Age-Related Mitochondrial Alterations Contribute to Myocardial Responses During Sepsis by Jiayue Du, Qing Yu, Olufisayo E. Anjorin, Meijing Wang

“…Considering the importance of mitochondrial dysfunction in cardiac impairment, we aimed to investigate whether aging exacerbates the cardiac mitochondrial metabolic response to inflammation, thus leading to increased cardiac dysfunction in the elderly. …”
Get full text

Poor sleep quality indirectly contributes to higher sexual risk-taking by increasing the likelihood of engaging in substance use among LGBTQ+ individuals by Efe Sarı, Nevin Durdu, Beril Ay, Barış Sancak

“…BackgroundPoor sleep quality (PSQ) is disproportionately prevalent among LGBTQ+ individuals and has been linked to substance use, sexual dysfunction and sexual risk-taking (SRT). However, the interplay between sleep health, substance use, SRT, and sexual dysfunction remains underexplored in diverse LGBTQ+ populations. …”
Get full text

The relationship of epicardial obesity and levels of cardiac fibrosis markers by O. V. Gritsenko, G. A. Chumakova, O. V. Gruzdeva, I. V. Shevlyakov

“…Coronary artery disease, arterial hypertension, type 2 diabetes mellitus, the presence of left ventricular diastolic dysfunction were the exclusion criteria of the study.Results. …”
Get full text

Neuroimmunological blood brain barrier opening in experimental cerebral malaria. by Adela Nacer, Alexandru Movila, Kerstin Baer, Sebastian A Mikolajczak, Stefan H I Kappe, Ute Frevert

“…P. yoelii 17XL and P. yoelii YM caused lethal hyperparasitemia in all mouse strains; histopathological alterations, BBB dysfunction, or neurological signs were not observed. …”
Get full text

Genetic characteristics involving the PD-1/PD-L1/L2 and CD73/A2aR axes and the immunosuppressive microenvironment in DLBCL by Tingting Zhang, Zhenzhen Zhang, Xiubao Ren, Jin He, Zhengzi Qian, Bin Meng, Lei Jiao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Wenchen Gong, Huilai Zhang, Xianhuo Wang

“…The degree of T-cell dysfunction is correlated with clinical outcomes. Strategies that reverse T-cell dysfunction by inhibiting PD-1/PD-L1/L2, particularly in combination with CD73/A2aR, may show potential as effective therapeutic options for DLBCL.…”
Get full text

State of antioxidant blood system at physiological pregnancy and pregnancy complicated with bleeding by Z. I. Mikashinowich, Ye. V. Olempieva

“…It was established that hyper production of hydrogen peroxide and glutathione peroxidase activation at physiological pregnancy improved microcirculation due to vasodilatation effect of hydrogen peroxide. It was established that activation of superoxiddysmutase and myeloperoxidase at pregnancy complicated with hypertension developed endothelial dysfunction owing to citotoxic effects of hydrogen peroxide.…”
Get full text

PRECISION MEDICINE IN CLL: TREATMENT BASED ON MOLECULAR PROFILES by Esra Terzi Demirsoy

“…CK is linked to advanced disease, unmutated IGHV, TP53 mutations, adverse FISH abnormalities, and telomere dysfunction. Even within the CK subgroup, heterogeneity exists in the number and type of aberrations. …”
Get full text

Features of short-term heart rate variability in internally displaced people with type 2 diabetes mellitus by V.A. Serhiyenko, V.B. Sehin, V.I. Pankiv, A.A. Serhiyenko

“…The use of short-term HRV analysis can be both a cost-effective and scientifically sound approach for the early diagnosis of CAN in patients with T2DM. …”
Get full text

Modern antihyperglycemic therapy: safety and efficacy of glimepiride by Lyudmila Alexandrovna Ruyatkina, Maksim Yur'evich Sorokin

“…We also address cardioprotectiveproperties of glimeperide due to its anti-atherogenic activity, capacity to correct endothelial dysfunction and hemostatic system, as wellas absence of inhibitory effect on ischemic preconditioning.…”
Get full text

Myocardial impairment in rheumatoid arthritis patients with normal left ventricular function: findings from speckle tracking echocardiography by Rim Dhahri, Mahfoudhi Houaida, Ismail Dergaa, Lobna Ben Ammar, Halil İbrahim Ceylan, Youssef Ben Abderrazek, Insaf Fenniche, Sarra Chenik, Wafa Fehri, Raul Ioan Muntean, Imène Gharsallah

“…Traditional echocardiogram frequently overlooks early myocardial failure, necessitating more sensitive imaging modalities, such as speckle tracking echocardiography (STE), to effectively diagnose subclinical left ventricular systolic dysfunction (LVSD). …”
Get full text

Plumbagin ameliorates ferroptosis of ovarian granulosa cells in polycystic ovary syndrome by down-regulating SLC7A5 m6A methylation modification through inhibition of YTHDF1 by ZhaoWei Cai, RuoPeng Zhang, RongJu Liu, Li Zhao, LiLing Zhou

“…One of its core pathologies is ovarian granulosa cell (GC) dysfunction, and ferroptosis, as a novel cell death mode dependent on iron ions and lipid peroxidation, may be involved in the PCOS process, but the exact mechanism is unknown. …”
Get full text

Audit on Prolactin Monitoring for Patients on Oral/Intramuscular Risperidone and Intramuscular Paliperidone by Meekha Suresh

“…One of its common side effects is hyperprolactinemia, which can cause a range of symptoms. …”
Get full text

Remimazolam attenuated lipopolysaccharide-induced behavioral deficits and neuronal injury via activation of the Nrf2 pathway by Yi Wei, Sining Pan, Zhan Zhou, Ying Yang, Tianxiao Liu, Jing Chen, Yubo Xie

“…Abstract Sepsis is a severe disorder that is always accompanied by brain injury and dysfunction. This study aimed to evaluate the effects of remimazolam, a new ultra-short-acting sedative, on LPS-induced neuronal injury, and the role of Nrf2 signaling pathway involved. …”
Get full text

Kidney damage on fertility and pregnancy: A Mendelian randomization. by Jin Ren, Qiuyan Huang, Xiaowei Lie, Xingli Tong, Qi Yao, Ge Zhou

“…Besides, whether mild kidney dysfunction can affect fertility and pregnancy still needs exploration. …”
Get full text

Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells. by Dustin M Lee, Kyle J Sevits, Micah L Battson, Yuren Wei, Kimberly A Cox-York, Christopher L Gentile

“…These results may have implications for understanding the deleterious effects of high saturated fat diets on cardiovascular dysfunction and disease risk.…”
Get full text

Leucine-rich α-2 glycoprotein 1 (LRG1) during inflammatory complications after allogeneic stem cell transplantation and CAR-T cell therapy by John Greenwood, Petra Knaus, Stephen Moss, Olaf Penack, Lars Bullinger, Sarah Mertlitz, Katarina Riesner, Martina Kalupa, Nora Uhlig, Steffen Cordes, Lydia Verlaat, Mina Jamali, Ningyu Li, Hadeer Mohamed Elsayed Rasheed Mohamed, Jerome Jatzlau, Pedro Vallecillo-Garcia

“…A major clinical problem after allogeneic hematopoietic stem cell transplantation (alloHSCT) and after chimeric antigen receptor (CAR) T-cell therapy is the induction of hyperinflammatory side effects, which are typically associated with severe endothelial dysfunction.Methods We investigated LRG1 in preclinical models and in patient samples.Results In prospective studies, we found elevated LRG1 serum levels in patients with cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome after CAR-T-cell therapy as well as in patients with acute graft-versus-host disease (aGVHD) after alloHSCT.In preclinical models of aGVHD, we found vasculature-associated LRG1 upregulation as well as LRG1 pathway gene upregulation. …”
Get full text

Optical Imaging Demonstrates Tissue-Specific Metabolic Perturbations in Mblac1 Knockout Mice by Busenur Ceyhan, Parisa Nategh, Mehrnoosh Neghabi, Jacob A. LaMar, Shalaka Konjalwar, Peter Rodriguez, Maureen K. Hahn, Matthew Gross, Gregory Grumbar, Kenneth J. Salleng, Randy D. Blakely, Mahsa Ranji

“…Mutations in the C. elegans swip-10 gene result in dopamine (DA) dependent motor dysfunction accompanied by DA neuron degeneration. Recently, the putative human ortholog of swip-10 (MBLAC1) was implicated as a risk factor in AD, a disorder that, like PD, has been associated with mitochondrial dysfunction. …”
Get full text

Dietary yeast extract prevents alcoholic liver disease in mice via correcting gut dysbiosis and improving intestinal barrier function by Hao Han, Lei Tian, Yajing Dong, Yanyang Han, Xiaoman Wang, Qian Cheng, Haibo Zhang, Yan Zhang

“…The present study aimed to investigate the protective effects of YE on ALD and explore the underlying mechanism based on gut microbiota. …”
Get full text

Impact of dapagliflozin on metabolic phenotype, hormone levels, and fertility in female mice after prolonged high-fat diet by Xiaolin Chen, Zhuoni Xiao, Na Dai, Mingxia Fan

“…Throughout the experiment period, dapagliflozin exhibited favorable effects on reproductive function along with insulin sensitivity and luteinizing hormone (LH) release from the pituitary gland.DiscussionIn conclusion, this study demonstrates that dapagliflozin alleviated HFD-induced reproductive dysfunction independently of obesity, peripheral tissue insulin resistance, and systemic inflammation, suggesting its potential as a promising treatment for diet-related ovulation disorders.…”
Get full text

Mesenchymal stem cell-derived small extracellular vesicles reduced hepatic lipid accumulation in MASLD by suppressing mitochondrial fission by Yifei Chen, Fuji Yang, Yanjin Wang, Yujie Shi, Likang Liu, Wei Luo, Jing Zhou, Yongmin Yan

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver disease characterized by lipid accumulation in liver cells. …”
Get full text