Clinical efficacy and biomechanical analysis of a novel hollow pedicle screw combined with kyphoplasty for the treatment of Kümmell disease by Shixiao Zhong, Hui Zhong, Kun Huang, Yayu Zhao, Wen Lei, Weichao Li

“…Conclusion HPS‐KP was a safe and effective treatment for KD, effectively relieving pain, restoring vertebral height, and correcting local kyphosis, and it had better biomechanical stability and safety than ordinary single PKP and PKP combined with pediculoplasty in avoiding cement loosening and displacement.…”
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Steroid-responsive autoimmune psychosis with cerebrospinal fluid-restricted oligoclonal bands and positive tissue-based assay findings: a case series of three patients by Yuanyuan Luo, Hao Sun, Jian Fan, Xu Zhang, Ying He

“…Autoimmune psychosis should be considered when antipsychotic drugs or modified electroconvulsive therapy are not effective in patients with psychotic disorders.…”
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Hormonal modulation, mitochondria and Alzheimer’s prevention: the role of GLP-1 agonists and estrogens by Fernando Lizcano, Fernando Lizcano, Fernando Lizcano, Fernando Lizcano, Daniela Sanabria, Daniela Sanabria, Eliana Aviles, Eliana Aviles

“…Alzheimer’s disease (AD) is the most prevalent cause of dementia worldwide, disproportionately affecting women and lacking effective disease-modifying therapies. While traditional approaches have focused on amyloid β (Aβ) plaques and tau pathology, emerging evidence highlights the role of metabolic dysfunction, mitochondrial impairment, and hormonal signaling in the pathogenesis of AD. …”
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Chimeric exosomes-derived immunomodulator restoring lymph nodes microenvironment for sensitizing TNBC immunotherapy by Mengchi Sun, Yuxia Wu, Zhichao Chen, Boyan Zhang, Xiaoyang Liu, Peipei Ouyang, Ping Chen, Lujun Chen, Zhonggui He, Tao Han, Heran Li, Jin Sun, Shuang Cai, Qiuhua Luo

“…Abstract Immunotherapy is a breakthrough in the treatment of triple-negative breast cancer (TNBC), although it is only effective in a portion of patients. Our clinical studies find that pathological elevated level of reactive oxygen species (ROS) and lipid homeostasis imbalance are closely associated with dysfunction of dendritic cells (DCs) in the immunosuppressive lymph nodes (LNs) microenvironment of TNBC patients following immunotherapy, which greatly affect the immunotherapeutic efficacy. …”
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The interplay of factors in metabolic syndrome: understanding its roots and complexity by Md. Sharifull Islam, Ping Wei, Md Suzauddula, Ishatur Nime, Farahnaaz Feroz, Mrityunjoy Acharjee, Fan Pan

“…When cells become resistant to insulin’s effects, it disrupts various molecular pathways, leading to IR. …”
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Interferon-based anti-viral therapy for hepatitis C virus infection after renal transplantation: an updated meta-analysis. by Fang Wei, Junying Liu, Fen Liu, Huaidong Hu, Hong Ren, Peng Hu

“…The most frequent side-effect requiring discontinuation of treatment was graft dysfunction (14 cases, 45.1%). …”
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Reactive oxygen species induced by SARS-CoV-2 infection can induce EMT in solid tumors: Potential role of COVID-19 in chemo-resistance and metastasis by Melina Moulaeian, Saeid Ferdousmakan, Sara Banihashemi, Shadi Homayounfar, Ajay Prakash Pasupulla, Yalda Malekzadegan

“…We emphasize the disturbance of mitochondria dysfunction, the overproduction of ROS in SARS-CoV-2-infected cells, and its consequences for the beginning of EMT. …”
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Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation by Peng Wang, Jiayue Liu, Min Zhang, Juan Yang, Peihan Lian, Xiu Cheng, Jianhua Qin

“…Abstract Radiation‐induced brain injury (RIBI) is caused by exposure to high doses of ionizing radiation and characterized by severe cognitive dysfunction and brain necrosis. However, the pathogenesis of RIBI is not fully understood, and no effective intervention is available. …”
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Spot Urine PCR as an Independent Predictor of Renal Disease in Patients with Essential Hypertension by Spoorthi P. Yadagudde, Jayannan Jayasenan, Anbarasu Duraisamy

“…Conclusion: This study confirms a significant association between hypertension and proteinuria, with age, BMI, and blood pressure playing crucial roles in renal dysfunction. Spot urine PCR proved to be an effective and cost-efficient tool for early detection of kidney impairment in hypertensive patients. …”
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Non-surgical treatment of cervical radiculopathy in outpatient settings. Case report by Aleksei I. Isaikin, Ekaterina K. Kerimova, Kinan Mouki

“…CR can present with various clinical symptoms and their combination in the form of not only pain (usually with "distant" radiation) but also symptoms of dysfunction (hypoaesthesia, motor disorders, decreased tendon reflexes) in the innervation zone of the corresponding spinal roots. …”
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Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer Therapy by Tusher- Al-Arafat, Aihong Mao, Takanori Katsube, Bing Wang

“…In conclusion, elucidating the molecular mechanisms by which p53 influences radiosensitivity is essential for advancing our understanding of the radiation response in cancer cells and developing more effective therapeutic approaches to cancer treatment. …”
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Therapeutic aspects of hormone replacement therapy in postmenopausal women with metabolic syndrome: cardiologist’s opinion by T. V. Adasheva, V. S. Zadionchenko, O. N. Poryvkina, O. Yu. Demicheva, T. M. Terekhova, M. A. Mironova

“…No negative effects on metabolic profile or IR were observed. …”
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Post‐hoc analysis of the tofogliflozin post‐marketing surveillance study (J‐STEP/LT): Tofogliflozin improves liver function in type 2 diabetes patients regardless of BMI by Hiroyuki Uchinuma, Mitsunori Matsushita, Masaya Tanahashi, Hideki Suganami, Kazunori Utsunomiya, Kohei Kaku, Kyoichiro Tsuchiya

“…Weight loss has proven effective in treating metabolic dysfunction‐associated steatotic liver disease (MASLD) in obese patients with type 2 diabetes, with sodium‐glucose cotransporter 2 (SGLT2) inhibitors showing promising results. …”
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Cold exposure promotes the progression of osteoarthritis through downregulating APOE in cartilage by Yueqi Zhang, Mei Fu, Chun Zhou, Xiao Wang, Zengxin Jiang, Chang Jiang, Shengyang Guo, Zhiying Pang, Chenzhong Wang, Tao Yu, Senbo An, Xiuhui Wang, Zhe Wang

“…Conditional knockout of Apoe in cartilage aggravated cartilage degeneration, leading to lipid accumulation, increased ROS production, mitochondrial dysfunction, and elevated chondrocyte apoptosis. Treatment with RGX-104, an LXRβ agonist, reversely restored APOE expression, mitigated aberrant lipid accumulation and countered the detrimental effects of cold exposure on OA progression. …”
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Assisted reproductive technologies in multiple sclerosis by O.D. Shulga, M.I. Hrytsko, A.S. Romaniuk, O.G. Kotsiuba

“…In this regard, the method of in vitro fertilization and cryopreservation of oocytes as the most effective types of ART for patients with MS was considered in detail.…”
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miR-3653-3P EXPRESSION IN PERIPHERAL BLOOD OF PATIENTS WITH OVARIAN CARCINOMA by Fatma Seher Pektopal Delek, Demet Akdeniz Ödemiş, Özge Şükrüoğlu Erdoğan, Seda Kılıç Erciyas, Büşra Kurt Gültaşlar, Şeref Buğra Tunçer, Hülya Yazıcı

“…Ovarian cancer is a late-stage cancer with early and frequent recurrence, and there is still no effective treatment.There are no sensitive and specific biomarkers to be used effectively in the early diagnosis and treatment of the disease.Those currently used in the clinic are extremely insufficient for the early diagnosis and treatment follow-up of the disease, in terms of accurately determining the minimal residual disease.Many studies have shown that deregulation or dysfunction of miRNAs in the small non-coding RNA class contributes to cancer development However, it is known that the expressions of a number of miRNAs differ in ovarian cancer. …”
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Role of visceral adiposity in functional recovery after myocardial infarction in females by Yu. Zhukova, M. Zak

“…Unlike general obesity, visceral fat contributes to systemic inflammation, endothelial dysfunction, and poor cardiac recovery, particularly in women. …”
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Analysis of clinical characteristics and factors of central nervous system damage caused by acute bipyridine herbicide poisoning by Hu Tang, Xiaorong Chen, Nengzhi Xia, Bin Wu, Guangju Zhao, Yahui Tang, Zhongqiu Lu

“…Summary: Acute bipyridine herbicide poisoning poses a significant clinical challenge due to the lack of an effective antidote, with CNS damage leading to particularly poor outcomes. …”
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Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference by Olga Golounina, Ildar Minniakhmetov, Ramil Salakhov, Rita Khusainova, Ekaterina Zakharova, Igor Bychkov, Natalia Mokrysheva

“…In the context of endocrine disorders, molecular therapy is particularly effective in modulating pathogenic mechanisms such as defective insulin signaling, beta-cell dysfunction and hormonal imbalances. …”
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Simultaneous reconstruction of tibial osteomyelitis-complicated soft tissue defects using free flap transplantation in conjunction with the masquelet technique: a retrospective stu... by Baobao Xue, Yubo Pan, Bingxuan Wang, Haifeng Dang, Tian Li, Chao Yang, Junjun Fan

“…Wounds of all patients’ legs healed well, without complications (foot drop, joint dysfunction, or deformity in the affected limbs). Conclusion The anterolateral femoral free flap combined with Masquelet technique is an effective treatment strategy for tibial osteomyelitis combined with soft tissue defects. …”
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