Tirzepatide mitigates Stroke-Induced Blood-Brain barrier disruption by modulating Claudin-1 and C/EBP-α pathways by Duozi Wang, Jianhong Wang, Binghu Li, Shu Yang, Fuqiang Guo, Bo Zheng, Jian Wang

“…The blood-brain barrier (BBB) plays a critical role in protecting the brain, and its dysfunction after stroke exacerbates neuronal damage. …”
Get full text

Impact of Metabolic Syndrome On Hospital Outcome In Patients With Acute Coronary Syndrome In Hawler Teaching Hospital by Dilshad Abdulkadir Rasul, Abdulkareem Abdulwahhab Al-Othman

“…The objective of the study was to evaluate the effect of metabolic syndrome on in hospital complications, left ventricular systolic function and ischemic mitral regurgitation in patients with first acute coronary syndrome. …”
Get full text

Clinical Observation on the Third-lumbar Transverse Process Syndrome Treated by Chiropractic Gun Combined with Pulse Edge Needle by Yuanyang ZHANG, CongShan CHEN, Xueping WU, Wen LIANG, Yu HUANG, Xiaoming RAO, Zhiwei QIU

“…VAS score, the lumbar dysfunction score, ADL score and lumbar spine mobility were compared between the two groups before and after treatment, and after treatment were followed up in 2 weeks.Results:Compared with before treatment, VAS score and lumbar dysfunction score of the two groups treated after 2 weeks and 4 weeks were significantly decreased (<italic>P</italic>&lt;0.05), while the treatment group decreased more than the control group (<italic>P</italic>&lt;0.05). …”
Get full text

Leveraging radiotherapy to improve immunotherapy outcomes: rationale, progress and research priorities by Faith Hartley, Martin Ebert, Alistair M Cook

“…Here, we briefly reflect on the development of immune checkpoint inhibitors and the mechanistic insights revealed by an evolving understanding of T‐cell dysfunction in cancer, before providing an overview of the immunomodulatory effects of radiotherapy in the context of the T‐cell‐mediated antitumor immune response. …”
Get full text

Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking by Sumasri Guntupalli, Jocelyn Widagdo, Victor Anggono

“…There is considerable evidence that synapses are particularly vulnerable to AD, establishing synaptic dysfunction as one of the earliest events in pathogenesis, prior to neuronal loss. …”
Get full text

Oxidative stress accumulates in adipose tissue during aging and inhibits adipogenesis. by Hannes M Findeisen, Kevin J Pearson, Florence Gizard, Yue Zhao, Hua Qing, Karrie L Jones, Dianne Cohn, Elizabeth B Heywood, Rafael de Cabo, Rafael de Cabo, Dennis Bruemmer

“…However, the effect of increased oxidative stress on adipose tissue biology remains elusive. …”
Get full text

Genetic Polymorphism and the Rate of Development of Complications in Pneumonia of Varying Genesis by T. V. Smelaya, L. Ye. Salnikova, V. V. Moroz, A. M., Golubev, Yu. V. Zarzhetsky, A. V. Rubanovich

“…There were are genotypes associated with predisposition to community-acquired and nosocomial pneumonia (CAP and NP): GSTM I*, CYP1A1 606T/T, ACE D/D and those associated with a higher risk for complicated CAP. There were effects of the allelic variants of the ACE gene in developing complications, such as acute respiratory distress syndrome, multiple organ dysfunction, and sepsis: ACEI/I insertion homozygotes linked to survival and the alternative ACE D/D genotype to mortality. …”
Get full text

Short-term high-fat diet alters behavior, peripheral metabolism, and brain mitochondrial function in Swiss mice by ADRIANO EMANUEL MACHADO, PETERSON REZER, GIANNI MANCINI, ALEXANDRA LATINI, EDUARDO LUIZ G. MOREIRA

“…This study investigated the short-term effects (15, 25, and 35 days) of HFD in Swiss mice. …”
Get full text

Tat-specific antibodies associated with better HIV-associated motor function by Catarina E. Hioe, Clauvis Kunkeng Yengo, Xiaomei Liu, Reuben Davis, Gospel Enyindah-Asonye, Jéromine Klingler, Alex F. Tang, Juan C. Bandres, Anuradha Ganesan, Tahaniyat Lalani, Joseph Yabes, Brian K. Agan, Xiaokun Liu, David J. Volsky, Susan Morgello, Jessica Robinson-Papp

“…Deleterious central nervous system effects of extracellular Tat include dopaminergic neuron dysfunction, raising the possibility that Tat secretion may be linked to Parkinsonian motor features seen in people with HIV (PWH). …”
Get full text

Antibiotic Cocktail Exacerbates Esomeprazole-Induced Intestinal Dysmotility While Ameliorating Gastric Dyspepsia in Mice by Jing-Hua Wang, Song-Yi Han, Kyungjae Lee, Uijeong Han, Si-Kyung Cho, Hojun Kim

“…Therefore, this study aimed to investigate the effects of antibiotics on esomeprazole-induced GI motility dysfunction and explore the underlying mechanisms in a mouse model. …”
Get full text

Impact of General Anesthesia and Antioxidants on Cognitive, Static and Locomotor Functions During Laparoscopic Cholecystectomy by V. V. Moroz, V. T. Dolgikh, S. A. Karpitskaya

“…We studied the effect of general anesthesia and antioxidants on cognitive, static and locomotor functions during laparoscopic cholecystectomy. …”
Get full text

CITED2 Mediates Metabolic Reprogramming in Renal Tubular Epithelial Cells via the AKT Signaling Pathway to Induce Sepsis-Associated Acute Kidney Injury by Deng R, Yang H, Zhong W, Zhou J, Huang G, Zeng K

“…CITED2 silencing attenuated TECs metabolic dysfunction and reduced inflammation, thereby protecting the kidney from injury. …”
Get full text

EphrinB2 alleviates tubulointerstitial fibrosis in diabetic kidney disease by Lihua Ni, Qiuyuan Zhou, Xueyun Gao, Feng Chen, Ayinigaer Yusufu, Jin-Hu Chen, Cheng Yuan, Xiaoyan Wu

“…Conclusions EphrinB2 exerts protective effects against renal fibrosis and dysfunction in diabetic conditions by regulating fibrosis pathways, mitochondrial dynamics, and epithelial stability. …”
Get full text

Treatment outcome of recombinant thrombomodulin in patients with septic urinary tract infection-induced disseminated intravascular coagulation; a retrospective study by Dr Yoshihiro Hashimoto, Dr Ryohei Azuma, Dr Emi Nazato, Dr Masayuki Usami

“…Discussion: The results of this study provide evidence that rTM may have a beneficial effect on organ dysfunction in patients with septic UTI-induced DIC. …”
Get full text

Cardiovascular complications in patients with cancer: focus on anthracycline-induced cardiotoxicity by I. T. Murkamilov, K. A. Aitbaev, V. V. Fomin, I. O. Kudaibergenova, F. A. Yusupov, Zh. A. Murkamilova

“…The problems of anthracycline-induced cardiotoxicity, the deleterious effects of doxorubicin on the heart, as well as the cardioprotective effects of beta-blockers and agents acting on the renin-angiotensin-aldosterone system pathway are discussed. …”
Get full text

BMAL1 ameliorates type 2 diabetes-induced cognitive impairment via AREG upregulation and PI3K/Akt/GSK-3β pathway activation by Jialu Xu, Chunyu Li, Rongping Fan, Jiaxin Yin, Lei Xie, Xuemin Peng, Jing Tao, Weijie Xu, Shujun Zhang, Xiaoli Shi, Kun Dong, Xuefeng Yu, Xi Chen, Yan Yang

“…Further investigation revealed that BMAL1 directly activated the transcription of Areg, thereby activating the PI3K/Akt/GSK-3β pathway and ameliorating cognitive dysfunction. Moreover, these effects of BMAL1 were attenuated by LY294002, a PI3K inhibitor. …”
Get full text

Examining the role of novelty detection in 20- and 40-Hz auditory steady-state responses by Kentaro Takai, Shunsuke Sugiyama, Koji Inui, Yuka Ikegame, Hirohito Yano, Jun Shinoda, Makoto Nishihara, Kazutaka Ohi, Toshiki Shioiri

Get full text

Neurological Sequelae of Post-COVID-19 Fatigue: A Narrative Review of Dipeptidyl Peptidase IV-Mediated Cerebrovascular Complications by Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Usman Jaffer, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Mazira Mohamad Ghazali, Ebrahim Nangarath Kottakal Cheriya

“…Alarmingly, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) not only infects the lungs but also influences the heart and brain. Endothelial cell dysfunction and hypercoagulation, which we know occur with this infection, lead to thrombo-inflammation that can manifest as many myriad cardio-cerebrovascular disorders, such as brain fog, fatigue, cognitive dysfunction, etc. …”
Get full text

The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota by Lixuan Yang, Lixuan Yang, Yutian Ao, Yannan Li, Baoan Dai, Junnan Li, Wenzhe Duan, Kaiqiang Dong, Zhenyun Han, Rongjuan Guo

“…It exerts its effect, at least in part, by enhancing microbiota-mediated metabolism in vivo.…”
Get full text

A higher composite dietary antioxidant index is associated with a decreased risk of subclinical hyperthyroidism in adults: evidence from epidemiological studies by Jie Wu, Junxian Niu, Junxian Niu, Chuyu Jia, Qingkai Yang, Dewei Li, Xuqin Dong

“…Background and objectiveThyroid dysfunction is closely related to oxidative stress, and the intake of dietary antioxidants may affect thyroid function by regulating oxidative stress. …”
Get full text