Silver Nanoparticles Synthesized from <i>Enicostemma littorale</i> Exhibit Gut Tight Junction Restoration and Hepatoprotective Activity via Regulation of the Inflammatory Pathway by Hiral Aghara, Simran Samanta, Manali Patel, Prashsti Chadha, Divyesh Patel, Anamika Jha, Palash Mandal

“…These findings support the therapeutic potential of plant-based nanoparticles in mitigating ethanol-induced gut–liver axis dysfunction.…”
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The miR‐6779/XIAP axis alleviates IL‐1β‐induced chondrocyte senescence and extracellular matrix loss in osteoarthritis by Zongchao Li, Aonan Dai, Xiaoxiang Fang, Kexing Tang, Kun Chen, Peng Gao, Jingyue Su, Xin Chen, Shengwu Yang, Zhenhan Deng, Liangjun Li

“…XIAP knockdown partially improved IL‐1β‐induced chondrocyte senescence and dysfunction. Lastly, when co‐transfected with a miR‐6779 agomir, the XIAP overexpression vector partially attenuated the effects of miR‐6779 overexpression on chondrocytes; miR‐6779 improved IL‐1β‐induced senescence and dysfunction in chondrocytes through targeting XIAP. …”
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Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension by Xiao‐ting Tian, Zhou‐yang‐fan Peng, Yu‐si Wu, Yuan‐yuan Cao, Xue‐chun Li, Ying Li, Si‐Yuan Tang, Alex F. Chen, Xiao‐hui Li

“…METHODS AND RESULTS NLRP3 knockout or short hairpin RNA interference of GSDME was performed in PAH animal models to investigate its effect on PAH progression. In addition, the effects of BMPR2 deficiency and restoration of BMPR2 by BMP9 (bone morphogenetic protein 9) or FK506 on pyroptosis were explored both in animal and cell models. …”
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Exploring the nucleus accumbens circuit and oxytocin therapy in a Sapap3 knockout mouse model of trichotillomania by Yuan Wang, Jingjing Yu, Rui Ma, Yundong Chen, Shihao Lu, Jianqun Fang

“…These findings highlight NAc circuit dysfunction and complex oxytocin effects in TTM, suggesting therapeutic targets while emphasizing the need for sex-stratified.…”
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Mitigating morphine dependence and withdrawal: The role of venlafaxine and calcium channel blockers in mitochondrial damage and oxidative stress in the brain by Radman Amiri, Faezeh Fallah, Behnam Ghorbanzadeh, Ali Akbar Oroojan, Mohammad Amin Behmanesh, Soheila Alboghobeish

“…Background: The reasons for morphine dependence and withdrawal symptoms are oxidative stress and dysfunction of cell mitochondria in the brain. Venlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), mitigates oxidative stress, while calcium channel blockers (nimodipine/diltiazem) prevent Ca²⁺-mediated mitochondrial dysfunction. …”
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Gestational high-sucrose diet mediated vascular hyper-contractility in mesenteric arteries from offspring by Xinying Liu, Meng Liu, Chunxia Wang, Liting Duan, Qinggui Ren, Shuli Jiang, Jing Han, Hongwei Fu, Xiao Sun, Dongmei Man, Xueqin Feng

“…N(G)-Nitro-l-arginine methyl ester (L-NAME) increased PE-mediated vascular tension in CON group, while no effect in HS group, suggesting that endothelial nitric oxide (NO) system dysfunction in MAs exposed to prenatal HS. …”
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Neurotoxic mechanisms and safety assessment of nanomaterials in neurotoxicology by Shi Haonan

“…This research examines the neurotoxic effects associated with nanomaterials, focusing on their ability to induce oxidative stress, cause mitochondrial dysfunction, penetrate the blood-brain barrier, disrupt neurotransmitter systems, and generate genotoxic effects. …”
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Sex Differences in the Renal Function Decline of Patients with Type 2 Diabetes by Ayami Kajiwara, Ayana Kita, Junji Saruwatari, Hiroko Miyazaki, Yuki Kawata, Kazunori Morita, Kentaro Oniki, Akira Yoshida, Hideaki Jinnouchi, Kazuko Nakagawa

“…The increased susceptibility to poor metabolic control seemed to contribute to a higher risk of renal dysfunction in females with T2DM. Our study highlights the importance of aggressive therapeutic intervention to improve metabolic profiles at early stage, especially in females.…”
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Dual inhibition of hepatic ACLY and ACSS2: A synergistic approach to combat NAFLD through lipogenesis reduction and mitochondrial enhancement by Mengdi Zhang, Jinliang Ji, Yuanyuan Lei, Fujian Qin, Yitong Tao, Ning Li, Jinlei Bian, Zhiyu Li, Maode Lai, Zhixia Qiu

“…Further, ACLY inhibition led to polyunsaturated fatty acid accumulation, triggering mitochondrial dysfunction. The resulting ROS redirected carbon flux into acetate, activating the ACSS2-acetyl-CoA pathway, which promoted lipid biosynthesis and exacerbated mitochondrial dysfunction—a vicious cycle that fueled inflammation and liver damage. …”
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Doxorubicin-Induced Cardiotoxicity and the Emerging Role of SGLT2 Inhibitors: From Glycemic Control to Cardio-Oncology by Iacob-Daniel Goje, Greta-Ionela Goje, Valentin Laurențiu Ordodi, Valentina Gabriela Ciobotaru, Vlad Sabin Ivan, Roxana Buzaș, Oana Tunea, Florina Bojin, Daniel-Florin Lighezan

“…Doxorubicin (DOX) is a cornerstone of hematologic malignancy treatment, but it is limited by its dose-dependent cardiotoxicity, leading to systolic and diastolic cardiac dysfunction and, ultimately, dilated hypokinetic cardiomyopathy. …”
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MetALD: Clinical aspects, pathophysiology and treatmentKeypoints by Jordi Gratacós-Ginès, Silvia Ariño, Pau Sancho-Bru, Ramon Bataller, Elisa Pose

“…Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-related liver disease (ALD) are the most prevalent causes of chronic liver disease worldwide. …”
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EFFICACY OF REMAXOL AND ADEMETHIONINE IN EXPERIMENTAL LIVER DAMAGE CAUSED BY A COMBINATION OF RESERVE-SERIES ANTITUBERCULOSIS DRUGS AND ALCOHOL by D. S. Sukhanov, E. B. Artyushkova, V. T. Dudka, S. V. Okovityi

“…The hepatic and endothelial protective effects of remaxol and S-adenosyl-L-methionine were studied on 24 male rats with liver damage caused by reserve-series antituberculosis drugs in combination with alcohol. …”
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ADIPOKINES AS MODIFIABLE RISK FACTORS OF CARDIOVASCULAR DISEASE by N. G. Veselovskaya, G. A. Chumakova, A. A. Kozarenko, M. I. Boxler

“…Leptin, a hormone produced by white adipocytes, plays an important part in endothelial dysfunction, thrombogenesis, and atherogenesis. In obesity, the concentration of adiponectin, which has anti-atherogenic, anti-inflammatory, and insulin-sensitizing effects, is substantially decreased. …”
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Endocrine Fever by Sanjay Kalra, Saptarshi Bhattacharya, Atul Dhingra, Jaideep Khare, Sushil Jindal

“…Keywords: Fever, infection, immunity, adverse effect, diabetes, thyrotoxicosis …”
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GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action by Emmelie Cansby, Mara Caputo, Emma Andersson, Rasool Saghaleyni, Marcus Henricsson, Ying Xia, Bernice Asiedu, Matthias Blüher, L. Thomas Svensson, Andrew J. Hoy, Margit Mahlapuu

“…Metabolic dysfunction–associated steatotic liver disease has emerged as a leading global cause of chronic liver disease. …”
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Association between hydrocarbon exposure and risk of stroke: a systematic literature review by Muhammed Shabil, Abhay M. Gaidhane, Nasir Vadia, Soumya V. Menon, Kattela Chennakesavulu, Rajashree Panigrahi, Ganesh Bushi, Diptismita Jena, Anju Rani, Sanjit Sah, Mahendra Singh, Prakasini Satapathy, Khang Wen Goh, Nosaibah Razaqi

“…Common in occupational and environmental contexts, hydrocarbons induce oxidative stress, systemic inflammation, and endothelial dysfunction, disrupting vascular health. This systematic review examines the association between hydrocarbon exposure and stroke, emphasizing specific metabolites and their cerebrovascular effects. …”
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HEART MORPHOLOGY, STRUCTURE, AND FUNCTION IN OBESITY by G. A. Chumakova, N. G. Veselovskaya, A. A. Kozarenko, Yu. V. Vorobyeva

“…In obese individuals, metabolic, dyshormonal, and hemodynamic changes directly affect myocardial structure and function. Mitochondrial dysfunction and oxidative stress, insulin resistance and hyperglycaemia, dysadipokinemia, and direct lipotoxic effects of lipids and free fatty acids on myocardium are important pathogenetic mechanisms of cardiac remodelling and cardiac functional changes in obesity. …”
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Preclinical Research into Basic Mechanisms of Radiation-Induced Heart Disease by M. Boerma, M. Hauer-Jensen

“…Radiation-induced heart disease (RIHD) is a potentially severe side effect of radiotherapy of thoracic and chest wall tumors if all or part of the heart was included in the radiation field. …”
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Anaemia and chronic heart failure by T. A. Kazantseva, Radjesh Radjan, M. A. Efremovtseva, L. G. Alexandriya, Zh. D. Kobalava, V. S. Moiseev

“…The main pathogenetic mechanism of anaemia development in CHF is absolute or relative erythropoietin deficit, due to pro-inflammatory cytokine effects, and renal dysfunction. The recent studies have demonstrated that correcting even moderate anaemia in CHF results in increased exercise tolerance, reduced NYHA functional class, improved quality of life, cardiac morphology and function, decreased need for diuretics, and reduced hospitalization incidence. …”
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Dynamics and challenges of the institutional crisis in Ecuador by Erick Geovanny Salazar-Ponce, Yenniffer Díaz-Romero, Mario Mitsuo Bueno-Fernández, Teresa Irina Salazar Echeagaray

“…Furthermore, the study highlights the importance of understanding institutional destabilization and dysfunction by analyzing the interaction between these elements, emphasizing the impact of institutional uncertainty and the complex distribution of power on governance effectiveness and public policy implementation. …”
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