Air toxins disorder the NF-kB Pathway leads to immune disorders and immune diseases in the human health by Cui Cui, Rui Yang, Hao Chen, Danyang Li, Xiaodi Sun, Yutao Wang, Qi Pan

“…Prolonged activation of the NF-κB pathway is implicated in the pathogenesis of pulmonary disorders.cardiovascular conditions, and immune dysfunction. Understanding these mechanisms is crucial for identifying therapeutic targets and designing effective interventions. …”
Get full text

Tourette Syndrome in Children: An Updated Review by Jung-Chieh Du, Ting-Fang Chiu, Kun-Mei Lee, Hsin-Lin Wu, Ya-Chi Yang, Shu-Yeh Hsu, Chung-Shu Sun, Betau Hwang, James F. Leckman

“…The pathophysiology of TS mainly involves dysfunction of basal ganglia-related circuits and hyperactive dopaminergic innervations. …”
Get full text

Construction of a novel lipid drop-mitochondria-associated genetic profile for predicting the survival and prognosis of lung adenocarcinoma by Ruijuan Cai, Hongsheng Lin, Qianwen Cheng, Qiyuan Mao, Chuchu Zhang, Ying Tan

“…Conclusion Our results suggest that the LD-M risk score is an effective prognostic indicator for individualized treatment of LUAD.…”
Get full text

Astragalus polyphenols attenuates doxorubicin-induced cardiotoxicity by activating the PI3K/AKT/NRF2 pathway. by Xueyang Bai, Hua Wei, Gangqiong Liu, Ling Li

“…Inhibition of this pathway using LY294002 and ML385 abolishes the protective effects of ASP, suggesting that ASP mediates its effects through the PI3K/AKT/NRF2 signaling axis.…”
Get full text

Is chronic neck pain related to scapular dyskinesia? A systematic review by Norollah Javdaneh, AmirHossein Barati, Sadredin Shojaedin, Roohollah Mohammadi Mirzaei

“…Conclusions The study implies that physical therapy practices should consider assessing and addressing scapular kinematics in patients with neck pain, as scapular dysfunction may contribute to their symptoms. Understanding the relationship between neck pain and scapular mechanics may inform more effective treatment strategies and individualized care plans. …”
Get full text

FCN-PD: An Advanced Deep Learning Framework for Parkinson’s Disease Diagnosis Using MRI Data by Manal Alrawis, Farah Mohammad, Saad Al-Ahmadi, Jalal Al-Muhtadi

“…<b>Background/Objectives:</b> Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and a diminished quality of life. …”
Get full text

The Efficacy of Pelvic Floor Rehabilitation in the Treatment of Urinary Incontinence in Female Athletes: A Systematic Review by Andrea Demeco, Giulia Bartocci, Noemi Astore, Beatrice Vignali, Antonello Salerno, Stefano Palermi, Ruben Foresti, Chiara Martini, Cosimo Costantino

“…The selection of articles was conducted using a specific search string: “[((pelvic floor dysfunction) OR (urinary incontinence) OR (dyspareunia) OR (dysuria)) AND ((sport) OR (sports)) AND ((female) OR (woman) OR (women) OR (girl)) AND ((rehabilitation) OR (rehab) OR (pelvic rehabilitation) OR (exercise))]”. …”
Get full text

Pharmacological and non-pharmacological interventions to prevent delirium after cardiac surgery: a protocol for a systematic review and meta-analysis by Maria Pufulete, Rachel Perry, Terrie Walker-Smith, Ben Gibbison, Jonathan David Barnes, Elizabeth Cottuli de Cothi, Rahul Kota

“…It occurs in up to 50% of patients after cardiac surgery and is associated with increased mortality, prolonged intensive care and hospital stay and long-term cognitive dysfunction. Identifying effective preventive interventions is important. …”
Get full text

Protein Kinases as Mediators for miRNA Modulation of Neuropathic Pain by Leah Chang, Zala Čok, Lei Yu

“…Neuropathic pain is a chronic condition resulting from injury or dysfunction in the somatosensory nervous system, which leads to persistent pain and a significant impairment of quality of life. …”
Get full text

Kinematic Integration Network With Enhanced Temporal Intelligence and Quality-Driven Attention for Precise Joint Angle Prediction in Exoskeleton-Based Gait Analysis by Lyes Saad Saoud, Irfan Hussain

“…Exoskeleton robots offer transformative potential in aiding the rehabilitation of patients with lower limb motor dysfunction, where precise and real-time prediction of knee joint angles is critical. …”
Get full text

A New Perspective on Overfeeding in the Intensive Care Unit (ICU): Challenges, Dangers and Prevention Methods by Vlad-Dimitrie Cehan, Alina-Roxana Cehan, Mihai Claudiu Pui, Alexandra Lazar

“…Prolonged overfeeding can lead to insulin resistance and hepatic dysfunction, exacerbating glycemic control, increasing the risk of infectious complications, and worsening clinical outcomes. …”
Get full text

The Use of Extracorporeal Liver Support Systems In Acute Decompensated Liver Failure by R. A. Ibadov, Ye. L. Ismailov, S. Kh. Ibragimov

“…A comprehensive approach to extracorporeal detoxification is highly effective, providing a more significant reduction of SOFA and MELD scores, increasing the proportion of regression of multiple organ dysfunction and reducing mortality.…”
Get full text

Optimal therapeutic strategy for treating patients with hypertension and atherosclerosis: focus on olmesartan medoxomil by R. P. Mason

“…In patients with hypertension, the ARB olmesartan medoxomil provides effective blood pressure lowering, with inflammatory marker studies demonstrating significant RAAS suppression. …”
Get full text

Cellular and Molecular Interactions in CNS Injury: The Role of Immune Cells and Inflammatory Responses in Damage and Repair by Jai Chand Patel, Meenakshi Shukla, Manish Shukla

“…Secondary damage develops over hours to days and is marked by ionic imbalance, mitochondrial dysfunction, oxidative stress, and chronic inflammation, which further aggravates tissue damage. …”
Get full text

Lipid metabolism in health and disease: Mechanistic and therapeutic insights for Parkinson’s disease by Bingqing Qin, Yuan Fu, Ana-Caroline Raulin, Shuangyu Kong, Han Li, Junyi Liu, Chunfeng Liu, Jing Zhao, Ting Gao

“…These disturbances are involved in key pathological processes, such as α-synuclein aggregation, organelle dysfunction, lipid-mediated neuroinflammation, and impaired lipid homeostasis. …”
Get full text

Efficacy and safety of paclitaxel drug-coated balloon angioplasty for stenosis of hemodialysis vascular access: 6-month results from a brazilian multicenter prospective study by Leonardo de Oliveira Harduin, Thiago Almeida Barroso, Julia Bandeira Guerra, Márcio Gomes Filippo, Leonardo Cortizo de Almeida, Carlos Alexandre Rosa Gama, Brunno Ribeiro Vieira, Renata Silveira Mello, Adriano Martins Galhardo, Jorge Paulo Strogoff-de-Matos

“…Conclusions DCB angioplasty was shown to be safe and effective for treating peripheral stenosis in vascular access.…”
Get full text

Heart transplantation in diabetic recipients by V. N. Poptsov, E. A. Spirina, E. N. Zolotova, V. M. Zakharevich, N. N. Koloskova, N. P. Mozheiko, A. A. Sibiakina, I. L. Poz, A. I. Skokova, V. V. Boronova, V. Yu. Voronkov, V. M. Khatutskii

“…Heart transplantation (HT) in patients with preexisting type 2 diabetes (T2D) is associated with high risk of infectious and non-infectious complications (renal dysfunction, multifocal atherosclerosis,  transplant coronary artery disease, etc.) that can negatively affect recipient survival in the early and late periods after HT.Objective: to assess the effect of pre-transplant T2D on early and long-term outcomes of HT based on a  singlecenter retrospective study. …”
Get full text

Cardiac function of colorectal cancer mice is remotely controlled by gut microbiota: regulating serum metabolites and myocardial cytokines by Zhan-Kui Gao, Chao-Yuan Fan, Bo-Wen Zhang, Jia-Xin Geng, Xing Han, Dan-Qi Xu, Muhammad Arshad, Hao-Xuan Sun, Jiong-Yi Li, Xiangyuan Jin, Xiao-Qin Mu

“…Intestinal microbes from healthy mice were transferred to colorectal cancer mice, which vastly reversed the disorder of the gut microbiota and effectively alleviated cardiac dysfunction. Moreover, FMT regulated the expression of serum metabolites such as uridine triphosphate (UTP), tiamulin, andrographolide, and N-Acetyl-D-glucosamine, as well as cytokines like TGF-β, IRF5, and β-MHC in the heart. …”
Get full text

Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques by Yulin Liu, Junjie Zhang, Yuxiang Zhao, Feixiang Fang, Siyu Zhang, Qiqi An, Jian Zhuang, Feng Xu, Fei Li

“…And the antioxidant‐resveratrol effectively improves the phagocytosis dysfunction of the impaired microglia. …”
Get full text

New Treatment Strategies of Depression: Based on Mechanisms Related to Neuroplasticity by Yu-Jhen Huang, Hsien-Yuan Lane, Chieh-Hsin Lin

“…Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has rapid and lasting antidepressive effects in previous studies. In addition to ketamine, other glutamatergic modulators, such as sarcosine, also show potential antidepressant effect in animal models or clinical trials. …”
Get full text