yu Duan, Wenpeng Li, Yue Yuan, Jing Shi, Liang Cheng, Yue Li

“…Intriguingly, the protective effect was lost in the butyrate-deficient F. prausnitzii strain. …”
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Dual Roles of Plasma miRNAs in Myocardial Injuries After Polytrauma: miR-122-5p and miR-885-5p Reflect Inflammatory Response, While miR-499a-5p and miR-194-5p Contribute to Cardiom... by Jiaoyan Han, Liudmila Leppik, Larissa Sztulman, Roberta De Rosa, Victoria Pfeiffer, Lewin-Caspar Busse, Elena Kontaxi, Elisabeth Adam, Dirk Henrich, Ingo Marzi, Birte Weber

“…Notably, the miR-194-5p mimic significantly enhanced the cytotoxic effects of the polytrauma cocktail, while miR-499a-5p boosted effects of LPS/nigericin stimulation in cardiomyocytes. …”
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In a Canine Model of Septic Shock, Cardiomyopathy Occurs Independent of Catecholamine Surges and Cardiac Microvascular Ischemia by Verity J. Ford, Willard N. Applefeld, Jeffrey Wang, Junfeng Sun, Steven B. Solomon, Harvey G. Klein, Jing Feng, Juan Lertora, Parizad Parizi‐Torabi, Robert L. Danner, Michael A. Solomon, Marcus Y. Chen, Charles Natanson

“…Using a septic shock model that reproduces the reversible cardiomyopathy seen over 10 days associated with human septic shock, we investigated the effects of catecholamines on microcirculatory perfusion and cardiac dysfunction. …”
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Puerarin, a key bioactive ingredient of Radix Puerariae, inhibits oxidative stress and protects against homocysteine-induced cardiac injury via PI3K/Akt/Nrf2/HO-1 signaling by Shuang Jiang, Cong Li, Yanxing Han, Jiandong Jiang, Yuhong Wang

“…Using H9c2 cardiomyocytes and a guinea pig model of hyperhomocysteinemia (HHcy), we demonstrated that Pue attenuated Hcy-induced cardiotoxicity, oxidative stress, mitochondrial dysfunction and apoptosis. The cardioprotective effects of Pue were exerted by activating the PI3K/Akt/Nrf2/HO-1 signaling axis. …”
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Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway by Libo Wang, Libo Wang, Fei Lin, Runran Miao, Tianhao Zhao, Yuan Liu, Lin Yang, Min Zhang, Min Zhang

“…Docking simulations predicted that wogonin forms a stable complex with Sirt1 through hydrogen-bonding and hydrophobic interactions, which was further validated by biotin-affinity pulldown assays.ConclusionWogonin exerts protective effects against cardiac dysfunction and fibrosis in PF mice by modulating Sirt1/γ-H2AX-mediated pathways to reduce DNA damage and apoptosis. …”
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Epicardial Adipose Tissue and Heterogeneity Parameters Combined with Inflammatory Cells to Predict the Value of Heart Failure with Preserved Ejection Fraction Patients Post Myocard... by Yu-jiao Song, Xiao-ying Zhao, Lu-jing Wang, Ting Ning, Ming-tian Chen, Pei Liu, Si-wen Chen, Xin-xiang Zhao

“…Abstract Background and purpose Epicardial adipose tissue (EAT) comprises three distinct lipid components, each exerting differential effects on cardiovascular diseases. During disease progression, dynamic alterations in lipid composition and spatial distribution contribute to the inherent heterogeneity of EAT. …”
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Identifying and Validating Indicators of Ritualism in the Iranian Higher Education System: A Mixed-Methods Study by Seyed Hedayat Davarpanah, Reza Hoveida, Mostafa Bagherian Far

“…Consequently, addressing ritualism as a dysfunction within university performance is crucial. …”
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Developmental polychlorinated biphenyl (PCB) exposure impacts on voiding physiology persist into adulthood and influence sensitivity to bladder stimuli in mice by Monica Ridlon, Audrey Spiegelhoff, Conner L Kennedy, Thomas Lavery, Kathy Wang, Julia Tlapa, Tamryn Jordan, Lindsey Felth Tanaka, Kimberly Keil Stietz

“…Urinary voiding physiology testing through void spot assays, uroflowmetry, and cystometry demonstrated several sex- and dose- dependent effects of PCB exposure at 12 weeks of age. Further, patterns of dysfunction were either maintained, newly acquired, or reversed compared to those from younger adult mice in a previous study. …”
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Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease by Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue

“…Abstract Parkinson's disease (PD) is exacerbated by dysfunction of inter‐organelle contact, which depends on cellular responses to the mechanical microenvironment and can be regulated by external mechanical forces. …”
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MT2A promotes angiogenesis in chronically ischemic brains through a copper–mitochondria regulatory mechanism by Ni Mo, Chuyang Tai, Yang Yang, Cong Ling, Baoyu Zhang, Lei Wei, Cian Yao, Hui Wang, Chuan Chen

“…Additionally, MT2A overexpression alleviated CPO-induced mitochondrial dysfunction and cytotoxicity, improving HUVEC viability. …”
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E2F1/CDK5/DRP1 axis mediates microglial mitochondrial division and autophagy in the pathogenesis of cerebral ischemia‐reperfusion injury by Ya‐Jing Yuan, Tingting Chen, Yan‐Ling Yang, Hao‐Nan Han, Li‐Ming Xu

“…E2F1 facilitated CDK5 transcription, leading to DRP1 phosphorylation, exacerbating neurotoxic effects. Silencing E2F1 improved neurobehavioral outcomes in CIRI mice. …”
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Mechanisms of alleviating sepsis-induced rat lung and kidney damage by inhibiting expression of miRNA-939 by Anwaier Apizi, Jian Li, Yan Li, Zhaoxia Yu, Ruifeng Chai

“…These findings highlight the therapeutic potential of targeting miRNA-939 in the management of sepsis-induced organ dysfunction.…”
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Coagulopathy and acute pancreatitis: pathophysiology and clinical treatment by Lan Li, Lan Li, Qingyuan Tan, Qingyuan Tan, Xueying Wu, Xiaowen Mou, Xiaowen Mou, Ziqi Lin, Tingting Liu, Wei Huang, Wei Huang, Lihui Deng, Tao Jin, Tao Jin, Qing Xia, Qing Xia

“…Finally, increased fibrin generation and impaired break down lead to deposition of (micro) vascular clots, which may contribute to tissue ischemia and ensuing organ dysfunction. Despite the high burden of coagulopathy that have a negative impact on AP patients’ prognosis, there is no effective treatment yet. …”
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Salvianolic Acid A Activates Nrf2-Related Signaling Pathways to Inhibit Ferroptosis to Improve Ischemic Stroke by Yu-Fu Shang, Wan-Di Feng, Dong-Ni Liu, Wen-Fang Zhang, Shuang Xu, Dan-Hong Feng, Guan-Hua Du, Yue-Hua Wang

“…Following OGD/R, ML385 (Nrf2 inhibitor) prevents SAL-A from inhibiting oxidative stress, ferroptosis, and mitochondrial dysfunction in b.End.3 cells. In conclusion, SAL-A inhibits ferroptosis to ameliorate ischemic brain injury, and this effect is mediated through Nrf2.…”
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Single cell analysis identified IFN signaling activation contributes to the pathogenesis of pediatric steroid-sensitive nephrotic syndrome by Qiu-Yu Li, Fei Liu, Xiaoyi Li, Minchao Kang, Linnan Bai, Tong Tong, Chen Zheng, Yanyan Jin, Xiaojing Zhang, Yi Xie, Dandan Tian, Yuanqing Pan, Jingjing Wang, Haidong Fu, Na Jiao, Junnan Wu, JianHua Mao

“…Accumulating evidence suggests that B-cell dysfunction also plays a role. Nevertheless, a comprehensive understanding of the mechanisms and effective treatment strategies remains incomplete. …”
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Case Report: Robust and durable response to the combination of tislelizumab and chemotherapy in advanced thymic epithelial tumors: a case series by Lantian Zhang, Yuqi Zhang, Shuke Li, Yan Wang, Yan Wang, Yue Yu, Jing He, Wen Gao

“…Grade 1–2 AEs were adrenal insufficiency (n=1), thyroid dysfunction (n=1), and pneumonia (n=1).ConclusionsOur study findings suggest that the combination of immunotherapy and chemotherapy yields durable clinical responses in patients with TETs, suggesting its potential as a safe and effective first-line treatment strategy for advanced TETs. …”
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