Ptprd deficiency promotes tau hyperphosphorylation and impairs cognitive function in aged mice by Analía Foncea, Nayhara Franchini, Isidora Tobar, Sebastián Thienel, Ignacio N. Retamal, Gonzalo I. Cancino, Francisca Cornejo

“…Indeed, hyperphosphorylation of tau closely contributes to neuronal dysfunction leading to neurodegenerative diseases, including tauopathies, which are characterized by excessive and aberrant tau phosphorylation and cognitive decline. …”
Get full text

Current View on the Use of Extracorporeal Detoxification Methods for the Treatment of Rhabdomyolysis (Review) by S. V. Masolitin, D. N. Protsenko, I. N. Tyurin, O. A. Mamontova, M. A. Magomedov

“…The solution to this issue can potentially help to better correct the electrolyte disturbances and could protect against organ dysfunction, which would improve the outcome in patients with rhabdomyolysis.…”
Get full text

Neural stem cells traffic functional mitochondria via extracellular vesicles. by Luca Peruzzotti-Jametti, Joshua D Bernstock, Cory M Willis, Giulia Manferrari, Rebecca Rogall, Erika Fernandez-Vizarra, James C Williamson, Alice Braga, Aletta van den Bosch, Tommaso Leonardi, Grzegorz Krzak, Ágnes Kittel, Cristiane Benincá, Nunzio Vicario, Sisareuth Tan, Carlos Bastos, Iacopo Bicci, Nunzio Iraci, Jayden A Smith, Ben Peacock, Karin H Muller, Paul J Lehner, Edit Iren Buzas, Nuno Faria, Massimo Zeviani, Christian Frezza, Alain Brisson, Nicholas J Matheson, Carlo Viscomi, Stefano Pluchino

“…However, the function and the contribution of these cargoes to the broad therapeutic effects of NSCs are yet to be fully understood. Mitochondrial dysfunction is an established feature of several inflammatory and degenerative CNS disorders, most of which are potentially treatable with exogenous stem cell therapeutics. …”
Get full text

Clinical, pathogenetic and prognostic value of diabetic retinopathy’s progression after phacoemulsification in patients with the essential hypertension by N. S. Khodjaev, V. V. Chernikh, K. E. Kuntysheva

“…The changes in the balance of the evaluated parameters inpatients, receiving other medicines, were characterized with the increase of proangiogenic and endothelial dysfunction. It was a predictor of vascular changes. …”
Get full text

Respiratory Biomechanics, Intrapulmonary Water, and Pulmonary Oxygenizing Function During Uncomplicated Operations under Extracorporeal Circulation by I. A. Kozlov, A. A. Romanov

“…At the end of surgery, pulmonary oxygenizing dysfunction (POD) was detected in 5 (17.2%) patients with increased BMI. …”
Get full text

The body weight-walking distance product as a superior parameter in determining the VO2 on-kinetics in coronary artery disease by I.S. Rocco, W.J. Gomes, M. Viceconte, B.C. Matos-Garcia, F.S. Menezes-Rodrigues, F.S. Tallo, R.M. Arida, N.A. Hossne Junior, R. Arena, S. Guizilini

“…The D·W demonstrated potential to be better than the distance walked in determining VO2 on-kinetics in participants with CAD with and without left ventricular dysfunction.…”
Get full text

The Role of Neurotrophic Modulation in COPD and Its Influence on Airway Pathophysiology: A Systematic Review and Meta-Analysis by Zeeshan Hussain, Mona Rani, Soobia Pathan, Seemi Tanvir, Madeeha Minhas, Saif Ur Rahman, Muhammad Arsalan Shah

“…Results: Of 10 studies included, mixed findings were seen: some reported a rise in NGF and BDNF levels linked to airway inflammation and remodeling, while some found decreased neurotrophin associated with skeletal muscle dysfunction. A pooled effect size of 0.711 [0.553, 0.869] was observed for neurotropic procurement, -0.32 [-0.58, -0.05] for airway remodeling, and 4.26 [2.21, 6.31] for airway inflammation. …”
Get full text

Angiogenesis in Atrial Fibrillation: A Literature Review by Jie Lin, Haihuan Lin, Zhijun Xu, Zhihui Yang, Chenglv Hong, Ying Wang, Haocheng Lu

“…This review synthesizes evidence highlighting angiogenesis’s dual role in AF pathogenesis: while excessive or dysregulated angiogenesis promotes atrial remodeling through fibrosis, and electrical dysfunction via VEGF, ANGPT, and FGF signaling pathways, compensatory angiogenesis exerts protective effects by improving tissue perfusion to alleviate ischemia and inflammation. …”
Get full text

Mesenchymal stem cells protect the integrity of the alveolar epithelial barrier through extracellular vesicles by inhibiting MAPK-mediated necroptosis by Tao Ruan, Jiaming Han, Chengxu Xue, Fengyuan Wang, Juntang Lin

“…JNK inhibition SP600125, and ERK inhibition U0126 or inhibition of necroptosis with Nec-1 or GSK872 diminished the beneficial anti-epithelial barrier dysfunction effects of MenSCs or MenSC-EVs. Conclusions Our results suggest that human menstrual blood-derived endometrial stem cells mitigate lung injury and improve alveolar barrier properties by inhibiting MAPK-mediated necroptosis through extracellular vesicles, supporting the application of MenSCs or MenSC-derived extracellular vesicles to treat ALI or ARDS.…”
Get full text

Intestinal Microbial-tissue Complex and Chronic Heart Failure (part 1): Pathogenesis by A. A. Vlasov, S. P. Salikova, N. V. Golovkin, V. B. Grinevich

“…It's also shown that the direct cardiotoxic effect of microbial molecules (lipopolysaccharides, peptidoglycans, trimethylamine-N-oxide, etc.), which interact with the receptors of cardiomyocytes and microenvironment cells, can cause the development of myocardial remodeling and its dysfunction. …”
Get full text

Risk factors for postoperative delirium in orthopedic surgery patients: a systematic review and meta-analysis by Yanan Niu, Qiang Wang, Jin Lu, Piao He, Hai-Tao Guo

“…Study quality was assessed using the Newcastle-Ottawa Scale (NOS), and meta-analyses were performed using random-effects models to calculate pooled risk ratios (RR) and weighted mean differences (WMD) with 95% confidence intervals (CI).Results A total of 19 studies involving 4,410 patients were included. …”
Get full text

Establishment of rat model for aspiration pneumonia and potential mechanisms by Hanbing Hu, Junfeng Chen, Yiru Shao, Yuedong Tang, Yu Dun, Obulkasim Memet, Xuanrong Bao, Jie Shen

“…Concentration‐dependent effects of HCl and LPS on lung damage were identified, alongside cytokine elevation and microvascular dysfunction. …”
Get full text

Metabolome disruption of pregnant rats and their offspring resulting from repeated exposure to a pesticide mixture representative of environmental contamination in Brittany. by Nathalie Bonvallot, Cécile Canlet, Florence Blas-Y-Estrada, Roselyne Gautier, Marie Tremblay-Franco, Sylvie Chevolleau, Sylvaine Cordier, Jean-Pierre Cravedi

“…These observations may reflect liver dysfunction with increased relative liver weight and total lipid content. …”
Get full text

Roles of ACSL4/GPX4 and FSP1 in oxalate-induced acute kidney injury by Keng Ye, Ruilong Lan, Zhimin Chen, Kunmei Lai, Yankun Song, Guoping Li, Huabin Ma, Hong Chen, Yanfang Xu

“…Conversely, Fsp1 knockout in MTECs had the opposite effects. In addition, as expected, overexpression of the ferroptosis inhibitors GPX4 or FSP1 in MTECs significantly reduced CaOX-induced lipid peroxidation and cell ferroptosis. …”
Get full text

Ectasia da artéria basilar e acidente vascular cerebral: aspectos clínicos de 21 casos Basilar ectasia and stroke: clinical aspects of 21 cases by Roberto de Magalhães Carneiro de Oliveira, José Osmar Cardeal, José Geraldo de Camargo Lima

“…Main symptoms were hemiparesia, cranial nerves dysfunction, and cerebellar ataxia. Cerebral infarcts associated with EB were due to different mechanisms: arterial thrombosis, artery-to-artery embolism, mass effect with angulation and obstruction of the vertebral and basilar branches.…”
Get full text

Association of maternal thyroid function and gestational diabetes with pregnancy outcomes: a retrospective cohort study by Chang Zou, Qinxin Shen, Yuanyuan Yang, Yini Liao, Qiaoling Du

“…BackgroundGestational diabetes mellitus (GDM) and thyroid dysfunction share demographic overlap in at-risk populations, both exerting adverse effects on pregnancy. …”
Get full text

Features of anorectal function after radiation therapy in patients with rectal cancer by O. I. Kit, O. G. Bondarenko, Yu. A. Gevorkyan, N. V. Soldatkina, M. A. Gusareva, N. G. Kosheleva, A. A. Solntseva, D. S. Petrov, D. A. Savchenko

“…The severity of anorectal dysfunction was assessed using the Wexner anal incontinence scale.Results. …”
Get full text

Arterial blood pressure in schoolchildren, who were born after caesarian section by S. V. Popov, T. Yu. Loboda, O. I. Smiyan, E. K. Redko, I. E. Zaitsev

“…They were hospitalized in the pediatric department with a diagnosis of vegetative dysfunction and with complaints of periodic increase in blood pressure. …”
Get full text

Premorbid factors of early post-stroke cognitive impairment by A. А. Grishina, A. M. Tynterova, Y. E. Skalin

“…The aim of this study is to identify and substantiate early cognitive dysfunction in patients with brain damage in the acute period of ischemic stroke.Materials and research methods. …”
Get full text

Gut Microbiota and Vascular Diseases: An Update by Jiaqi Wu, Yuxuan Li, Peipei Yang, Jiantao Fu, Yidong Wang

“…In past decades, the gut microbiota has been found to be an indispensable population exerting effects on hosts under physiological and pathological conditions. …”
Get full text