Reproductive Challenges in Ruminants Under Heat Stress: A Review of Follicular, Oocyte, and Embryonic Responses by Danisvânia Ripardo Nascimento, Venância Antonia Nunes Azevedo, Regislane Pinto Ribeiro, Gabrielle de Oliveira Ximenes, Andreza de Aguiar Silva, Efigênia Cordeiro Barbalho, Laryssa Gondim Barrozo, Sueline Cavalcante Chaves, Maria Samires Martins Castro, Erica Costa Marcelino, Leopoldo Rugieri Carvalho Vaz da Silva, André Mariano Batista, José Roberto Viana Silva

“…Oocyte maturation, both nuclear and cytoplasmic, is also compromised, and embryo quality declines under elevated thermal conditions. These effects are linked to intracellular disturbances, including oxidative imbalance, mitochondrial dysfunction, and altered hormonal signaling. …”
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Mechanical tricuspid valve thrombosis in pregnancy: a case report and literature review on anticoagulation challenges and fetal protection strategies by San Zhu, San Zhu, Can Luo, Can Luo, Bing Luo, Bing Luo, Yaoyao Zhang, Yaoyao Zhang, Qiang Wei, Qiang Wei

“…At 33 + 2 weeks, worsening symptoms and echocardiographic evidence of tricuspid valve dysfunction prompted anticoagulation transition from warfarin to LMWH combined with vitamin K. …”
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Endothelial delivery of simvastatin by LRP1-targeted nanoparticles ameliorates pathogenesis of alzheimer’s disease in a mouse model by Ting-Ting Pan, Yan-Yun Sun, Yi-Fan Shi, Mei Zhao, Naveed Ullah Khan, Hai-Yan Chen, Wen-Li Ji, Jie Li, Liang Han, Quan-Hong Ma

“…Abstract Blood-brain barrier (BBB) dysfunction is an early pathological hallmark of Alzheimer’s disease (AD), occurring prior to amyloid-β (Aβ) accumulation. …”
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Efficacy of brachytherapy for locally advanced bladder cancer: a single-center retrospective clinical study by Xuebing Han, Huiqing Chen, Bin Wang

“…This surgery increases the LRFS, develops better personalized treatment plans, and improves treatment effectiveness. In addition, the treatment is safe and effective, with only limited adverse effects.…”
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Efficacy of red algae and artichoke extracts in disrupting antioxidant/PI3K/RBP-4 pathway in high-fat diet-induced metabolic disorders in rats by Bashayer Khaled Alrashidi, Alshimaa A. Abd-Elmoneam, Ahmad Z. Ghareeb, Doaa A. Ghareeb

“…Natural products rich in nontoxic phytochemicals are cost-effective and widely used to manage insulin resistance, reducing drug interactions. …”
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Percutaneous Pulmonary Valve Implantation In Native Right Ventricular Outflow Tract Using Myval™ Without Pre‐Stenting by João Luiz Langer Manica, Raul Ivo Rossi Filho, Carlos Augusto Cardoso Pedra, Fabio Vieira Caovilla, Francisco Chamié, Carlo Benatti Pilla, Pablo Thomé, Vinicius Fraga, Marcelo Ribeiro, Germana Cerqueira Coimbra, João Henrique Aramayo Rossi, Ênio Guerios, João Vitor Slaviero, Santiago Raul Arrieta

“…Results Seventeen patients underwent to percutaneous pulmonary valve implantation to treat large and native dysfunctional RVOT. The mean patient age was 26.2 ± 13.0 years, and the mean patient weight was 64.8 ± 14.8 kg. …”
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Simultaneous radical cystectomy and nephroureterectomy: A case series by Gavin G. Calpin, Steven M. Anderson, Mark Broe, Ijaz Cheema, Niall F. Davis, Dilly Little

“…Conclusion: The results from this study demonstrate that combined laparoscopic and open RCNU is an effective treatment for both panurothelial cancer and MIBC with severe upper tract dysfunction.…”
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Electroacupuncture improves cardiac function in hyperlipidemic rats by enhancing efferocytosis in myocardial macrophages via the PPARγ-LXRα-MerTK pathway by Yong-Li Han, Shu-Wen Jin, Xiao-Li Pan, Hong-Xing Zhang

“…Background and aim: Electroacupuncture (EA) is an effective treatment for hyperlipidemia because it decreases the protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor alpha (LXRα). …”
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Beating Heart Coronary Artery Bypass Grafting with Preemptive Impella^™ 5.5 Assist Device in Ischemic Cardiomyopathy by Francesco Cabrucci, Massimo Baudo, Yoshiyuki Yamashita, Amanda Yakobitis, Courtney Murray, Gianluca Torregrossa

“…The Impella provided effective circulatory support, ensuring stable hemodynamics throughout the postoperative stay without complications.…”
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Practical experience and clinical results of reconstructive surgical correction of primary and secondary mitral regurgitation by V. V. Osaulenko, V. O. Hubka, K. O. Chmul, S. Yu. Nakonechnyi, R. I. Budahov

“…Mitral valve surgery is indicated in symptomatic patients with severe insufficiency and asymptomatic individuals with left ventricular systolic dysfunction, pulmonary hypertension, or atrial fibrillation. …”
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Combination therapy of rituximab and mycophenolate in patients with systemic sclerosis and primary cardiac involvement refractory to cyclophosphamide: a retrospective exploratory a... by Gabriela Riemekasten, Jens Y Humrich, Susanne Schinke, Peter Lamprecht, Hanna Grasshoff, El-Baraa Adjailia, Konstantinos Fourlakis, Sebastian T Jendrek

“…We performed a retrospective medical records analysis at our centre to explore the therapeutic effects of a combination therapy with rituximab (RTX) and mycophenolate (MMF) in 10 patients with SSc-related primary cardiac involvement refractory to previous primary treatment with cyclophosphamide (CP).SSc-related primary cardiac involvement was defined as the presence of troponin T elevation and of at least one of the following cardiac manifestations: right or left ventricular systolic or diastolic dysfunction, myocarditis, pericarditis, heart blocks or ventricular arrhythmias. …”
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Luteolin: a natural product with multiple mechanisms for atherosclerosis by Chanjun Wan, Chanjun Wan, Qingzhi Liang, Yirong Ma, Yang Wang, Liqiang Sun, Liqiang Sun, Junyu Lai, Junyu Lai, Jianguang Wu, Jianguang Wu, Zhengtao Chen, Zhengtao Chen

“…Therefore, the development of safe and effective therapeutic drugs holds immense social and economic significance. …”
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KDM1A Promotes Immunosuppression in Hepatocellular Carcinoma by Regulating PD-L1 through Demethylating MEF2D by Yonglan Wang, Kun Cao

“…Immune checkpoint inhibitor therapy targeting antiprogrammed cell death-1 (anti-PD-1) or its ligand (anti-PD-L1) is effective in the treatment of some hepatocellular carcinomas (HCC). …”
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Transjugular intrahepatic portosystemic shunt for the treatment of portal hypertension complications: A single-center retrospective cohort by Jianbin Zhang, MD, Qiangqiang Nie, MD, Bin He, MD, Bo Ma, MD, Xueqiang Fan, MD, Peng Liu, MD, Zhidong Ye, MD

“…Conclusions: TIPS is a safe and effective treatment modality for portal hypertension complications. …”
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Negative correlation between school bullying and multi-dimensional health in adolescent female migrants: a digital visual analog scale study by Yueping Song, Yueping Song, Yueping Song, Yifei Li, Yifei Li, Kai Zhou, Jia Tang, Jia Tang, Xuemeng Chen, Gaowang Liu, Gaowang Liu

“…The digital VAS developed in this study proves to be an effective and sensitive tool for educators and clinicians to monitor and address the adverse health outcomes of bullying. …”
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Nuclear factor erythroid 2‐related factor 2 ameliorates disordered glucose and lipid metabolism in liver: Involvement of gasdermin D in regulating pyroptosis by Xuyun Xia, Qin Zhang, Xia Fang, Ling Li, Gangyi Yang, Xiaohui Xu, Mengliu Yang

“…Abstract Background The epidemic of metabolic dysfunction‐associated fatty liver disease linked to excessive high‐fat diet (HFD) consumption has sparked widespread public concern. …”
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Boosting Hydroxyl Radical Generation with Nitrogen Vacancy–Modified Carbon Nitride for Triggering Dual Damage of Cancer Nucleus DNA–Mitochondria against Hypoxic... by Zhang Y, Liu M, Xue S, Li N, Hong J, Gu J, Ren X, Li H, Xu J, Zhang C, Liang T, Zhao B, Wang X

“…Under illumination, NV-PCN generates a burst of •OH around the nuclei and mitochondria of Cal-27 cells, which effectively kills the cells via synchronously leading to DNA damage and mitochondrial dysfunction. …”
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Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach by Mark Widder, Chance Carbaugh, William van der Schalie, Ronald Miller, Linda Brennan, Ashley Moore, Robert Campbell, Kevin Akers, Roseanne Ressner, Monica Martin, Michael Madejczyk, Blair Dancy, Patricia Lee, Charlotte Lanteri

“…In the military, combat wound infections can progress rapidly to life-threatening sepsis. The discovery of effective small-molecule drugs to prevent and/or treat sepsis is a priority. …”
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Single-cell transcriptome sequencing reveals the immune microenvironment in bronchoalveolar lavage fluid of checkpoint inhibitor-related pneumonitis by Linpeng Zheng, Fenglin Lin, Dingqin Cai, Longyao Zhang, Chenrui Yin, Yaxian Qi, Lingyou Sun, Lingchen Li, Xiewan Chen, Jianbo Zhu, Jianguo Sun

“…Current research points to potential links with T cell subset dysfunction and autoantibody increase, but the specific mechanisms underlying different grades of CIP are understudied. …”
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Heterogeneous immune landscapes and macrophage dynamics in primary and lung metastatic adenoid cystic carcinoma of the head and neck by Xuelian Wang, Xuelian Wang, Tingyao Ma, Hongfei Liu, Shujing Zhang, Guoliang Yang, Yue Zhao, Lu Kong, Ran Gao, Xiaohong Chen

“…Higher immune cell infiltration in lung metastases is countered by the presence of suppressive tumor-associated macrophages, which may limit effective anti-tumor responses.…”
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