Adverse childhood experiences (ACEs) and cardiovascular development from childhood to early adulthood: study protocol of the Niagara Longitudinal Heart Study by Terrance J Wade, Deborah D O’Leary, Kylie S Dempster, Adam J MacNeil, Danielle S Molnar, Jennifer McGrath, John Cairney

“…Collectively referred to as adverse childhood experiences (ACEs), this toxic environment is prevalent among children, with recent Canadian estimates of child abuse at 27%–32%, and severe household dysfunction at 49%. Based on these prevalence rates, the potential effect of ACEs on CVD is more significant than previously thought. …”
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Cardiac Resynchronization Therapy in the Cardiorenal Syndrome by Margot K. Davis, Sean A. Virani

“…The cardiorenal syndrome (CRS) is a complex clinical syndrome in which dysfunction of either the heart or the kidneys affects the functioning of the other organ system. …”
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Combination antihypertensive therapy in patients with arterial hypertension and coronary heart disease by T. E. Morozova, T. B. Andrushchishina

“…In patients with AH and CHD, the rational, pathogenetic pharmacotherapy using a combination of an ACE inhibitor zofenopril and a highly cardio-selective and vasodilating BAB nebivolol demonstrates antihypertensive and antiischemic action, decreases the risk of potential adverse cardio-metabolic effects, reduces the severity of endothelial dysfunction, and, consequently, improves quality of life.…”
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Gastroesophageal Reflux Disease: Diagnosis, Medication, Balneotherapy by A. E. Shklyaev, V. M. Dudarev

“…Emphasis is placed on the special role of slightly acidic and slightly alkaline reflux in the pathogenesis of GERD, which, in combination with dysfunction of the lower esophageal sphincter and impaired motor-evacuation function of the stomach, are important factors, determining the the lack of effectiveness of standard antisecretory therapy. …”
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TREATMENT FOR CHRONIC HEART FAILURE IN ELDERLY SUBJECTS by A. S. Poskrebysheva, N. A. Shostak, E. S. Trofimov

“…The physiological features of the elderly and significant comorbidity frequently have a considerable impact on the effects of drugs and the magnitude of side effects. …”
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Use It or Lose It: Environmental Enrichment as a Means to Promote Successful Cognitive Aging by Karyn M. Frick, Jamie D. Benoit

“…Environmental enrichment has become increasingly utilized in rodent models of aging and neurodegenerative disease in order to prevent or reverse cognitive decline and neuronal dysfunction. However, the potential application of this body of work to human cognitive aging has rarely been discussed. …”
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Clinical characteristics of MASLD/MetALD/MAFLD/NAFLD and the relative risk analysis on metabolic disorders by Hong-ye Peng, Chun-li Lu, Mo Zhao, Xiao-qiang Huang, Shu-xia Huang, Zi-wen Zhuo, Jing Liu, Yan-ping Lu, Wen-liang Lv

“…Our findings suggest that MAFLD is a more effective indicator for identifying patients at increased risk for metabolic disorders.…”
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High-intensity intermittent exercise regulates oxidative stress and improves endothelial progenitor cell function in patients with essential hypertension by Jixin ZHI, Tiantian WANG, Shuang REN, Chenyu WANG

“…High-intensity intermittent exercise is an effective prevention and treatment method of various chronic diseases; however, little attention has been paid to its effects and mechanisms on endothelial progenitor cells. …”
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A temperature-ultrasound sensitive nanoparticle delivery system for exploring central neuroinflammation mechanism in stroke-heart syndrome by Mingzhou Jiang, Zhidong Zhu, Ziyu Zhou, Zhiqiang Yan, Kai Huang, Rongrong Jiang, Xi Fan, Milayi Jieensi, Liewen Pang, Yiqing Wang, Xiaotian Sun

“…DATS/MION-LPE can targetedly effect on ischemic brain, exhibiting cerebral and cardiac protective effects including downregulated cerebral NLRP3 and HDAC6 expressions, upregulated SIRT1 expressions in brain, reduced IL-1β and ATP in circulation, and alleviated cardiac impairment. …”
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Early outcomes of kidney transplantation in recipients with type 1 diabetes mellitus and end‑stage kidney disease resulting from diabetic nephropathy by K. E. Lazareva, I. V. Dmitriev, A. G. Balkarov, N. V. Shmarina, N. S. Zhuravel, Yu. A. Anisimov, V. O. Alexandrova

“…Although T1D patients remain the most severe category of dialysis patients, our findings suggest that KT is an effective treatment option for them with high graft and recipient survival rates.…”
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Serum Norepinephrine and Cholesterol Concentrations as Novel Diagnostic Biomarkers for Vitamin E Deficiency in Holstein Cows by Yuxi Song, Xuejie Jiang, Yu Hao, Rui Sun, Yunlong Bai, Chuang Xu, Cheng Xia

“…Vitamin E deficiency (VED) represents a common micronutrient deficiency in dairy cows (DCs), leading to severe degenerative diseases, oxidative stress, immune dysfunction, and various health issues, ultimately causing significant economic losses for the global dairy sector. …”
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Semaglutide treatment for PRevention Of Toxicity in high-dosE Chemotherapy with autologous haematopoietic stem-cell Transplantation (PROTECT): study protocol for a randomised, doub... by Filip K Knop, Hannelouise Kissow, Maria Ebbesen Sørum, Anne Ortved Gang, Dorte Maegaard Tholstrup, Sif Gudbrandsdottir, Brian Kornblit, Klaus Müller

“…Introduction Cancer treatment with high-dose chemotherapy damages the mucosal barrier of the gastrointestinal (GI) tract and is associated with severe toxicity involving mucositis, severe inflammation and organ dysfunction. Currently, there is no effective prophylaxis against this. …”
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A case of hospital-acquired pneumonia associated with Chryseobacterium indologenes infection in a patient with HIV infection and review of the literature by Vincenza Chiara Mazzola, Eleonora Bono, Luca Pipitò, Benedetta Romanin, Claudia Gioè, Antonio Anastasia, Sara Cannella, Roberta Virruso, Celestino Bonura, Antonio Cascio

“…Fluoroquinolones, trimethoprim-sulfamethoxazole, and cefiderocol may serve as effective treatment options, emphasizing the importance of susceptibility-guided management.…”
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Poor sleep quality remains a major challenge among tertiary education students in Ghana: A cross-sectional study in a Ghanaian University by David Larbi Simpong, Ansumana Bockarie, Akosua Bema Kumah, Alex Bismark Atta-Owusu, Mordecai Eshun, Bernice Akua Frimpong, Beatrice Bachella, George Nkrumah Osei

“…Despite the recognized importance of good sleep for students, there is a need for a deeper understanding of the sleep problems faced by university students to inform effective campus support services and interventions. …”
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Mobile health-based remote interaction management intervention for patients with low anterior resection syndrome: study protocol for a randomised controlled trial by Ting Wang, Peng Zhou, Min Fu, Shihui Yu, Shaohua Hu, Hongye He, Xueying Pang, Danqiao Yin, Degang Zhu

“…Introduction Low anterior resection syndrome (LARS) involves bowel dysfunction after sphincter-preserving surgery for rectal resection that significantly impacts patients’ quality of life (QoL). …”
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Lactylation-related gene signature accurately predicts prognosis and immunotherapy response in gastric cancer by Xuezeng Sun, Haifeng Dong, Rishun Su, Jingyao Chen, Wenchao Li, Songcheng Yin, Changhua Zhang

“…Utilizing both anti-lactylation and anti-PD-L1 may prove to be an effective approach for treating GC in clinical settings. …”
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Association of DNA damage response pathway genes with rheumatoid arthritis risks: a case-control study by Muhammad Zahid Hussain, Muhammad Haris Khan, Muhammad Shahbaz Haris, Rida Huzaira, Ammarah Munawar, Maria Fazal Ul Haq, Rabia Shafique, Ishrat Mahjabeen

“…RA has the symptoms of inflammation, joint dysfunction, and reduction in life expectancy. The main causes of RA are family history, immunogenicity, smoking, and genetic factors. …”
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Development of an electrocardiographic prediction model for outflow tract idiopathic premature ventricular contraction with decreased left ventricular ejection fraction by Pinliang Liao, Xiaolian Cai, Wen Zhang, Min Ou, Heling Ren, Maoqin Shu

“…Currently, there is a lack of predictive models to assess the risk of idiopathic PVCs associated with left ventricular dysfunction, leading to over or under treatment for IPVC. …”
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Invasive and Non-Invasive Neuromodulation for the Treatment of Substance Use Disorders: A Review of Reviews by Tyler S. Oesterle, Nicholas L. Bormann, Majd Al-Soleiti, Simon Kung, Balwinder Singh, Michele T. McGinnis, Sabrina Correa da Costa, Teresa Rummans, Mohit Chauhan, Juan M. Rojas Cabrera, Sara A. Vettleson-Trutza, Kristen M. Scheitler, Hojin Shin, Kendall H. Lee, Mark S. Gold

“…Conclusions: As novel and more effective therapies for the treatment of SUD are desperately needed, procedural interventional psychiatry holds promise. …”
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Metformin Induces Apoptosis and Ferroptosis of Ovarian Cancer Cells Under Energy Stress Conditions by Yulun Wu, Ziying Zhang, Minhui Ren, Yao Chen, Jingying Zhang, Jiarui Li, Feng Gao, Yongli Bao, Yanxin Huang, Xiaoguang Yang, Zhenbo Song

“…Therefore, it is crucial to find drugs that can effectively kill cancer cells in this energy stress setting. …”
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