Corticospinal Intermittent Theta Burst Stimulation Propelling Sensorimotor Function Recovery in Complete Spinal Cord Injury: Protocol for a Randomized Controlled Trial by Deeksha Patel, Rohit Banerjee, Kamran Farooque, Deepak Gupta, Bhavuk Garg, Nand Kumar, Kanwal Preet Kochhar, Suman Jain

“…Spinal cord injury (SCI) causes damage to neurons and results in sensorimotor dysfunction. The effect of iTBS on recovery of motor and sensory dysfunction in complete SCI (cSCI) is still elusive. …”
Get full text

Propofol Suppresses Ferroptosis via Modulating eNOS/NO Signaling Pathway to Improve Traumatic Brain Injury by Zi‐Lei Zheng, Xu‐Peng Wang, Yu‐Fei Hu, Wen‐Guang Li, Qi Zhou, Fang Xu, Qiu‐Jun Wang

“…The results of MWM and NOR tests indicated that propofol significantly improved the long‐term cognitive dysfunction induced by TBI. Propofol exerts neuroprotective effects by increasing the expression of eNOS protein and the content of NO. …”
Get full text

Epicardial adipose tissue volume is associated with impaired left ventricular strain in patients with metabolic syndrome: the mediating role of myocardial energetic efficiency by Wei-Feng Yan, Jin Wang, Yuan Li, Shi-Qin Yu, Yu Jiang, Xue-Ming Li, Yi-Ning Jiang, Ke Shi, Yue Gao, Shan Huang, Zhi-Gang Yang

“…Abstract Background Epicardial adipose tissue volume (EATV) has been linked to cardiac dysfunction in metabolic syndrome (MetS), but the underlying mechanisms remain unclear. …”
Get full text

Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function by Longwei Sun, Junpeng Huang, Xiangyang Dou, Zhenyu Dong, Yuan Li, Shujing Tan, Ran Yu, Chengmin Li, Weiguo Zhao

“…Resveratrol (RES) is a polyphenolic compound with antioxidant, anti-inflammatory and multiple other physiological effects. However, its effect on oxidative damage triggered by NEFAs in bovine mammary epithelial cells is rarely reported. …”
Get full text

Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in t... by Olalekan Bukunmi Ogunro, Mojisola Esther Karigidi, Gideon Ampoma Gyebi, Areej Turkistani, Ahmad H. Almehmadi

“…At the same time, donepezil hydrochloride did not demonstrate similar effects.…”
Get full text

Irisin: Emerging Therapeutic Targets for Cognitive Impairment-Related Diseases by Mei Ma, Guangchan Jing, Yue Tian, Ruiying Yin, Mengren Zhang

“…Conclusion This review delves into the positive effects of irisin on cognitive impairment, examines the signalling pathways related to fibronectin type III domain-containing 5 (FNDC5)/irisin and provides future perspectives for research on the anti-cognitive impairment effects of irisin. …”
Get full text

Metabolites derived from medicinal plants modulating voltage-gated sodium channel activity: A systematic review by José Luis Estela-Zape, Mayra Liliana Pizarro-Loaiza, Gabriel Arteaga, Santiago Castaño, Leonardo Fierro

“…These compounds exhibited analgesic, antiarrhythmic, and neuroprotective properties, suggesting their therapeutic potential for disorders linked to Nav channel dysfunction. Conclusions: Plant-derived metabolites that modulate Nav channels present significant therapeutic potential for treating neurological disorders, offering more targeted treatments with fewer side effects. …”
Get full text

Salidroside protects against myocardial infarction via activating MIF-mediated mitochondrial quality control by Baiyang You, Jie Zhang, Chuyan Yang, Yaoshan Dun, Dake Qi, Yuqiong Long, Jing Cheng, Yuan Lin, Nanjiang Zhou, Tanghao Zeng, Jie Dong, Suixin Liu

“…Abstract Background Salidroside is a potential therapeutic agent for myocardial infarction (MI), exerting therapeutic effects on macrophage migration inhibitory factor (MIF)-regulated mitochondrial quality control. …”
Get full text

The PKM2 activator TEPP‐46 suppresses cellular senescence in hydrogen peroxide‐induced proximal tubular cells and kidney fibrosis in CD‐1db/db mice by Shin‐ichiro Ishihara, Md. Imrul Kayes, Hirofumi Makino, Hiroaki Matsuda, Asako Kumagai, Yoshihiro Hayashi, Sara Amelia Ferdaus, Emi Kawakita, Daisuke Koya, Keizo Kanasaki

“…ABSTRACT Aim/Introduction Senescence is a key driver of age‐related kidney dysfunction, including diabetic kidney disease. Oxidative stress activates cellular senescence, induces abnormal glycolysis, and is associated with pyruvate kinase muscle isoform 2 (PKM2) dysfunction; however, the mechanisms linking PK activation to cellular senescence have not been elucidated. …”
Get full text

Radiographic identification method of safe medial pinning zone and its clinical efficacy in pediatric supracondylar humeral fracture fixation by Hongbin Liu, Yong Zhu, Yi Hu, Kaihu Li, Haitao Long, Zhangyuan Lin, Ruibo Zhao, Buhua Sun, Shushan Zhao, Liang Cheng

“…A retrospective analysis was performed to assess the safety and effectiveness of pin placement. Furthermore, in a case of postoperative ulnar nerve dysfunction, the standard medial pinning technique was replaced with the defined safe entry approach. …”
Get full text

<i>Lactobacillus rhamnosus</i> GG Modulates Mitochondrial Function and Antioxidant Responses in an Ethanol-Exposed In Vivo Model: Evidence of HIGD2A-Dependent OXPHOS Remodeling in... by Celia Salazar, Marlen Barreto, Alfredo Alfonso Adriasola-Carrasco, Francisca Carvajal, José Manuel Lerma-Cabrera, Lina María Ruiz

“…This probiotic may represent a promising therapeutic strategy to mitigate mitochondrial dysfunction associated with early-life alcohol exposure.…”
Get full text

Silenced SOX2‐OT alleviates ventricular arrhythmia associated with heart failure by inhibiting NLRP3 expression via regulating miR‐2355‐3p by Yuming Liang, Boqun Wang, Huijuan Huang, Maoyun Wang, Qianwen Wu, Yaxin Zhao, Yan He

“…Inhibiting miR‐2355‐3p reversed the effect of SOX2‐OT in rats with VA‐HF. Conclusions Silencing SOX2‐OT alleviated cardiac dysfunction in rats by reducing the activation of NLRP3 inflammasomes via regulating miR‐2355‐3p.…”
Get full text

Does Nissen fundoplication improve deglutition in children? by Tutku Soyer, Şule Yalçın, Numan Demir, Asuman Nur Karhan, İnci Nur Saltık-Temizel, Hülya Demir, Feridun Cahit Tanyel

“… A prospective study was performed to evaluate the effect of Nissen fundoplication (NF) on deglutition in children. …”
Get full text

Features of functional state restoration among military personnel after traumatic brain injury combined with acubarotrauma by A. V. Shvets, Yu. V. Podolian, M. I. Holinko

“…It has been established that the presence of comorbid pathology before its treatment had a significant effect on sensory and cognitive impairment, dysfunction of the auditory analyzer both prior to and after the treatment and, conversely, anxiety manifestations prior to and after the treatment somatic manifestations and affective reactions after treatment were negatively correlated with the factor of acubarotrauma. …”
Get full text

Mesenchymal Stem Cells Alleviate DHEA-Induced Polycystic Ovary Syndrome (PCOS) by Inhibiting Inflammation in Mice by Qi Xie, XingLiang Xiong, Na Xiao, Ke He, Maosheng Chen, Jing Peng, Xian Su, Hua Mei, Yanni Dai, Dan Wei, Ge Lin, Lamei Cheng

“…Chronic inflammation is considered to be the cause of ovarian dysfunction. Increasing evidence in animal studies and in preliminary clinical trials has demonstrated that MSCs possess immunomodulatory effects via their interaction with immune cells. …”
Get full text

Mitochondrial Amount Determines Doxorubicin‐Induced Cardiotoxicity in Cardiomyocytes by Weiyao Xiong, Bin Li, Jianan Pan, Dongjiu Li, Haihua Yuan, Xin Wan, Yanjie Zhang, Lijun Fu, Junfeng Zhang, Ming Lei, Alex Chia Yu Chang

“…Abstract Doxorubicin, an anthracycline commonly used for treating cancer patients, is known for its cardiotoxic side‐effects. Although dose‐dependent, but susceptibility remains variable among patients, and childhood‐exposure‐adult‐onset remains challenging. …”
Get full text

The role of heme in sepsis induced Kupffer cell PANoptosis and senescence by Tingting Li, Joseph Adams, Peilin Zhu, Tao Zhang, Fei Tu, Amy Gravitte, Xiaojin Zhang, Li Liu, Jared Casteel, Valentin Yakubenko, David L. Williams, Chuanfu Li, Xiaohui Wang

“…Furthermore, we show that hemopexin, a heme scavenger, effectively mitigates sepsis-induced Kupffer cell death and senescence, enhances bacterial clearance, and improves survival outcomes in both young and aged mice. …”
Get full text

Aminooxyacetic acid ameliorates alcohol-induced learning and memory deficits through BDNF-TrkB pathway and calcium homeostasis by Zhen Sun, Meinan Nie, Xunling Wang, Bolin Jiao, Jiayi Fu, Ailin Du

“…The increase of intracellular Ca2+ concentration can directly cause mitochondrial dysfunction, destroy normal physiological signal transduction, and accelerate the process of learning and memory decline. …”
Get full text

L-arginine regulates mitochondrial function and oxidative stress in the acute kidney injury model of unilateral ureter obstruction by Seyed Mohammad Amin Kashani, Narges Abdoli, Forouzan Khodaei, Zahra Honarpishefard, Tahereh Golzar, Nazi Dastkhosh, Azad Salimi, Negar Azarpira, Hossein Niknahad, Reza Heidari

“…This study aims to investigate the protective effects of ARG in an animal model of UUO-induced AKI. …”
Get full text

Exploration of the mechanism underlying the impact of artificial light on guinea pig ovarian function via proteomics and acetylation analyses by Jiayu Shi, Yuliang Wang, Linfang Li, Ruxin Wang, Yao Peng, Tingting Zhou, Donglai Hu, Jie Chen, Yong Tan

“…Objective: This study aims to explore the effects of artificial light on ovarian function in female guinea pigs and the possible mechanism. …”
Get full text