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4781
Modern View on the Etiology and Methods of Treatment of Bruxism: а Review
Published 2024-12-01“…When choosing one of the intervention options to suppress or reduce the activity of bruxism, it is necessary to take into account the corresponding indications, contraindications and side effects of each treatment option, as well as the individual characteristics of the patient. …”
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4782
Perioperative period in heart transplantation with extremely prolonged ischemic times (>6 hours)
Published 2022-09-01“…Our own experience shows that HTx from donors with prolonged ischemic time could be effective.…”
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4783
Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention
Published 2025-07-01“…Multi-domain interventions like FINGER effectively combine dietary modifications with lifestyle changes to delay dementia onset in at-risk older adults. …”
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4784
Bifidobacterium animalis subsp. lactis genome resources and metabolite profiling at the strain level and their ability to alleviate anxiety-like behavior in a sleep-deprived mouse...
Published 2025-12-01“…Bifidobacterium animalis subsp. lactis is a well-known probiotic with potential benefits for alleviating sub-health symptoms, including immune dysfunction and anxiety. Given the strain-specific nature of its probiotic effects, identifying effective strains for sub-health alleviation is crucial. …”
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4785
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice
Published 2025-01-01“…Hydroxyurea (HU), a sickle cell disease (SCD) drug approved by FDA, shows protective effect in nephropathy. This study aims to understand whether the application of HU could be effective to treat DKD.MethodsThe streptozotocin (STZ)-induced diabetic mice, and high glucose (HG)-treated human renal mesangial cells (HRMCs) were used to investigate the effect of HU on DKD. …”
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4786
Platelet Activation on Lung Function During Ex Vivo Lung Perfusion, Lung Transplantation, and the Role of Antiplatelet Therapy: A Narrative Review
Published 2025-09-01“…Studies on EVLP have found an association between platelet activation and adverse effects on lung function, whereas in lung transplantation, platelet activation appears to play a role in primary graft dysfunction. …”
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4787
Drug Pipeline for MASLD: What Can Be Learned from the Successful Story of Resmetirom
Published 2025-02-01“…Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), represent a growing global health problem linked to obesity, insulin resistance, and dyslipidemia. …”
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4788
Suppressing TLR4 alleviates cerebral injury in heatstroke rats through the modulation of microglial polarization
Published 2025-12-01“…The TLR4 antagonist TAK-242 was administered to evaluate its impact on neurological dysfunction, brain edema, learning and memory deficits, and histopathological alterations in the hippocampus.Results The inhibition of TLR4 using TAK-242 led to a significant reduction in neurological dysfunction and brain edema in rats subjected to HS. …”
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4789
Care of a patient with heat stroke combined with multi-organ failure treated with extracorporeal membrane oxygenation combined with continuous renal replacement therapy
Published 2025-01-01“…The comprehensive diagnosis encompassed HS, multiple organ dysfunction syndrome, electrolyte imbalance and hypoalbuminemia. …”
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4790
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression
Published 2015-11-01“…Abstract Adipocyte dysfunction correlates with the development of diabetes. …”
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4791
Dietary Genistein Influences Number of Acetylcholine Receptors in Female Diabetic Jejunum
Published 2017-01-01“…Background. Intestinal dysfunction in the ob/ob mouse model of diabetes mimics that seen clinically. …”
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4792
Lipid Dysmetabolism in Canine Chronic Liver Disease: Relationship Between Clinical, Histological and Immunohistochemical Features
Published 2025-03-01“…Chronic liver diseases (CLDs) in dogs are progressive conditions that often lead to liver failure. Metabolic dysfunctions such as cholestasis, obesity, hyperlipidemia, and endocrine disorders play a key role in human liver diseases like MASLD (Metabolic Dysfunction Associated Steatotic Liver Disease) and MASH (Metabolic Dysfunction Associated Steatohepatitis), but their significance in canine CLDs is poorly understood. …”
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4793
Transcutaneous Temperature-controlled Radiofrequency for Vaginal Rejuvenation
Published 2024-10-01“…Background: Vaginal laxity and sexual dysfunction are commonly experienced by women, but are typically stigmatized and considered inappropriate to discuss openly. …”
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4794
Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone
Published 2025-01-01“…These systemic metabolic alterations are aligned with our previously published proteomics findings in cardiac tissues from the same rats, which showed elevated inflammatory markers (e.g., IL-6, TNF-α) and mitochondrial dysfunction. In conclusion, this study provides new insights into the systemic metabolic effects of air pollutant exposure, identifies novel metabolic targets of pollutant-induced toxicity, highlights the complex interactions resulting from combined exposure to multiple pollutants, and underscores the importance of assessing the combined effects of multiple pollutants in air pollution risk assessments.…”
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4795
Angiotensin II infusion induces marked diaphragmatic skeletal muscle atrophy.
Published 2012-01-01“…Both CHF and CKD patients have respiratory muscle dysfunction, however the potential effects of Ang II on respiratory muscles are unknown. …”
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4796
Air Pollution Microplastics with the Potential Risk of Lung Disease: A Systematic Review
Published 2025-06-01“…Their accumulation in lung tissue may lead to oxidative stress, inflammation, and epithelial barrier dysfunction. This systematic review evaluates the respiratory health effects of AMPs exposure. …”
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4797
Differential ferroptosis regulation in red and white gastrocnemius under obesity and its Attenuation by exercise and dietary restriction
Published 2025-07-01“…HFRV partially reversed ferroptosis in RG by upregulating GPX4, while the effects in WG were limited. Lipid peroxidation and iron accumulation were more effectively attenuated in RG than in WG following HFRV intervention. …”
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4798
Heat therapy preserves myofibre size and SERCA‐mediated Ca2+ uptake in the mouse soleus after tenotomy surgery
Published 2025-05-01“…Heat shock protein 70 (HSP70) is a heat‐inducible chaperone protein that binds to SERCA and protects against its dysfunction. While previous research has shown HT to upregulate HSP70 in rodent muscle, even in the unloaded state, the effects of HT on SERCA function in rodent skeletal muscle under these conditions remain unknown. …”
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4799
Latent profile analysis of psychiatric symptoms and the Ability to Participate in Social Roles and Activities
Published 2025-07-01“…While diagnosis had a statistically significant effect on class membership, the effect size was negligible. …”
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4800
Functional disruption of stress modulatory circuits in a model of temporal lobe epilepsy.
Published 2018-01-01“…Whether neuroendocrine dysregulation and psychiatric comorbidities reflect direct effects of epilepsy-related pathologies, or secondary effects of disease burden particular to humans with epilepsy (i.e. social estrangement, employment changes) is not clear. …”
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