Hand Flexibility Assessment System Based on Pneumatic Actuation and Sensing by XIA Yuanhao, GAO Ting, WANG Wanzhu, WANG Yalan, CHEN Shiqi, ZHANG Yue, CHEN Xinyuan

“…During multiple finger flexions by the user, an opposing effect is generated between the user and the system. …”
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Caregivers’ experiences of being asked about adverse childhood experiences and receiving support from an integrated health and social care hub: a qualitative study by Ashraful Kabir, Harriet Hiscock, Hueiming Liu, Lingling Chen, Rebecca Bosward, Natalie White, Sarah Loveday, Wilhelmina Ebbett

“…Using a semistructured interview guide, 29 in-depth interviews were conducted with caregivers of children who were experiencing a range of adversities, including maltreatment and household dysfunction, child neglect, parent mental illness, domestic violence, family conflict, community dysfunction, discrimination, poverty or financial hardship. …”
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Structural and functional changes of the heart in patients with coronary heart disease who have had coronavirus disease COVID-19 by S. M. Manuilov, N. S. Mykhailovska

“…The aim of the study: to investigate the effect of the previous COVID-19 coronavirus disease on the features of cardiac remodeling in patients with coronary heart disease (CHD). …”
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Black Rice Extract Reduces Body Weight, Waist Circumference, Body Mass Index and Lipopolysaccharide in Obese Subjects: A Preliminary Study by Armanto Makmun, Agussalim Bukhari, Nurpudji Astuti Taslim, Aminuddin Aminuddin, Ferry Sandra

“…In obesity, inflammation can be induced by leaky gut due to the intestinal tight junction barrier dysfunction. Zonula occludens-1 (ZO-1) plays a role in developing intestinal tight junction barrier dysfunction and gut microbiota imbalance, thus promote the translocation of bacterial endotoxin characterized by lipopolysaccharide (LPS) into circulation. …”
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Detecting subclinical cardiotoxicity during immune checkpoint inhibitor therapy: a combined GLS and ECG repolarization analysis by Dogac Oksen, Muhammed Heja Gecit, Sukru Arslan, Muzaffer Aslan, Yunus Emre Yavuz, Saban Secmeler, Veysel Oktay

“…GLS was negatively correlated with QT dispersion (r = -0.845, p < 0.05) and Tp-e intervals (r = -0.478, p = 0.052).ConclusionGLS and ECG repolarization parameters, particularly QT dispersion and Tp-e intervals, effectively detect subclinical myocardial dysfunction in patients with cancer undergoing ICI therapy. …”
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General physical impairments in migraine patients beyond cervical function by Roy La Touche, Teresa García-Pastor, Álvaro Reina-Varona, Alba Paris-Alemany, Mónica Grande-Alonso

“…Abstract Previous research has focused on the possibility of cervical dysfunction in migraine patients, similar to what is observed in patients with tension-type headaches. …”
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Covalent Grafting of Inorganic Selenium to the Water-Soluble and Nondigestive Chinese Yam Polysaccharides Causes Greater Protection of IEC-6 Cells with Acrylamide Injury by Zhen-Xing Wang, Li-Li Zhang, Xin-Huai Zhao

“…Both YPSe-I and YPSe-II could also manifest higher effectiveness than YP in maintaining cell barrier integrity against the acrylamide-induced barrier disruption. …”
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Does Long-Term Sport Practice Facilitate the Development of Idiopathic Bradycardia Requiring Early Pacemaker Implantation During the Course of Life? by Sergei Bondarev, Leonardo Brotto, Francesca Graziano, Alberto Cipriani, Domenico Corrado, Alessandro Zorzi

“…This may suggest a contributing role of cumulative sports activity volume in the development of idiopathic sinus/AV node dysfunction.…”
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Monosodium glutamate exacerbated the lipopolysaccharide-induced reproductive toxicity of male Wistar rats by Olalekan Bukunmi Ogunro, Folake Olubukola Asejeje, Zainab Olamide Hamzat

“…Abstract Background Monosodium glutamate (MSG) is a common food additive that has been linked to oxidative stress and reproductive dysfunction. Lipopolysaccharide (LPS), a bacterial endotoxin, is known to induce systemic inflammation, leading to oxidative damage and hormonal disruption. …”
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Neopterin mediates sleep deprivation-induced microglial activation resulting in neuronal damage by affecting YY1/HDAC1/TOP1/IL-6 signaling by Xuan Li, Ziyu Kong, Ke Cai, Fujian Qi, Sen Zhu

“…Hippocampus is an important region of the brain for learning, memory, and emotions. Dysfunction of hippocampus can lead to severe learning and memory disorder, significantly affecting quality of life. …”
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Uncovering the Efficacy and Mechanism of Zhenwu Decoction for Hypothyroidism Based on Non-Targeted Metabolomics by Wang Y, Li Y, Tang M, Zhang L, Zhu S

“…ZW corrected metabolic dysfunction through multi-target regulation.Conclusion: ZW exerts therapeutic effects by modulating glucose-6-phosphate, bile acids, and critical metabolic pathways, thereby advancing our understanding of hypothyroidism pathophysiology and underscoring its potential for clinical translation and therapeutic development.Keywords: hypothyroidism, Zhenwu decoction, metabolomics, traditional Chinese medicine, metabolic mechanism…”
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Prophylactic Treatment of Probiotic and Metformin Mitigates Ethanol-Induced Intestinal Barrier Injury: In Vitro, In Vivo, and In Silico Approaches by Farhin Patel, Kirti Parwani, Priyashi Rao, Dhara Patel, Rakesh Rawal, Palash Mandal

“…However, cotreatment with probiotic V and Met largely ameliorated the ethanol-induced mucosal barrier dysfunction, TJ disruption, and gut oxidative stress compared with ethanol-exposed monolayers and individual treatment of either agent. …”
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Efficacy of endoscopic ultrasound-guided biliary drainage of malignant biliary obstruction: a systematic review and meta-analysis of randomized controlled trials by Yousaf Zafar, Hafsa Azam, Muhammad Abdullah Bin Azhar, Fabeeha Shaheen, Syed Sarmad Javaid, Laila Manzoor, Muaaz Masood, Rajesh Krishnamoorthi

“…Conclusions EUS-BD outperformed ERCP-BD and PTBD in reducing stent dysfunction, postprocedural pancreatitis, and tumor ingrowth or overgrowth.…”
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HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…However, the adverse effects were almost completely eliminated by pharmacological blockade of the dynamin-related protein 1 (Drp1) inhibitor, Mdivi-1, which inhibits mitochondrial fission during cardiac I/R(P < 0.05). …”
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Neutrophil percentage-to-albumin ratio mediates the association between life’s crucial 9 with cardiorenal syndrome: a secondary data analysis from NHANES by Zhe Fang, Jiawen Zhao, Hongyang Gong

“…CRS refers to a syndrome in which dysfunction in either the heart or kidneys leads to acute or chronic dysfunction in the other organ. …”
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Specifics of epilepsy treatment during the first year of life in preterm infants and extremely preterm neonates by I. V. Makedonska

“…Bronchopulmonary dysplasia, liver and gastrointestinal tract dysfunction evolving can prevent not only the implementation of the anticonvulsant therapy, but also the increase of the AEP dose to the medium therapy level. …”
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The Impact of Acquired Hypothyroidism on the Growth and Metabolic Profiles of Pediatric Patients: A Retrospective Monocentric Study by Elena Malavolta, Ignazio Cammisa, Giulia Rotunno, Lucia Celeste Pane, Federica Arzilli, Giorgio Sodero, Donato Rigante, Clelia Cipolla

“…<b><i>Background</i>:</b> Hypothyroidism is the most common thyroid dysfunction in childhood, resulting from the decreased biological activity of thyroid hormones in tissues. …”
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Exon-variant interplay and multi-modal evidence identify endocrine dysregulation in severe psychiatric disorders impacting excitatory neurons by Karolina Worf, Natalie Matosin, Nathalie Gerstner, Anna S. Fröhlich, Anna C. Koller, Franziska Degenhardt, Holger Thiele, Marcella Rietschel, Madhara Udawela, Elizabeth Scarr, Brian Dean, Fabian J. Theis, Nikola S. Mueller, Janine Knauer-Arloth

“…Both common and rare genetic variants contribute to neural dysfunction, impacting cognition and behavior. This study investigates the molecular effects of genetic variants on human cortical single-cell types using a single-exon analysis approach. …”
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Hand Flexibility Assessment System Study Based on Pneumatic Actuation and Sensing by XIA Yuanhao, GAO Ting, WANG Wanzhu, WANG Yalan, CHEN Shiqi, ZHANG Yue, CHEN Xinyuan

“…During multiple finger flexions by the user, an opposing effect is generated between the user and the system. …”
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Unveiling the dual threat: combined elevated triglyceride-glucose index and intracranial arterial stenosis burden for enhanced stroke risk stratification by Baoyi Liao, Baoyi Liao, Guilin Meng, Guilin Meng, Xueyuan Liu, Xueyuan Liu

“…Mechanistic pathways were delineated through causal mediation analysis employing Quasi-Bayesian approximation (100 Monte Carlo simulations) to quantify mediating effects between metabolic dysfunction and cerebrovascular outcomes.ConclusionThe synergistic combination of elevated TyG index and ICAS burden demonstrated superior prognostic value for 3-month stroke recurrence risk compared to either parameter independently, suggesting that concurrent assessment of insulin resistance (via TyG index) and vascular imaging biomarkers (via ICAS burden) may refine early risk stratification. …”
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