CLINICAL APPROACHES TO INTERPRETATION OF CLINICAL TRAILS RESULTS ON BETA-BLOCKERS FOR THE TREATMENT OF PATIENTS WITH CHRONIC HEART FAILURE by S. R. Giljarevskiy, I. M. Kuzmina

“…Data about bisoprolol usage for prevention of sudden death in patients with left ventricle systolic dysfunction is also presented.…”
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Altered liver sinusoidal endothelial cells in MASLD and their evolution following lanifibranor treatment by Pierre-Emmanuel Rautou, Shivani Chotkoe, Louise Biquard, Guillaume Wettstein, Denise van der Graaff, Yao Liu, Joris De Man, Christophe Casteleyn, Sofie Thys, Winnok H. De Vos, Pierre Bedossa, Michael P. Cooreman, Martine Baudin, Jean-Louis Abitbol, Philippe Huot-Marchand, Lucile Dzen, Miguel Albuquerque, Pierre Broqua, Jean-Louis Junien, Luisa Vonghia, Manal F. Abdelmalek, Wilhelmus J. Kwanten, Valérie Paradis, Sven M. Francque

“…Background & Aims: Data on changes in liver sinusoidal endothelial cells (LSECs) in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and their response to treatment are limited. …”
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Space exploration and risk of Parkinson’s disease: a perspective review by Nilufar Ali, Afshin Beheshti, Greg Hampikian

“…Abstract Systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors Parkinson’s disease (PD). …”
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Sleep Deficiency and Deprivation Leading to Cardiovascular Disease by Michelle Kohansieh, Amgad N. Makaryus

“…Not only does sleep deficiency lead to neurological and psychological disorders, but also the literature has explored the adverse effects of sleep deficiency on the cardiovascular system. …”
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Noninvasive pulsed radiofrequency for trigeminal neuralgia: Off the beaten path – Case series by Sukanya Mitra, Prateek Upadhyay, Jasveer Singh, Prashant Ahlawat

“…Trigeminal neuralgia (TN) is a debilitating condition characterized by excruciating facial pain resulting from dysfunction in the trigeminal nerve. Treatment options are limited. …”
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Research progress on the application of antiplatelet drugs in arteriovenous fistula for hemodialysis by Ma Shi-jie, Deng Fei

“…However， arteriovenous fistula often leads to access dysfunction due to thrombosis. Antiplatelet drugs， due to their positive effect on inhibiting thrombosis， are considered as potential therapeutics to prevent arteriovenous fistula thrombosis. …”
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Cytomegalovirus Worsens Necrotizing Enterocolitis Severity in Mice via Increased Toll-Like Receptor 4 SignalingSummary by Daniel Scheese, Peng Lu, Hannah Moore, Koichi Tsuboi, Cody Tragesser, Johannes Duess, Zachariah Raouf, Maame F. Sampah, Daphne Klerk, Mahmoud El Baassiri, Hee-seong Jang, Sierra Williams-McLeod, Asuka Ishiyama, Steve N. Steinway, Sanxia Wang, Menghan Wang, Thomas Prindle, Jr., William B. Fulton, Chhinder P. Sodhi, David J. Hackam

“…Mechanistically, CMV infection triggered proinflammatory pathways, disrupted cellular metabolism, and upregulated Tlr4 expression, leading to mitochondrial dysfunction and nuclear factor-kB translocation. These effects were notably absent in Tlr4-deficient mice. 5'-N-ethylcarboxamido adenosine treatment reversed CMV-induced NEC severity by reducing mitochondrial dysfunction and TLR4-driven nuclear factor-kB activation. …”
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FL3 mitigates cardiac ischemia-reperfusion injury by promoting mitochondrial fusion to restore calcium homeostasis by Zikan Zhong, Yutong Hou, Changzuan Zhou, Jiahui Wang, Longzhe Gao, Xiaoyu Wu, Genqing Zhou, Shaowen Liu, Yingjie Xu, Wen Yang

“…The results demonstrated that FL3 effectively reduced myocardial apoptosis, infarct size, and cardiac dysfunction caused by IR injury. …”
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New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer’s disease by Aneta Houfková, Monika Schmidt, Ondřej Benek, Ivo Fabrik, Rudolf Andrýs, Lucie Zemanová, Ondřej Soukup, Kamil Musílek

“…Results The overexpression of HSD10 or APPSwe/Ind led to mitochondrial dysfunction and reduced viability, particularly under glucose-deprived conditions. …”
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Jiaotai pill and its main component enhance islet hormone secretion in type 2 diabetic rats by activating the THP1/TGase2/SERT/5-HT1FRpathway by Hongcui Han, Xiaobin Huang, Yanyi Li, Peng Wang, Qing Miao, Yujie Zhang

“…Objective: To investigate the relationship between Jiaotai pill (JTP), its main component berberine (BBR), and the serotonin (5-HT) system in regulating islet hormone secretion and alleviating pancreatic β-cell dysfunction during type 2 diabetes mellitus (T2DM) progression. …”
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«MEMORIES OF FUTURE»: CHANGE IN VERAPAMIL SIGNIFICANCE IN THE TREATMENT OF PATIENTS WITH ISCHEMIC HEART DISEASE AND ARTERIAL HYPERTENSION by S. R. Gilyarevskiy

“…Verapamil therapy in patients with HT and IHD without heart failure/systolic dysfunction and/or recent myocardial infarction may have advantages due to achievement of the sufficient antiischemic effect with less HR reduction.…”
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Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy by Zhian Chen, Yutong Wang, Zhenhao Li, Meijuan Chen, Yingshi Li, Chuyue Lu, Zhenyu Lin, Hua Zheng, Lujia Chen, Qianbing Zhang

“…Lysosomes is emerging as a promising therapeutic target for improving immunotherapy, which dysfunction would trigger lysosomal membrane permeabilization increase and subsequent leakage of reduced iron, which contributed to ferroptosis through cell-intrinsic Fenton chemistry. …”
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Irisin attenuates cardiac injury and improves prognosis in rats with hemorrhagic shock by maintaining mitochondrial homeostasis via the AMPK/Drp1 pathway by Zheng Zhang, Zheng Zhang, Zheng Zhang, Yufang Zhang, Yufang Zhang, Xiaofang Zou, Jiake Li, Yunfei Chi, Hailiang Bai, Bin Wei, Huiting Yun, Huiting Yun, Quanxi Zhang, Quanxi Zhang, Weihua Cao, Haiyan Liu, Hongjie Duan

“…Mitochondrial dysfunction is central to the pathogenesis of cardiac dysfunction in HS. …”
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Development of a Water-Soluble Nanomicellar Formulation Loaded with Trans-Resveratrol Using Polyethylene Glycol Monostearate for the Treatment of Intracerebral Hemorrhage by Kengo Banshoya, Aoi Machida, Saki Kawamura, Tetsuhiro Yamada, Riko Okada, Yui Kawamoto, Hikaru Kimura, Sachi Shibata, Yuhzo Hieda, Yoshiharu Kaneo, Tetsuro Tanaka, Masatoshi Ohnishi

“…<b>Background/Objectives:</b> Trans-resveratrol (Res) has been reported to possess many biological activities, including neuroprotective effects, owing to its anti-inflammatory and antioxidant properties. …”
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VigorBaby dietary supplement administration to mice during pregnancy and lactation alleviated ovarian disorders induced by Zearalenone in offsprings by Xuan Liu, Wen-Meng Bian, Yan-Qin Feng, Jia-Tian Tang, Ning Zuo, Jun-Jie Wang, Massimo De Felici, Xin Wang, Wei Shen

“…The current study demonstrated that ZEN exposure increased reactive oxygen species (ROS), DNA damage, and mitochondrial dysfunction in the ovaries of neonatal offspring, leading to primordial follicle (PF) impairment. …”
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DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids by Gen Yamamoto, Raquel Carvalho-Gontijo Weber, Wonseok Lee, Vivian Zhang, Haeum Jang, Sadatsugu Sakane, Xiao Liu, Hyun Young Kim, David A. Brenner, Na Li, Tatiana Kisseleva

“…Background &amp; Aims: Metabolic dysfunction and alcohol-associated liver disease (MetALD) results in the development of liver steatosis, inflammation, fibrosis, and hepatocellular carcinoma (HCC). …”
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Protective role of 3-oxypyridine derivatives in rats’ steroid-induced osteoporosis associated with reduced oxidative stress and recovery of nitric oxide formation by A. P. Danilenko, K. S. Trunov, M. V. Pokrovsky, L. M. Danilenko, M. V. Korokin, O. S. Gudyrev, A. A. Khentov, N. P. Masalytina, I. A. Tatarenkova, A. V. Cherednichenko, E. V. Boeva, I. S. Koklin, E. I. Taran

“…The study results showed that composition No. 1 (50 mg/kg) has an osteoprotective activity, effectively prevents a decrease in the level of the regional bone tissue microcirculation and in the development of an endothelial dysfunction. …”
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The platelet to high-density lipoprotein cholesterol ratio is associated with thyroid hormone abnormalities based on NHANES 2007 to 2012 data by Wu Li, Peng Wu

“…Weighted multiple linear and logistic regression models were used to assess the relationship between PHR and thyroid hormone levels, as well as the prevalence of thyroid dysfunction. Subgroup analyses, smoothing curve fitting, and threshold effect analyses were also conducted to further explore potential associations. …”
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Insulin Resistance, Adiponectin, and Dyslipidemia as Key Determinants of Metabolic and Reproductive Dysregulation in Polycystic Ovary Syndrome by Krarr Haider Haddawi, Bushra Raouf Yaseen, Redha Dawud Abd Alredha, Kareem Obayes Handool

“…Logistic regression indicated that HOMA-IR was the most significant predictor of PCOS (OR=28, 95% CI 4.86–161.44, p=0.0002), whereas higher adiponectin levels offered significant protective effects (OR=0.54, 95% CI 0.36–0.82, p=0.0039). CONCLUSION: Insulin resistance, dyslipidemia, and low adiponectin levels are strongly associated with PCOS and metabolic dysfunction in Iraqi women. …”
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Genetic landscape of hypertrophic cardiomyopathy in Hong Kong Chinese population by Derek P. H. Lee, Derek P. H. Lee, Ye Cao, Lilei Zhang

“…Patients with P/LP variants were associated with an increased risk of developing left ventricular dysfunction. Future studies on the potential founder effects of these recurrent variants, cumulative effects of multiple variants, and longitudinal follow up of HCM patients would be useful.…”
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