Odoribacter splanchnicus-derived extracellular vesicles alleviate inflammatory bowel disease by modulating gastrointestinal inflammation and intestinal barrier function via the NLR... by Jinfu Zhuang, Zhicheng Zhuang, Bin Chen, Yuanfeng Yang, Hengkai Chen, Guoxian Guan

“…Based on IBD model mice induced by dextran sulfate sodium (DSS), the effects of Os-EVs on IBD symptoms, intestinal barrier dysfunction, and colonic apoptosis, inflammation as well as NLRP3 inflammasome activation were analyzed. …”
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Sex differences in the longitudinal relationship of low-grade inflammation and echocardiographic measures in the Hoorn and FLEMENGHO Study. by Sharon Remmelzwaal, Joline W J Beulens, Joline W J Beulens, Petra J M Elders, Coen D A Stehouwer, Zhenyu Zhang, M Louis Handoko, Yolande Appelman, Vanessa van Empel, Stephane R B Heymans, Lutgarde Thijs, Jan A Staessen, A Johanne van Ballegooijen

“…<h4>Background</h4>This study aimed to determine the within-person and between-persons associations of low-grade inflammation (LGI) and endothelial dysfunction (ED) with echocardiographic measures related to diastolic dysfunction (DD) in two general populations and whether these associations differed by sex.…”
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TRAP1 Improves Diabetic Retinopathy by Preserving Mitochondrial Function by Li Y, Xu W, Zhao G, Guo Y, Wang L, Du Q, Fei Y, Hu X, Hu H, Chen L, Xu Y

“…High glucose levels correspondingly diminished TRAP1 expression in ARPE-19 cells, causing decreased cellular viability, increased ROS generation, and mitochondrial dysfunction. Notably, the overexpression of TRAP1 effectively preserved mitochondrial homeostasis under stress, mitigated mitochondrial impairment, and enhanced cellular viability. …”
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Vasodilator drugs and heart-related outcomes in systemic sclerosis: an exploratory analysis by Arsène Mekinian, Vincent Cottin, Zahir Amoura, Eric Hachulla, Yannick Allanore, David Launay, Luc Mouthon, Benjamin Chaigne, Sébastien Rivière, Olivier Fain, Brigitte Granel, Alain Lescoat, Denis Wahl, Christian Agard, Grégory Pugnet, Ariel Cohen, Emmanuel Chatelus, Bernard Bonnotte, Thomas Papo, Viviane Queyrel, Elisabeth Diot, Achille Aouba, Fabrice Carrat, Pierre Kieffer, Nadine Magy-Bertrand, Arnaud Hot, Olivier Lidove, Robin Dhote, Jean-Christophe Lega, Marie-Hélène Balquet, Jean-Emmanuel Kahn, Anne Laure Fauchais, Alain Le Quellec, Olivier Espitia, Alexis F Guedon, Jean Baptiste Gaultier

“…We did not find a significative effect on PAH. Regarding bosentan, ACE inhibitors and iloprost, none of them neither showed a significant effect on diastolic dysfunction, altered ejection fraction &lt;50% or PAH.Conclusions Using causal methods, our study is the first and largest suggesting that sildenafil might have benefits among SSc patients regarding diastolic dysfunction and altered ejection fraction occurrence. …”
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Glial Perturbation in Metal Neurotoxicity: Implications for Brain Disorders by Olayemi K. Ijomone, Ileje I. Ukwubile, Vivian O. Aneke, Tobiloba S. Olajide, Happiness O. Inyang, Omolabake I. Omotosho, Toheeb O. Oyerinde, Victor E. Anadu, Tolulope J. Gbayisomore, Oritoke M. Okeowo, David A. Oyeniran, Olumide A. T. Ogundahunsi, Omamuyovwi M. Ijomone

“…The mechanisms through which these metals exert their effects include the generation of reactive oxygen species, mitochondrial dysfunction, activation of inflammatory pathways, and disruption of cellular signaling. …”
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Gut dysbiosis impairs hippocampal plasticity and behaviors by remodeling serum metabolome by Guoqiang Liu, Quntao Yu, Bo Tan, Xiao Ke, Chen Zhang, Hao Li, Tongmei Zhang, Youming Lu

“…Reconstitution with normal gut flora produced therapeutic effects against both adult neurogenesis and behavioral deficits in the dysbiosis mice. …”
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Melatonin and spermidine protect early mouse embryos from ethylparaben toxicity by restoring histone modifications and subcellular structures by Yong-feng Wang, Yu-ting Wan, Qing Tian, Ying Yin, Jia-wei Xu, Li-quan Zhou

“…This arrest coincides with elevated reactive oxygen species levels, mitochondrial dysfunction, DNA damage, and apoptosis. Transcriptomic analysis reveals widespread gene dysregulation following EtP exposure, characterized by the downregulation of maternal-effect genes, cleavage-stage embryo genes, and mitochondria-associated genes. …”
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Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure by Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang

“…This effect persists beyond birth, leading to bile acids local increase and subsequent enhancement of ERS, ultimately inducing cellular dysfunction in adult adrenal glands.…”
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Dementia in People With Multiple Sclerosis: A Systematic Review and Meta‐Analysis by Omid Mirmosayyeb, Danial Dehghani Firouzabadi, Soroush Oraee, Mohammadreza Alinejadfard, Mohammad Yazdan Panah, Saeed Vaheb, Hamed Ghoshouni, Vahid Shaygannejad

“…ABSTRACT Introduction Multiple sclerosis (MS), as an autoimmune demyelinating disorder, is associated with cognitive dysfunction. Dementia can result from severe cognitive dysfunction or other pathways in MS, but the exact mechanisms and prevalence are unknown. …”
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Subjective and objective vestibular changes that occur following paediatric cochlear implantation: systematic review and meta-analysis by Michael Yong, Emily Young, Jane Lea, Hannah Foggin, Erica Zaia, Frederick K. Kozak, Brian D. Westerberg

“…Abstract Objective Cochlear implantation can result in post-operative vestibular dysfunction of unknown clinical significance. The objective of this study was to characterize the presence, magnitude, and clinical significance of vestibular dysfunction that occurs after pediatric cochlear implantation. …”
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Multiple low-dose radiation prevents type 2 diabetes-induced renal damage through attenuation of dyslipidemia and insulin resistance and subsequent renal inflammation and oxidative... by Minglong Shao, Xuemian Lu, Weitao Cong, Xiao Xing, Yi Tan, Yunqian Li, Xiaokun Li, Litai Jin, Xiaojie Wang, Juancong Dong, Shunzi Jin, Chi Zhang, Lu Cai

“…However, the above beneficial effects were weakened once LDR treatment was extended to 8 weeks.…”
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Normative Data for the D-KEFS Tower Test in Greek Adult Population Between 20 and 85 Years Old by Marianna Tsatali, Despina Eleftheriadou, Nikoleta Palla, Magda Tsolaki, Despina Moraitou

“…Consequently, it cannot be effectively used to detect executive dysfunction in neurological and psychiatric populations or for research purposes. …”
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Levosimendan, milrinone, and dobutamine in experimental acute pulmonary embolism by Mads D. Lyhne, Simone J. Dragsbaek, Jacob V. Hansen, Jacob G. Schultz, Asger Andersen, Jens Erik Nielsen‐Kudsk

“…We aimed to investigate the cardiovascular effects of three clinically relevant inodilators: levosimendan, milrinone, and dobutamine in acute pulmonary embolism. …”
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Symbiotic anti-oxidant, anti-glycation, and anti-inflammatory qualities of a combination of thiamine and niacin protected type-2 diabetic male rats against both macro and micro-vas... by Sina Mahdavifard, Hamid Reza Malekzadeh

“…The vitamins also had a more corrective effect on glucose-lipid metabolism, insulin sensitivity, and renal function through a stronger lowering effect on hepatic NF-kβ expression.…”
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Cell-Permeable Microprotein from Panax Ginseng Protects Against Doxorubicin-Induced Oxidative Stress and Cardiotoxicity by Bamaprasad Dutta, Shining Loo, Antony Kam, Xiaoliang Wang, Na Wei, Kathy Qian Luo, Chuan-Fa Liu, James P. Tam

“…Ginsentides, such as the 31-residue TP1, coordinate multiple biological systems to prevent vascular dysfunction and endoplasmic reticulum stress induced by internal and external stressors. (2) Methods: We assessed the protective effects of ginsentide TP1 on DOX-induced cardiotoxicity using both in vitro functional studies on H9c2 cardiomyocytes and in vivo animal models by zebrafish and ICR mouse models. …”
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CSN6 aggravates inflammation and Myocardial injury in macrophage of sepsis model by MIF by Qianying Song, Changming Zhou, Yufei Liu, Liping Wang, Huiyi Lv, Cuiying Zhang, Xuanqi Wang

“…Caregivers closely monitor patients’ organ function indicators in the intensive care unit,which is essential for the early identification and management of organ dysfunction cauxsd by sepsis. Hence, we investigated the effects of CSN6 on sepsis and its underlying mechanism. …”
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Citalopram therapy in rehabilitation period of myocardial infarction among patients with Type 2 diabetes mellitus and affective disorders by M. E. Statsenko, N. N. Shilina

“…Three-month citalopram (Opra) therapy in post-infarction rehabilitation period effectively treated affective disorders, reduced psychological stress levels and improved night sleep in patients with Type 2 diabetes mellitus and chronic heart failure. …”
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Profound Grief and Pulmonary Fibrosis – A Case Report by Joyce Leong, Lay Ling Tan, Chiang Choo Goh

“…TCM informs that psychological issues usually manifest as physiological dysfunction of the related organ. This encourages clinicians to consider the effects on various organs during management of mental disorders. …”
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Aldosterone-Related Cardiovascular Disease and Benefits of Mineralocorticoid Receptor Antagonists in Clinical Practice by Maria Alfarano, MD, PhD, Giulia Marchionni, MD, Jacopo Costantino, MD, Federico Ballatore, MD, Romina Verardo, PhD, Fabio Miraldi, MD, Francesco Luigi Ciciarello, MD, Luigi Petramala, MD, Claudio Letizia, MD, Andrea Frustaci, MD, Cristina Chimenti, MD, PhD

“…High levels of aldosterone induce reactive oxygen species with consequent oxidative stress and mitochondrial dysfunction. Moreover, aldosterone induces myocardial hypertrophy through increase of sarcomere mass mediated by pro-hypertrophic effect mediated by a G protein-coupled receptor kinase 5 cytosolic signaling and retention of ions and water regulated by aquaporins. …”
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Dual-targeted siRubicon delivery strategy triggers hepatocellular lipophagy for mitigating liver steatosis by Tingting Lan, Qiushi Li, Mingxing Yu, Xu Duan, Tao Ming, Shuo Li, Chunjiong Wang, Yi Zhu, Zhongyang Shen, Deling Kong, Yang Liu

“…Abstract Metabolic dysfunction-associated steatotic liver disease is marked by fat accumulation and inflammation, partly due to impaired lipophagy—a cellular process in which lipid droplets are broken down through autophagy. …”
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