Apigenin as a multifaceted antifibrotic agent: Therapeutic potential across organ systems by Xiaoyong Hu, Djandan Tadum Arthur Vithran, Zhaoying Yang, Ting Zou, Yuanyuan Dou, Hongjian Li

“…Despite its significant impact on global morbidity and mortality, effective antifibrotic treatments remain limited. Apigenin, a plant-derived flavonoid found in common sources such as parsley, chamomile, and celery, has garnered attention for its potent antifibrotic, antioxidant, and anti-inflammatory effects. …”
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Unraveling the pathogenesis of bone marrow hematopoietic injury and the therapeutic potential of natural products by Jing Long, Hengzhou Lai, Yuqing Huang, Fengming You, Yifang Jiang, Qixuan Kuang

“…Natural products, particularly those derived from Chinese herbal medicines and other natural sources, have emerged as promising therapeutic options due to their distinctive mechanisms and minimal side effects. A deeper understanding of the underlying mechanisms of bone marrow hematopoietic injury could illuminate how natural products exert their effects, thereby optimizing treatment strategies and offering safer, more effective options for patients. …”
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The M2 Macrophages Importance Role in Psoriasis by Ahmed Hussein Hasan Alshihmani, Mahmoud Mahmoudi, Ramiar Kamal Kheder, Afsane Fadaee, Seyed‐Alireza Esmaeili

“…The disease is influenced by a combination of genetic factors, environmental triggers, immune system dysfunction, and its systemic nature with comorbidities like cardiovascular diseases and depression. …”
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Leveraging T cell co-stimulation for enhanced therapeutic efficacy of trispecific antibodies targeting prostate cancer by Jiaqi Zhao, Xinyu Gu, Yanping Sun, Linling Zhou, Jie Bi, Liqiang Pan

“…Furthermore, T cells treated with co-stimulatory trispecific antibodies demonstrated enhanced metabolic activity characterized by increased oxidative phosphorylation and elevated glycolysis.Conclusions Collectively, incorporating co-stimulatory receptor targeting domains represents a potentially effective strategy to unlock the full therapeutic potential of T-cell-engaging antibodies for the treatment of solid tumors.…”
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Efficient Extraction of Synovial Chondromatosis Utilizing the Loose Body Vacuum by Jesus E. Cervantes BS, Eric Hu BS, Stephanie A. Boden MD, Shane J. Nho MD, MS

“…Background: Synovial chondromatosis is a benign proliferation of the synovial membranes surrounding joints and tendon sheaths that may cause serious joint instability and dysfunction. If left untreated, loose bodies generated within the joint can lead to accelerated joint destruction. …”
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A preliminary follow-up study on irreversible electroporation therapy in older patients with prostate cancer by Zhi-Yu Xia, Jun Yang, Fan Xiao, Jin-Zhou Xu, Xing-Yu Zhong, Shao-Gang Wang, Qi-Dong Xia

“…Complications included urinary issues in 3 patients (27.3%), urethral pain in 2 patients (18.2%), and sexual dysfunction in 1 patient (9.1%). Conclusion This study suggests that IRE therapy is a safe and effective treatment option for older prostate cancer patients, with promising results in preserving urinary and sexual functions. …”
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Comparison of Anterior and Posterior Approach Bilateral Sacrospinous Ligament Fixation for Vaginal Vault Prolapse by Fatih Şahin, Ramazan Adan

“…Conclusions: AB-SSLF is an effective method in the surgical treatment of apical and anterior pelvic prolapse. …”
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A weighted bag of visual words model for predicting fetal growth restriction at an early stage by Ani Dong, Yiheng Zhang, Weiling Li, Mengjie Chen

“…Although ultrasound has been the gold standard for many years to define FGR, it remains less than ideal for early detection of FGR. Placental dysfunction is a key factor in the development of FGR. …”
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3D alveolar organoid drug screening model for targeting TGF-β1 in pulmonary fibrosis by Hyeong-jun Han, Hyunyoung Kim

“…Excessive deposition of extracellular matrix (ECM) results in fibrotic remodeling, alveolar destruction, and irreversible lung dysfunction. In addition to myofibroblast activation and ECM deposition, repetitive lung epithelial cell damage and reprogramming areconsidered to be closely involved in IPF pathogenesis. …”
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Histone-driven hypercoagulation contributes to the lethal triad of acute trauma-induced coagulopathy by Christian Karl Braun, Marco Mannes, Doreen Tabea Spiegelburg, Frederik Müller, Amadeo Klitzing, Anke Schultze, Andreas Bauer, Gerhard Achatz, Markus Huber-Lang

“…This condition exacerbates trauma complications and contributes to organ dysfunction and mortality, prompting the need to better define its complex pathomechanisms in the blood. …”
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The significance of melatonin as one of the signaling substrates in the expression of psychopathological disorders in the late period after traumatic brain injury by M. O. Ovcharenko, Ye. Yu. Verbytskyi, T. M. Radchenko, V. Ye. Kazakov, I. O. Chumakova

“…The mechanisms underlying these disorders may be related to dysfunction of the hypothalamus and interhemispheric interactions. …”
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Reperfusion injury or cytokine storm? Utilizing plasmapheresis in severe trauma-induced multiorgan failure: a case report by Gun Woo Kim, Suyeong Hwang, Kyoung Hoon Lim, Sung Hoon Cho

“…These two conditions may exhibit similar clinical features, necessitating supportive care primarily to prevent organ dysfunction. However, plasmapheresis may represent an effective treatment option in cases of severe progression.…”
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A RARE CASE OF SPONTANEOUS PNEUMOCEPHALUS AS A COMPLICATION OF NONTRAUMATIC CEREBROSPINAL FLUID RHINORRHEA. AN EVIDENCEBASED REVIEW by E. V. Shelesko, O. S. Zaitsev, N. A. Chernikova

“…In this article we report an effective treatment of spontaneous cerebrospinal fluid leak, complicated by pneumocephaly and meningitis. …”
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Efficacy and safety of multiple doses of levomilnacipran extended-release for the treatment of major depressive disorder by Huang Q, Zhong X, Yun Y, Yu B, Huang Y

“…Weighted mean difference (WMD) and risk ratio (RR) with 95% confidence interval (CI) were calculated and pooled using fixed-effects model or random-effects model. Results: Five randomized placebo-controlled trials including 2,637 patients were analyzed. …”
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Efficacy of Gunja Beeja Ointment versus Diclofenac Sodium Ointment in the Management of Avabahuka (Frozen Shoulder): A Research Protocol for a Randomised Controlled Trial by Shreya Parkhi, Sadhana Durgaprasad Misar

“…There is a need for a safe and effective Ayurvedic herbal drugs which can be beneficial in such cases. …”
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Ciclosporin A proof of concept study in patients with active, progressive HTLV-1 associated myelopathy/tropical spastic paraparesis. by Fabiola Martin, Hannah Castro, Carolyn Gabriel, Adine Adonis, Alexandra Fedina, Linda Harrison, Liz Brodnicki, Maria A Demontis, Abdel G Babiker, Jonathan N Weber, Charles R M Bangham, Graham P Taylor

“…<h4>Introduction</h4>Patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) become progressively impaired, with chronic pain, immobility and bladder, bowel and sexual dysfunction. Tested antiretroviral therapies have not been effective and most patients are offered a short course of corticosteroids or interferon-α, physiotherapy and symptomatic management. …”
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Drug‐like sphingolipid SH‐BC‐893 opposes ceramide‐induced mitochondrial fission and corrects diet‐induced obesity by Vaishali Jayashankar, Elizabeth Selwan, Sarah E Hancock, Amandine Verlande, Maggie O Goodson, Kazumi H Eckenstein, Giedre Milinkeviciute, Brianna M Hoover, Bin Chen, Angela G Fleischman, Karina S Cramer, Stephen Hanessian, Selma Masri, Nigel Turner, Aimee L Edinger

“…In sum, the sphingolipid analog SH‐BC‐893 robustly and acutely blocks ceramide‐induced mitochondrial dysfunction, correcting diet‐induced obesity and its metabolic sequelae.…”
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Prophylaxis of Ischemic Damage to the Ovaries, Taking Into Account Peculiarities of Blood Supply to the Uterus During Endovascular Treatment of Le Yo Fibroids by L. S. Kokov, M. M. Damirov, O. N. Oleinikova, A. A. Medvedev, G. Y. Belozyorov

“…The application of the developed technique did not show dysfunction of the ovaries in both the short and long-term follow-up period up to 18 months in the Group II.Conclusion The separating UA occlusion is a safe and effective way of preventing ischemic damage in the presence of signoficant utero-ovarian inter-arterial nastomoses.…”
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Potential Targets and Mechanisms of Jiedu Quyu Ziyin Decoction for Treating SLE-GIOP: Based on Network Pharmacology and Molecular Docking by Jie Li, Run-yu Chang, Lin-feng Chen, Su-hai Qian, Rong-yun Wang, Ji-le Lan, Lin Huang, Xing-hong Ding

“…Systemic lupus erythematosus (SLE) is characterized by poor regulation of the immune response leading to chronic inflammation and multiple organ dysfunction. Glucocorticoid (GC) is currently one of the main treatments. …”
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Retinal Inflammation and Reactive Müller Cells: Neurotrophins’ Release and Neuroprotective Strategies by Bijorn Omar Balzamino, Andrea Cacciamani, Lucia Dinice, Michela Cecere, Francesca Romana Pesci, Guido Ripandelli, Alessandra Micera

“…In the physiological retina, some glial cell types sustain neuron activities by guaranteeing ion homeostasis and allowing effective interaction in synaptic transmission. Upon insults, glial cells interact with neuronal and the other non-neuronal retinal cells, at least in part counteracting the biomolecular changes that may trigger retinal complications and vision loss. …”
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