A Case Report of Severe Coagulopathy in Antenatal COVID-19 by Anna Sand, Roza Chaireti, Maria Sennström, Karin Pettersson, Maria Magnusson

“…She developed a severe placental dysfunction with intrauterine fetal distress and perinatal death. …”
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Fuse your mitochondria, lose appetite: an anorexic, anti‐obesity sphingolipid by Carolin Muley, Alexander Bartelt

“…Abstract Aberrant production of ceramides, the precursors of complex sphingolipids, is a hallmark of obesity and strongly linked to metabolic dysfunction (Meikle and Summers 2017). Ceramides are formed by recycling or de novo synthesis from sphingosine and a fatty acid side chain moiety. …”
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Cardiovascular events after polychemotherapy of multiple myeloma: modern ways to diagnostics by B. B. Samura, M. O. Panasenko

“…Heart dysfunction that occurred after using cytostatic drugs and monoclonal antibodies may be a limit factor in the treatment of multiple myeloma. …”
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The Relationship between Complements and Age-Related Macular Degeneration and Its Pathogenesis by Liyuan Chu, Chaoran Bi, Caiming Wang, Hongyan Zhou

“…Its pathogenesis may be related to mitochondrial dysfunction, inflammation, apoptosis, autophagy, complement, intestinal flora, and lipid disorders. …”
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Management of acute heart failure in the intensive care unit by Chidhambharam Lakshmanan, Priyavarthini Venkatachalapathy, Parvathy S. Menon, R. Vikram Rajkumar

“…Early achievement of these goals will help avoid deleterious effects of inotropes on already failing myocardium and a smooth transition to oral HF medicines. …”
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Maple syrup urine disease-treatment and outcome in patients of Turkish descent in Germany by Eva Simon, Udo Wendel, Peter Schadewaldt

“… Maple syrup urine disease (MSUD) is a rare autosomal recessive disorder that causes acute and chronic brain dysfunction because of a neurotoxic effect of the accumulating branched chain amino acids (BCAA) and their corresponding keto acids. …”
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The relevance of covenant theology to fatherlessness in Kenya: A youth and family ministry perspective by K.M. Ndereba

“… This article explores fatherlessness within the Kenyan society, as well as its causes and effects. The article uses a practical theological methodology that unpacks the doctrine of reformed covenant theology (RCT) and its implications for strengthening the church’s ministries to young people and families within the context of fatherlessness in Kenya. …”
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Pathomorphological features of the structure of the uterus of fetuses from mothers with pregnancy complicated by pre-eclampsia of varying degrees of severity by V. D. Markowski, L. S. Kupriyanova

“…Identified features can manifest themselves in reproductive dysfunction in the future ontogenesis.…”
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Psychomotor Agitation in Critically Ill Patients and the Role of Sedation by M. Fedarau, F. Compolo, P. J. Papadakos

“…The immunomodulating effects of sedation also must be explored, as these properties may greatly affect outcome. …”
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Sleep in Juvenile Idiopathic Arthritis: An Exploratory Investigation of Heart Rate Variability by M. C. Lopes, S. Roizenblatt, L. M. A. Soster, K. Spruyt

“…Reduced HRV across all sleep stages in these patients suggests underlying autonomic nervous dysfunction. Addressing sleep disturbances in patients with chronic pain may serve as an effective strategy for managing their cardiovascular risk.…”
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Targeting mesothelin-CD24 axis repolarizes tumor-associated macrophages to potentiate PD-1 blockade therapy in high-grade serous ovarian cancer by Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Haiou Liu, Chenyang Wang, Kankan Cao, Yujing Zhong, Xueling Wang, Xuyao Xu

“…Background High-grade serous ovarian cancer (HGSOC) is a highly aggressive malignancy marked by an immunosuppressive tumor microenvironment that hinders effective immune responses. A key feature of this environment is the extensive infiltration of myeloid cells, which contributes to immune evasion. …”
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Characteristics and Features of the Circulatory System Status in Patients with Liver Cirrhosis as a Disease of Multiple Organ Lesions: Pathogenesis; Diagnostics; Principles of thei... by Farmaha M., Abrahamovych M., Ferko M.

“…These vasoactive substances are able to make the cardiodepressive effect and potentially participate in the pathogenesis of cardiomyopathy in the cirrhotic patients. …”
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Exploration of bioactive variants of the BMP7-derived p[63–82] peptide for ameliorating the OA-associated chondrocyte phenotype by Jessica S. J. Steijns, Tim J. M. Welting, Andy Cremers, Guus G. H. van den Akker, Pieter J. Emans, Lodewijk W. van Rhijn, Marjolein M. J. Caron

“…Abstract Introduction Osteoarthritis is a highly prevalent, age-associated joint disease characterized by cartilage degeneration, joint dysfunction, and chronic pain. We previously developed a bone morphogenetic protein 7 derived peptide p[63–82], which may be a novel disease-modifying treatment option for OA. …”
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Baricitinib for refractory Takayasu arteritis: a prospective cohort study in a tertiary referral centre by Jing Li, Li Wang, Li Zhang, Xiaofeng Zeng, Xinping Tian, Shangyi Jin, YunJiao Yang, Ziyue Zhou, Chenglong Fang

“…One patient withdrew baricitinib due to liver dysfunction.Conclusion Baricitinib 4 mg daily is effective for refractory TAK and is well tolerated.…”
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Parameters of leukopoiesis and thrombocytopenia in early urosepsis as potential predictors of a lethal outcome in hospitalized patients by S. V. Fedosenko, Yu. O. Rodionova, A. I. Ivanova, M. B. Arzhanik, O. L. Semenova, S. V. Nesterovich, E. A. Starovoitova, A. P. Zima, D. A. Vinokurova, E. М. Kamaltynova, V. V. Kalyuzhin

“…The baseline level of organ dysfunction graded by the SOFA (Sequential Organ Failure Assessment) score was significantly higher in deceased patients than in survivors (6 points vs. 3 points, respectively; p = 0.001). …”
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Dasatinib and Quercetin Combination Increased Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy by Antonio Battaglia-Vieni, Vanessa Marchant, Lucia Tejedor-Santamaria, Cristina García-Caballero, Elena Flores-Salguero, María Piedad Ruiz-Torres, Sandra Rayego-Mateos, Ana Belen Sanz, Alberto Ortiz, Marta Ruiz-Ortega

“…<b>Background/Objectives</b>: Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the elderly. …”
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Impact of Physical Exercise on Menopause Symptoms and Health-related quality of life - a literature review by Agnieszka Wąsowicz, Marcelina Sztyler-Krąkowska, Jan Siwiec, Natalia Smyl, Julia Szatkowska, Olga Śpiołek, Mateusz Teofilak, Aleksandra Słowikowska, Franciszek Kędziora, Dariusz Fabian

“…Yoga is highly effective in reducing vasomotor, psychosocial, and physical symptoms, with long-term antioxidant benefits but limited effects on hormonal levels (FSH, DHEA-S). …”
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Clinical value of laboratory indicators for predicting disease progression and death in patients with COVID-19: a retrospective cohort study by Ying Wang, Qian Wang, Jie Cheng, Jun Lin, Jian-Ping Wang, Jian Shang, Jing Wan, You-qin Yan, Wen-bin Liu, Hai-Ping Zhang, Xiao-yue Wang, Zi-ang Li

“…Survival analysis suggested that the patients with a high level of CRP, NLR or D-dimer performed shorter overall survival time (all p&lt;0.05).Conclusions The combination of CRP, NLR and D-dimer could be an effective predictor for the aggravation and death in patients with COVID-19. …”
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Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents by Chongshan Dai, Erjie Tian, Hui Li, Subhajit Das Gupta, Zhihui Hao, Zhanhui Wang, Tony Velkov, Jianzhong Shen

“…Aflatoxins are highly toxic to mammals and are known to cause a series of detrimental effects, including neuro-, hepato-, nephron-, and immuno-toxicity. …”
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Complex therapy of musculoskeletal pain: the role of centrally acting muscle relaxants by A. E. Karateev, L. I. Alekseeva, I. F. Akhtyamov, L. M. Antonenko, F. I. Devlikamova, I. S. Dydykina, S. A. Zhivolupov, A. V. Kuzin, V. A. Parfenov, I. N. Samartsev, M. M Tanashyan, N. V. Titova

“…The importance of this problem is determined by the widespread prevalence of MSDs, osteoarthritis (OA), acute and chronic non-specific back pain (NBP), periarticular soft tissues lesions. Introduction of effective methods of treatment of musculoskeletal pain (MSP) into medical practice is one of the fundamental tasks of modern medicine.The pathogenesis of MSP includes mechanisms such as injury, inflammation, peripheral sensitization, biomechanical disorders, dysfunction of the nociceptive system and psychoemotional disorders. …”
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