Long-Term Use of Metronidazole Mimicking Hepatic Encephalopathy by Umar Ghaffar, Kiran Lukose, Mohammad As Sayaideh, Bhagwan Dass, Nila S. Radhakrishnan

“…Metronidazole, a widely used antibiotic is associated with a rare but serious set of adverse effects termed Metronidazole Induced Encephalopathy. …”
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A patient with atrial fibrillation and comorbidities in clinical practice by A. S. Skotnikov, E. A. Algiyan, Zh. M. Sizova

“…The authors discuss the interconnection of atrial fibrillation and these diseases, and also note the need for protection of such patients (prevention of cardioembolic stroke and other systemic embolism, reduction of coronary risk, improvement of prognosis, slowing the progression of renal dysfunction, increasing medical adherence, etc.) by adequate antithrombotic therapy that does not lose effectiveness and/or safety in presence of multiple diseases and polypharmacy.…”
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ANGIOTENSIN RECEPTOR BLOCKERS WITH PLEIOTROPIC PROPERTIES: A NEW STANDARD IN CARDIOVASCULAR RISK MANAGEMENT AND TREATMENT OF HYPERTENSION by V. I. Podzolkov, M. V. Pisarev

“…The evidence base for the use of telmisartan as a drug with pleiotropic effect in patients with arterial hypertension and associated diseases (diabetes mellitus, obesity, renal dysfunction) is discussed.…”
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THE FEATURES OF ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH METABOLIC SYNDROME by L. V. Kremneva, O. V. Abaturova, S. V. Shalaev

“…Results of multicenter studies on assessment of clinical efficacy of groups of antihypertensive drugs, their effects on metabolic parameters, the ability to prevent the development of cardiovascular events, diabetes mellitus, and renal dysfunction are presented.…”
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The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent... by Dunya Aydos, Zeynep Busra Aksoy, Mehmet Altay Unal, Kamil Can Akcali, Ceylan Verda Bitirim, Belma Turan

“…Objective Considering a relationship between the trafficking of incretin receptors in a manner not anticipated by the standard way of cAMP as a primary actor in TZPD action, together with the role of cAMP depression in cardiac dysfunction, here, we aimed to elucidate a pattern of unintended receptor interactions of TZPD and molecular processes underlying the pleiotropic effects of TZPD through modulation of the β-adrenoceptors (β-ARs) signaling in cardiomyocytes. …”
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Modulation of atherogenesis biomarkers by PCSK9 inhibitors in Lp(a)-stimulated human coronary artery endothelial cells by Rahayu Zulkapli, Suhaila Abd Muid, Seok Mui Wang, Mohd Yusmiaidil Putera Mohd Yusof, Hapizah Nawawi

“…This study explores the critical role of Lp(a) in driving PCSK9 expression and atherogenesis biomarkers, evaluates the protective effects of PCSK9i on endothelial activation, dysfunction and inflammation in Lp(a)-stimulated human coronary artery endothelial cells (HCAECs), and investigates their potential to mitigate monocyte adhesion, a key process in early atherogenesis. …”
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Evidence-Based Analysis of the Emergency Temporary Cardiac Pacing (Electrical Stimulation from Metal Wire Electrode) by Meng Liu, Xuming Lin, Qiaoyin Tan, Xiaotong Han

“…MYO (myoglobin) has no impact relationship to DDI. (5) ALT has a significant positive relationship with APTT (partial thromboplastin time). (6) Alb (albumin) and TBIL (total bilirubin) have a significant positive effect on PLT (platelet) count, while pro-BNP (B-type natriuretic peptide) and MYO have a significant negative effect on PLT. (7) CK has a significant positive effect on INR (international normalized ratio). (8) The relationship between sinus node dysfunction and VT significantly affect the pacing frequency (beats/minute). …”
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Withania somnifera Root Extract Enhances Chemotherapy through 'Priming'. by Aine Brigette Henley, Ling Yang, Kun-Lin Chuang, Meliz Sahuri-Arisoylu, Li-Hong Wu, S W Annie Bligh, Jimmy David Bell

“…Moreover, we showed that this effect was not seen in non-cancerous cells.…”
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ИНСУЛИНОРЕЗИСТЕНТНОСТЬ КАК ВЕДУЩИЙ ФАКТОР РИСКА ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА ПРИ САХАРНОМ ДИАБЕТЕ 2 ТИПА... by А. К. Кошкарбаева, С. Н. Афанасьев

“…This review reflects role of free fatty acids, cytokines and hormones produced by adipocytes, the mechanism of insulin resistance in type 2 diabetes. Effect of insulin on oxidative stress, endothelial dysfunction development, reduced nitric oxide secretion, smooth muscle cell hyperplasia, changing the content of plasminogen activator inhibitor were studied. …”
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Pitfalls in Interventional Pain Medicine: Hyponatremia after DDAVP for a Patient with Von Willebrand Disease Undergoing an Epidural Steroid Injection by Talal W. Khan, Abdulraheem Yacoub

“…Desmopressin (DDAVP), a synthetic analog of vasopressin, has been used in patients with von Willebrand disease (VWD), mild hemophilia A, and platelet dysfunction to reduce the risk of bleeding associated with surgical and interventional procedures. …”
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Metabolic Complications and Increased Cardiovascular Risks as a Result of Androgen Deprivation Therapy in Men with Prostate Cancer by Bhavin R. Shastri, Subhashini Yaturu

“…Androgen deprivation therapy has additional systemic effects that include sexual dysfunction, psychological changes and more important are the metabolic changes. …”
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Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol by Mohamed Ahmed

“…Abstract Aging is a multifactorial biological process driven by oxidative stress, chronic inflammation, genomic instability, and mitochondrial dysfunction. Recent research underscores the potential of naturally derived compounds to modulate these aging hallmarks. …”
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Diagnosis and Management of Heatstroke by I Gede Yasa Asmara

“…The pathophysiology of heatstroke involves a combination of direct heat effects on the host, the systemic inflammatory and coagulopathic response. …”
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Chronic mental stress and ischemic injury: Mechanisms and implications – A mini review by Yuequan Zhu, Leticia Simo, Xiaokun Geng, Fengwu Li, Yuchuan Ding

“…We discuss mechanisms at the cellular, subcellular, and epigenetic levels, including differential brain cell sensitivity, mitochondrial dysfunction, and novel epigenetic modifications like lactylation. …”
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Cardiovascular complications of polychemotherapy of oncohematological diseases: Modern approaches to diagnostics by B. B. Samura

“…Heart dysfunction that occurred after using of cytostatic drugs and monoclonal antibodies may be a limit factor in treatment of oncohematological diseases. …”
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How Can we Battle the Scourge of Diarrhea? 2003 Mckenna Memorial Lecture by Kim E Barrett

“…Recent information regarding the mechanisms whereby invasive bacteria cause diarrhea is also reviewed along with effects of beneficial bacteria (so-called probiotics) in limiting dysfunction associated with enteric infections. …”
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Illuminating the impact of N-terminal acetylation: from protein to physiology by Nina McTiernan, Ine Kjosås, Thomas Arnesen

“…We also provide an overview of the impact of N-terminal acetylation, including its effects on protein folding, subcellular targeting, protein complex formation, and protein turnover. …”
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GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care by Agnieszka Parfianowicz, Alicja Surma

“…This paper explores their mechanisms of action, clinical benefits, and potential synergistic effects, emphasizing their impact on cardiovascular and renal outcomes. …”
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Dichotomous roles of IL-36 and IL-38 in cardiovascular disease by Haifeng Zhang, Wenhui Huang, Shisan Bao

“…IL-36 typically promotes inflammation, contributing to endothelial dysfunction, atherogenesis, and myocardial injury. In contrast, IL-38 exerts predominantly anti-inflammatory effects, modulating immune responses and promoting tissue repair. …”
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Resveratrol-Enhanced Human Neural Stem Cell-Derived Exosomes Mitigate MPP+-Induced Neurotoxicity Through Activation of AMPK and Nrf2 Pathways and Inhibition of the NLRP3 Inflammaso... by Ming-Chang Chiang, Yu-Ping Yang, Christopher J. B. Nicol, Tairui Chiang, Chiahui Yen

“…Parkinson’s disease (PD) is a progressive neurodegenerative disorder primarily characterized by the loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction, oxidative stress, and neuroinflammation are recognized as critical pathological mechanisms driving neurodegeneration in PD. …”
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