Prostate cancer management—helping your patient choose what is best for him by Christiaan F. Heyns, Andre van der Merwe

“…The main complications are erectile dysfunction and urinary incontinence. The use of brachytherapy is increasing, although there is no convincing evidence that it is more effective or has fewer complications than external beam radiotherapy. …”
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Role of LIMK1-cofilin-actin axis in dendritic spine dynamics in Alzheimer’s disease by Fabiola Paciello, Martina Battistoni, Sara Martini, Chiara Simone, Francesco Pastore, Raimondo Sollazzo, Claudio Grassi, Cristian Ripoli

“…However, resolving inconsistencies in cofilin regulation is essential to developing effective treatments for AD.…”
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Robotic-assisted tendon transplantation—approach for pelvic organ prolapse repair: a case report by Dominique Koensgen, Charlotte Lukannek, Carolin Schroeder, Lucia A. Otten, Amadeus Hornemann, Alexander Mustea

“…The patient’s postoperative recovery was swift without residual prolapse, voiding dysfunction, or urinary incontinence reported at any of the follow-up examinations, conducted at 8 weeks, 3 months, 6 months, and 1 year after the operation. …”
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Therapeutic utility of Perfluorocarbon Oxygent in limiting the severity of subarachnoid hemorrhage in mice by Mohammad Ejaz Ahmed, Naseem Akhter, Sumbul Fatima, Saif Ahmad, Shailendra Giri, Md Nasrul Hoda, Abdullah Shafique Ahmad

“…These data show the beneficial effects of PFC-Oxygent in limiting the severity of SAH. …”
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Nanomolecular silencing of TSC22D4 mRNA via a DNAsome-siRNA for enhancing insulin sensitization in hepatocytes by Ameneh Mohammadi, Pedram Ebrahimnejad, Saeid Abediankenari, Zahra Kashi, Pooria Gill

“…Real-time PCR results confirmed effective siRNA targeting, significant cellular uptake of the nanocomplexes, and successful silencing of TSC22D4 expression. …”
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Dietary L-proline supplementation ameliorates autism-like behaviors and modulates gut microbiota in the valproic acid-induced mouse model of autism spectrum disorder by Jingjing Fang, Ruixuan Geng, Seong-Gook Kang, Kunlun Huang, Tao Tong

“…Pro significantly attenuates repetitive behaviors and social dysfunction in ASD mice. The correlation analysis revealed that the beneficial effects of Pro on autism-like behaviors are related to the modulation of gut microbiota structure and composition. …”
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The gut–eye axis: from brain neurodegenerative diseases to age-related macular degeneration by Qianzi Jin, Suyu Wang, Yujia Yao, Qin Jiang, Keran Li

“…Unfortunately, the specific pathogenesis remains unclear, and effective early treatment options are consequently lacking. …”
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<i>Staphylococcus aureus</i> Endocarditis Immunothrombosis by Francesco Nappi

“…This shift is of concern as it is associated with <i>Staphylococcus Aureus</i> which has a high virulence rate and a tendency to form a biofilm, meaning that non-surgical therapy may not be effective. It is imperative to deliberate on the likelihood of platelet blood clot formation, which may be accompanied by bacterial infestation and the development of a biofilm. …”
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Ultrasound-guided selective supraclavicular nerve block combined with modified clavipectoral fascial plane block for midshaft clavicule fracture surgery: a case report by Fei Jiang, Na-na Li, Yong Yang, Di Liu

“…Conclusion The SSCPB technique achieves optimal anesthesia for mid-clavicular fracture surgery by combining SSNB with MCPB. This approach effectively prevents diaphragmatic paralysis and upper limb dysfunction, making it particularly suitable for patients with concomitant cardiopulmonary injuries or comminuted fractures. …”
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Cardiovascular Aging by Marco Tana, Rachele Piccinini, Livia Moffa, Ettore Porreca, Fernando Tana, Claudio Tana

“…Moreover, combining serum biomarkers with appropriate imaging tests can be an effective strategy to stratify and direct the most suitable treatment.…”
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Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9‐ADAR2 delivery to motor neurons by Takenari Yamashita, Hui Lin Chai, Sayaka Teramoto, Shoji Tsuji, Kuniko Shimazaki, Shin‐ichi Muramatsu, Shin Kwak

“…A single intravenous injection of AAV9‐ADAR2 in conditional ADAR2 knockout mice (AR2), which comprise a mechanistic mouse model of sporadic ALS, caused expression of exogenous ADAR2 in the central neurons and effectively prevented progressive motor dysfunction. …”
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Utility of Neutrophil-To-Lymphocyte Ratio as Prognostic Marker of Dilated Cardiomyopathy in Children by Sadaf Liaqat, Sajid Hussain Sherazi

“… Background: Dilated cardiomyopathy (DCM) is a frequent form of cardiomyopathy exhibiting systolic and/or diastolic dysfunction, leading to varying degrees of heart failure (HF). …”
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Validation of the Malta Gait Scale: A Time-Efficient Tool for Poststroke Assessment by Valerio Sarmati, Carlos Carmona, Alessandro Morciano, Samuel Gutiérrez, Ingrid Velásquez, José Fernández

“…Over 80% of stroke survivors experience walking dysfunction, impacting quality of life. Rehabilitation is crucial for gait recovery, and accurate assessments facilitate tailored programs. …”
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Мodification of Mechanical Limbal Stem Cell Deficiency Model by A. V. Bezushko, A. S. Dubovikov, A. N. Kulikov, S. V. Churashov, V. F. Chernysh, A. A. Suetov, I. O. Gavriluk

“…Ocular surface diseases related with limbal epithelial stem cells dysfunction were united in term “limbal stem cell  deficiency” (LSCD). …”
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Signaling pathways and targeted therapy for pulmonary hypertension by Joseph Adu-Amankwaah, Yue Shi, Hequn Song, Yixuan Ma, Jia Liu, Hao Wang, Jinxiang Yuan, Kun Sun, Qinghua Hu, Rubin Tan

“…While the approaches targeting these pathways form the foundation of standard PH treatment, the challenge remains to develop more effective therapeutic strategies. Evidence of pathological characteristics in PH illustrates other cell signaling pathways that also participate in the proliferation, apoptosis, extracellular matrix remodeling, mitochondrial dysfunction, inflammation, endothelial-to-mesenchymal transition, ferroptosis, pyroptosis, and the intricate network of cell-cell interactions of endothelial cells, smooth muscle cells, fibroblasts, and macrophages. …”
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Porphyromonas gingivalis bacterium as a risk factor for Alzheimer’s disease! by Andrei V. Kozlov, Artem V. Lyamin, Aleksei A. Neilenko, Anna V. Yanchenko, Alena A. Ereshchenko

“…It is concluded that focusing on this bacterium as a risk factor for Alzheimer’s disease development will help to develop an effective therapy and/ or a set of preventive measures.…”
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Determination of molecular mechanisms of development and course of experimental diabetes mellitus in Wistar rats by T. V. Ivanenko

“…Understanding these mechanisms is crucial for the development of effective methods for treating and preventing diabetes. …”
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Molecular Insights into the Interaction of Orexin 1 Receptor Antagonists: A Comprehensive Study Using Classical and Quantum Computational Methods by Caio Sena, Pedro Albuquerque, Jonas Oliveira, Davi Vieira

“…They are often associated with long-term health consequences, including cardiovascular disease, immune dysfunction, and cognitive impairment. While traditional treatments, such as sedatives and hypnotics, can be effective, they are limited by issues of tolerance and dependence. …”
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Interaction between mitochondrial oxidative stress and myocardial fibrosis in the context of diabetes by Pu-Hua Zhang, Nuo-Nan Li, Nuo-Nan Li, Xiang Gu, Chun-Xia Zhou, Zhen-Zhen Jiang, Xian-Jun Luo, Xian-Jun Luo, Hong-Wen Zhu, Xiao-Yong Zhu

“…Myocardial fibrosis (MF), which often accompanies diabetes, plays a pivotal role in the progression of cardiac dysfunction and heart failure (HF). Recent research has highlighted mitochondrial oxidative stress (OS) as a fundamental mechanism driving MF in diabetic conditions. …”
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Correction of Antithrombin III Deficiency in Disseminated Intravascular Coagulation by Ye. L. Neporada, N. A. Vorobyeva, E. V. Nedashkovsky

“…Objective: to compare the effects of AT concentrate and FFP on the activity of AT and on the clinical course of DIC. …”
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