A Rare Presentation of Transfusional Hemochromatosis: Hypogonadotropic Hypogonadism by Rifki Ucler, Erdal Kara, Murat Atmaca, Sehmus Olmez, Murat Alay, Yaren Dirik, Aydin Bora

“…With this case, we aim to raise awareness of hypogonadotropic hypogonadism in patients with intensive transfused thalassemia major even if not severe hemochromatosis so that hypogonadism related complications, such as osteoporosis, anergia, weakness, sexual dysfunction, and infertility, could be more effectively managed in these patients.…”
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Decoding glycosylation in cardiovascular diseases: mechanisms, biomarkers, and therapeutic opportunities by Gang Li, Kaidi Ren, Yage Jin, Yang Yang, Yi Luan

“…Dysregulated glycosylation is generally believed as a key driver in the pathogenesis of cardiovascular diseases (CVDs), contributing to adverse cardiac remodeling, mitochondrial dysfunction, metabolic dysregulation, and vascular inflammation. …”
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Morphological abnormalities in mitochondria of the skin of patients with sporadic amyotrophic lateral sclerosis by Gabriel E. Rodríguez, Deniselle M. Claudia González, Gisella M. Gargiulo Monachelli, Juan J. López Costa, Alejandro F. de Nicola, Roberto E. P. Sica

“…OBJECTIVES: Mitochondrial dysfunction has been reported in the central nervous system, hepatocytes and peripheral blood lymphocytes from patients with sporadic amyotrophic lateral sclerosis (SALS). …”
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Decreased Neuronal Bursting and Phase Synchrony in the Hippocampus of Streptozotocin Diabetic Rats by Zhimei Qiao, Kangning Xie, Kai Liu, Guoliang Li

“…Diabetic encephalopathy is one of the complications of diabetes. Cognitive dysfunction is the main consequence. Previous findings from neuroanatomical and in vitro electrophysiological studies showed that the structure and function of the hippocampus is impaired in diabetes, which may underlie the cognitive dysfunction induced by diabetes. …”
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Targeting synaptic plasticity to bridge translational gaps in sepsis-associated encephalopathy by Koji Hoshino

“…Sepsis-associated encephalopathy (SAE) is a frequent yet underrecognized complication of sepsis that significantly contributes to long-term cognitive dysfunction in survivors. Despite advances in sepsis management, there is currently no established therapy targeting SAE, and translational gaps between basic and clinical research persist. …”
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Fatigue in Parkinson’s disease—A narrative review by Baikuntha Panigrahi, Kanchana S. Pillai, Divya M. Radhakrishnan, Roopa Rajan, Achal K. Srivastava

“…However, considering the effects of fatigue on the quality of life (QoL) of individuals with PD, it is crucial to review its causes and management strategies. …”
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Metabolic and functional cardiac changes at II-type pancreatic diabetes and abdominal adiposity in rats by M. V. Kolbina, V. T. Dolgikh, V. I. Chesnokov

“…Accumulation of lactate, metabolic acidosis, decrease of glucose efficiency and dysfunction of cardiac hystiocyte calcium pump with the development of diastolic myocardium dysfunction contribute to the development of metabolic disturbances.…”
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Black ginger (Kaempferia parviflora): A source of functional ingredient for food, nutraceutical and pharmaceutical applications by Sook Chin Chew, Kar Lin Nyam

“…Circadian rhythm, cardioprotective, anti-cancer, anti-obesity, anti-ulcer, anti-inflammatory, and physical performance enhancement have been reported with the health-promoting effects of black ginger. Moreover, black ginger extracts have protected against cellular damage and dysfunction, including fibroblast dysfunction, and modulate inflammatory responses. …”
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DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. by Erin Munkácsy, Maruf H Khan, Rebecca K Lane, Megan B Borror, Jae H Park, Alex F Bokov, Alfred L Fisher, Christopher D Link, Shane L Rea

“…In an effort to uncover how the detrimental effects of mitochondrial dysfunction might be alleviated, we examined how the nematode C. elegans not only adapts to disruption of the mitochondrial electron transport chain, but in many instances responds with extended lifespan. …”
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Long-Term Functional and Anatomical Outcome after Descemet Stripping Automated Endothelial Keratoplasty: A Prospective Single-Center Study by Jeroen van Rooij, Angela Engel, Lies Remeijer, Hugo van Cleijnenbreugel, René Wubbels

“…A significant and prolonged functional gain can be achieved by posterior lamellar grafting for endothelial dysfunction.…”
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Electroacupuncture improves sleep deprivation-induced cognitive impairment by suppressing hippocampal inflammatory response in mice by Guoyan Li, Jingbo Liu, Kejing Zhang

“…Sleep deprivation (SD) is known to induce neurocognitive dysfunction, with hippocampal inflammation emerging as a critical mediator. …”
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A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates by Xiu Wang, Shi Jin, Weina Hu

“…In this review, we discuss the importance of using NHPs models in understanding diabetic cardiomyopathy (DCM) in humans with aspects of correlations between hyperglycemia and cardiac dysfunction progression, glucose overload, and altered glucose metabolism promoting cardiac oxidative stress and mitochondria dysfunction, glucose, and its effect on cardiac resynchronization therapy with defibrillator (CRT-d), the currently available diabetic NHPs models and the limitations involved in the use of NHP models.…”
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Thyroid Function in patients with Ischemic Heart Diseases by Maha Arshed Hamdi Mageed

“… The effects of thyroid hormones on the cardiovascular system are the most clinically useful and sensitive signs of thyroid dysfunction. …”
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The Role of Vitamin D in Parkinson's Disease by Fatma Öznur Afacan, Didem Önay Derin

“…Links have been found between vitamin D levels and non-motor symptoms like mood disorders, orthostatic hypotension, and olfactory dysfunction, as well as motor severity. However, information on vitamin D's effects on non-motor symptoms is limited. …”
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Performance of a Two-Week Rehabilitation Improves Motor Function in Inpatients with Progressive Supranuclear Palsy: A Pre–Post Study by Naomi Matsuda, Yasuyuki Takamatsu, Makoto Sawada, Ikuko Aiba

“…<b>Background</b>: Progressive supranuclear palsy (PSP) is characterized by early postural instability and gait dysfunction, with frequent falls. Rehabilitation is an important therapeutic approach for motor dysfunction in patients with PSP. …”
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Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice by Micah L. Willis, Micah L. Willis, Roland F. Seim, Laura E. Herring, Angie L. Mordant, Thomas S. Webb, Gilbert R. Upchurch, Ashish K. Sharma, Bruce A. Cairns, Philip A. Efron, Philip A. Efron, Shannon M. Wallet, Leon G. Coleman, Leon G. Coleman, Robert Maile, Robert Maile

“…IntroductionSevere injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. …”
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Molecular mechanism of melatonin-mediated mitophagy regulating proline production to ameliorate skin aging by Tao Quan, Ran Li, Ting Gao

“…However, proline supplementation could also exert an anti-aging effect, while it had no effect on the mitochondrial dysfunction. …”
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Resveratrol ameliorates high glucose and high-fat/sucrose diet-induced vascular hyperpermeability involving Cav-1/eNOS regulation. by Xiao Lin Peng, Wei Qu, Lin Zhi Wang, Bin Qing Huang, Chen Jiang Ying, Xiu Fa Sun, Li Ping Hao

“…However, currently, the exact protective effect and involved mechanisms of Res on endothelial dysfunction-hyperpermeability have not been completely clarified. …”
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MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS by Chunlai Yin, Xue Yan, Jinyi Ren, Cheng Zhang, Jiaqing Liu, Zilong Wang, Jing Liu, Weiping Li, Xia Li

“…Notably, we observed an upregulation of lipid metabolism in these MSCs, which appears to contribute to their dysfunction. Intriguingly, the aberrant lipid metabolic profile can be effectively reversed by the administration of etomoxir (ETO), an inhibitor of carnitine palmitoyltransferase 1A (CPT-1A). …”
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Angiotensin Receptor-Neprilysin Inhibitor for Chronic Kidney Disease: Strategies for Renal Protection by Erika Hishida, Daisuke Nagata

“…Hence, vigilant blood pressure monitoring is essential to optimizing the renal benefits of ARNI and minimizing adverse effects. Evidence supporting the renal benefits of ARNI continues to evolve; therefore, ARNI could mitigate renal dysfunction in select patient populations. …”
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