Ferrostatin-1 improves acute sepsis-induced cardiomyopathy via inhibiting neutrophil infiltration through impaired chemokine axis by Jialin Li, Jialin Li, Fang Xiao, Fang Xiao, Bingsen Lin, Bingsen Lin, Zhilei Huang, Mingyue Wu, Huan Ma, Ruoxu Dou, Xiaodong Song, Zhongxing Wang, Changjie Cai, Xiangdong Guan, Jie Xu, Jie Xu, Fu-Li Xiang, Fu-Li Xiang

“…However, the effects of Fer-1 in cardiac dysfunction in the early stages of cecal ligation and puncture (CLP) induced sepsis remains unclear. …”
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Garlic-Derived Exosome-Like Nanovesicles: A Promising Natural Nanotherapy for Periodontitis via PHGDH/PI3K/AKT-Mediated Metabolic and Inflammatory Regulation by Yu C, Liu Y, Yu X, Liu J, Cao P, Liu G, Cai Y, Zhang Y, Luan Q

“…Garlic-derived exosome-like nanovesicles (GaELNs), as a natural therapeutic agent, have demonstrated significant therapeutic effects in conditions such as colitis, liver dysfunction, osteoarthritis, and adipose tissue inflammation, yet their potential in treating periodontitis has not been explored.Methods: In this study, GaELNs were extracted using a simplified and rapid method and characterized for their morphology and concentration. …”
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Mirabegron induces selective changes in the faecal microbiota of HFHFr rats without altering bile acid composition by Roger Bentanachs, Roger Bentanachs, Lluïsa Miró, Lluïsa Miró, Patricia Ramírez-Carrasco, Rosa M. Sánchez, Rosa M. Sánchez, Rosa M. Sánchez, Manuel Bernabeu, Concepció Amat, Concepció Amat, Marta Alegret, Marta Alegret, Marta Alegret, Anna Pérez-Bosque, Anna Pérez-Bosque, Núria Roglans, Núria Roglans, Núria Roglans, Juan C. Laguna, Juan C. Laguna, Juan C. Laguna

“…IntroductionMetabolic dysfunction-associated steatotic liver (MASL), the initial, asymptomatic stage of the metabolic dysfunction-associated steatotic liver disease, is directly involved in the progression to steatohepatitis. …”
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Wharton’s jelly-derived mesenchymal stem cells ameliorate high altitude-induced heart injury by promoting type 2 macrophage polarization via COX2-PGE2 pathway by Wenhong Zhang, Wenhong Zhang, Li Zhao, Jing Cui, Jing Cui, Yan Zhang, Dongtao Li, Zhibo Hong, Jiamin Liu, Shan Wang, Ningkun Zhang, Yang Li, Yu Chen, Yu Chen

“…However, few studies have focused on the cardioprotective effects of WJMSCs against HAHI (high-altitude-induced heart injury, HAHI). …”
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Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression by Cuilin Zhu, Cuilin Zhu, Qing Liu, Yale Su, Yale Su, Yixin Zhang, Yixin Zhang, Aanal Patel, Adam Greasley, Jifu Jiang, Douglas Quan, Douglas Quan, Douglas Quan, Weiping Min, Weiping Min, Weiping Min, Weiping Min, Weiping Min, Kexiang Liu, Xiufen Zheng, Xiufen Zheng, Xiufen Zheng, Xiufen Zheng, Xiufen Zheng, Xiufen Zheng

“…BackgroundRenal failure and dysfunction remain one of the most significant morbidities impacting patient’s life. …”
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Systemic inflammation and metabolic syndrome components in threshold/subthreshold posttraumatic stress disorder and food addiction in a Polish community sample by Monika M. Stojek, Marta Łukowska, Jagoda Różycka, Maryla Sokołowska, Joanna Zielińska, Ari Nowacki, Roksana Duszkiewicz, Anna Psurek, Vasiliki Michopoulos

“…It is unclear whether addictive-like eating patterns contribute to the metabolic dysfunction in PTSD.Objective: We examined the relative contributions of PTSD, FA, and sex – as well as their interactive effects – to the systemic inflammation (CRP) and metabolic syndrome components (MetS: waist circumference, glucose, triglycerides, HDL cholesterol, insulin) in a general population of the Upper Silesia region in Poland.Method: N = 187 participants (52.7% women) completed Yale Food Addiction Scale 2.0 (FA symptoms count), Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) semi-structured interview (PTSD or other trauma and stressor-related disorder (OTSR) diagnosis presence), anthropometric assessment, and phlebotomy in a fasted state.Results: A series of hierarchical linear regressions indicated that greater number of FA symptoms had a significant effect on greater waist circumference, while PTSD/OTSR diagnosis had a significant effect on higher insulin levels. …”
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Widespread pain syndrome in long COVID-19: melatonin as an adjuvant treatment by Amine Souissi, Pablo Prieto-González, Helmi Ben Saad

“…Melatonin targets shared pathological pathways, offering a promising approach to reducing inflammation, oxidative stress, and neuroendocrine dysfunction. The present mini-review explores the therapeutic potential of melatonin in the treatment of LC19, focusing on its effects on WPS and inflammation.…”
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Forceps minor control of social behaviour by Franziska Stoller, Eleanor Hinds, Tudor Ionescu, Elmira Khatamsaz, Hugh M. Marston, Bastian Hengerer

“…This study provides direct evidence for a causal relationship between DMN integrity and social dysfunction, with potential implications for developing targeted treatments in precision psychiatry.…”
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Carthami flos regulates gastrointestinal motility functions by Iksung Kim, Jinsoo Bae, Byung Joo Kim

“…This investigation studied the effects of Carthami flos (CF), a natural product, on GI motility. …”
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Anti-Inflammatory Properties of Sirtuin 6 in Human Umbilical Vein Endothelial Cells by Martha Lappas

“…A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with endothelial dysfunction include proinflammatory cytokines, adhesion molecules, and matrix degrading enzymes. …”
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Porphyromonas gingivalis Induces Apoptosis and Autophagy via ER Stress in Human Umbilical Vein Endothelial Cells by Masaaki Hirasawa, Tomoko Kurita-Ochiai

“…To determine how periodontal infections contribute to endothelial dysfunction, we examined the effect of Porphyromonas gingivalis on human umbilical vein endothelial cells (HUVEC). …”
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A Preliminary Study on the Use of Haptic Feedback to Assist Users with Impaired Arm Coordination During Mouse Interactions by N. G. Tsagarakis, D. G. Caldwell

“…Physical movement impairments caused by central nervous system dysfunction or by muscle spasms generated from other neurological damage or dysfunction can often make it difficult or impossible for affected individuals to interact with computer generated environments using the conventional mouse interfaces. …”
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Paraneoplastic acral vascular syndrome in a patient with advanced oropharyngeal squamous cell carcinoma; case report and literature review by Ancuța Năstac, Lucian Negreanu, Alexandru Constantinescu, Octavian Andronic, Andreea Dobromirescu

“…This form of digital ischemia likely stems from endothelial dysfunction and prothrombotic effects induced by the tumor through a paraneoplastic mechanism. …”
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Dendritic cells in multiple myeloma: from immune evasion to therapeutic potential by Melanie Andrea Jordan, Johannes Morschl, Stella E. Autenrieth

“…Extensive evidence indicates that in the presence of myeloma cells, DC numbers are notably reduced, and their phenotype and function are altered, impairing their ability to present antigens and activate robust T-cell responses effectively. Despite rapid advances in MM treatment, with promising strategies such as DC-based vaccines being already achieved, DC dysfunction remains a substantial hurdle, associated with or contributing to poor therapeutic outcomes, disease relapse, and MM’s persistence as an incurable disease. …”
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Lactate metabolism and lactylation in kidney diseases: insights into mechanisms and therapeutic opportunities by Yuhua Cheng, Linjuan Guo

“…The lactate-lactylation axis is central to the Warburg effect in ccRCC, where tumor cells preferentially rely on glycolysis rather than oxidative phosphorylation. …”
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The Impact of Churg–Strauss Syndrome on Nasal Function and Quality of Life: An Underexplored Dimension by Luca Galassi, Federica Facchinetti

“…Early diagnosis and intervention are essential to mitigate these effects and improve patient outcomes. A multidisciplinary approach that combines pharmacological treatment, surgical options, and psychosocial support is critical to managing both the physical and emotional challenges of nasal dysfunction in EGPA. …”
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Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics by Yanghanzhao Wang, Hao Zhang, Changhong Miao

“…Furthermore, in old sepsis patients, the synergistic effects of both sepsis and aging may cause immunosenescence-associated alterations more significantly, resulting in more severe immune dysfunction and a worse prognosis. …”
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Mitochondrial Contribution to Parkinson's Disease Pathogenesis by Anthony H. V. Schapira, Matthew Gegg

“…Several genetic causes are now known to induce loss of dopaminergic cells and parkinsonism, and study of the mechanisms by which these mutations produce this effect has provided important insights into the pathogenesis of PD and confirmed mitochondrial dysfunction and oxidative stress pathways as central to PD pathogenesis. …”
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Honokiol Protected against Heatstroke-Induced Oxidative Stress and Inflammation in Diabetic Rats by Chuan-Chih Hsu, Li-Fan Chen, Mao-Tsun Lin, Yu-Feng Tian

“…We aimed at investigating the effect of honokiol on heatstroke in an experimental rat model. …”
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Systemic organoprotection with inhaled nitric oxide (literature review) by I. A. Mandel, A. G. Yavorovsky, M. A. Vyzhigina, P. V. Nogtev, E. Yu. Khalikova, D. S. Kozlova, A. V. Bayrashevskaya, K. A. Temirova, T. A. Demura, E. N. Zolotova

“…This review describes possible ways of implementing the organоprotective effect of NO, however, the exact mechanism remains not fully understood. …”
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