Functional Constipation in Children: overview and new outcomes by Kamila Stępień, Maria Przygoda, Joanna Śnieżna, Gabriela Trestka, Sabina Adamczyk, Urszula Zelik, Jakub Dziewic, Wojciech Florczak, Wiktoria Domino, Jagienka Włodyka, Karol Dzwonnik

“…A multidisciplinary approach is essential for effective treatment, addressing both physiological and psychological aspects to optimize long-term health outcomes for children with FC. …”
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Energy metabolism: An emerging therapeutic frontier in liver fibrosis by Iram Irshad, Saleh A Alqahtani, Kenichi Ikejima, Ming-Lung Yu, Manuel Romero-Gomez, Mohammed Eslam

“…Although there have been significant advancements in understanding the molecular mechanisms involved in liver fibrosis, effective therapeutic strategies to reverse or halt the condition remain limited. …”
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Harnessing nanotechnology for stem-cell therapies: revolutionizing neurodegenerative disorder treatments – a state-of-the-art update by Neevashini Chengebroyen, Anmol Seelan, Kamal Yoonus Thajudeen, Saad Ali Alshehri, Aritra Biswas, Israrahmed Adur, Vino Sundararajan, Sajitha Lulu Sudhakaran, Harpreet Singh

“…Neurodegenerative disorders, marked by the gradual degeneration and dysfunction of neurons, pose substantial clinical challenges due to the paucity of effective therapeutic strategies and the intricate and multifactorial nature of their underlying pathophysiology. …”
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A Scientometric Assessment of MAFLD in Children and Adolescents from 2007–2024 by Raju Vaishya, Anupam Sibal, Brij Mohan Gupta, Ghouse Modin N Mamdapur, Abhishek Vaish

“…Purpose: Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is a growing concern in children and adolescents, with prevalence estimated between 7.6% and 9.6%. …”
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Advances in Structural Biology for Anesthetic Drug Mechanisms: Insights into General and Local Anesthesia by Hanxiang Liu, Zheng Liu, Huixian Zhou, Rongkai Yan, Yuzhen Li, Xiaofeng Zhang, Lingyu Bao, Yixin Yang, Jinming Zhang, Siyuan Song

“…Future research aims to develop receptor-subtype-specific anesthetics, Nav1.7-selective local anesthetics, and investigate the neural mechanisms of anesthesia-induced unconsciousness and postoperative cognitive dysfunction (POCD). By integrating structural biology, AI-driven drug discovery, and neuroscience, anesthesia research is evolving toward safer, more effective, and personalized strategies, enhancing clinical outcomes and patient safety.…”
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sLithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage by Yu Zhang, Qiqi Lou, Hao Lian, Ran Yang, Ruolin Cui, Leyang Wang, Bitao Ma, Lingli Hou, Lilun Jin, Weiran Teng

“…This study confirmed that LA@ZIF-8 inhibits the pro-inflammatory phenotype of RAW264.7 macrophages through the NF-ĸB signaling pathway, effectively alleviates mitochondrial dysfunction, and delays articular cartilage degeneration caused by the joint inflammatory microenvironment mediated by synoval macrophages. …”
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Primary Graft Failure after Heart Transplantation by Arjun Iyer, Gayathri Kumarasinghe, Mark Hicks, Alasdair Watson, Ling Gao, Aoife Doyle, Anne Keogh, Eugene Kotlyar, Christopher Hayward, Kumud Dhital, Emily Granger, Paul Jansz, Roger Pye, Phillip Spratt, Peter Simon Macdonald

“…It manifests as severe ventricular dysfunction of the donor graft and carries significant mortality and morbidity. …”
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Increased Anticoagulant Requirement in Total Hip Replacement Patients Post-COVID: A Comparative Study in the Indian Population by Anteshwar Birajdar, Mukesh Phalak, Tushar Chaudhari, Damarla Meghana

“…The use of LMWH in adjusted doses was effective and did not increase bleeding risk, underscoring the need for tailored anticoagulation protocols. …”
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Comparative Efficacy and Tolerability of Treatments for Erythromelalgia: A Systematic Review by Abdullah S. Algarni, Reem M. Alharthi, Shaden O. Alqurashi, Ruba M. Alghanmi, Rimaz R. Aldawsari, Maysaa A. Alghamdi, Ramy Samargandi

“…This syndrome can be significantly debilitating, and finding effective treatment options often proves to be quite difficult. …”
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Albumin-bilirubin grade as an alternative to Child–Pugh class for evaluating liver function within staging systems for hepatocellular carcinoma by Ming-Cheng Guan, Qian Ding, Qian Zhao, Na Li, Ren-Xia Zhang, Shi-Yu Zhang, Ji Wang, Hong Zhu

“…Results The study identified severity of liver dysfunction, malignancy of tumor, and health status of patients as crucial factors of prognosis in HCC. …”
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Functional and structural brain remodeling in patients with degenerative cervical myelopathy following cervical decompression surgery by Bingyong Xie, Haoyu Ni, Jiyuan Yao, Zhibin Xu, Sicheng Bian, Haoxiang Wang, Kun Zhu, Xianyong Wu, Peiwen Song, Yuanyuan Wu, Yongqiang Yu, Fulong Dong

“…Abstract Background Degenerative cervical myelopathy (DCM) represents a prevalent etiology of neurological dysfunction, for which cervical decompression surgery (CDS) constitutes the principal therapeutic intervention. …”
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Efficacy of a combination of dutasteride, tadalafil, and solifenacin in the treatment of previously unsuccessful patients by Kirill Kosilov, Irina Kuzina, Vladimir Kuznetsov, Olga Barabash, Ekaterina Fedorishcheva

“…Conclusions: The simultaneous administration of standard doses of dutasteride, solifenacin, and tadalafil for 3 months is safe, effective, and can be recommended for patients with BPH to reduce symptoms of obstruction and hyperactivity of the bladder and maintain sexual function.…”
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Dual Role of Lysosome in Cancer Development and Progression by Xiao-Qiong Chen, Quan Yang, Wei-Min Chen, Zi-Wei Chen, Guang-Hui Guo, Xuan Zhang, Xiao-Ming Sun, Tao Shen, Fu-Hui Xiao, Yun-Feng Li

“…A myriad of studies has shown that the dysfunction of lysosome is implicated in human aging and various age-related diseases, including cancer. …”
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Comparison of Oliceridine to Remifentanil for Optimal Analgesia in Mechanical Ventilation (CO-ROAM): Study Protocol for a Multicenter Randomized Controlled Trial by Jing-chao Luo, Sen Lu, Xi-liang Fu, Jun Shen, Hong-li He, Chun Pan, Xiao-bo Huang

“…This new drug offers the potential for effective pain relief with fewer side effects. However, its efficacy and safety profile in mechanically ventilated ICU patients remain to be fully elucidated. …”
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Atrial Cardiomyopathy and Cryptogenic Stroke by G. R. Ramazanov, E. A. Kovaleva, R. A. Novikov, S. S. Petrikov

“…Until recently, the dominant point of view, suggesting that the main cause of CS is paroxysmal atrial fibrillation (AF) and for the secondary prevention of IS in this cohort of patients, oral anticoagulants may be more effective than antiplatelet agents, has not been confirmed. …”
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EFFICACY OF CORONARY BYPASS AND RADIOFREQUENCY ABLATION IN ATRIAL FIBRILLATION PATIENTS WITH CHRONIC KIDNEY DISEASE by B. G. Iskenderov, O. N. Sisina, M. N. Mamedov

“…To evaluate the influence of kidney dysfunction on the efficacy of simultaneous coronary bypass grafting together with radiofrequency ablation (RFA) in patients with comorbid persisting atrial fibrillation (AF) and chronic kidney disease (CKD).Material and methods. …”
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Atherosclerosis and Cardiovascular Complications in People Living with HIV: A Focused Review by Michele Salvatore Paternò Raddusa, Andrea Marino, Benedetto Maurizio Celesia, Serena Spampinato, Carmen Giarratana, Emmanuele Venanzi Rullo, Bruno Cacopardo, Giuseppe Nunnari

“…This paper explores the multifaceted relationship between HIV infection, ART, and cardiovascular health, focusing on the mechanisms by which HIV and ART contribute to increased cardiovascular risk, including the promotion of endothelial dysfunction, inflammation, immune activation, and metabolic disturbances. …”
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To Increase the Practice of Hand Washing with the Correct 7-Step Technique for 2 Minutes for Doctors Conducting Vaginal Deliveries from Baseline to 80 % in 4 Weeks by Sarika Gautam, Nisha Malik, Meenakshi Chauhan, Vani Malhotra, Savita Singhal, Roopa Malik, Smiti Nanda

“…Germs are transmissible from one person to another. Hand washing is an effective measure to prevent infection in a health care setting. …”
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Clinico-epidemiology and resistance patterns of community-acquired and hospital-acquired staphylococcus aureus sepsis in children by Sahar Siddiqui, Mohd Suhail Lone, Umar Amin Qureshi, Rayees Khanday

“…Complications (such as septic shock, respiratory failure, and multi-organ dysfunction) were more frequently encountered in patients with HA-SA. …”
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Health technology assessment (HTA) of prostatic urethral lift (PUL) for the treatment of benign prostatic hyperplasia (BPH) in the Italian context by Agostino Fortunato, Eugenio Di Brino, Michele Basile, Debora Antonini, Filippo Rumi

“…Traditional treatments like transurethral resection of the prostate (TURP) and Holmium Laser Enucleation (HoLEP) are effective but often associated with complications and sexual dysfunction. …”
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