Pregnancy-related acute kidney injury leads to hypertension, reduced kidney function and cognitive impairment in postpartum rats by Ashley Griffin, Jamie Szczepanski, Shauna-Kay Spencer, Shauna-Kay Spencer, Lucia Solis, Teylor Bowles, Reanna Robinson, Jan M. Williams, Patrick B. Kyle, Kedra Wallace, Kedra Wallace

“…Mean arterial pressure and birth outcomes were used to assess the global effects of AKI, and liver enzymes were used to assess HELLP. …”
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Long-Term Impact of Recurrent Acute Otitis Media on Balance and Vestibular Function in Children by Mirko Aldè, Pietro Bosi, Stefanie Muck, Thomas Mayr, Paola Di Mauro, Valentina Berto, Beatrice Gaia Aleandri, Francesco Folino, Stefania Barozzi, Diego Zanetti, Paola Marchisio

“…The present study aimed to evaluate the long-term effects of rAOM on balance and vestibular function in pediatric patients. …”
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Modulation of Abnormal Vasoconstriction Through 2‐Hydroxyisobutyrylation of Tropomyosin 3 Lys141: Targeting Histone Deacetylase 3 as a Key Approach by Pan‐Pan Pang, Jiang‐Xin Liu, Wen‐Bin Su, Wen‐Cong Gao, Guan‐Rong Qiao, Jing Yuan, Yong‐Tang Zheng, Chang‐Bo Zheng

“…This was further validated by adenoviral transfection of isolated blood vessels with a Lys141‐mutated TPM3 construct, which abolished the effects of HDAC3 on TPM3 Khib modification and vascular contractility. …”
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Low‐Magnitude High‐Frequency Vibration Attenuates Sarcopenia by Modulating Mitochondrial Quality Control via Inhibiting miR‐378 by Yu‐Feng Long, Can Cui, Qianjin Wang, Zhen Xu, Simon Kwoon‐Ho Chow, Ning Zhang, Ronald Man Yeung Wong, Elvis Chun‐Sing Chui, Rebecca Schoenmehl, Christoph Brochhausen, Clinton Rubin, Gang Li, Ling Qin, Da‐Zhi Yang, Wing‐Hoi Cheung

“…Although mitochondrial dysfunction is increasingly implicated in sarcopenia, the underlying mechanisms are not fully discovered. …”
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Prophylactic endoscopic pylorus dilatation prior to esophagectomy for esophageal cancer to prevent delayed gastric emptying, study protocol for a placebo-controlled randomized tria... by C. Mann, F. Berlth, V. J. Lozanovski, M. Passalacqua, E. Hadzijusufovic, E. Uzun, G. Capovilla, M. Valmasoni, H. Lang, P. P. Grimminger

“…Abstract Introduction Delayed gastric emptying (DGE) due to pyloric dysfunction remains a common postoperative complication after esophagectomy for cancer and can lead to severe secondary complications. …”
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Integrative analysis identifies IL-6/JUN/MMP-9 pathway destroyed blood-brain-barrier in autism mice via machine learning and bioinformatic analysis by Cong Hu, Heli Li, Jinru Cui, Yunjie Li, Feiyan Zhang, Hao Li, Xiaoping Luo, Yan Hao

“…Pharmacological intervention using ventricular JNK inhibitor administration effectively downregulated JUN and MMP-9 expression. …”
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Integrated proteomics analysis and network pharmacology to elucidate the mechanism of Zhilong Huoxue Tongyu Capsule alleviate hypertensive retinopathy in Ang II infusion mice model by Jiao Wu, Wen Xie, Yucen Xie, Maryam Mazhar, Junguo Duan, Junguo Duan

“…Finally, TEM results also verified that ZLHXTY alleviated pyroptosis in retinal cells.ConclusionOur results suggest that ZLHXTY by regulating the NLRP3/Caspase-1/GSDMD axis, inhibiting pyroptosis, thereby relieving retinal dysfunction and vascular injury in HR mice.…”
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Feasibility and Safety of Ex Vivo Delivery of Rituximab to Lung Allografts in Transplant Recipients at High Risk for Epstein-Barr Virus–associated Posttransplant Lymphoproliferativ... by Victor H. Ferreira, PhD, Rafaela V. P. Ribeiro, MD, PhD, Faranak Mavandadnejad, PhD, Matthew Ierullo, MSc, Beata Majchrzak-Kita, MSc, Aizhou Wang, PhD, Lianne Singer, MD, Shaf Keshavjee, MD, Marcelo Cypel, MD, PhD, Deepali Kumar, MD, Atul Humar, MD

“…One patient experienced primary graft dysfunction. Peripheral B-cell counts were reduced immediately posttransplant and remained low in some patients, whereas others rebounded over the weeks posttransplant, and serum rituximab levels were undetectable after 2 wk. …”
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Correlation of safety and efficacy of atezolizumab therapy across indications by Jarushka Naidoo, Guru Sonpavde, Mark A Socinski, Rajat Mohindra, Corey Carter, Laurent Essioux, Gonzalo Durán-Pacheco, G Scott Chandler, Vidya Maiya, Javier Puente, Jose Vicente Cardona

“…Most irAEs are mild-to-moderate but severe irAEs may pose clinical management challenges and affect patient outcomes.Methods We assessed the association between irAE grade (G) and specific organ involvement with overall survival (OS) in 9,521 patients across 14 studies involving atezolizumab as mono (IO) or with chemo/targeted (C-IO) therapy as compared with chemo/targeted therapy (C) in advanced non-small cell lung, small-cell lung, renal cell, urothelial, and triple-negative breast cancers. We used a mixed-effect Cox proportional hazard model for time-varying covariates to address immortal-time bias; adjusted for baseline factors associated with irAEs and OS to control for confounding bias; and focused on five common irAEs (dermatologic, thyroid dysfunction, hepatitis, pneumonitis, and colitis) to avoid low statistical power for rare events.Results For patients treated with IO or C-IO, G1-2 irAEs were associated with improved OS (HR=0.65, p<0.01) and G3-4 irAEs showed a slight increased risk of death (HR=1.18, p=0.10) versus patients without irAEs. …”
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Outcomes of pediatric heart transplantation in children with selected genetic syndromesCentral MessagePerspective by Sarah Wilkens, MD, MPH, Jaimin Trivedi, MBBS, MPH, Deborah Kozik, MD, Andrea Nicole Lambert, MD, MSCI, Bahaaldin Alsoufi, MD

“…Objective: Genetic syndromes (GSs) are often linked to congenital heart disease (CHD) and cardiomyopathy (CM). The effect of GSs on survival following pediatric heart transplant (HT) has not been well described. …”
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Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration by Ya-Jun Gong, Zhi-Lin Zou, Kai-Rui Qiu, Qiang Wang, Xiao-Lai Zhou

“…Furthermore, METTL3 and NSUN6 were found to have a protective effect, while MRM1 was associated with an increased risk of AMD. …”
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Some aspects of morphogenesis of diabetic encephalopathy by V. A. Tumanskiy, Yu. N. Avramenko

“…It is known that it is a multifactor effect in the development of which the main role is led by the vascular dysfunction with the reduction of blood supply and ischemia of brain tissue, as well as direct toxic influence of hyperglycemia and disorder of trophism of nerve tissue [7]. …”
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Predictors, prevalence and prognostic role of pulmonary hypertension in patients with chronic kidney disease: a systematic review and meta-analysis by Chunlong Lin, Qilong Ge, Lei Wang, Pan Zeng, Mingmin Huang, Dan Li

“…All of pooled analyses were performed using the random-effects model.Results Fifty observational studies involving 17,558 CKD patients were selected. …”
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Homeostasis Changes of Tear-Producing System with the Background of Cosmetic Procedures in Periorbital Area by V. N. Trubilin, E. G. Poluninа, D. V. Andzhelova, V. V. Kurenkov, S. G. Kapkova, K. V. Chinenova

“…It has been shown that the combined effect of cosmetological procedures (tattooing the eyelids, eyelash extensions, injections of dermal fillers and botulinum toxin in the periorbital region) aggravates the course and prognosis of Dry Eye Syndrome and meibomian glands dysfunction. …”
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Prevalence of polypharmacy in patients with a diagnosis of liver cirrhosis treated in the Gastroenterology service of the La Raza National Medical Center by Martín Rivera-Huizar, Javier I. Carrillo-Rojas, Francisca Martinez-Silva

“…The classification of liver dysfunction found a predominance of Child Pugh B with 49%. …”
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The anti-aging potential of antihypertensive peptides of Pariset, a dataset of algal peptides by Isaac Karimi, Parisa Olfati, Layth Jasim Mohammed, Jawad Kadhim Tarrad, Ahmed M. Amshawee, Maryam A. Hussain, Helgi B. Schiöth

“…IntroductionCellular senescence drives aging and disease by promoting inflammation and tissue dysfunction. The kidneys, highly susceptible to aging, worsen with hypertension, increasing chronic disease risk. …”
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Migraine and stroke: correlation, coexistence, dependence - a modern perspective by Michał Borończyk, Anna Zduńska, Julia Węgrzynek-Gallina, Olga Grodzka, Anetta Lasek-Bal, Izabela Domitrz

“…While microemboli associated with PFO may provoke ischemic events and migraine attacks, the effectiveness of PFO closure in alleviating migraine symptoms has produced varying results. …”
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Lactate-Induced Mitochondrial Calcium Uptake 3 Aggravates Myocardial Ischemia–Reperfusion Injury by Promoting Neutrophil Extracellular Trap Formation by Hongru Zhang, Lei Liu, Chuchu Shen, Xinxue Jiang, Jing Liu, Jing Chen, Senlei Xu, Yanfei Mo

“…Up-regulated MICU3 interacted with VDAC1, facilitating MAM formation, excessive Ca2+ uptake, mitochondrial dysfunction, mitophagy activation, and NET activation. …”
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P-12 METHYL GROUP DONOR SUPPLEMENTATION IN A MetALD MODEL: REGULATION OF GUT MICROBIOTA AND METABOLIC PARAMETERS by Carolina Díaz Canul, Angel Omar Vázquez Esqueda, Rebeca Rosas Campos, Rebeca Escutia Gutiérrez, Natalia Gómez Gómez, Monica Ibarra Hernández, Marina Galicia Moreno, Juan Armendáriz Borunda, Ana Sandoval Rodriguez

“…Conflict of interest: No Introduction and Objectives: Patients who meet both MASLD (Metabolic dysfunction-associated steatotic liver disease) and alcohol-related fatty liver disease (ALD) criteria are categorized as having MetALD (Metabolic and alcohol-related liver disease) and its damage is characterized by metabolic dysfunction, gut dysbiosis and liver inflammation, resulting in steatosis and fibrosis. …”
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Sevoflurane-Induced Thrombocytopenia in Post-Robotic-Assisted Paraesophageal Hernia Repair by Sara Alhaj, James Tran, Muhammad Nazim, Praveen Tumula, Hassan Ahmed

“…The liver plays an important role in thrombopoiesis by releasing megakaryocyte growth factors. Therefore, liver dysfunction can present as thrombocytopenia or other platelet dysfunctions. …”
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