The dynamics of markers of a shock state in traumatic blood loss depending on fluid resuscitation type. by D. A. Krishtafor, O. M. Klygunenko

“…Restriction of fluid resuscitation volume allows to successfully treat shock and decrease multiple organ dysfunction, number of complications and mortality.…”
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Causes of development and progression of cardiorenal syndrome in heart failure patients. Prevention methods by V. V. Davydov, E. L. Arekhina

“…High doses of furosemide in the treatment of acute decompensated HF sometimes damaged the kidneys due to hypovolemia and hypokalemia. Such side effects of furosemide as a neuroendocrine activation with subsequent vasoconstriction and the development of endothelial dysfunction due to oxidative stress are considered. …”
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Effets du statut d’emploi sur la santé et la sécurité au travail : le cas des auxiliaires familiales et sociales et des infirmières de soins à domicile au Québec by Esther Cloutier, Madeleine Bourdouxhe, Élise Ledoux, Hélène David, Isabelle Gagnon, François Ouellet, Catherine Teiger

“…As for organizational dysfunction, precarious employees have less margin of maneuver to compensate for it. …”
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Role and Place of Hyperbaric Oxygenation in Hepatic Failure by P. N. Savilov

“…Results: The therapeutic and preventive effects of HBO during therapy for liver cell failure were due to the ability of hyperbaric oxygen to regulate metabolic processes in the sick organism. …”
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ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy by Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Lowie Adyns, Lotte Vanbrabant, Priscilla W. Gikandi, Gert De Hertogh, Sofie Struyf, Ghislain Opdenakker

“…The protease, a disintegrin and metalloproteinase with thrombospondin type 1 motif member 13 (ADAMTS13), known to cleave only the von Willebrand factor (VWF), has powerful regulatory effects on microvascular platelet adhesion, thrombosis, inflammation, and endothelial dysfunction. …”
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Platelet aggregation function test for children in order to determine the normative values in different age groups by O. B. Gordeeva, M. S. Karaseva, M. A. Babaikina, N. D. Vashakmadze, M. A. Soloshenko, O. Ya. Smirnova, D. S. Ovchinnikov

“…Individual laboratories may vary in their reference ranges for platelet count, but the normal range of platelet count remains 150 to 450 × 109/л. Platelet dysfunction is often not diagnosed, since of throm bocytopathies in most cases do not have clear symptoms, in some cases clinical manifestations of platelet dysfunction are even absent. …”
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Assessing thyroid health: phenotypic age compared to chronological age by Dongyu Yang, Cihang Lu, Haonan Zhang, Xiaoguang Shi, Ying Sun, Ying Shao, Shuting Fan, Lijun Tian, Di Teng

“…IntroductionAging is associated with thyroid dysfunction, but the role of phenotypic age, a biological aging measure derived from nine clinical biomarkers and chronological age, remains unclear.MethodsThis cross-sectional study included 6,681 adults from the National Health and Nutrition Examination Survey (NHANES, 2007–2012) with complete thyroid function and age data. …”
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Circ_0081343 promotes autophagy and alleviates pyroptosis via PI3 K/AKT/HIF-1α axis in hypoxia-induced fetal growth restriction of mice by Linmei Zheng, Rong Tang, Fiaz Ahmad, Junbo Fang, Lei Shi, Xiaoju Chen, Jing Li

“…Therefore, we investigated the effects of circ_0081343 overexpression in the FGR mouse model induced by maternal hypoxia. …”
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Brown adipose tissue: a potential therapeutic target for preventing cardiovascular disease in metabolic disorders by Tamara Egan Beňová, Matúš Sýkora, Katarína Ondreják Andelová, Veronika Farkašová, Marek Lepáček, Marta Šoltésová Prnová, Pavel Babál, Dávid Janko, Natália Andelová, Miroslav Ferko, Barbara Szeiffová Bačová

“…Echocardiography revealed diastolic dysfunction in T2D rats, which was attenuated by Cemtirestat. …”
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Evaluating the health and fitness benefits of a 6-month FES-cycling program on a recumbent trike for individuals with motor complete SCI: a pilot study by N. Sanna, R. Nossa, E. Biffi, E. Guanziroli, E. Diella, S. Ferrante, F. Molteni, D. Peruzzo, N. Casali, A. Mastropietro, G. Rizzo, M. Tarabini, A. Pedrocchi, E. Ambrosini

“…Bone health, spasticity, bowel dysfunction, and pain levels did not significantly change overall. …”
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Interleukin‐6 induces cognitive impairment via toll‐like receptor 4 (TLR4)‐mediated neuroinflammation and neurodegeneration in mice with chronic kidney disease by Yangping Shentu, Shuqing Ma, Simin Ye, Yaozhe Ying, Luhui Wang, Yun Zhu, YunTing Wang, Nan Jiang, Zongyuan Zhao, Chenfei Zheng, Chaosheng Chen, Yongheng Bai, Ying Zhou

“…A positive correlation between cytokine concentrations and serum creatinine levels, as well as a significant positive correlation with cognitive dysfunction, were observed. Correlation analyzes demonstrated that hippocampal cytokine levels were positively correlated with serum creatinine levels and cognitive dysfunction in CKD model mice. …”
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Identifying Socio-Technical Risks in Open-Source Software for Scholarly Communications: Tools, Metrics, and Opportunities for Libraries to Support Sustainable Development by Pierre Lasou, Tomasz Neugebauer, Pamela Carson

“…The tool is complex and requires the user to have software development skills to use it effectively. It lacked sufficient documentation, which made interpreting the results challenging. …”
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Glycogen storage disease type Ib: modern understanding of the pathogenesis of neutropenia and prospects for its treatment with empagliflozin by Andrej N. Surkov, Aleksandr A. Baranov, Lejla S. Namazova-Baranova, Anna L. Arakelyan, Evgenij E. Bessonov, Natal’ya V. Zhurkova

“…In the modern literature, it is reported about a minor, but very successful experience of its use in patients with GSD Ib (outside the framework of official indications for use) and a beneficial effect on neutrophil dysfunction and its clinical consequences. …”
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Study of the Functional State of the Proximal Renal Tubules in Patients with Asymptomatic Chronic Heart Failure in Dyslipidemia and its Correction with Simvastatin Treatment by V. Yu. Kopylov

“…To study indicators of epithelial dysfunction in the proximal renal tubules by determining the activity of organ-specific enzymes neutral α-glucosidase (NAG) and L-alanine aminopeptidase (LAAP), in patients with the initial stage of chronic heart failure in dyslipidemia, and the possibility of reducing with simvastatin.Material and methods. …”
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Knockout of bcas3 gene causes neurodevelopment defects in zebrafish by Huihui Liu, Nianyi Sun, Zhenxing Liu, Jinze Li, Xianqin Zhang

“…Behavior analysis revealed abnormal motor dysfunction, such as social impairment, increased anxiety and heightened aggression. …”
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Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance by Giulia Dematteis, Chunmei Gong, Justyna Malecka, Elisa Tonelli, Armando Genazzani, Laura Tapella, Anna Maria Eleuteri, Dmitry Lim, Laura Bonfili

“…Abstract Background Alzheimer’s disease (AD) is the major age-related form of dementia in which dysfunctional ubiquitin-proteasome system (UPS) and autophagy represent primary mechanisms leading to accumulation of misfolded proteins, dysfunction of astroglial cells, neuroinflammation and neurodegeneration. …”
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Application of Damage Control tactics in the treatment of patients with generalized peritonitis and septic shock by A. Е. Demko, S. A. Shlyapnikov, I. M. Batyrshin, A. V. Оsipov, J. S. Оstroumova, D. S. Sklizkov, D. V. Fomin

“…Both groups are representative in terms of demographics, comorbidity, severity of peritonitis and organ dysfunction.RESULTS. The groups differed significantly in the duration of preoperative preparation (p=0.028) and surgery (p=0.025). …”
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Atrial fibrillation in patients with dilated cardiomyopathy: prevalence, risk factors and prognostic significance by T. G. Vaikhanskaya, T. A. Dubovik, O. D. Levdansky, T. V. Kurushko, N. G. Danilenko

“…In patients with AF, initially more pronounced manifestations of right ventricular contractile dysfunction (TAPSE: 13,1±3,4 vs 15,5±4,6 mm; p=0,0001) and LV diastolic dysfunction (E/A: 2,9±1,5 vs 2,1±1,3; p=0,006; E/e' 15,6±6,9 vs 11,8±7,2; p=0,019), more dilated left atrium (left atrial volume index: 63,3±19 vs 50±18,7 ml/m2; p=0,006). …”
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Pyruvate kinase M2 activation maintains mitochondrial metabolism by regulating the interaction between HIF-1α and PGC-1α in diabetic kidney disease by Jimin Park, Young Su Joo, Bo Young Nam, Gyuri Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han

“…Abstract Background Pyruvate kinase isoform M2 (PKM2) activation has been suggested as a potential protective mechanism against kidney injury by improving mitochondrial dysfunction and anaerobic glycolysis. However, the underlying molecular mechanisms are unclear. …”
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Comparing the clinical efficacy of prostate enucleation by the Millin method and enucleation performed using a holmium laser (HoLEP) with a prostate volume more than 80 cm<sup>3</s... by S. N. Volkov, V. S. Stepanchenko, V. I. Tereshchenko, A. R. Dzharimok, O. R. Grigoryan, R. K. Mikheev

“…As a result of the study, there was no statistically significant effect of using HoLEP on erectile dysfunction in patients, which suggests the potential of this technique for a lower incidence of worsening erectile dysfunction compared with open intervention.Conclusions. …”
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