Neuroglobin: A promising candidate to treat neurological diseases by Ivan Millan Yañez, Isabel Torres-Cuevas, Marisol Corral-Debrinski

“…Despite the progress made in the last decades in the understanding of a growing number of genetic and molecular causes of central nervous diseases, therapies that are effective to diminish or halt neuronal dysfunction/death are rare. …”
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Unmasking the Invisible Threat: Biological Impacts and Mechanisms of Polystyrene Nanoplastics on Cells by Wenxia Bu, Ye Cui, Yueyuan Jin, Xuehai Wang, Mengna Jiang, Ruiyao Huang, JohnPaul Otuomasiri Egbobe, Xinyuan Zhao, Juan Tang

“…This review systematically explores the biological effects and mechanisms of PS-NPs on cellular systems, encompassing oxidative stress, mitochondrial dysfunction, DNA damage, inflammation, and disruptions in autophagy. …”
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Choline Alphoscerate: A Therapeutic Option for the Management of Subthreshold Depression in the Older Population by Nicolò Granata, Marco Vercesi, Annamaria Bonfanti, Claudio Mencacci, Ilaria Coco, Mario Mangrella, Roberto Piazza, Giancarlo Cerveri

“…Treating StD in older adults is challenging due to the limited efficacy and side effects of traditional antidepressants. As a result, clinicians often adopt a “watchful waiting” strategy, which increases the risk of StD progressing into MDD or MCI. …”
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Analysis of fatty acid profiles of micronutrients and pharmaceuticals based on omega-3 polyunsaturated fatty acid extracts from natural sources by I. Yu. Torshin, O. A. Gromova, A. A. Garanin

“…Micronutrient and pharmaceutical preparations based on ω3-PUFA are widely used for cardioprotection (prevention of atherosclerosis, endothelial dysfunction, chronic inflammation, excessive thrombus formation), support of reproductive function during pregnancy and improvement of neurological development of children. …”
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The efficacy and safety of fecal microbiota transplantation in the treatment of sarcopenia: a retrospective study by Bo Yang, Xinhui Li, Jiahui Wang, Yue Xu, Le Wang, Zhifeng Wu, Di Zhao, Long Huang, Ning Li, Qiyi Chen, Zhongchen Liu

“…Targeting the gut-muscle axis has emerged as a promising therapeutic strategy to mitigate age-related muscle atrophy and dysfunction. Methods This study employed fecal microbiota transplantation (FMT) to restore intestinal homeostasis in patients with sarcopenia. …”
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Dual 500-μs wide pulse neuromuscular electrical stimulation enhancing sensorimotor cortical excitability by Yun Zhao, Yanying Yan, Xiaoling Zhang, Guanghui Xie, Renqaing Yang, Shuaidong Zou, Fengmei Gao, Wencheng Sun

“…BackgroundNeuromuscular electrical stimulation (NMES) is an effective tool to improve motor activation of patients with motor dysfunction. …”
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Thallium-induced neurocardiotoxicity in zebrafish: Protective role of adaptive UPR and DNA repair by Yung Chang, Chia-Hsien Wu, Jia-Huang Chen, Tsuyoshi Inoue, Chih-Kang Chiang

“…However, effective strategies to mitigate Tl toxicity remain lacking. …”
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Conditioned Medium of Bone Marrow-Derived Mesenchymal Stromal Cells as a Therapeutic Approach to Neuropathic Pain: A Preclinical Evaluation by Kelly Barbosa Gama, Dourivaldo Silva Santos, Afrânio Ferreira Evangelista, Daniela Nascimento Silva, Adriano Costa de Alcântara, Ricardo Ribeiro dos Santos, Milena Botelho Pereira Soares, Cristiane Flora Villarreal

“…Neuropathic pain is a type of chronic pain caused by injury or dysfunction of the nervous system, without effective therapeutic approaches. …”
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Serum endocan levels in fresh IVF/ICSI cycles in women with endometriosis: a comparative prospective study by Mehmet Ufuk Ceran, Nafiye Yilmaz, Eser Colak, Nilufer Bayraktar, Yusuf Aytac Tohma, Hulusi Bulent Zeyneloglu

“…Background: The current study tested the level of endocan, which is thought to have an effective role in both endothelial dysfunction and inflammation, in infertile women with endometriosis treated with in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). …”
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Interaction Between Periodontitis and MASLD: Pathophysiological Associations and Possibilities of Prevention and Therapy by Martina Juzbašić, Matej Tomas, Ana Petrović, Marija Hefer, Renata Sikora, Ana Mačković, Stjepan Siber, Martina Smolić

“…The aim is to offer novel insights that can help develop better prevention strategies and more effective treatments for both diseases.…”
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Phytomedicine Potential of <i>Oroxylum indicum</i> Root and Its Constituents: Targeting Alzheimer’s Disease by Rattana Summat, Pornthip Waiwut, Supawadee Daodee, Natsajee Nualkaew, Khemjira Phemphunananchai, Puguh Novi Arsito, Yaowared Chulikhit, Orawan Montakantirat, Charinya Khamphukdee, Chantana Boonyarat

“…Alzheimer’s disease (AD) is a neurodegenerative condition characterized by a gradual decline in cognitive function, for which few effective treatments exist. This study investigated the neuroprotective potential of <i>Oroxylum indicum</i> root extract and its key constituents (baicalein, chrysin, oroxylin A) against AD hallmarks. …”
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General Principles of Treatment of Multiple Sclerosis in Children by Shorobura M.

“…Side effects of glucocorticoid effect should be minimized and not using prolonged scheme (over 21 days) of methylprednisolone. …”
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Sensory neuron–specific block of multifaceted sodium channels mitigates neuropathic pain behaviors of osteoarthritis by Seung Min Shin, Brandon Itson-Zoske, Hao Xu, Hongfei Xiang, Fan Fan, Quinn H. Hogan, Hongwei Yu

“…Multiple voltage-gated sodium channels (NaVs) in the peripheral sensory neurons (PSNs) regulate action potentials and their dysfunction contributes to the pain pathogenesis of osteoarthritis (OA). …”
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Decoding the genome of SARS-CoV-2: a pathway to drug development through translation inhibition by Shan-Na Wu, Ting Xiao, Hui Chen, Xiao-Hong Li

“…We also discuss the current strategies for blocking SARS-CoV-2 translation through viral RNA degradation or RNA element dysfunction.…”
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Clinical efficacy of distractor combined with arthroscopy-assisted minimally invasive screw fixation for calcaneal fractures by Kunming Ren, Yanmei Wang, Jie Zhao, Xuecheng Sun, Xiaoming Yang, Naibo Feng

“…These fractures can result in severe pain, swelling, and dysfunction of the heel. Surgical intervention is essential to reduce the risk of post-traumatic arthritis and restore foot function. …”
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Small Molecule Drug C381 Attenuates Brain Vascular Damage Following Repetitive Mild Traumatic Injury by Lulin Li, Andy Nguyen, Brian Zhao, Ryan Vest, Lakshmi Yerra, Bryan Sun, Jian Luo

“…Traumatic brain injury (TBI) remains a significant public health concern, with no effective therapeutic interventions to ameliorate the enduring consequences. …”
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Potential applications and mechanisms of natural products in mucosal-related diseases by Wang Lin, Wang Lin, Xie Ruishi, Xie Ruishi, Xu Caijiao, Xu Caijiao, Luo Haoming, Luo Haoming, Hua Xuefeng, Yao Jiyou, Lu Minqiang, Zhou Shuo, Zhou Shuo, Zhu Ming, Zhu Ming, Li Dongyang, Li Dongyang, Fang Xiaoxue, Fang Xiaoxue

“…Current mainstream treatments for mucosa-associated diseases primarily involve glucocorticoids and immunosuppressants, but their long-term use may cause adverse effects. Therefore, the development of safer and more effective therapeutic strategies has become a focus of research. …”
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Development of a Mitochondrial Permeability Transition‐Driven Necrosis‐Related Prognostic Signature in Cervical Cancer: Integrating Bulk Transcriptomic and Single‐Cell Data by Jiaojiao Niu, Sreenivasan Sasidharan

“…Then, risk score was an independent prognostic factor for CC, and a nomogram demonstrated effective predictive accuracy for CC survival outcomes. …”
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Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents by Jie Dai, Qianyue Li, Ziyi Li, Zhonglin Zang, Yan Luo, Chenghe Zhou

“…The highly active <b>19a</b> with rapid bactericidal properties displayed imperceptible resistance development trends, negligible hemolytic toxicity, and effective biofilm inhibitory effects. Preliminary explorations on antibacterial mechanisms revealed that compound <b>19a</b> could cause membrane damage, embed in intracellular DNA to hinder bacterial DNA replication, and induce metabolic dysfunction. …”
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STUDY OF URSODEOXYCHOLIC ACID INFLUENCE ON EFFICACY AND SAFETY OF STATIN THERAPY IN PATIENTS WITH DISEASES OF THE LIVER, GALL BLADDER AND/OR BILIARY TRACT (THE RAKURS STUDY) by S. Yu. Martsevich, N. P. Kutishenko, L. Yu. Drozdova, O. V. Lerman, V. A. Nevzorova, I. I. Reznik, G. V. Shavkuta, D. A. Yahontov

“…To assess the potential of ursodeoxycholic acid (UDCA) in the prevention of liver dysfunction in patients with cardiovascular diseases (CVD) and high risk of cardiovascular events (CVE) with indications for statins use.Material and methods. …”
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