Diabetic neuropathy: cutting-edge research and future directions by Yang Yang, Bing Zhao, Yuanzhe Wang, Hongli Lan, Xinyu Liu, Yue Hu, Peng Cao

“…The pathogenesis of DN is multifaceted, involving hyperglycemia, dyslipidemia, oxidative stress, mitochondrial dysfunction, and inflammation, which collectively damage peripheral nerves. …”
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Case report: Long-term efficacy and safety of semaglutide in the treatment of syndromic obesity in Prader Willi syndrome - case series and literature review by Andrijana Koceva, Andrijana Koceva, Katarina Mlekuš Kozamernik, Katarina Mlekuš Kozamernik, Andrej Janež, Andrej Janež, Rok Herman, Rok Herman, Simona Ferjan, Simona Ferjan, Mojca Jensterle, Mojca Jensterle

“…Obesity development in PWS is driven by dysfunction in neural pathways involved in satiety and reward, dysregulation in hormones regulating satiety and food intake, altered body composition and reduced energy expenditure, as well as the presence of various hormone deficiencies. …”
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Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopat... by Kalpita Banerjee, Soumyabrata Munshi, Oishimaya Sen, Vishmadeb Pramanik, Tapasi Roy Mukherjee, Sasanka Chakrabarti

“…Background. The cytotoxic effects of dopamine (DA) on several catecholaminergic cell lines involve DA oxidation products like reactive oxygen species (ROS) and toxic quinones and have implications in the pathogenesis of sporadic Parkinson's disease (PD). …”
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Case Report: Surgical resection of giant ventricular fibroma in an infant utilizing 3D imaging guidance by Jin Lu, Jin Lu, Yu Chen, Yu Chen, Xingchen Lian, Peipei Chang, Ping Wen, Na Zou, Lin Ma, Yuhang Liu

“…This case highlights the significance of timely surgical intervention, combined with 3D imaging to develop a meticulous surgical plan and early use of ECMO to maintain cardiac function in patients with postoperative cardiac dysfunction. This can help to ensure the safety and effectiveness of giant cardiac fibromas resection in infants and young children.…”
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From hospital discharge to long-term care: Unmet rehabilitation needs in cauda equina syndrome patients from a national UK cohort by Holly Roy, Krithika Anil, Jack Read, Marcus J. Drake, Ingrid Hoeritzauer, Julie Woodfield

“…Objectives: Although long term disability may be a consequence of cauda equina syndrome (CES), the evidence base for the effect of rehabilitation or different rehabilitation strategies is lacking. …”
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Biochanin A and its possible involvement in Parkinson’s disease management by Amninder Kaur, Simran Kaur, Amir Mushtaq, Diksha Dalal, Shubham Kumar, Anish Singh

“…To investigate its safety, bioavailability, and effectiveness in people, more translational and clinical research is necessary. …”
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Targeting PFKFB3 to restore glucose metabolism in acute pancreatitis via nanovesicle delivery by Hai Jiang, Zhipeng Xu, Qi Song, Junjie Tao, Jia Liu, Qiang Wang, Huaisheng Zhang, Heng Zhu, Qiliang Li, Lei Li

“…The therapeutic effects of PFKFB3 inhibition via nanovesicle-based delivery were evaluated using both in vivo and in vitro AP models. …”
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Impact of smoking and physical activity on cardiovascular outcomes in type 2 diabetes across steatotic liver disease categories by So Hyun Cho, Gyuri Kim, Kyu-na Lee, Rosa Oh, Ji Yoon Kim, Myunghwa Jang, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim

“…Abstract This study investigated the effect of smoking and regular physical activity (PA) on the composite risk of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM) across different steatotic liver disease (SLD) categories. …”
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Synergistic Autophagy-Related Mechanisms of Protection Against Brain Aging and AD: Cellular Pathways and Therapeutic Strategies by Bogdan Cordos, Amelia Tero-Vescan, Ian N. Hampson, Anthony W. Oliver, Mark Slevin

“…Patient stratification based on the biomarkers of autophagy impairment, inflammation, and metabolic dysfunction could optimize therapeutic responses. While this strategy shows strong preclinical promise, careful attention to timing, dosing, and cell-specific responses is crucial to maximize benefits and avoid adverse effects. …”
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Sternotomy or thoracotomy for neonatal repair of coarctation of the aorta with aortic arch hypoplasiaCentral MessagePerspective by Peter Chiu, MD, MS, Addison Gearhart, MD, Ajami Gikandi, BA, Supreet Marathe, MD, Margaret Holland, PA-C, Shinichi Goto, MD, Sunil J. Ghelani, MD, Aditya K. Kaza, MD

“…The objective of this study was to evaluate the comparative effectiveness of the 2 approaches in patients with arch hypoplasia. …”
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The Impact of BK Virus and Cytomegalovirus Infections on Graft in Renal Transplant Patients: Experience of a Tertiary Hospital in Turkey by Şükran KÖSE, Sabri ATALAY, Yıldız ULU, Ufuk SÖNMEZ, Süheyla SERİN SENGER

“…In this retrospective study, we investigated the frequency of BKV and CMV infections and their effects on graft. Materials and Methods: The data of 118 renal transplant recipients who were transplanted and followed-up between January 2010 and January 2011 were reviewed. …”
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SIRT1/PGC-1α-mediated mitophagy participates the improvement roles of BMAL1 in podocytes injury in diabetic nephropathy: evidences from in vitro experiments by Yanxia Rui, Yinfeng Guo, Linying He, Min-er Wang, Henglan Wu

“…Abstract Background Dysfunction in podocyte mitophagy has been identified as a contributing factor to the onset and progression of diabetic nephropathy (DN), and BMAL1 plays an important role in the regulation of mitophagy. …”
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Neuroprotective Role of Transchalcone in Parkinson‘s Disease through AMP-activated Protein Kinase-mediated Signaling Pathway by Yao Cheng, Shaik Althaf Hussain, Turki Mayudh Alrubie, Xiaomin Zhang

“…Parkinson’s disease (PD) is a gradually worsening neurodegenerative condition marked by the deterioration of dopaminergic neurons, motor dysfunction, and mitochondrial dysfunction. Trans-chalcone, a natural flavonoid, has shown promise in various disease models because of its antioxidant and anti-inflammatory features. …”
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The Impact of Statins before High-Risk CABG on Postoperative Multiple Organ Function by Jiayang Wang, Wen Yuan, Kui Zhang, Nan Liu, Dong Liu, Yujie Zhou

“…SOFA maximum was significantly lower in the PST group compared with the control group and the incidence of the severe multiorgan dysfunction was dramatically reduced in the PST group. …”
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Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection. by Luis M Beltrán, Rocío Muñoz Hernández, Rebeca S de Pablo Bernal, José S García Morillo, Jesús Egido, Manuel Leal Noval, Sara Ferrando-Martinez, Luis M Blanco-Colio, Miguel Genebat, José R Villar, Rafael Moreno-Luna, Juan Antonio Moreno

“…Antiretroviral treatment had no effect on the concentrations of ADMA and sTWEAK, biomarkers associated with endothelial function. …”
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Mitochondria-derived peptide MOTS-c restores mitochondrial respiration in type 2 diabetic heart by Toan Pham, Andrew Taberner, Andrew Taberner, Anthony Hickey, June-Chiew Han

“…At the subcellular level, MOTS-c treated mitochondria showed increased OXPHOS respiration and ROS levels and decreased ATP hydrolysis rate during anoxic conditions.DiscussionThese findings demonstrate beneficial effects of MOTS-c treatment on glucose homeostasis and suggest a useful therapeutic option for diabetic-related cardiomyopathy and mitochondrial dysfunction.…”
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Special correlation between diet and MASLD: positive or negative? by Jia Liu, Changmeng Li, Yun Yang, Jingtao Li, Xiaoguang Sun, Yinqiang Zhang, Runping Liu, Fafeng Chen, Xiaojiaoyang Li

“…Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic and systemic metabolic liver disease characterized by the presence of hepatic steatosis and at least one cardiometabolic risk factor (CMRF). …”
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Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality by Jaimin M. Patel, Elizabeth Sapey, Dhruv Parekh, Aaron Scott, Davinder Dosanjh, Fang Gao, David R. Thickett

“…Background. Neutrophil dysfunction in sepsis has been implicated in the pathogenesis of multiorgan failure; however, the role of neutrophil extracellular traps (NETs) remains uncertain. …”
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Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease by Xiaoyue Lian, Zhenghao Liu, Zuobin Gan, Qingshan Yan, Luyao Tong, Linan Qiu, Yuntao Liu, Jiang-fan Chen, Zhihui Li

“…It summarizes emerging evidence from neuroimaging and experimental studies that highlight the close correlation between the glymphatic system and clinical symptom severity in patients with Parkinson’s disease, as well as the effect of glymphatic dysfunction on α-synuclein accumulation in Parkinson’s disease models. …”
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Low anterior resection syndrome and methods of its assessment (literature review) by O. K. Bondarenko, Yu. A. Gevorkyan, N. V. Soldatkina, M. A. Gusareva, N. G. Kosheleva, A. A. Solntseva, M. N. Duritsky, D. A. Savchenko

“…Low anterior resection syndrome is a common problem due to the increased incidence of rectal cancer and the high incidence of anorectal dysfunction during sphincter-preserving surgical interventions. …”
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