Rosacea pathogenesis and topical treatment options – a review by Aleksandra Okońska, Julia Kozakiewicz, Michał Ziemba, Joanna Kałuska, Tomasz Suprun, Aleksandra Sokół, Klaudia Mościszko, Katarzyna Nowicka, Wiktor Klimek, Maria Majewska

“…Summary: Rosacea is driven by multifactorial mechanisms, including neurovascular hyperreactivity, immune system dysregulation, sebaceous gland dysfunction, microbial imbalances, and genetic predisposition. …”
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Identifying kinematic biomarkers of the dystrophic phenotype in a zebrafish model of Duchenne muscular dystrophy by Jeffrey J. Widrick, Matthias R. Lambert, Felipe de Souza Leite, Youngsook Lucy Jung, Junseok Park, James R. Conner, Eunjung Alice Lee, Alan H. Beggs, Louis M. Kunkel

“…For each of these predictors, mutant and wild-type larvae differed markedly with effect sizes ranging from 2.4 to 3.7 standard deviations. …”
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Use of computer stimulating programs in patients with post-stroke cognitive impairment by S. V. Prokopenko, T. V. Dyadyuk, E. Yu. Mozheyko, A. F. Bezdenezhnykh, T. D. Koryagina, T. S. Anay-Ool

“…Further investigations will be able to evaluate the effectiveness of CSPs in patients with PSCI in the later periods of IS.…”
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Allergic bronchopulmonary aspergillosis as an initial manifestation of cystic fibrosis: Diagnostic and therapeutic implications in the era of CFTR modulators by Georgia Mitropoulou, MD, Zisis Balmpouzis, MD, Aurelia Oberhansli-Wavre, MD, Michael Morris, PhD, Sylvain Blanchon, MD, Alain Sauty, MD, Angela Koutsokera, MD, PhD

“…This case illustrates the evolving understanding of CF as a spectrum of disorders in which CFTR dysfunction may manifest subtly and variably, necessitating a high index of suspicion and a comprehensive diagnostic approach to ensure timely treatment in the era of highly effective CFTR modulators.…”
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A novel sodium Iron silicate composite with chitosan for efficient removal of Cd(II) ions from water by Mohamed S. Kamel, Ehab A. Abdelrahman, Zinab M. Anwar, Samir M. El Rayes, Mortaga M. Abou-Krisha, Raed M. Hegazey, Hanan Alhussain

“…Regeneration using HCl confirmed the effective reusability of both adsorbents over five successive cycles. …”
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Therapeutic Potential of Ginger Ethanolic Extract, Ginger-Loaded Chitosan ‎Nanoparticles, and Chitosan Nanoparticles in Induced Type 2 Diabetes Mellitus in Dogss in Induced Type 2... by Rasema M Hameed, Alaa K Mahmood

“…Current therapeutic options are often limited by side effects and variable efficacy, highlighting the need for more effective and safer treatments. …”
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S-ketamine facilitates motor function recovery after brachial plexus root avulsion and reimplantation in mice by Ronghua Huang, Ronghua Huang, Bingbiao Lin, Lingtai Yu, Lingtai Yu, Qichen Luo, Hongyan Tian, Chenrui Li, Naili Wei, Shaohui Zhuang, Jian Chen, Yalan Li, Yalan Li

“…BackgroundBrachial plexus root avulsion (BPRA) often occurs in high-speed traffic accidents or shoulder dystocia, resulting in motor dysfunction. S-ketamine, a clinical anesthetic and antidepressant drug, is an NMDA receptor antagonist that may be effective against glutamate excitotoxicity after nerve injury. …”
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Gamma-oryzanol: a novel promising supplement for diabetes mellitus by Mustapha Ismail Radda, Norsuhana Omar, Rozaziana Ahmad, Rohana Abdul Jalil, Wan Rosli Wan Ishak, Anani Aila Mat Zin, Aminah Che Romli

“…This review aimed to examine the effects of γ-ORZ on diabetes, promoting further research and encouraging the adoption of BR in dietary practices. …”
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Prediction Models for Postoperative Delirium of Cardiovascular Surgery (PODOCVS): Protocol for a Systematic Review by Xuling Zhao, Yike Wang, Liju Li, Meijuan Lan, Xiaodi He

“…Advances in its early diagnosis and treatment have mitigated some of the initial adverse effects of PODOCVS, but models for predicting risk in patients who have already developed PODOCVS remain inadequate for effective secondary prevention. …”
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A nationwide population-based cross-sectional time series study of hospitalized chronic liver disease burden in Thailand from 2017 to 2022 by Rungfah Saehan, Apichat Kaewdech, Pimsiri Sripongpun, Naichaya Chamroonkul, Teerha Piratvisuth, Suthat Liangpunsakul, Ponlagrit Kumwichar

“…Alcohol-associated liver disease was the leading cause (30.8%), followed by chronic hepatitis B (11.3%), hepatitis C (10.3%), and metabolic dysfunction-associated steatotic liver disease (MASLD, 9.6%). …”
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Enhanced Blood‐Brain Barrier Penetrability of BACE1 SiRNA‐Loaded Prussian Blue Nanocomplexes for Alzheimer's Disease Synergy Therapy by Xiaoyuan Ding, Yanyu Hu, Xiaotong Feng, Zekun Wang, Qile Song, Chunxue Dai, Bangjia Yang, Xiaoyan Fu, Dongdong Sun, Cundong Fan

“…The results indicated that PRM‐siRNA significantly blocked Aβ aggregation and attenuated Aβ‐induced neurotoxicity and apoptosis in vitro by inhibiting ROS‐mediated oxidative damage and mitochondrial dysfunction through regulating the Bcl‐2 family. PRM‐siRNA in vivo effectively improved APP/PS1 mice learning and memory by alleviating neural loss, neurofibrillary tangles and activation of astrocytes and microglial cells in APP/PS1 mice by inhibiting BACE1, oxidative damage and tau phosphorylation. …”
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Coexisting Lung Cancer and Pulmonary Tuberculosis: A Comprehensive Review From Incidence to Management by Wendi Zhou, Hongxu Lu, Jiamin Lin, Jialou Zhu, Jizhen Liang, Yalin Xie, Jinxing Hu, Ning Su

“…Conversely, cancer patients, whether due to the disease itself or immune dysfunction caused by anti‐tumor treatments, may be more susceptible to TB. …”
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Lung transplant bridging strategies in patients with idiopathic pulmonary fibrosis: An SRTR database analysis by Yota Suzuki, MD, Rachel L. Deitz, MD, MPH, John Ryan, PhD, Ernest Chan, MD, Masashi Furukawa, MD, Chadi Hage, MD, Pablo G. Sanchez, MD

“…Conversion to VA ECMO may be considered early when there is a sign of right ventricular dysfunction.…”
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Discriminative Validity and Reliability of the Single-Leg Squat and Single-Leg Landing Frontal Plane Kinematics in Individuals with Lower Limb Functional Deficits by Jean Marlon Machado, Marcelo Peduzzi de Castro, Amandda de Souza, Carlos Alberto Atherinos Pierri, Francisco Xavier de Araujo, Heiliane de Brito Fontana, Caroline Ruschel

“…Background/Objectives: Kinematic measurements obtained from functional tests have been used to identify associated and risk factors for the development of lower limb dysfunction, allowing targeted interventions to reduce potential risks and guide rehabilitation. …”
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Outcomes of Prostatic Artery Embolization for Treating Benign Prostatic Hyperplasia Symptoms: A Prospective Single‐Center Study by Sina Delazar, Sina Azadnajafabad, Kavous Firouznia, Mohammad Reza Nowroozi, Erfan Amini, Maryam Fotouhi, Hossein Ghanaati

“…Complications occurred in eight (17.4%) cases, including five cases of erectile dysfunction and three cases of urinary tract infection. …”
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Remdesivir inhibits endothelial activation and atherosclerosis by coupling TAL1 to TRAF6 by Hanning Zhang, Ruru Li, Qianqian Huo, Li Li, Min Li, Shunxin Hu, Changjie Ren, Zongyin Wu, Chenghu Zhang

“…Abstract Background Atherosclerosis is characterized by complex pathological processes, including endothelial dysfunction and inflammation. The underlying pathogenic mechanisms have been well elucidated; however, effective treatments are yet to be validated. …”
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The Choice of Treatment Tactics in Patients with Severe Acute Pancreatitis Taking Into Account the Factor of Intra-Abdominal Hypertension by B. M. Belik, G. M. Chirkinyan, R. S. Tenchurin, Z. A. Abduragimov, D. V. Mareyev, A. R. Dadayan, M. A. Oskanyan, A. R. Sapraliyev

“…To assess the role and clinical significance of IAP monitoring in patients with severe AP with various manifestations of organ dysfunction and, offer a set of therapeutic measures aimed at resolving intra-abdominal hypertension.Material and methods. …”
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Prosthesis survival situation and complications following total hip arthroplasty in hemophilic patients: a systematic review by Lei Chen, Shineng Lin, Wenlu Zhou, Yiqing Ling, Zhenyu Shi, Qinwen Ge, Wenbin Liu, Ju Li, Peijian Tong, Huihui Li, Taotao Xu

“…Key risk factors included reduced bone mineral density, recurrent hemarthrosis, and immune dysfunction (HIV) due to clotting factor infusions. …”
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m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs by Xiaoniu Dai, Yusi Cheng, Wei Luo, Jing Wang, Cuifen Wang, Xinxin Zhang, Wei Zhang, Jie Chao

“…Despite mounting evidence suggesting that fibrosis is reversible, effective treatments for fibrotic diseases are lacking. …”
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Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions by Olexandr Kuryata, Oleh Akimov, Mykola Riabushko, Heorhii Kostenko, Viktoriia Kostenko, Artur Mishchenko, Svetlana Nazarenko, Natalia Solovyova, Vitalii Kostenko

“…At the same time, preparations of 5-ALA may potentially be effective not only in the treatment of prediabetes and type 2 diabetes mellitus (T2DM), but also in other conditions associated with systemic inflammation, oxidative or nitrosative stress, mitochondrial dysfunction, as well as disorders of carbohydrate and lipid metabolism.It has been concluded that the promising advancement of formulations containing 5-ALA may pave the way for new strategies in preventing and treating these diseases, with subsequent preclinical and clinical trials likely to follow.…”
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