Hydroxyurea-Increased Fetal Hemoglobin Is Associated with Less Organ Damage and Longer Survival in Adults with Sickle Cell Anemia. by Courtney D Fitzhugh, Matthew M Hsieh, Darlene Allen, Wynona A Coles, Cassie Seamon, Michael Ring, Xiongce Zhao, Caterina P Minniti, Griffin P Rodgers, Alan N Schechter, John F Tisdale, James G Taylor

“…Cox regression analysis revealed deceased subjects had more hepatic dysfunction (elevated alkaline phosphatase, Hazard Ratio = 1.005, 95% CI 1.003-1.006, p<0.0.0001), kidney dysfunction (elevated creatinine, Hazard Ratio = 1.13, 95% CI 1.00-1.27, p = 0.043), and cardiopulmonary dysfunction (elevated tricuspid jet velocity on echocardiogram, Hazard Ratio = 2.22, 1.23-4.02, p = 0.0082). …”
Get full text

Phenotypic changes in immune cells induced by granulocyte and monocyte adsorptive apheresis in patients with severe COVID‐19: An ex vivo study by Ryo Hisamune, Kazuma Yamakawa, Katsuhide Kayano, Noritaka Ushio, Takeshi Wada, Kohei Taniguchi, Akira Takasu

“…Abstract Aims SARS‐CoV‐2 causes systemic immune dysfunction, leading to severe respiratory dysfunction and multiorgan dysfunction. …”
Get full text

Adipokines and Cardiometabolic Heart Failure with Preserved Ejection Fraction: A State-of-the-Art Review by Nikolaos Theodorakis, Magdalini Kreouzi, Christos Hitas, Dimitrios Anagnostou, Maria Nikolaou

“…Adiponectin generally offers protective effects but presents a paradox, where elevated levels may correlate with worse outcomes, which may reflect either a compensatory response to cardiac dysfunction or a maladaptive state characterized by adiponectin resistance. …”
Get full text

Impact of Adipose Tissue and Lipids on Skeletal Muscle in Sarcopenia by Soo Yeon Jang, Kyung Mook Choi

“…Intracellular lipid metabolites may induce lipotoxicity in cell signalling of muscle cells, but effects might differ by types or chemical structure. …”
Get full text

Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model by Zheng M, Chen Z, Xie J, Yang Q, Mo M, Chen L

“…Plasmid transfection experiments further confirmed that Y2O3 NPs mediate disordered Cu output through ATP7A.Results: Y2O3 NP exposure induced cognitive and memory dysfunction in rats. This effect was related to the disruption of copper homeostasis in neuronal cells caused by Y2O3 NPs, which induced cuproptosis. …”
Get full text

Bridging the Translational Gap in Heart Failure Research: Using Human iPSC-derived Cardiomyocytes to Accelerate Therapeutic Insights by Leslye Venegas-Zamora, Matthew Fiedler, William Perez, Francisco Altamirano

“…Such an approach could improve our understanding of this disease and lead to more effective treatments.…”
Get full text

Eating Disorders in Athletes: The Female Athlete Triad and RED-S - A Literature Review by Monika Fidyk, Michał Bolek, Bartosz Jagieła, Aleksandra Kędzia, Dominika Musialska, Magda Minkiewicz, Maciej Dyda

“…Multidisciplinary support is essential for effective management and long-term recovery. …”
Get full text

New high-tech biocomplex for the correction of metabolism disorders at diabetes by M. I. Kalimullin, S. S. Sady, A. N. Austrievskikh, V. M. Poznyakovsky

“…Clinical evidence of the effectiveness and functional orientation of the developed product through its use in the complex treatment of patients with type II diabetes has been presented. …”
Get full text

Progress in the study of the mechanism of ferroptosis in coronary heart disease and clinical intervention strategies by Yingzhi Liu, Zixuan Yu, Yuwen Lu, Yue Liu, Lingli Chen, Jie Li

“…Future research directions should include in-depth mechanistic exploration and the development of more effective, safer clinical interventions targeting the ferroptosis pathway in cardiovascular disease.…”
Get full text

Chinese primary knee osteoarthritis progression cohort (CPKOPC) to evaluate the progression of knee osteoarthritis in the Beijing population: a prospective cohort study protocol by Lin Zeng, Minwei Zhao, Yupeng Liang, Xinguang Wang, Hua Tian

“…Introduction Millions of patients are currently suffering from pain and dysfunction caused by osteoarthritis (OA), and billions of dollars have been invested into treatment. …”
Get full text

Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in hypertensive patients: A prospective cross-sectional study by Sudha S, Birunthavathi M, Mythili M, Sai Sailesh Kumar Goothy

“…Chronic inflammation may contribute to epithelial dysfunction and atherogenesis and is associated with high blood pressure. …”
Get full text

The Therapeutic Potential of Low-Intensity Pulsed Ultrasound in Enhancing Gallbladder Function and Reducing Inflammation in Cholesterol Gallstone Disease by Fang Chen, Run Guo, Tian Chen, Liping Liu, Fan Ding, Gang Zhao, Bo Zhang

“…Background: Cholesterol gallstone disease (CGS) is often accompanied by gallbladder contraction dysfunction and chronic inflammation, but effective therapeutic options remain limited. …”
Get full text

Correlation of Clinical Neuromusculoskeletal and Central Somatosensory Performance: Variability in Controls and Patients With Severe and Mild Focal Hand Dystonia by Nancy N. Byl, Srikantan S. Nagarajan, Michael M. Merzenich, Tim Roberts, Alison McKenzie

“…If these findings represent aberrant learning, then effective rehabilitation must incorporate the principles of neuroplasticity. …”
Get full text

Involvement of Norepinephrine in the Control of Activity and Attentive Processes in Animal Models of Attention Deficit Hyperactivity Disorder by D. Viggiano, L. A. Ruocco, S. Arcieri, A. G. Sadile

“…Drugs that modulate norepinephrine (NE) transmission are also effective in ADHD patients, thus leading to the hypothesis of a NEergic disorder. …”
Get full text

Marine-derived new peptaibols with antibacterial activities by targeting bacterial membrane phospholipids by Shang Chen, Dong Liu, Liyang Wang, Aili Fan, Mengyue Wu, Ning Xu, Kui Zhu, Wenhan Lin

“…To discover structurally novel and antibiotic metabolites, we screened the in-house marine fungus genome library and found a fungus Stephanonectria keithii LZD-10-1 containing a non-ribosomal peptide synthetase (NRPS) cluster with 18 modules to synthesize a new subfamily of peptaibols with effective eradication against MDR pathogens. Targeting isolation of the cultured fungus afforded six new peptaibols, which exhibit the ability to kill MDR bacteria by targeting bacterial membrane phospholipids, especially phosphatidylglycerol (PG), leading to the dysfunction of bacterial membranes. …”
Get full text

Sentinels of neuroinflammation: the crucial role of myeloid cells in the pathogenesis of gliomas and neurodegenerative diseases by Blanca Cómitre-Mariano, Gabriel Vellila-Alonso, Berta Segura-Collar, Lucía Mondéjar-Ruescas, Juan M. Sepulveda, Ricardo Gargini

“…This review aims to elucidate the mechanisms underlying myeloid cell dysfunction and neuroinflammation in two groups of neurological pathologies with significant social impact and a limited efficacy of their treatments: the most common primary brain tumors –gliomas-, and the most prevalent neurodegenerative disorders -Alzheimer’s and Parkinson’s disease. …”
Get full text

PI3Kγ signaling controls trafficking of CD8+ T cells between lymphoid and non-lymphoid organs and drives hypertension in a murine model by Marialuisa Perrotta, Sara Perrotta, Lorenzo Carnevale, Agnese Migliaccio, Fabio Pallante, Ryszard Nosalski, Tomasz J. Guzik, Stefania Fardella, Emilio Hirsch, Valentina Fardella, Azzurra Zonfrilli, Jacopo Pacella, Matthias P. Wymann, Giuseppe Lembo, Daniela Carnevale

“…Lastly, an enhanced PI3Kγ signaling mediates the bystander activation of CD8+ T cells and proves effective in transferring the hypertensive phenotype between mice.…”
Get full text

Enteroviral Transverse Myelitis Presenting as Acute Ataxia in Children: A Case Series by Luka Švitek, Dominik Ljubas, Nina Krajcar, Maja Vrdoljak Pažur, Ana Tripalo Batoš, Irena Tabain, Srđan Roglić, Lorna Stemberger Marić

“…TM is a syndrome characterized by acute or subacute spinal cord dysfunction, leading to neurological deficits below the level of the lesion. …”
Get full text

Hematological Changes Provoked by Natural Alkaloids by Olubayode Bamidele, Abigail Oluwatomisin Popoola, Lawrence Dayo Adedayo, Funmilola Adelowo, David Inaolaji, Dennis Seyi Arokoyo

“…These alterations might be useful or deleterious depending on the alkaloid and its concentration. Understanding these effects is essential for the safe and effective use of plant-based therapies.…”
Get full text

A CASE OF THE «BERLIN HEART EXCOR» BIVENTRICULAR ASSIST DEVICE IMPLANTATION AS A BRIDGE TO HEART TRANSPLANTATION FOR A PATIENT WITH DILATED CARDIOMYOPATHY AND TERMINAL HEART FAILUR... by D. S. Khvan, A. M. Chernyavsky, V. U. Efendiev, D. A. Sirota, D. V. Doronin, A. V. Fomichev, M. G. Galstyan, M. O. Zhulkov

“…Patients with terminal heart failure, refractory to drug therapy, are severe category of cardiology. The possibility of effective correction of multi-organ failure and an increase in the life-time of patients with critical cardiac insuffi ciency has been proved with the use of biventricular assist device (BiVAD). …”
Get full text