Pattern Electroretinogram in Glaucoma Suspects with Signs of Conversion: Diagnosis, Assessment, and Monitoring Treatment – Case Report by Andrew Tirsi, Richard Adamovich-Zeitlin, Hanwen Yang, Bhakti Patel, Derek Orshan, Daniel Zhu, Oksana Procyk, Nicholas Leung, Stephen Obstbaum, Celso Tello

“…However, when the treatment was not applied consistently as prescribed, and when longer periods of nontreatment occurred, PERG parameters transiently deteriorated, demonstrating the presence of a transient RGC dysfunction state. PERG demonstrates the potential in monitoring the effectiveness of IOP lowering treatment in newly diagnosed subjects for not only chronic IOP elevation, but for transient IOP elevation detections as well. …”
Get full text

Systemic IGF-1 administration prevents traumatic brain injury induced gut permeability, dysmorphia, dysbiosis, and the increased number of immature dentate granule cells by Lavanya Venkatasamy, Jaclyn Iannucci, Aleksandr Pereverzev, Jonathan Hoar, Emily Huber, Angel Ifegbo, Reagan Dominy, Yumna El-Hakim, Kathiresh Kumar Mani, Alan Dabney, Rachel Pilla, Farida Sohrabji, Lee A. Shapiro

“…The goal of this study was to assess the effects of systemic IGF-1 treatment in a rat model of TBI on GI outcomes. …”
Get full text

Inhibition of microRNA-139-5p by glucagon-like peptide-1 ameliorates oxidative stress-induced vascular endothelial cell damage via targeting SOD1/GCLc by Jiaqi Zhang, Jiake Mo, Ying Liu, Xubiao Meng, Weian Tang, Lanfang Fu, Jing Xiong, Zhaohui Mo

“…This provides further evidence for the vascular protective effects of GLP-1 intervention in diabetes.…”
Get full text

Mechanisms and clinical translation of ICOS/ICOSL signaling pathway blockade in delaying vascular complications of type 2 diabetes by Haiyan Zhang, LiBo Ruan, Xuemei Fu, Jinwen Yu, Qingrong Ruan, Yiyu Li, Hongying Wang, Heng Shao, Haoran Dong, Jianglan Cui

“…Conclusion Blocking the ICOS/ICOSL signaling pathway effectively mitigates vascular inflammation and endothelial dysfunction in T2DM with atherosclerosis. …”
Get full text

Electroacupuncture as adjunctive therapy for insomnia via targeting the GABAergic microbiota-gut-brain axis: a mini review by Xiao Wang, Lijuan Yan, Xiaodong Zhang, Xiang Liu, Xiang Liu, Bin Yang

“…The aforementioned effects collectively resolve insomnia’s multifactorial etiology. …”
Get full text

Pd Icosahedral Nanoparticles Promote Skin Wound Healing by Enhancing SP1-HBEGF Axis-Mediated Keratinocytes Proliferation by He F, Li M, Zhao H, Zhao H, Meng X, Zhang Y, Tang Y, Huang H, Li J, Xie H, Wang B

“…The acute full-thickness skin excision wound mouse model was used to access the wound healing potential and screen out the effective materials—Pd Icos NPs. Next evaluate the biotoxicity and safety of Pd Icos NPs and both in HaCaT cells and in vivo. …”
Get full text

THE ANALYSIS OF THE PREVALENCE OF DENTAL ANOMALIES IN UZHHOROD SCHOOLCHILDREN by V.S. Melnyk, L.F. Horzov, O.Yu. Rivis, M.E. Izay

“…The study showed that regular check-ups are the most effective methods for identifying patients with tooth anomalies in schoolchildren and can significantly reduce the number of patients who need this type of treatment with an adequate orthodontic care management. …”
Get full text

Electroconvulsive therapy improves distal colonic motility via the subdiaphragmatic vagus nerve in depressive-like mice by Mengyao Dai, Yanzhang Li, Yanghua Tian

“…Abstract Depression is a common mood disorder characterized by persistent sadness, loss of interest or pleasure, and a range of cognitive and physical symptoms such as gastrointestinal dysfunction that significantly impair daily functioning. …”
Get full text

Therapeutic Potential of Hexahydrocurcumin in the Regeneration and Protection of the Retinal Pigment Epithelium by Ilona Nowak, Robert Kubina, Barbara Strzałka-Mrozik

“…However, further studies, including clinical trials, are essential to confirm its efficacy and elucidate the precise mechanisms underlying HHC’s protective effects on RPE cells.…”
Get full text

Garlic-Derived Allicin Attenuates Parkinson’s Disease via PKA/p-CREB/BDNF/DAT Pathway Activation and Apoptotic Inhibition by Wanchen Zeng, Yingkai Wang, Yang Liu, Xiaomin Liu, Zhongquan Qi

“…The experimental results show that ALC administration can alleviate the cytotoxicity of SH-SY5Y induced by 6-OHDA and simultaneously improve the motor dysfunction and dopaminergic neuron loss in PD mice. …”
Get full text

Multidimensional exploration of hydrogels as biological scaffolds for spinal cord regeneration: mechanisms and future perspectives by Chenxi Han, Chenxi Han, Jiao Jiao, Jiao Jiao, Chan Gong, Chan Gong, Jiatao Li, Jiatao Li, Min Zhao, Min Zhao, Xiao Lu, Xiao Lu

“…While current therapies focus on alleviating symptoms and restoring functionality, achieving effective neural regeneration in the spinal cord continues to be a significant challenge. …”
Get full text

Evolving perspectives on aortic stenosis: the increasing importance of evaluating the right ventricle before aortic valve intervention by Vitaliy Androshchuk, Omar Chehab, Joshua Wilcox, Benedict McDonaugh, Natalie Montarello, Ronak Rajani, Bernard Prendergast, Tiffany Patterson, Simon Redwood

“…Finally, we will review the emerging evidence reinforcing the negative impact of RV dysfunction on clinical outcomes in AS patients treated with AVR.…”
Get full text

Adherence to Pelvic Floor Physical Therapy During COVID-19: A Retrospective Study by Nicole P. Jenkins, Gregory W. Vurture, Amber Wai-San Chan, Stephanie Sansone, Nina Jacobson, Scott W. Smilen

“…COVID-19 introduced widespread challenges in healthcare access and was demonstrated to be a significant stressor for patients with pelvic floor dysfunction (PFD). Pelvic Floor Physical Therapy (PFPT) is a first line behavioral modification to address PFD. …”
Get full text

Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy by Liqun Dai, Jie Liu, Tingyu Yang, Xiaorui Yu, Yi Lu, Lili Pan, Siming Zhou, Diyun Shu, Yuanhao Liu, Wuyu Mao, Zhiyong Qian

“…Abstract Cancer remains a major health challenge, with the effectiveness of chemotherapy often limited by its lack of specificity and systemic toxicity. …”
Get full text

Acupuncture for post-cesarean pain and gastrointestinal function recovery: a meta-analysis and systematic review by Hejing Liu, Kehan Xing, Cai Liao, Jiapei Wang, Chenglin Tang, Siqin Huang

“…ObjectivePostoperative pain and gastrointestinal dysfunction are common complications after cesarean section, significantly affecting maternal recovery and quality of life. …”
Get full text

[18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation by Isabel Day, Mikayla Tamboline, Lindsay Lueptow, Irina Zhuravka, Taryn Diep, Ilona Tkachyova, Shili Xu, Andreas Schulze, Gerald S. Lipshutz

“…These data demonstrate that [18F]FDG-PET and [18F]-MPPF-PET may serve as appropriate and sensitive biomarkers that could be used to assess the efficacy of not only new approaches in treating mutations of the creatine transporter SLC6A8 and their effectiveness in normalizing brain metabolism but also in enhancing our understanding of the mechanism of brain dysfunction that occurs in this complex brain disorder.…”
Get full text

Evaluation of the Efficiency of Alveolar Opening in Cardiosurgical Patients with Low Left Ventricular Ejection Fraction by Yu. G Zorina, V. V. Moroz, A. M Golubev, Yu. V. Nikiforov

“…Twenty patients with a LVEF of less than 40% after ACBS and with postoperative pulmonary oxygenizing dysfunction (PaO2/FiO2 less than 250) (Group 1) were examined. …”
Get full text

Severe Myocardial Involvement and Persistent Supraventricular Arrhythmia in a Premature Infant Due to Enterovirus Infection: Case Report and Literature Review by Carolina Montobbio, Alessio Conte, Andrea Calandrino, Alessia Pepe, Francesco Vinci, Alessandra Siboldi, Roberto Formigari, Luca Antonio Ramenghi

“…Collaboration between neonatologists and pediatric cardiologists is crucial for effective treatment and follow-up.…”
Get full text

Prospective Cohort Study of Trastuzumab Biosimilar CT-P6 in HER2-Positive Gastric Cancer: Japanese Real-World Outcomes by Hiroya Taniguchi, Kiyohiro Nishikawa, Tatsuo Haneji, Naoki Izawa, Hiroshi Imamura, Hironori Yamaguchi

“…Four cardiac disorders were reported: two of grade 1 cardiac dysfunction and two of severe ischemic heart disease. …”
Get full text

Reproductive Health in Women with Major β-Thalassemia: Evaluating Ovarian Reserve and Endocrine Complications by Vasileios Tsilionis, Efthalia Moustakli, Stefanos Dafopoulos, Athanasios Zikopoulos, Sotirios Sotiriou, Athanasios Zachariou, Konstantinos Dafopoulos

“…It also investigates how metabolomics can provide insights into the disease’s metabolic alterations and inform current and emerging therapeutic strategies to mitigate complications and optimize patient outcomes, potentially leading to more effective and personalized treatments.…”
Get full text