Intraoperative phrenic nerve stimulation to prevent diaphragm fiber weakness during thoracic surgery. by Guilherme Bresciani, Thomas Beaver, A Daniel Martin, Robbert van der Pijl, Robert Mankowski, Christiaan Leeuwenburgh, Coen A C Ottenheijm, Tomas Martin, George Arnaoutakis, Shakeel Ahmed, Vinicius M Mariani, Wei Xue, Barbara K Smith, Leonardo F Ferreira

“…Thoracic surgery rapidly induces weakness in human diaphragm fibers. The dysfunction is thought to arise from combined effects of the surgical procedures and inactivity. …”
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Chromatin remodeling in lymphocytic function and fate: the multifaceted roles of SWI/SNF complex by Renjie Miao, Yun Liu, Yun Liu, Shuo Shen, Wenxin Wang, Wenxin Wang, Shengjun Wang, Shengjun Wang

“…During lymphocytic differentiation and functional development, the SWI/SNF complex exerts its effects by binding to specific transcription factors (TFs) or DNA sequences via its subunits, which are thereafter recruited to the promoter or enhancer regions of target genes, rendering each subunit crucial wherein. …”
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Advances in Autophagy–Lysosomal Pathway and Neurodegeneration via Brain–Gut Axis by Ping Yao, Hailong Han

“…Past reviews have mainly studied the ALP’s direct neuroprotective effects or the gut microbiota’s role in neurodegeneration separately. …”
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Association between methylmalonic acid and composite dietary antioxidant index and diabetic retinopathy: data from National Health and Nutrition Examination Survey by Xue Pan

“…Abstract Background Oxidative stress and mitochondrial dysfunction play an important role in diabetic retinopathy (DR), and serum methylmalonic acid (MMA) levels are related to oxidative stress and mitochondrial dysfunction. …”
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A comparative study of ovulation induction by clomiphene citrate vs letrozole by Hemant Deshpande, Madhukar Shinde, Neha Ellath, Vidya Gaikwad

“…Objectives: The present study was conducted to compare ovulation induction by clomiphene citrate and letrozole in women with ovulatory dysfunction. Methodology: In this open label comparative randomized clinical trial, patients aged 20 to 40 years with infertility diagnosed with ovulatory dysfunction were treated with either letrozole or clomiphene citrate in the Obstetrics and Gynecology OPD, of Dr. …”
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Reln-Dab1 pathway mitigates retinal ganglion cell apoptosis in retinal ischemia-reperfusion injury by Ning Xu, Zongyuan Li, Xiangwen Zeng, Yilin Jiang, Tunan Sun, Shuyu Liu, Na Li, Zhao Li, Yifei Huang, Liqiang Wang

“…After supplementing exogenous Reelin protein and adeno-associated virus (AAV)-targeted regulation of Reln in vivo, morphological and functional experiments demonstrated its effectiveness in protecting RGCs survival, maintaining morphological integrity of the retina, and inhibiting post-injury retinal dysfunction. …”
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iPSC-derived cardiomyocytes and engineered heart tissues reveal suppressed JAK2/STAT3 signaling in LMNA-related emery-dreifuss muscular dystrophy by Hangping Fan, Zongkuai Yang, Hangying Ying, Jiuxiao Zhao, Xiaochen Wang, Junhao Gong, Lingying Li, Xujie Liu, Tingyu Gong, Qing Ke, Lenan Zhuang, Ping Liang

“…Conversely, pharmacological or genetic activation of JAK2/STAT3 signaling effectively rescues both the arrhythmic and contractile dysfunction phenotypes in EDMD iPSC-CMs via improvements in mitochondrial function. …”
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Early developmental origins of cortical disorders modeled in human neural stem cells by Xoel Mato-Blanco, Suel-Kee Kim, Alexandre Jourdon, Shaojie Ma, Sang-Hun Choi, Alice M. Giani, Miguel I. Paredes, Andrew T. N. Tebbenkamp, Fuchen Liu, Alvaro Duque, Flora M. Vaccarino, Nenad Sestan, Carlo Colantuoni, Pasko Rakic, Gabriel Santpere, Nicola Micali

“…This work opens perspectives to explore human brain dysfunction at early phases of development.…”
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Dietary Fiber as Prebiotics: A Mitigation Strategy for Metabolic Diseases by Xinrui Gao, Sumei Hu, Ying Liu, S. A. Sanduni Samudika De Alwis, Ying Yu, Zhaofeng Li, Ziyuan Wang, Jie Liu

“…This review focuses on the application of DF in modulating metabolic diseases with special attention on the effect of DF on intestinal dysfunction. Furthermore, the molecular mechanisms through which DF alleviates intestinal disorders are discussed, including modulating the secretion of gastrointestinal neurotransmitters and hormones, the expression of aquaporins, and the production of short-chain fatty acids.…”
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Mechanistic insights into Nrf2-driven pathogenesis and therapeutic targeting in spinal cord injury by Tao Xie, Tao Xie, Jiyu Xu, Xinyu Liu, Yaquan Yu, Yang Lu, Tao Wang, Feng Gao, Hui Yuan, Hui Yuan

“…Spinal cord injury (SCI) is a traumatic disease of the central nervous system that can result in significant tissue damage and neurological dysfunction. The pathophysiological process of SCI encompasses both primary and secondary injuries, involving various pathological mechanisms such as oxidative stress, inflammation, autophagy, ferroptosis, and mitochondrial dysfunction. …”
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Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson’s disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation by Chunyan Mu, Kaiquan Shao, Mingyu Su, Yurong Guo, Yuxiang Qiu, Ruiao Sun, Sihan Sun, Yaoyu Sun, Chenkai Liu, Wei Wang, Xiaoling Qin, Chuanxi Tang

“…Restoring GCase glycosylation, limiting GlcCer synthesis, or blocking ERK signaling mitigates these effects. This study highlights LPC’s role in promoting α-synuclein aggregation and autophagolysosomal dysfunction, advancing our understanding of PD pathology.…”
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Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity by Ikko Sakamoto, Shuichi Shibuya, Hidetoshi Nojiri, Kotaro Takeno, Hiroshi Nishimune, Keisuke Yaku, Takashi Nakagawa, Muneaki Ishijima, Takahiko Shimizu

“…In the present study, we examined the pathological effects of mitochondrial dysfunction induced by mitochondrial superoxide dismutase (SOD2) depletion on glycogen metabolism. …”
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Cardiomyocyte-derived USP13 protects hearts from hypertrophy via deubiquitinating and stabilizing STAT1 in male mice by Jibo Han, Liming Lin, Zimin Fang, Diyun Xu, Lintao Wang, Bozhi Ye, Xue Han, Xiaohong Long, Julian Min, Gaojun Wu, Guang Liang, Yi Wang

“…Abstract Cardiac hypertrophy leads to ventricular dysfunction and heart failure. Deubiquitinating enzymes are responsible for preserving the substrate protein stability and are essential to myocardial hypertrophy. …”
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Glycolipid Metabolism Disorder in the Liver of Obese Mice Is Improved by TUDCA via the Restoration of Defective Hepatic Autophagy by Qinyue Guo, Qindong Shi, Huixia Li, Jiali Liu, Shufang Wu, Hongzhi Sun, Bo Zhou

“…However, the mechanism underlying how TUDCA is involved in insulin resistance is not fully understood. We tested the effects of TUDCA on autophagic dysfunction in obese mice. …”
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The green tea component (−)-epigallocatechin-3-gallate protects against cytokine-induced epithelial barrier damage in intestinal epithelial cells by Rita Rosenthal, Anne Waesch, Kopano Valerie Masete, Alain S. Massarani, Jörg-Dieter Schulzke, Nina A. Hering

“…Among other beneficial effects, EGCG was shown to be protective in inflammatory bowel disease (IBD), a condition associated with barrier dysfunction. …”
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Metabolic reprogramming of macrophages in the context of type 2 diabetes by Leonel Witcoski Junior, Jordana Dinorá de Lima, Amanda Girardi Somensi, Lucas Brito de Souza Santos, Giulia Leonel Paschoal, Thalita Suemy Uada, Thais Sibioni Berti Bastos, André Guilherme Portela de Paula, Rebeca Bosso Dos Santos Luz, Andressa Pacheco Czaikovski, Mariana Rodrigues Davanso, Tarcio Teodoro Braga

“…In contrast, pro-resolutive macrophages, which prioritize fatty acid metabolism, have different effects on glucose homeostasis. Metaflammation, a chronic low-grade inflammation, is induced by pro-inflammatory macrophages and significantly contributes to the progression of T2D, creating an environment conducive to metabolic dysfunction. …”
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Hemoperfusion Combined With Continuous Renal Replacement Therapy in the Management of ARDS COVID‐19 Patients: A Quasi‐Experimental Study by Seyed MohammadReza Hashemian, Ameneh Jafari, Batoul Khoundabi, Hamidreza Jamaati, Payam Rahimi

“…ABSTRACT Background and Aims Critically ill patients in COVID‐19 to the intensive care unit (ICU) may develop multiple organ dysfunction syndrome, with some requiring extracorporeal organ support. …”
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Engineered MEVs for photoreceptor-targeted delivery of USP25 to alleviate diabetic retinopathy by Yaoxiang Sun, Shenyuan Chen, Xiaoyuan Qi, Yuntong Sun, Zhengmei Jiang, Jie Chang, Yongjun Ma, Jin Huang, Benshuai You, Fengtian Sun

“…MEVsMH42-USP25 exhibited elevated repairing efficiency to attenuate retinal dysfunction and photoreceptor loss in db/db mice. Our study develops an MEV-based nanocarrier for photoreceptor-targeted delivery and highlights the effectiveness of MEVsMH42-USP25 as novel therapeutics for DR. …”
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4-Hydroxycinnamic acid attenuates neuronal cell death by inducing expression of plasma membrane redox enzymes and improving mitochondrial functions by Sujin Park, Yoon A Kim, Jaewang Lee, Hyunsoo Seo, Sang-Jip Nam, Dong-Gyu Jo, Dong-Hoon Hyun

“…Some therapeutic applications focus on enhancing neuronal cell survival during the pathogenesis of neurodegenerative diseases, including mitochondrial dysfunction. Plasma membrane (PM) redox enzymes are crucial in maintaining cellular physiology and redox homeostasis in response to mitochondrial dysfunction. …”
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Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer by Jun-Bo Yuan, Gui-Xin Gu, Bang-Ming Jin, Qing Han, Bing-Hui Li, Li Zhang, Bin Xu, Xuan Zhu, Guang-Hui Jin

“…Furthermore, loss of menin led to mitochondrial dysfunction, elevated levels of reactive oxygen species (ROS), and genome instability. …”
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