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4681
A systematic review on the determinants of long‐term kidney sequelae after hypertensive diseases of pregnancy
Published 2025-07-01“…Abstract Introduction Preeclampsia is a pregnancy syndrome defined by high blood pressure (≥140/90 mmHg) and at least one other associated complication, including proteinuria, maternal organ dysfunction, or uteroplacental dysfunction, after 20 weeks of gestation. …”
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4682
Resumption of Employment after Cervical Cancer Surgery: a 3-Year Follow-Up Study of Long-term Outcomes
Published 2024-12-01“…This emphasizes the need for effective strategies to support patients in resuming their occupational activities post-treatment. …”
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4683
Clinical efficacy of exercise therapy for lumbar disc herniation: a systematic review and meta-analysis of randomized controlled trials
Published 2025-03-01“…Exercise therapy, as an economically effective treatment method, can enhance the strength of core muscle groups and effectively alleviate the symptoms of LDH. …”
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4684
Analysing the role of ultraviolet A1 phototherapy in the treatment of primary cutaneous lichen amyloidosis in a patient with skin phototype 1
Published 2025-07-01“…The successful resolution of refractory pruritus with UVA1 phototherapy suggests it as an effective treatment for widespread, treatment-resistant LA. …”
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4685
Engineering fibroblast with reprogramming and spheronization for bone defect repair
Published 2025-08-01“…However, the stem and progenitor cells that give rise to osteoblasts, as well as osteoblasts themselves, exhibit dysfunction with aging. Although chemical reprogramming of fibroblasts into osteoblasts has been achieved, effective cell-based therapies or living materials have not been established in clinical practice. …”
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4686
Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved]
Published 2024-10-01“…Our primary hypothesis is that people with bipolar disorder have some pathophysiological change at the level of the retina which makes them hypersensitive to the visual and non-visual effects of light, and therefore more susceptible to circadian rhythm dysfunction. …”
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4687
Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‐Dependent Manner
Published 2018-09-01“…Arginase activity, p32 protein expression, spermine amount, and [Ca2+]m were increased in the aortas from apolipoprotein E (ApoE−/−) mice fed a high‐cholesterol diet, and intravenous administration of small interfering RNA against p32 restored Ca2+/Ca2+/calmodulin‐dependent kinase II‐dependent eNOS Ser1177 phosphorylation and improved endothelial dysfunction. The effects of arginase II downregulation were not associated with elevated NO production when tested in aortic endothelia from eNOS knockout mice. …”
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4688
Targeted Overexpression of Mitochondrial ALDH2 in Coronary Endothelial Cells Mitigates HFpEF in a Diabetic Mouse Model
Published 2025-07-01“…Common pathophysiological mechanisms in HFpEF include oxidative stress, microvascular dysfunction, and chronic unresolved inflammation. Our lab focuses on oxidative stress-mediated cellular dysfunction, particularly the toxic effects of lipid peroxidation products like 4-hydroxy-2-nonenal (4HNE). …”
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4689
DOBUTAMINE USAGE IN CARDIOLOGICAL PRACTICE
Published 2016-01-01“…Dobutamine is inotropic drug indicated in systolic dysfunction. Data on dobutamine pharmacology, its effects on hemodynamics, coronary and peripheral blood flow, myocardial electrophysiology are presented. …”
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4690
IMIDAZOLINE RECEPTOR AGONISTS: DO WE KNOW EVERYTHING ABOUT THEIR CAPABILITIES?
Published 2015-12-01“…Moxonidine advantages, namely positive effects on insulin resistance, endothelial dysfunction, lipid profile, and plasma fibrinolytic activity are considered.…”
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4691
HYPERTHYROIDISM AND ATRIAL FIBRILLATION
Published 2017-07-01“…Particular attention is paid to the effect on the heart of subclinical thyrotoxicosis, which is defined as a dysfunction of the thyroid gland, characterized by low serum concentration of thyrotropin, normal values of free thyroxine and free triiodothyronine. …”
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4692
Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile aci...
Published 2025-03-01“…Metasilicate-based alkaline mineral water (AMW) has shown potential therapeutic effects on gastrointestinal disorders; however, the mechanisms involved and their overall effects on the gut-liver axis have not been explored. …”
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4693
Fetal and obstetrics manifestations of mitochondrial diseases
Published 2024-09-01“…Therefore, perturbation on mitochondrial function can have a pathological effect on pregnancy. Several shreds of evidence collected in preclinical models revealed that severe mitochondrial dysfunction is incompatible with life or leads to critical developmental defects, highlighting the importance of correct mitochondrial function during embryo-fetal development. …”
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4694
Immune checkpoint inhibitor-associated acute kidney injury and mortality: An observational study.
Published 2021-01-01“…AKI directly related to the effect of checkpoint inhibitor toxicity did not increase mortality. …”
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4695
Stellate ganglion block attenuates chronic stress induced depression in rats.
Published 2017-01-01“…The objective of this study was to determine the antidepressant-like effects of SGB on the autonomic system and the HPA axis, apoptosis-related proteins, related spatial learning and memory impairment, and sensorimotor dysfunction.…”
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4696
Apelin from Perivascular Adipose Tissue Is Involved in the Regulation of Vasorelaxation and Renal Function in Metabolic Syndrome
Published 2024-10-01“…The perivascular adipose tissue (PVAT) regulates the arterial tone by releasing vasoactive molecules. PVAT dysfunction favoring the vasorelaxation response could contribute to the development of kidney disease in metabolic syndrome (MetS). …”
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4697
Antioxidant and Anti-Inflammatory Benefits of <i>Gymnema inodorum</i> Leaf Extract in Human Umbilical Vein Endothelial Cells Under Peroxynitrite Stress
Published 2025-04-01“…Endothelial dysfunction driven by oxidative and nitrosative stress is a critical factor in the pathogenesis of diabetes-related vascular complications. …”
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4698
Dysbiosis and Metabolic Dysregulation of Salivary Microbiota in Schizophrenia
Published 2025-02-01“…Correlations between microbial dysbiosis and elevated levels of certain metabolites, such as L-methionine sulfoxide (L-MetO) and tyramine, were observed, suggesting links to oxidative stress.Conclusion: The study highlights the presence of significant dysbiosis and metabolic dysfunction in the salivary microbiota of SZ patients, suggesting that alterations in the oral microbiome may contribute to SZ pathogenesis. …”
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4699
Ultrasmall Superparamagnetic Magnetite Nanoparticles as Glutamate-Responsive Magnetic Resonance Sensors
Published 2025-07-01“…Despite the utility of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in diagnosing such conditions, the development of effective glutamate-sensitive contrast agents remains a challenge. …”
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4700
Transplantation of Cardiac Mesenchymal Progenitor Cell Sheets for Myocardial Vascularization after an Infarction (Experimental Study)
Published 2018-12-01“…The use of TEC helps to reduce or temporarily eliminate the effect of factors that contribute to progressive heart dysfunction by local paracrine exposure and activation of the revascularization processes in the affected zone.…”
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