Single-cell mitochondrial morphomics reveals cellular heterogeneity and predicts complex I, III, and ATP synthase Inhibition responses by Ratneswary Sutharsan, Maddi Biaut Hontaas, Yan Li, Hao Xiong, Hartwig Preckel, Carolyn M. Sue, Gautam Wali

“…In contrast, oligomycin which affects ATP synthesis by directly inhibiting ATP synthase showed relatively less severe alterations in neurite-related mitochondrial features, highlighting a distinct effect of the mode of action between inhibitors. By incorporating the most affected cells into machine learning models, we significantly improved the prediction accuracy of mitochondrial dysfunction outcomes − 81.97% for antimycin, 75.12% for rotenone, and 94.42% for oligomycin. …”
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Ginkgo biloba extract alleviates oxygen and glucose deprivation/reperfusion injury in cardiac microvascular endothelial cells by regulating NF-κB and CHOP signaling pathways throug... by Mukaddas ABDURAHMAN, Zhenyang GUO, Junbo GE, Hua LI

“…On the contrary, when SIRT6 was knocked down, the protective effects were significantly reduced. ConclusionsGBE improves endothelial cell dysfunction, endoplasmic reticulum stress, and endothelial cell apoptosis caused by OGD/R injury by promoting the expression of SIRT6 protein, thus regulating the NF-κB inflammatory pathway and CHOP signaling pathway.…”
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Statin Monotherapy Not Inferior to Aspirin or Combined Aspirin and Statins Reducing the Incidences of Cirrhosis, HCC, and Mortality in MAFLD/MASH Patients: A Population Cohort Stud... by Lee CH, Huang YH, Hsu TJ, Yen TH, Hsieh SY

“…We aimed to clarify whether combined aspirin and statins exert a synergistic effect on prevention of cirrhosis and HCC in patients with MAFLD/MASH.Patients and Methods: Patients and their clinical data were collected from the National Health Insurance Research Database (NHIRD), encompassing about 20 million population. …”
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Evaluation of Chlorogenic Acid in Parkinson’s Disease Model: An In-vitro Study in 6-OHDA Induced SH-SY5Y Cell Line by Sunprakathi Alwarsamy Perumalsamy, Kranthi Karunai Kadal, Gowri Viswanathan, Kavitha Ramasamy

“…Conclusion: The findings provide evidence that CGA may exert an anti-PD effect through its action on mitochondrial dysfunction and the release of pro-apoptotic factors. …”
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The Use of Autologous Omentum Transposition as a Therapeutic Intervention to Reduce the Complication of Ischemia/Reperfusion Injuries in a Rat Model by Amirreza Shamshirgaran, Abdolreza Mohammadi, Parisa Zahmatkesh, Gholamreza Mesbah, Fateme Guitynavard, Zahra Saffarian, Alireza Khajavi, Leonardo Oliveira Reis, Seyed Mohammad Kazem Aghamir

“…Background: Ischemia/reperfusion injury (IRI) causes cellular dysfunction and death in organs like the kidney, heart, and brain. …”
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POSTRADIAL SIALOZOADENITIS IN PATIENTS WITH PAPILLARY CARCINOMA OF THE THYROID GLAND by V. A. Kovalenko, A. V. Kopchak, A. E. Kovalenko

“…The authors present the results of investigation of 42 patients with salivary gland dysfunction after radioactive iodine-131 ablation therapy concerning papillary thyroid carcinoma. …”
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Alternative therapy interaction with warfarin: what doctors should know by T. B. Kozlova, T. V. Taratuta, M. B. Aksenova, T. V. Khlevchuk

“…This paper reviews the main mechanisms of warfarin interactions with other agents, which underlie adverse effect development: platelet dysfunction, gastro-intestinal effects, suppressed intestinal synthesis of vitamin K, disturbed warfarin metabolism, or disrupted vitamin K cycle. …”
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PERIODONTAL DISEASES AND SYSTEMIC VASCULITIS: A VIEW THROUGH THE PRISM OF INTERDISCIPLINARY STUDIES by T. V. Beketova, E. I. Selifanova

“…The paper also discusses the prospect of interdisciplinary studies focused on the examination of the biological effects of PDs in SV and other rheumatic diseases.…”
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Research progress in neuromodulation in treatment of traumatic spinal cord injury by HUANG Mudan, RONG Limin

“…The residual neurological dysfunction after traumatic spinal cord injury seriously affects the life status and quality of life of patients. …”
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THE ROLE OF ENTEROSORBENTS IN TREATMENT OF ENDOGENOUS INTOXICATION SYNDROME by N. I. Ursova

“…The critical point of endogenous intoxication pathogenesis is dysfunction of microbiocenosis and intestinal barrier. …”
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The Negative Impact of Sildenafil on Behavior and Psychology by Prashant Mahajan, Somoshri Banerji, Rudrika Bodh

“…Sildenafil citrate, widely recognized under the brand name Viagra, has been a game changer in the management of erectile dysfunction (ED). While its therapeutic benefits in treating ED are well-established, its recreational use has led to significant psychological, behavioral, and social concerns. …”
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Research advances of protein N-glycosylation’s biological functions and analytical methods and its role in kidney disease by 任伟夫, 边琪

“…As one of the most important post-translational modifications, glycosylation plays a significant role in the functions of proteins.N-glycosylation exerts critical effects in different biological processes among various forms of glycosylation, whereas aberrant glycosylation leads to multiple organ system dysfunction, such as congenital disorders of glycosylation or immune disease.Advanced mass spectrometry has been widely applied for uncovering the role of N-glycosylation in clinical practices and scientific researches.This reviews summarized synthetic processes, biological roles and mass-spectrometry-based analytical methods of N-glycosylation and focused upon the latest findings of N-glycosylation in renal physiology and nephropathy.…”
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Diagnosis and Management of Heatstroke by I Gede Yasa Asmara

“…The pathophysiology of heatstroke involves a combination of direct heat effects on the host, the systemic inflammatory and coagulopathic response. …”
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Neuroprotection neurotrophic cerebroprotector Сerebroсurin in terms of modeling acute stroke by S. A. Morguntsova

“…Results of the study revealed the advantage of intrathecal route of administration before the intraperitoneal. The effect is manifested in increased survival of animals, decrease the manifestations of mitochondrial dysfunction, oxidative stress inhibition, activation of the antioxidant system in rat brain. …”
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Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection by Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen

“…Elevated plasma calpain activity is strongly associated with an increased risk of TAD and organ dysfunction. Both endogenous and exogenous calpain inhibitors effectively prevent TAD onset and progression in murine models induced by β‐aminopropionitrile (BAPN). …”
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Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2/mPGES-1/PGE2 Cascade by Haiping Wang, Zhanjun Jia, Jing Sun, Liang Xu, Bing Zhao, Kezhou Yu, Meng Yang, Tianxin Yang, Rong Wang

“…The current study aimed to evaluate the protective effects of OA-NO2 against cisplatin-induced kidney injury in mice. …”
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Increased Visual Response Delay Impact on Sensorimotor Control in Persons With Multiple Sclerosis by Julie C. Wagner, Frankie M. Ingram, Vincenzo Daniele Boccia, Matilde Inglese, Maura Casadio, Camilla Pierella, Andrea Canessa, Robert A. Scheidt, Scott A. Beardsley

“…Multiple Sclerosis negatively affects hand function in 60% of cases. Upper extremity dysfunction in persons with Multiple Sclerosis (PwMS) has previously been linked to slower, more variable movement, increased visual response delays (Tv), and neuroimaging evidence of altered brain activity; yet no one knows how these aspects relate to each other. …”
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Lysosphingolipids in ceramide-deficient skin lipid models by Georgios Paraskevopoulos, Lukáš Opálka, Andrej Kováčik, Anna Paraskevopoulou, Eleni Panoutsopoulou, Irene Sagrafena, Petra Pullmannová, Robert Čáp, Kateřina Vávrová

“…Conversely, these molecules partially mitigated the negative effects of ceramide deficiency, particularly with 5%–10% SPC, which reduced permeability even compared to control with “healthy” lipid composition. …”
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Interplay of hypoxia, immune dysregulation, and metabolic stress in pathophysiology of type 1 diabetes by Rahul Mittal, Rahul Mittal, Joana R. N. Lemos, Joana R. N. Lemos, Prem Chapagain, Prem Chapagain, Khemraj Hirani, Khemraj Hirani

“…Hypoxia in the pancreatic islets arises from inflammation, vascular dysfunction, hyperglycemia, and immune cell infiltration, creating a microenvironment that exacerbates β-cell dysfunction and amplifies autoimmune responses. …”
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High-risk alcohol consumption is associated with mitochondrial damage-associated molecular patterns in people living with HIV by Shannon R. Gilstrap, Micheal D. Ho, Joanna M. Hobson, Dyan M. White-Gilliam, Khalid Freij, Michael A. Owens, Shameka L. Cody, S. Justin Thomas, Robert E. Sorge, Burel R. Goodin

“…These results suggest that the effects of alcohol consumption on mitochondrial damage and dysfunction may be exacerbated by HIV infection. …”
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