Gut Microbiota and Metabolic Dysfunction-Associated Steatotic Liver Disease by Emidio Scarpellini, Marialaura Scarcella, Jan F. Tack, Giuseppe Guido Maria Scarlata, Michela Zanetti, Ludovico Abenavoli

“…Its imbalance, namely “dysbiosis”, has been linked to disordered metabolism. Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the features of deranged human metabolism and is the leading cause of liver cirrhosis and hepatocellular carcinoma. …”
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Intestinal Microbiota in Patients with Chronic Heart Failure and Systolic Dysfunction by M. V. Fadeeva, A. V. Kudryavtseva, G. S. Krasnov, M. R. Skhirtladze, V. T. Ivashkin

“…The study included 60 heart failure patients with systolic dysfunction diagnosed according to the results of echocardiographic examination. …”
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Molecular mechanisms for pathophysiology and therapy of cardiac dysfunction in heart failure by Dhalla Naranjan S., Elimban Vijayan, Adameova Adriana Duris, Goyal Ramesh K.

“…It is evident that elevated levels of plasma vasoactive hormones and growth factors as well as increased preload and afterload play critical roles in stimulating various signal transduction pathways for the occurrence of increased ventricular wall stress, cardiac remodelling and subsequent cardiac dysfunction. These alterations are associated with development of oxidative stress, myocardial inflammation, endothelial dysfunction, metabolic defects, intracellular Ca2+-handling abnormalities, apoptosis, fibrosis and changes in the extracellular matrix. …”
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Features of women’s reproductive dysfunctions associated with prolonged stressful situations by O. H. Horbatiuk, A. S. Shatkovska, A. P. Hryhorenko, O. V. Vaskiv, I. O. Bets, I. M. Kustovska, A. I. Petrash

“…In women with stress-related amenorrhea there is a violation of the relationship in the hypothalamic – pituitary system while maintaining the negative feedback loops of the pituitary-ovarian axis or ovarian depletion; post-traumatic stress disorders have a significant pathological effect on the reproductive system of women who have experienced such suffering.…”
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Acute kidney disease in mice is associated with early cardiovascular dysfunction by Pauline Caillard, Youssef Bennis, Cédric Boudot, Denis Chatelain, Pierre Rybarczyk, Agnès Boullier, Sabrina Poirot, Dimitri Titeca-Beauport, Sandra Bodeau, Gabriel Choukroun, Saïd Kamel, Isabelle Six, Julien Maizel

“…They showed significant impairment of aorta relaxation and systolic-diastolic heart function, both on D15 and D45. Such dysfunction was associated with downregulation of the expression of two contractile proteins, αSMA and SERCA2a, with a more pronounced effect on D15 than on D45. …”
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Altered brain dynamics in post-stroke cognitive and motor dysfunction by Xiaoying Liu, Guihua Song, Xiaoyun Zhuang, Ying Zhang, Xiaoyang Wang, Yin Qin, Yin Qin

“…BackgroundCurrent research is predominantly focused on the single dysfunction after stroke, but the potential changes in brain dynamics of post-stroke cognitive and motor dysfunction (PSCMD) remain unclear, which hinders a deep understanding of its rehabilitation effects. …”
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Vascular markers of cognitive dysfunction in patients with uncontrolled arterial hypertension by V. I. Podzolkov, A. E. Bragina, D. U. Natkina, N. A. Druzhinina, T. A. Safronova

“…The presence of arterial hypertension (AH) leads to the development of cognitive dysfunction, in the genesis of which a significant role is assigned to vascular factors. …”
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Gestational Diabetes as a Predictor of Sexual Dysfunction in Pregnant Women by Ommolbanin Zare, Masoumeh Simbar, Giti Ozgoli, Adeleh Bahar, Hamid Alavi Majd

“…Results: The frequency of sexual dysfunction was 87.3% in women with gestational diabetes and 34.67% in low-risk pregnant women. …”
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Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy by Ali A. Khan, BSPH, Fayez H. Fayad, BA, Chan W. Kim, MD, Feven Ataklte, MD, Phinnara Has, MS, Ali Nebipasagil, PhD, Zolt Arany, MD, PhD, Athena Poppas, MD, Wen-Chih Wu, MD, MPH, Gaurav Choudhary, MD, Tasnim F. Imran, MD, MPH

“…Pooled ORs and 95% CIs were calculated using random-effect models. Results: Five studies (N = 472, n = 117 with RV dysfunction; 1,212 person-years of follow-up) met criteria. …”
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The use of polyphenols extracted from Chinese sweet leaf tea (Rubus suavissimus S. Lee.) as novel drugs for the treatment of metabolic dysfunction associated steatotic liver diseas... by Yu Pan, Yu Liu, Yixuan Huo, Suren R Sooranna, Lu Chen, Lijun Yin, Zhigang Yan, Danna Huang, Lihe Jiang, Wuwei Wu

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Synergistic effects of berberine and curcumin-loaded chitosan nanoparticles in Nile tilapia: mitigating high-carbohydrate diet-induced metabolic dysfunction, hepatic injury, and immune-inflammatory responses by Ekramy Elmorsy, Ali A. El-Raghi, Ibrahim T. El-Ratel, Mahmoud A. Hassan, Helal F. Hetta, Mohamed E. Mohamed, Kasim S. Abass, Samah F. Ibrahim, Heba Allah M. Elbaghdady

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Effect of intravenous versus inhaled anesthetics on blood-brain barrier dysfunction and neuroinflammation in elderly patients undergoing major surgery: study protocol of a randomized controlled trial by Wongook Wi, Hyo-Jin Kim, Sira Bang, Oh Joo Kweon, Doyeon Kim, Eun Jung Oh

“…Therefore, we will compare the effect of intravenous anesthetics and inhaled anesthetics on BBB dysfunction and the change of inflammatory markers after surgery. …”
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The moderating effect of dietary fiber intake on the association between sleep pattern and liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES by Guoqing Jia, Mengzhen Jia, Chuntao Li

“…Abstract Background Insufficient nocturnal sleep was associated with a higher risk of fibrosis in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Effects of Intermittent Fasting on Liver Steatosis and Fibrosis, Serum FGF-21 and Autophagy Markers in Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized Controlled Trial by Tugce Ozlu Karahan, Elvan Yilmaz Akyuz, Demet Yilmaz Karadag, Yusuf Yilmaz, Fatih Eren

“…Background: This randomized controlled study sought to determine the effect of intermittent fasting on anthropometric measurements, fibroblast growth factor (FGF)-21, and autophagy markers, as well as on hepatic steatosis and fibrosis levels in overweight or obese patients with metabolic dysfunction-associated fatty liver disease (MAFLD). …”
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Effects of cerebellar repetitive transcranial magnetic stimulation on stroke rehabilitation: A systematic review and meta-analysis by Xin Wang, Guilan Huang, Daoran Wang, Lu Sun, Haobo Leng, Kai Zheng, Xinlei Xu, Guofu Zhang, Caili Ren

“…Conclusions: Existing evidence suggests that cerebellar rTMS holds promise in mitigating post-stroke swallowing dysfunction and motor dysfunction. Stimulation by cerebellar rTMS appears to be an efficacious technique for enhancing stroke rehabilitation.…”
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Comparative Effects of Tadalafil Cream Versus Oral Tadalafil on Males with Erectile Disfunction Regarding Relationship Dynamics: A Secondary Analysis of Dyadic Adjustment Outcomes... by Dragoș-Mihail Trifu, Daniel-Corneliu Leucuța, Martina-Luciana Pintea-Trifu, Florin Elec, Nicolae Crișan, Dan Eniu, Ioan Coman

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Acute Effect of Three Aerobic Exercise Intensities on Glomerular Filtration Rate in Healthy Older Adults by Marina Trejo-Trejo, Luis M. Gómez-Miranda, Arnulfo Ramos-Jiménez

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Effect of Lingnan Painless Apitherapy combined with McKenzie Therapy on Patients with Lumbar Disc Herniation by Hongbo WU, Xinghua CHEN, Ruike ZHANG, Qinglu LUO, Yongming CHENG

“…Objective:To observe the clinical efficacy of Lingnan painless apitherapy combined with McKenzie therapy on patients with lumbar disc herniation(LDH).Methods:A total of 80 patients with LDH who were treated in the department of rehabilitation medicine of the fifth affiliated hospital of Guangzhou medical university from February 2019 to June 2020 were randomly divided into the control group and the observation group according to the random number table method, with 40 cases in each group.The control group received magnetic thermal-vibration therapy and McKenzie therapy.The Japanese magnetic thermal-vibration therapy instrument(TM-3200)was used in the magnetic thermotherapy, the appropriate intensity(high, hot, warm and low temperature)was selected according to the patient's feeling and symptoms, 20 minutes each time, once a day, seven times a week, continuous treatment for two weeks.In addition, the patients with LDH received McKenzie therapy, which was assisted by the therapist or the patient actively completed the flowing training, such as prone position stretching, prone position stretching combined with compression, standing position lateral movement and so on.Each step rested for one minute, once every two days, continuous treatment for two weeks.The observation group received Lingnan painless apitherapy on the basis of treatment in the control group after half an hour's rest.Before treatment, the patients were given apitherapy tolerance test, performing apitherapy with one bee on each Zusanli acupoints on both sides.After apitherapy for 15 minutes, if there was no adverse reaction, the patients were given painless apitherapy with a quiet and comfortable environment, every other day.In this treatment, both sides of Huatuo Jiaji acupoints on the lumbar spinous processes were selected, and Huatuo Jiaji acupoints on both sides of the 5th lumbar spinous process were selected in the first treatment, one acupoint on the left and one on the right.After that, two acupoints were added each time, and each acupoint was treated by one bee.According to the order of Jiaji points on the 4th, 3rd, 2nd and 1st lumbar vertebrae, the number of bee needles increased to 10 bees.Before treatment and two weeks after treatment, visual analogue scales(VAS)was used to evaluate the pain degree, Oswestry disability index(ODI)was used to assess the lumbar spine dysfunction, and TCM syndrome score was used to evaluate the therapeutic effect, and the clinical efficacy was evaluated by <italic>the diagnosis and curative effect standards of TCM diseases</italic>.Results:Before treatment, there was no significant difference in the VAS score, ODI score and TCM syndrome score between the observation group and the control group(<italic>P</italic>&gt;0.05).Compared with treatment before, the VAS score, ODI score and TCM syndrome score after treatment for two weeks of the two groups were significantly reduced, with a statistically significant difference(<italic>P</italic>&lt;0.05).Compared with the control group, the VAS score and TCM syndrome score of the observation group were lower than those of the control group, with a statistically significant difference(<italic>P</italic>&lt;0.05), but there was no considerable difference in ODI score between the two groups(<italic>P</italic>&gt;0.05), and the clinical efficacy of the observation group(95%)was significantly higher than that of the control group(80%)(<italic>P</italic>&lt;0.05).Conclusion:Lingnan painless apitherapy combined with McKenzie therapy can significantly improve the pain degree and lumbar spine dysfunction of patients with LDH, which have a good effect and it is worthy of clinical promotion.However, it's necessary to develop large-sample randomized controlled trials and follow-up, to provide more reliable basis for clinical treatment of LDH.…”
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Effect of Vitamins B12 and D Deficiency in Thyroid, Skin, Oral, and Respiratory Disease by Praveen K. Tagore, Prashant Harit, Manish K. Sachan, Mahendra K. Bharti, Pratima Singh, Gauri Harit

“…Early detection and supplementation may help mitigate these adverse effects.…”
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The Effects of the COVID-19 Pandemic on Abnormal Uterine Bleeding According to the PALM-COEIN Classification by Onur Bektas, Kivilcim Bektas, Sirin Aydin, Gulsen Dogan Durdag, Husnu Celik

“…This was statistically shown to be due to ovulatory dysfunction and endometrial problems (with p-values of 0.033 and 0.024, respectively). …”
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