Efficient strategy for alleviating neuronal apoptosis and oxidative stress damage of Alzheimer's disease through dual targeting BCL-2 gene promoter i-motif and β-amyloid by Dongsheng Ji, Jiahui Zhang, Jihai Liang, Zhi-Shu Huang, Bing Shu, Ding Li

“…Alzheimer's disease (AD) is a severe neurodegenerative disorder characterized by abnormal metabolism of β-amyloid (Aβ) precursor proteins and neuronal apoptosis, ultimately leading to cognitive dysfunction. The pathogenesis of AD is complex, and current single-target therapies are not effective in preventing the rapid progression of AD, which highlights the urgent need for developing multi-target drugs. …”
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Low Serum Cholinesterase Levels Predict Poor Prognosis in Patients with Ovarian Cancer by Su H, Liao D, Huang C, Liu Q, Yu L

“…Multivariate Cox regression analysis identified low serum ChE levels as an independent predictor of poor overall survival and disease-free survival.Conclusion: Low serum ChE levels are independently associated with poor prognosis in ovarian cancer patients, reflecting systemic inflammation, malnutrition, and potential hepatic dysfunction. These findings suggest that ChE could serve as a cost-effective and non-invasive biomarker for risk stratification and prognosis in clinical practice.Keywords: cholinesterase, ovarian cancer, disease-free survival, overall survival…”
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<i>Weizmannia coagulans</i> BC99 Improve Cognitive Impairment Induced by Chronic Sleep Deprivation via Inhibiting the Brain and Intestine’s <i>NLRP3</i> Inflammasome by Qiaoqiao Sun, Jiajia Fan, Lina Zhao, Zhen Qu, Yao Dong, Ying Wu, Shaobin Gu

“…<i>Weizmannia coagulans</i> BC99, a Gram-positive, spore-forming, lactic acid-producing bacterium is renowned for its resilience and health-promoting properties, <i>W. coagulans</i> BC99 survives harsh environments, including high temperatures and gastric acidity, enabling effective delivery to the intestines. The consequences of chronic sleep deprivation (SD) include memory deficits and gastrointestinal dysfunction. …”
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Potential relationship between cuproptosis and sepsis-acquired weakness: an intermediate role for mitochondria by Luying Yang, Leiyu Xie, Min Li, Yanmei Miao, Jun Yang, Shaolin Chen, Xinglong Ma, Peng Xie, Peng Xie

“…Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. …”
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Septal alcohol ablation in patients with hypertrophic cardiomyopathy and left ventricular outflow tract obstruction by Mariia S. Nozdriakova, Dmitrii A. Zalyubovsky, Dmitriy S. Maznev, Dmitrii S. Evdokimov, Aleksei S. Sergeev, Eugene A. Shloydo

“…AIM: To evaluate the effectiveness of septal alcohol ablation and the progression of heart failure in patients following the procedure. …”
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Environmental occurrence, hazards, and remediation strategies for the removal of cadmium from the polluted environment by Shehla Sattar, Muhammad Yahya, Sarfa Aslam, Rahib Hussain, Syed Muhammad Mukkarram Shah, Zahid Rauf, Ahmad Zamir, Rafi Ullah, Asim Shahzad

“…Exposure to cadmium can lead to a range of health issues, including gastrointestinal distress, lung and kidney cancer, mutagenic and teratogenic effects, liver dysfunction, and fragile bone deformation. …”
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Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression by Xiaoxia Fu, Fei Sun, Faxi Wang, Junai Zhang, Biying Zheng, Jixin Zhong, Tiantian Yue, Xuebao Zheng, Jun-Fa Xu, Cong-Yi Wang

“…Colitis is a major form of inflammatory bowel disease which involved mucosal immune dysfunction. Aloperine is an alkaloid isolated from the shrub Sophora alopecuroides L. and has been recognized as an effective treatment for inflammatory and allergic diseases. …”
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Phosphatidylcholine Ameliorates Palmitic Acid‐Induced Lipotoxicity by Facilitating Endoplasmic Reticulum and Mitochondria Contacts in Intervertebral Disc Degeneration by Shuangshuang Tu, Yijun Dong, Chuanfu Li, Mingxin Jiang, Liqun Duan, Wenzhi Zhang, Xi Chen

“…Despite its high prevalence, the pathogenesis of IDD remains unclear, and effective pharmacological interventions are lacking. …”
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From bench to bedside: the role of gastrointestinal stem cells in health and disease by Xiaopeng Bai, Eikichi Ihara, Yoshimasa Tanaka, Yosuke Minoda, Masafumi Wada, Yoshitaka Hata, Mitsuru Esaki, Haruei Ogino, Takatoshi Chinen, Yoshihiro Ogawa

“…Future investigations should be directed toward unraveling the mechanisms that underpin stem cell dysfunction in various gastrointestinal pathologies, as well as exploring combination therapies that harness the regenerative capacities of stem cells in conjunction with immunomodulatory treatments. …”
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Critical illness in immunocompromised patients: insights into relapse or persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): case series report by Olga H. Hernández-Ortiz, Juan Felipe Llano, Ana Milena Sánchez, Fabian Jaimes, A. Melissa Moreno, Laura S. Perez-Restrepo, Jaime Usuga, Erwin Camacho, Jorge E. Osorio, Juan Pablo Hernández-Ortiz

“…Such studies are pivotal in shaping advanced treatment strategies and driving the development of innovative therapeutics, including more effective vaccines targeting the virus. High-risk comorbidities and pre-existing immunocompromised states have been identified as significant factors contributing to increased susceptibility to severe coronavirus disease 2019. …”
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Identification of a distinctive immunogenomic gene signature in stage-matched colorectal cancer by Pankaj Ahluwalia, Ashis K. Mondal, Ashutosh Vashisht, Harmanpreet Singh, Ahmet Alptekin, Kalyani Ballur, Nivin Omar, Meenakshi Ahluwalia, Kimya Jones, Amanda Barrett, Vamsi Kota, Ravindra Kolhe

“…This gene-based stratification offers a cost-effective approach to personalized cancer management. …”
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Brain tau PET-based identification and characterization of subpopulations in patients with Alzheimer’s disease using deep learning-derived saliency maps by Yanxiao Li, Xiuying Wang, Qi Ge, Manuel B Graeber, Shaozhen Yan, Jian Li, Shuyu Li, Wenjian Gu, Shuo Hu, Tammie L. S. Benzinger, Jie Lu, Yun Zhou

“…Moreover, a significant interaction effect of sex and APOE ε4 on tau deposition was observed in the SLo group, but no such effect was found in the SHi group. …”
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FMT reduces systemic inflammatory response in severe acute pancreatitis by increasing the abundance of intestinal Bifidobacteria and fecal bacteria by Yanning Mao, Yandong Huang, Weiwei Zhang, Huiping Liang, Fengming Liu, Qi Luo, Chunqin Xu, Yi Qin, Jiawen Liu, Shaobo Tang, Huaying Liu, Xiaolong Ge

“…In conclusion, this research supports FMT as a safe and effective intervention for treating SAP patients. …”
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Pathophysiology and management of burn injury-induced pain by Zerong You, Shubhika Jain, Shiqian Shen, Jianren Mao, J.A. Jeevendra Martyn

“…Opioids, the mainstay for moderate to severe pain relief after major burn injury, with time, have poor analgesic and serious side effects. Accurate assessment pain of BIP and its biology at different stages of treatment helps to provide effective treatments of the different etiological factors that cause BIP and their sequelae. …”
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Impact of naringenin in inhibition of protein glycation in diabetic rats as a protection mechanism against nephropathy by Taha A. Kumosani, Abeer Alnefayee, Elie Barbour, Mohammed Qari, Tarek Ahmed, Said S. Moselhy

“… Protein glycation is one of the most serious issues in diabetes playing a critical role in the development of many cellular dysfunction as aging, cardiovascular diseases and neural disorders. …”
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Noninvasive Retinal Markers in Diabetic Retinopathy: Advancing from Bench towards Bedside by Søren Leer Blindbæk, Thomas Lee Torp, Kristian Lundberg, Kerstin Soelberg, Anna Stage Vergmann, Christina Døfler Poulsen, Ulrik Frydkjaer-Olsen, Rebecca Broe, Malin Lundberg Rasmussen, Jimmi Wied, Majbrit Lind, Anders Højslet Vestergaard, Tunde Peto, Jakob Grauslund

“…So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. …”
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Ameliorating potential of Auricularia auricula-judae polysaccharides in mitigating hypercaloric diet-induced behavioral disorders through gut microbiota regulation by Yujie Fei, Jingwen Zhang, Sijia Yuan, Ye Liu, Xiaoru Wang, Xiaoru Wang, Meng Wang, Meng Wang, Haoan Zhao, Qian Liu, Qian Liu, Qian Liu

“…This study investigated the effects of AAP on hypercaloric diet-induced cognitive dysfunction in mice and the underlying mechanisms. …”
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Development of Delirium in the Intensive Care Unit in Patients after Endovascular Aortic Repair: A Retrospective Evaluation of the Prevalence and Risk Factors by Yohei Kawatani, Yoshitsugu Nakamura, Yujiro Hayashi, Tetsuyoshi Taneichi, Yujiro Ito, Hirotsugu Kurobe, Yuji Suda, Takaki Hori

“…Delirium is an acute form of nervous system dysfunction often observed in patients in the intensive care unit. …”
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H-151 attenuates lipopolysaccharide-induced acute kidney injury by inhibiting the STING–TBK1 pathway by Lei Xia, Jia-hui Jiang, Jie-yu Liu, Tian-yi Zhang, Yu-xin Dong, Qi-hui Liu, Yan-Fen Chai, Yan-cun Liu, Song-tao Shou

“…Sepsis is a severe systemic infectious disease that often leads to multi-organ dysfunction. One of the common and serious complications of sepsis is renal injury. …”
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Blood-brain barrier repair: potential and challenges of stem cells and exosomes in stroke treatment by Xiaochen Fu, Xiaochen Fu, Jia Li, Jia Li, Shoujun Yang, Jiapeng Jing, Jiapeng Jing, Qinzhi Zheng, Qinzhi Zheng, Ting Zhang, Ting Zhang, Zhuo Xu

“…BBB dysfunction serves as a key factor in the development of cerebral edema, inflammation, and further neurological damage in stroke patients. …”
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