AGGRESSIVE BEHAVIOR CORRECTION BY THE TRANSPLANTATION OF IN VITRO MODULATED IMMUNE CELLS by E. V. Markova, E. V. Serenko, M. A. Knyazheva

“…The most frequent increase in aggressiveness occurs in patients with depressive disorders, schizophrenia, reactive psychoses and adjustment disorders, which are known to be characterized by immunological dysfunction. Antipsychotics are widely used in the correction of psychomotor agitation; the antipsychotic effect of these drugs is manifested in the achievement of a sedative effect. …”
Get full text

Heart Rate Variability Biofeedback Training Can Improve Menopausal Symptoms and Psychological Well-Being in Women with a Diagnosis of Primary Breast Cancer: A Longitudinal Randomiz... by Karina Dolgilevica, Elizabeth Grunfeld, Nazanin Derakshan

“…Effective non-pharmacological solutions to address these are currently lacking. …”
Get full text

Current developments in robotic assistance technology for total knee arthroplasty: a comprehensive overview by Hongli Zhang, Xing-an Jiang, Bing-chen Jin, Hong-hao Zhang, Jun-bo Liang

“…Abstract Knee arthritis is a common degenerative joint disease, usually with joint swelling, chronic pain, and dysfunction as the main clinical manifestations. At present, the conservative treatment for knee arthritis is mostly using anti-inflammatory and analgesic drugs, but the effect is mostly temporary, and can not prevent its progress and surgery is usually the last treatment method. …”
Get full text

Targeting SARM1 as a novel neuroprotective therapy in neurotropic viral infections by Sheng He, Yanyan Zhu, Xinyue Wang, Gaofeng Zhang, Kaijian Hou, Xianzhu Xia, Zhenyou Jiang, Xiaoqian Gong, Pingsen Zhao

“…Currently, there is a lack of effective targeted treatments for this disease, which poses a significant public health concern. …”
Get full text

The approaches to prevention and therapy of cardiovascular disorders in children with chronic bronchopulmonary pathology by G. O. Lezhenko, О. Ye. Pashkova

“…The purpose of this study was to develop and evaluate the algorithm for cardiovascular disorders prevention and therapy effectiveness in children with chronic bronchopulmonary pathology. …”
Get full text

Desensitization for Vitamin B12 Hypersensitivity and How to Do It by Kinga Lis

“…Vitamin B12 deficiency causes dysfunction of various organs and systems in the body, including the central nervous system. …”
Get full text

The efficacy and safety of antiviral drugs of direct action in liver recipients with recurrence of chronic hepatitis C genotype 1 after transplantation by О. M. Tsiroulnikova, D. V. Umrik, I. A. Miloserdov, Е. Т. Egorova, R. A. Latypov

“…There have been no cases of irreversible liver transplant dysfunction or death of the recipient.The conclusion. …”
Get full text

Periscopic technique in Norwood operation is associated with better preservation of early ventricular functionCentral MessagePerspective by Puneet Bhatla, MD, TK Susheel Kumar, MD, Luv Makadia, MD, Brandon Winston, MPH, Catherine Bull, PNP-BC, James C. Nielsen, MD, David Williams, MD, Sujata Chakravarti, MD, Richard G. Ohye, MD, Ralph S. Mosca, MD

“…Patients with baseline RV dysfunction and significant tricuspid valve regurgitation were excluded. …”
Get full text

Identification of foam cell like M2 macrophages, AEBP1 biomarkers, and resveratrol as potential therapeutic in MASLD using Ecotyper and WGCNA by Hua Ye, Mengxia Sun, Wenjing Luo, Dahua Chen, Jiacheng Cai, Jia Dong, Liangshun Zhang, Huiwei Liu, Jinyu Kang, Feng Xu

“…Bidirectional Mendelian randomization (MR) analysis was used to validate the causal effect of AEBP1 on metabolic dysfunction-associated steatohepatitis (MASH). …”
Get full text

Deep brain stimulation on cognition in epilepsy: A concentration on learning and memory by Beibei Shen, Yi Shi, Yanlu Fu, Yina Cao, Yi Wang, Jiajia Fang

“…Cognitive dysfunction is one of the common comorbidities of epilepsy. …”
Get full text

Serum biomarkers of cardiovascular complications in COVID-19 by R. M. Gumerov, D. F. Gareeva, P. A. Davtyan, R. F. Rakhimova, T. I. Musin, Sh. Z. Zagidullin, A. E. Pushkareva, M. R. Plotnikova, V. Sh. Ishmetov, V. N. Pavlov, L. J. Motloch, N. Sh. Zagidullin

“…The coronavirus disease 2019 (COVID-19) affects not only the respiratory system, but also the cardiovascular system in 20-28% of cases, causing endothelial dysfunction, vasculitis, hyper- and hypocoagulation, myocarditis, endothelial dysfunction and other adverse effects. …”
Get full text

The organ function preservation characteristics of natural orifice specimen extraction (NOSES) surgery for colorectal cancer by Zhu Zhe, Fu Chuangang

“…Patients undergoing successful NOSES surgery for colorectal cancer tend to have earlier-stage disease with smaller tumors, and the risk of postoperative sexual dysfunction is lower. With thorough preoperative assessment and appropriate intraoperative management, postoperative anal dysfunction caused by various factors can be effectively avoided. …”
Get full text

Hypopituitarism and Cardiovascular Risk by Ivana Kraljević MD, PhD, Mirsala Solak MD, PhD, Ante Mandić MD, PhD, Katarina Mlekuš Kozamernik MD, Maja Raičević MD, PhD, Anida Divanović Slato MD, Zlata Kovačević MD, Emir Muzurović MD, PhD

“…Additionally, the presence of chronic inflammation and endothelial dysfunction further increases the risk of CVD in these patients. …”
Get full text

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing... by Zixuan Dong, Xiaobing Liu, Shichun Li, Xiaoling Fu

“…Moreover, as a versatile delivery vehicle for mitochondria, Mito@euMVs hold promising for treating mitochondrial dysfunction and aging‐related conditions.…”
Get full text

Gene therapy prevents onset of mitochondrial cardiomyopathy in neonatal mice with Ndufs6 deficiency by Xiaoxian Zhang, Li Huang, Cheng Li, Jinjuan Yang, Fuyu Duan, Qiang Su, Yuelin Zhang, Meng Kou, Xiaoya Zhou, Liyan Guo, Shaoxiang Chen, Yongxia Niu, Ziyue Li, Sihua Ou, Min Zhang, Kenneth King-Yip Cheng, Jianlong Wu, Xiang Xu, Qizhou Lian

“…AAV9-hNdufs6 therapy effectively prevented neonatal mice’s cardiac dysfunction onset, preserving CI activity and cristae structure for 11 months. …”
Get full text

Pulmonary arterial hypertension: Navigating the pathways of progress in diagnosis, treatment, and patient care by Miguel Azaredo Raposo, Daniel Inácio Cazeiro, Tatiana Guimarães, Nuno Lousada, Céline Freitas, Joana Brito, Susana Martins, Catarina Resende, Peter Dorfmüller, Rita Luís, Susana Moreira, Pedro Alves da Silva, Luís Moita, Mário Oliveira, Fausto J. Pinto, Rui Plácido

“…Recent advances in therapies targeting dysfunctional pathways beyond endothelial dysfunction may address the fundamental processes underlying the disease, raising the prospect of increasingly effective options for this high-risk group of patients with a historically poor prognosis. …”
Get full text

Examination of duodenal and colonic microbiome changes in mouse models of acute and chronic pancreatitis by Rabea Lange, Juliane Glaubitz, Fabian Frost, Andreas Geisz, Ali A. Aghdassi, F. Ulrich Weiss, Matthias Sendler

“…Mild acute pancreatitis, which is associated with a transient impairment of pancreatic secretion showed only minor changes in microbial composition, comparable to the ones seen in progressive dysfunctional mouse models of CP. The strongest changes were observed in a mouse model of severe AP, which suggest a direct effect of the immune response on gut microbiome in addition to a pancreatic dysfunction. …”
Get full text

Arterial hypertension in chronic kidney disease: current state of the problem by T. V. Zueva, T. V. Zhdanova

“…Because hypertension can be a cause and effect of CKD, its prevalence is higher and more difficult to control. …”
Get full text

Features of left ventricular remodeling in hypertension patients with comorbid gout by I. O. Daniuk, S. Ya. Dotsenko, D. G. Rekalov, I. V. Chorna

“…The significant increase in left ventricular mass, myocardial mass index and diastolic left ventricle dysfunction in patients with gout were revealed. Using the multivariate analysis of variance we determined an effect of hypertension degree, gout duration and abdominal obesity presence on the process of left ventricle remodeling. …”
Get full text

Gut Microbiota: Target for Modulation of Gut-Liver-Adipose Tissue Axis in Ethanol-Induced Liver Disease by Dhara Patel, Dixa Sharma, Palash Mandal

“…This review is aimed at the effect of ethanol on gut and adipose tissue in both rodent and human alcoholic models.…”
Get full text