Showing 4,681 - 4,700 results of 8,597 for search 'effective dysfunction', query time: 0.16s Refine Results
  1. 4681

    A systematic review on the determinants of long‐term kidney sequelae after hypertensive diseases of pregnancy by Marie Haudiquet, Marion D'Incau, Vincent Letouzey, Olivier Moranne

    Published 2025-07-01
    “…Abstract Introduction Preeclampsia is a pregnancy syndrome defined by high blood pressure (≥140/90 mmHg) and at least one other associated complication, including proteinuria, maternal organ dysfunction, or uteroplacental dysfunction, after 20 weeks of gestation. …”
    Get full text
    Article
  2. 4682
  3. 4683

    Clinical efficacy of exercise therapy for lumbar disc herniation: a systematic review and meta-analysis of randomized controlled trials by Shaojie Du, Shaojie Du, Zeyu Cui, Zeyu Cui, Shurui Peng, Shurui Peng, Jieyu Wu, Jieyu Wu, Jinhai Xu, Jinhai Xu, Wen Mo, Wen Mo, Jie Ye, Jie Ye

    Published 2025-03-01
    “…Exercise therapy, as an economically effective treatment method, can enhance the strength of core muscle groups and effectively alleviate the symptoms of LDH. …”
    Get full text
    Article
  4. 4684

    Analysing the role of ultraviolet A1 phototherapy in the treatment of primary cutaneous lichen amyloidosis in a patient with skin phototype 1 by Sam Hughes, Rossel Ahmad, Maryam Kakar, Novakovic Ljubomir, John Ferguson

    Published 2025-07-01
    “…The successful resolution of refractory pruritus with UVA1 phototherapy suggests it as an effective treatment for widespread, treatment-resistant LA. …”
    Get full text
    Article
  5. 4685

    Engineering fibroblast with reprogramming and spheronization for bone defect repair by Yanjiao Li, Bin Jiang, Zhen Wu, Zhaoxia Ma, Lihua Qiu, Wen Cui, Yunhui Zhao, Jinghe Yan, Daiping Ma, Xingfei Wu, Shu Liang, Sitao Wang, Yanqun Zhao, Mengting Wang, Min Hu

    Published 2025-08-01
    “…However, the stem and progenitor cells that give rise to osteoblasts, as well as osteoblasts themselves, exhibit dysfunction with aging. Although chemical reprogramming of fibroblasts into osteoblasts has been achieved, effective cell-based therapies or living materials have not been established in clinical practice. …”
    Get full text
    Article
  6. 4686

    Investigating light sensitivity in bipolar disorder (HELIOS-BD) [version 2; peer review: 2 approved] by Amber Roguski, Iain H. Campbell, Lyle Armstrong, Amy Ferguson, Baljean Dhillon, Majlinda Lako, Gerrit Hilgen, Jasna Martinovic, Tom MacGillivray, Renata L. Riha, Nicole Needham, Nayantara Santhi, Philipp Ritter, Manuel Spitschan, Malcolm von Schantz, Daniel J. Smith

    Published 2024-10-01
    “…Our primary hypothesis is that people with bipolar disorder have some pathophysiological change at the level of the retina which makes them hypersensitive to the visual and non-visual effects of light, and therefore more susceptible to circadian rhythm dysfunction. …”
    Get full text
    Article
  7. 4687

    Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32‐Dependent Manner by Bon‐Hyeock Koo, Hye‐Mi Hwang, Bong‐Gu Yi, Hyun Kyo Lim, Byeong Hwa Jeon, Kwang Lae Hoe, Young‐Guen Kwon, Moo‐Ho Won, Young Myeong Kim, Dan E. Berkowitz, Sungwoo Ryoo

    Published 2018-09-01
    “…Arginase activity, p32 protein expression, spermine amount, and [Ca2+]m were increased in the aortas from apolipoprotein E (ApoE−/−) mice fed a high‐cholesterol diet, and intravenous administration of small interfering RNA against p32 restored Ca2+/Ca2+/calmodulin‐dependent kinase II‐dependent eNOS Ser1177 phosphorylation and improved endothelial dysfunction. The effects of arginase II downregulation were not associated with elevated NO production when tested in aortic endothelia from eNOS knockout mice. …”
    Get full text
    Article
  8. 4688

    Targeted Overexpression of Mitochondrial ALDH2 in Coronary Endothelial Cells Mitigates HFpEF in a Diabetic Mouse Model by Guodong Pan, Bipradas Roy, Emmanuel Oppong Yeboah, Thomas Lanigan, Roland Hilgarth, Rajarajan A. Thandavarayan, Michael C. Petriello, Shailendra Giri, Suresh Selvaraj Palaniyandi

    Published 2025-07-01
    “…Common pathophysiological mechanisms in HFpEF include oxidative stress, microvascular dysfunction, and chronic unresolved inflammation. Our lab focuses on oxidative stress-mediated cellular dysfunction, particularly the toxic effects of lipid peroxidation products like 4-hydroxy-2-nonenal (4HNE). …”
    Get full text
    Article
  9. 4689

    DOBUTAMINE USAGE IN CARDIOLOGICAL PRACTICE by M. Yu. Giljarov

    Published 2016-01-01
    “…Dobutamine is inotropic drug indicated in systolic dysfunction. Data on dobutamine pharmacology, its effects on hemodynamics, coronary and peripheral blood flow, myocardial electrophysiology are presented. …”
    Get full text
    Article
  10. 4690

    IMIDAZOLINE RECEPTOR AGONISTS: DO WE KNOW EVERYTHING ABOUT THEIR CAPABILITIES? by D. V. Nebieridze, T. V. Kamyshova

    Published 2015-12-01
    “…Moxonidine advantages, namely positive effects on insulin resistance, endothelial dysfunction, lipid profile, and plasma fibrinolytic activity are considered.…”
    Get full text
    Article
  11. 4691

    HYPERTHYROIDISM AND ATRIAL FIBRILLATION by I. M. Marusenko, E. G. Petrova

    Published 2017-07-01
    “…Particular attention is paid to the effect on the heart of subclinical thyrotoxicosis, which is defined as a dysfunction of the thyroid gland, characterized by low serum concentration of thyrotropin, normal values of free thyroxine and free triiodothyronine. …”
    Get full text
    Article
  12. 4692

    Metasilicate-based alkaline mineral water improves the growth performance of weaned piglets by maintaining gut-liver axis homeostasis through microbiota-mediated secondary bile aci... by Jian Chen, Kanwar K. Malhi, Xiaowei Li, Xiangwen Xu, Jianxun Kang, Bichen Zhao, Yaru Xu, Xuenan Li, Jinlong Li

    Published 2025-03-01
    “…Metasilicate-based alkaline mineral water (AMW) has shown potential therapeutic effects on gastrointestinal disorders; however, the mechanisms involved and their overall effects on the gut-liver axis have not been explored. …”
    Get full text
    Article
  13. 4693

    Fetal and obstetrics manifestations of mitochondrial diseases by Alessia Adelizzi, Anastasia Giri, Alessia Di Donfrancesco, Simona Boito, Alessandro Prigione, Emanuela Bottani, Valentina Bollati, Valeria Tiranti, Nicola Persico, Dario Brunetti

    Published 2024-09-01
    “…Therefore, perturbation on mitochondrial function can have a pathological effect on pregnancy. Several shreds of evidence collected in preclinical models revealed that severe mitochondrial dysfunction is incompatible with life or leads to critical developmental defects, highlighting the importance of correct mitochondrial function during embryo-fetal development. …”
    Get full text
    Article
  14. 4694
  15. 4695

    Stellate ganglion block attenuates chronic stress induced depression in rats. by Weiwei Wang, Weidong Shi, Hua Qian, Xijin Deng, Tong Wang, Wenzhi Li

    Published 2017-01-01
    “…The objective of this study was to determine the antidepressant-like effects of SGB on the autonomic system and the HPA axis, apoptosis-related proteins, related spatial learning and memory impairment, and sensorimotor dysfunction.…”
    Get full text
    Article
  16. 4696

    Apelin from Perivascular Adipose Tissue Is Involved in the Regulation of Vasorelaxation and Renal Function in Metabolic Syndrome by Satomi Kagota, Kana Maruyama-Fumoto, Risa Futokoro, Kazumasa Shinozuka

    Published 2024-10-01
    “…The perivascular adipose tissue (PVAT) regulates the arterial tone by releasing vasoactive molecules. PVAT dysfunction favoring the vasorelaxation response could contribute to the development of kidney disease in metabolic syndrome (MetS). …”
    Get full text
    Article
  17. 4697

    Antioxidant and Anti-Inflammatory Benefits of <i>Gymnema inodorum</i> Leaf Extract in Human Umbilical Vein Endothelial Cells Under Peroxynitrite Stress by Onanong Nuchuchua, Suthasinee Seephan, Wanwisa Srinuanchai, Piya Temviriyanukul, Varisa Pongrakhananon

    Published 2025-04-01
    “…Endothelial dysfunction driven by oxidative and nitrosative stress is a critical factor in the pathogenesis of diabetes-related vascular complications. …”
    Get full text
    Article
  18. 4698

    Dysbiosis and Metabolic Dysregulation of Salivary Microbiota in Schizophrenia by Wang J, Lu L, Ren L, Zhu R, Jiang Y, Qiao Y, Li Y

    Published 2025-02-01
    “…Correlations between microbial dysbiosis and elevated levels of certain metabolites, such as L-methionine sulfoxide (L-MetO) and tyramine, were observed, suggesting links to oxidative stress.Conclusion: The study highlights the presence of significant dysbiosis and metabolic dysfunction in the salivary microbiota of SZ patients, suggesting that alterations in the oral microbiome may contribute to SZ pathogenesis. …”
    Get full text
    Article
  19. 4699

    Ultrasmall Superparamagnetic Magnetite Nanoparticles as Glutamate-Responsive Magnetic Resonance Sensors by Hannah Mettee, Aaron Asparin, Zulaikha Ali, Shi He, Xianzhi Li, Joshua Hall, Alexis Kim, Shuo Wu, Morgan J. Hawker, Masaki Uchida, He Wei

    Published 2025-07-01
    “…Despite the utility of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in diagnosing such conditions, the development of effective glutamate-sensitive contrast agents remains a challenge. …”
    Get full text
    Article
  20. 4700

    Transplantation of Cardiac Mesenchymal Progenitor Cell Sheets for Myocardial Vascularization after an Infarction (Experimental Study) by Konstantin V. Dergilev, Zoya I. Tsokolaeva, Ivan A. Ryzhkov, Elena V. Parfenova

    Published 2018-12-01
    “…The use of TEC helps to reduce or temporarily eliminate the effect of factors that contribute to progressive heart dysfunction by local paracrine exposure and activation of the revascularization processes in the affected zone.…”
    Get full text
    Article