Assessment of Clinical Characteristics and Outcomes of Liver Diseases Unique to Pregnancy at a Tertiary Hospital in Ethiopia: A Retrospective Cohort Study by Sintayehu Mekonnen, Henok Fisseha, Tewodros Getinet

“…A chi-square test was done to look for an association with a p value less than 0.05 considered statistically significant, and an odds ratio was determined to assess the effect size. Results. From 95 cases identified, preeclampsia/eclampsia with liver dysfunction accounted for 43 (45%), followed by hemolysis elevated liver enzyme and low platelet (HELLP syndrome) 35 (36.8%), hyperemesis gravidarum with liver dysfunction 9 (9.5%), acute fatty liver of pregnancy (AFLP) 7 (7.4%), and intrahepatic cholestasis of pregnancy 1 (1.1%). …”
Get full text

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review by Maryam N. ALNasser, Ghadir M. Alboraiy, Eman M. Alsowig, Fatimah M. Alqattan

“…This study aimed to evaluate the cholinesterase-inhibiting effects of various plant species and their compounds to identify new therapeutic candidates and reduce side effects. …”
Get full text

Association between Sympathetic Nervous System Activation, Obesity and Insulin Resistance by A. I. Kochetkov, O. D. Ostroumova, A. V. Starodubova, Т. М. Оstroumova, D. A. Bondarenko

“…In the second part of the paper experimental and clinical findings are presented indicating worsening of the hypertension mediated target-organ damage in the presence of concomitant obesity that emphases on the crucial role of amplified adrenergic stimuli in the formation of these disorders. The promoting effect of obesity and concomitant sympathetic nervous system overactivation on the development of left ventricular hypertrophy, endothelial dysfunction and vascular damage, renal dysfunction and cognitive decline are considered. …”
Get full text

Pathophysiology of Angiotensin II-Mediated Hypertension, Cardiac Hypertrophy, and Failure: A Perspective from Macrophages by Kelly Carter, Eshan Shah, Jessica Waite, Dhruv Rana, Zhi-Qing Zhao

“…Heart failure is a complex syndrome characterized by cardiac hypertrophy, fibrosis, and diastolic/systolic dysfunction. These changes share many pathological features with significant inflammatory responses in the myocardium. …”
Get full text

Length of gestation and birth weight are associated with indices of combined kidney biomarkers in early childhood. by Yuri Levin-Schwartz, Paul Curtin, Katherine Svensson, Nicolas F Fernandez, Seunghee Kim-Schulze, Gleicy M Hair, Daniel Flores, Ivan Pantic, Marcela Tamayo-Ortiz, María Luisa Pizano-Zárate, Chris Gennings, Lisa M Satlin, Andrea A Baccarelli, Martha M Tellez-Rojo, Robert O Wright, Alison P Sanders

“…Infants born prematurely or with low birth weights are more susceptible to kidney dysfunction throughout their lives. Multiple proteins measured in urine are noninvasive biomarkers of subclinical kidney damage, but few studies have examined the joint effects of multiple biomarkers. …”
Get full text

n-Butylidenephthalide recovered calcium homeostasis to ameliorate neurodegeneration of motor neurons derived from amyotrophic lateral sclerosis iPSCs. by Yu-Chen Deng, Jen-Wei Liu, Hsiao-Chien Ting, Tzu-Chen Kuo, Chia-Hung Chiang, En-Yi Lin, Horng-Jyh Harn, Shinn-Zong Lin, Chia-Yu Chang, Tzyy-Wen Chiou

“…Overall, this study supports the therapeutic effects of BP on ALS patient-derived neuron cells, and suggests that BP may be a promising candidate for future drug development.…”
Get full text

Alternate-day fasting differentially affects body composition, metabolic and immune response to fasting in male rats exposed to early-life adversity: Modulatory role of cafeteria d... by Sara C Sagae, Edson D R Paz, Bárbara Zanardini, Ana Claudia Amaral, Gabriela A Bronczek, Patrícia Koehler-Santos, Jarbas R de Oliveira, Celso R Franci, Márcio V F Donadio, Parker J Holman, Charlis Raineki

“…Alternate-day fasting (ADF) is a dietary regimen shown to improve immune and metabolic dysfunction related to obesity. Here, we evaluate if ADF can ameliorate the negative effects of early-life adversity and/or cafeteria diet on biological, immune and metabolic parameters. …”
Get full text

Dual-responsive nanoparticles targeting ACE-II senescence for therapeutic mitigation of acute lung injury by Linlin Gao, Fushuang Zheng, Zhiling Fu, Wei Wang

“…These nanoparticles (NPs) effectively activate the AMP-activated protein kinase (AMPK)/Sirtuin 1 (SIRT1) signaling pathway, inducing the mitochondrial unfolded protein response (UPRmt) and reversing senescence-associated cellular dysfunction. …”
Get full text

Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model. by Mary J Obayemi, Christopher O Akintayo, Adesola A Oniyide, Ayodeji Aturamu, Olabimpe C Badejogbin, Chukwubueze L Atuma, Azeezat O Saidi, Hadiza Mahmud, Kehinde S Olaniyi

“…<h4>Background</h4>Adipose and hepatic metabolic dysfunctions are critical comorbidities that also aggravate insulin resistance in obese individuals. …”
Get full text

The role of metabolic syndrome in the pathogenesis of knee osteoarthritis: a new view on the problem by G. V. Poryadin, A. N. Zakhvatov, T. V. Tarasova, V. O. Timoshkin

“…Currently, numerous studies undeniably prove the influence of metabolic syndrome on osteoarthritis (OA) progression.In hyperlipidemia, free fatty acids abnormally accumulate in the cartilage tissue and provoke cell dysfunction and necrosis. Studies show that palmitate and stearate have a pronounced proapoptotic effect on chondrocytes of the articular cartilage.Mediators of the systemic inflammatory response produced by the adipose tissue act as a significant link in the pathogenesis of metabolic OA in the knee joint. …”
Get full text

Synergistic reversal of intrahepatic HCV-specific CD8 T cell exhaustion by combined PD-1/CTLA-4 blockade. by Nobuhiro Nakamoto, Hyosun Cho, Abraham Shaked, Kim Olthoff, Mary E Valiga, Mary Kaminski, Emma Gostick, David A Price, Gordon J Freeman, E John Wherry, Kyong-Mi Chang

“…These findings provide new insights into the mechanisms of virus-specific T cell dysfunction, and suggest that the synergistic effect by combined inhibitory receptor blockade might have a therapeutic application against chronic viral infection in vivo, provided that it does not induce autoimmunity.…”
Get full text

Urolithin A supplementation to improve endothelial and cerebrovascular function in middle-aged adults with obesity: Study protocol for a double-blind placebo-controlled randomized... by Ana Clara da C. Pinaffi-Langley, Camila B. Pinto, Zsofia Szarvas, Anna Peterfi, Zalan Kaposzta, Peter Mukli, Mihaly Muranyi, Cameron D. Owens, Cheryl Adams, Ali Shahriari, Henry Kinnard, Jr., Bryan Ticer, Leah Anderson, Stefano Tarantini, Yan Daniel Zhao, Norman G. Hord, Andriy Yabluchanskiy

“…Conclusion: The results of this trial will provide important insights into the effect of UroA on endothelial dysfunction in adults with obesity. …”
Get full text

Cardiovascular disease and ACE inhibitors: focusing on enalapril by G. A. Baryshnikova

“…Enalapril is one of the best-studied ACE inhibitors, demonstrating high effectiveness in treating arterial hypertension, chronic heart failure, and left ventricular dysfunction, including that after myocardial infarction. …”
Get full text

Supplementation with the Postbiotic BPL1™-HT (Heat-Inactivated <i>Bifidobacterium animalis</i> subsp. Lactis) Attenuates the Cardiovascular Alterations Induced by Angiotensin II In... by Mario de la Fuente-Muñoz, Marta Román-Carmena, Sara Amor, Daniel González-Hedström, Verónica Martinez-Rios, Patricia Martorell, Antonio M. Inarejos-García, Reme García Bou, Sonia Guilera-Bermell, Ángel L. García-Villalón, Miriam Granado

“…In conclusion, supplementation with the postbiotic BPL1™ HT prevents endothelial dysfunction, lowers blood pressure, and has cardioprotective effects in an experimental model of hypertension induced by AngII infusion in mice.…”
Get full text

Regulation of Mitochondrial Function by Natural Products for the Treatment of Metabolic Associated Fatty Liver Disease by Tingting Shi, Liping Yu, Rangxiao Zhuang, Jianjun Xi, Ruoyu He, Yidan Shao, Jinsong Huang, Shourong Liu, Xingxin Yang

“…In this article, we describe the relationship between mitochondria and MAFLD and discuss the beneficial effects of natural products as a future anti-MAFLD strategy. …”
Get full text

SGLT2 inhibitor upregulates myocardial genes for oxidative phosphorylation and fatty acid metabolism in Gαq-mice by Jordan M. Chambers, Dominique Croteau, David R. Pimentel, Adam C. Gower, Marcello Panagia, Tomas Baka, Fuzhong Qin, Ivan Luptak, Wilson S. Colucci

“…Background: Mitochondrial dysfunction with decreased ATP production and increased release of reactive oxygen species (ROS) is a hallmark of the failing heart. …”
Get full text

Cranial radiation disrupts dopaminergic signaling and connectivity in the mammalian brain by Die Zhang, Riya Thomas, Thanh Thai Lam, Ines Veselinovic, David R. Grosshans

“…Abstract Cognitive impairment is a common and challenging side effect of cranial radiation therapy for brain tumors, though its precise mechanisms remain unclear. …”
Get full text

Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage by Natalia Lazzarin, Costanzo Moretti, Giovanna De Felice, Elena Vaquero, Dario Manfellotto

“…Our data support the hypothesis that in patients with RM the presence of TAI is an indirect sign of a subtle thyroid dysfunction detectable by a specific test. This test give the possibility to identify women with RM in which specific therapeutic approaches could effectively improve the possibility for a successful pregnancy.…”
Get full text

Takotsubo Syndrome in a Young Patient After a Neurosurgical Operation by E. V. Reznik, A. A. Pazova, A. M. Dunaeva, M. E. Tursheva, E. V. Selezneva

“…Cardiomyopathy syndrome (stress-cardiomyopathy) is an acute reversible systolic dysfunction of left (or rare right) ventricle without stenotic atherosclerosis and/or thrombosis of coronary artery. …”
Get full text

Resistant Hypertension and Obstructive Sleep Apnea by Akram Khan, Nimesh K. Patel, Daniel J. O’Hearn, Supriya Khan

“…The mechanism proposed is a pattern of intermittent hypoxia associated with hyperaldosteronism, increased sympathetic tone, endothelial dysfunction, and inflammation. In this review we discuss the association between OSA and resistant HTN, the physiologic mechanisms linking OSA with resistant HTN, and the effect of continuous positive airway pressure therapy (CPAP) on blood pressure in patients with resistant HTN. …”
Get full text